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1. 发明授权

US07256287B2 Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation 失效
标题翻译：用于调节IgE并抑制细胞增殖的苯基 - 氮杂 - 苯并咪唑化合物
公开(公告)号：US07256287B2
公开(公告)日：2007-08-14
申请号：US10661296
申请日：2003-09-12
申请人： Jagadish C. Sircar , Richard J. Thomas , Mark L. Richards , Anjana Sinha
发明人： Jagadish C. Sircar , Richard J. Thomas , Mark L. Richards , Anjana Sinha
IPC分类号： C07D237/26 , C07D237/28 , C07D239/00 , C07D257/08 , C07D251/00
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-aza-benzimidazole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. This invention further relates to small molecules which suppress cytokines and leukocytes.
摘要翻译：本发明涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE致病的任何疾病。本发明还涉及作为细胞增殖抑制剂的苯基 - 氮杂 - 苯并咪唑分子，因此可用作抗癌剂。本发明还涉及抑制细胞因子和白细胞的小分子。

2. 发明授权

US06911462B2 Benzimidazole compounds for regulating IgE 失效
公开(公告)号：US06911462B2
公开(公告)日：2005-06-28
申请号：US10103258
申请日：2002-03-20
申请人： Jagadish C. Sircar , Mark L. Richards , Michael G. Campbell , Michael W. Major
发明人： Jagadish C. Sircar , Mark L. Richards , Michael G. Campbell , Michael W. Major
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/4439 , A61K31/4545 , A61K45/06 , C07D235/02 , C07D235/18 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , A61K31/44 , C07D401/12 , C07D403/12
CPC分类号： A61K45/06 , A61K31/415 , A61K31/4184 , A61K31/4439 , A61K31/4545 , C07D235/02 , C07D235/18 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , A61K2300/00
摘要： This invention relates to a family of phenylbenzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.

3. 发明授权

US06919366B2 Benzimidazole derivatives as modulators of IgE 失效
标题翻译：苯并咪唑衍生物作为IgE的调节剂
公开(公告)号：US06919366B2
公开(公告)日：2005-07-19
申请号：US09983054
申请日：2001-10-16
申请人： Jagadish C. Sircar , Mark L. Richards , Michael G. Campbell , Michael W. Major
发明人： Jagadish C. Sircar , Mark L. Richards , Michael G. Campbell , Michael W. Major
IPC分类号： A61K31/00 , A61K31/415 , A61K31/4184 , A61K31/4545 , A61K45/06 , A61K31/423
CPC分类号： A61K31/415 , A61K31/00 , A61K31/4184 , A61K31/4545 , A61K45/06 , A61K2300/00
摘要： This invention relates to a family of benzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy, asthma, or any diseases where IgE is pathogenic.
摘要翻译：本发明涉及苯并咪唑类似物家族，其是对变应原的IgE应答的抑制剂。这些化合物可用于治疗过敏，哮喘或IgE致病的任何疾病。

4. 发明申请

US20090266720A1 System for Protecting Objects from Reactive Atmospheric Gases 审中-公开
标题翻译：保护物体免受反应性大气气体的影响
公开(公告)号：US20090266720A1
公开(公告)日：2009-10-29
申请号：US12108417
申请日：2008-04-23
申请人： Mark L. Richards
发明人： Mark L. Richards
IPC分类号： B65D81/20 , F17C5/00 , B65B31/02
CPC分类号： B65B31/06 , B65D81/2023 , B65D81/2061 , B65D81/2084 , B65D81/266
摘要： A method and device for protecting rope (the term “rope” meaning herein a traditional rope or any other item that would be degraded by contact with oxygen) from reactive atmospheric gases, the basic method comprising introducing a gas having a greater molecular weight than does oxygen, O2, termed a “heavy gas,” into a container having a low permeability to gas. Preferably, the heavy gas is an inert gas; and, most preferably, the heavy gas is argon. Also preferably, after introduction of the heavy gas, the heavy gas is removed, creating a vacuum within the container; and, most preferably the process of introduction and removal is repeated two times. Optionally, argon can be reintroduced into the container prior to sealing of the container. The device for protecting rope is, logically, the container and its contents resulting from the process just described.
摘要翻译：一种用于保护绳索的方法和装置（术语“绳索”是指传统绳索或任何其它可能与氧气接触而降解的物品）来自活性大气气体的方法和装置，所述基本方法包括引入分子量大于称为“重气体”的氧气O 2放入具有低气体渗透性的容器中。优选地，重质气体是惰性气体; 并且最优选地，重质气体是氩气。还优选地，在引入重质气体之后，去除重质气体，在容器内产生真空; 并且最优选将引入和去除的过程重复两次。任选地，在密封容器之前可以将氩气重新引入容器中。用于保护绳索的装置在逻辑上是由刚刚描述的过程产生的容器及其内容物。

5. 发明授权

US07375118B2 Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation 失效
标题翻译：用于调节IgE和抑制细胞增殖的苯基吲哚化合物
公开(公告)号：US07375118B2
公开(公告)日：2008-05-20
申请号：US10661139
申请日：2003-09-12
申请人： Jagadish C. Sircar , Jailall Ramnauth , Mark L. Richards
发明人： Jagadish C. Sircar , Jailall Ramnauth , Mark L. Richards
IPC分类号： A61K31/44 , A61K31/404 , C07D209/04 , C07D401/12
CPC分类号： C07D209/18 , A61K31/404 , A61K45/06 , C07D209/10 , C07D209/14 , A61K2300/00
摘要： The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-indole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. This invention further relates to small molecules which suppress cytokines and leukocytes.
摘要翻译：本发明涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE致病的任何疾病。本发明还涉及作为细胞增殖抑制剂的苯基 - 吲哚分子，因此可用作抗癌剂。本发明还涉及抑制细胞因子和白细胞的小分子。

6. 发明授权

US06759425B2 Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation 失效
标题翻译：用于调节IgE和抑制细胞增殖的苯并咪唑化合物
公开(公告)号：US06759425B2
公开(公告)日：2004-07-06
申请号：US10090044
申请日：2002-02-27
申请人： Jagadish C. Sircar , Mark L. Richards
发明人： Jagadish C. Sircar , Mark L. Richards
IPC分类号： A61K31415
CPC分类号： C07D401/12 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K45/06 , C07D235/18 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , A61K2300/00
摘要： The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to benzimidazole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents.
摘要翻译：本发明涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE致病的任何疾病。本发明还涉及作为细胞增殖抑制剂的苯并咪唑分子，因此可用作抗癌剂。

7. 发明授权

US06303645B1 Benzimidazole derivatives as modulators of IgE 失效
标题翻译：苯并咪唑衍生物作为IgE的调节剂
公开(公告)号：US06303645B1
公开(公告)日：2001-10-16
申请号：US09422397
申请日：1999-10-21
申请人： Jagadish C. Sircar , Mark L. Richards , Michael G. Campbell , Michael W. Major
发明人： Jagadish C. Sircar , Mark L. Richards , Michael G. Campbell , Michael W. Major
IPC分类号： A61K31415
CPC分类号： A61K31/00 , A61K31/415 , A61K31/4184 , A61K31/4545 , A61K45/06 , A61K2300/00
摘要： This invention relates to a family of diacyl benzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.
摘要翻译：本发明涉及二酰基苯并咪唑类似物家族，其是对变应原的IgE应答的抑制剂。这些化合物可用于治疗过敏和/或哮喘或任何IgE致病的疾病。

8. 发明授权

US5653455A Skiing sled and harness 失效
标题翻译：滑雪雪橇和线束
公开(公告)号：US5653455A
公开(公告)日：1997-08-05
申请号：US330364
申请日：1994-10-27
申请人： Mark L. Richards
发明人： Mark L. Richards
IPC分类号： B62B5/06 , B62B13/02
CPC分类号： B62B13/02 , B62B5/068
摘要： A sled to be pulled over snow by a skier, a snow shoer, or the like, with a waist attached, rigid towing member harness and a duffel container carried upon the sled. The sled has a plastic shell body with bottom runners designed to cause the sled to accurately follow the path of the skier.
摘要翻译：雪橇由滑雪者，雪橇等拉过雪，腰部连接着，刚性牵引构件线束和载重在雪橇上的行李箱。雪橇有一个塑料壳体，底部跑道设计用于使雪橇准确地跟随滑雪者的路径。

9. 发明授权

US06271390B1 Suppression of the IgE-dependent allergic response by benzimidazole analogs 失效
标题翻译：通过苯并咪唑类似物抑制IgE依赖性过敏反应
公开(公告)号：US06271390B1
公开(公告)日：2001-08-07
申请号：US09316870
申请日：1999-05-21
申请人： Jagadish C. Sircar , Mark L. Richards , Michael G. Campbell , Michael W. Major
发明人： Jagadish C. Sircar , Mark L. Richards , Michael G. Campbell , Michael W. Major
IPC分类号： B07D23518
CPC分类号： A61K31/415 , A61K31/00 , A61K31/4184 , A61K31/4545 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to small molecule inhibitors of the IgE response to allergens which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.
摘要翻译：本发明涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗变态反应和/或哮喘或IgE是致病性的任何疾病。

10. 发明授权

US07813735B2 Method and apparatus for performing a power efficient cell search in a multi-cell wireless communication system 有权
标题翻译：用于在多小区无线通信系统中执行功率有效的小区搜索的方法和装置
公开(公告)号：US07813735B2
公开(公告)日：2010-10-12
申请号：US11688286
申请日：2007-03-20
申请人： Frederic Monfet , Alpaslan Demir , Mark L. Richards
发明人： Frederic Monfet , Alpaslan Demir , Mark L. Richards
IPC分类号： H04W4/00
CPC分类号： H04B1/7083 , H04B1/70735 , H04B2201/70707
摘要： A method and apparatus for performing a power efficient cell search in a multi-cell wireless communication system are disclosed. A wireless transmit/receive unit (WTRU) having a memory that stores a cell identification list of prioritized previously top-ranked cell identities (IDs) is used to perform the cell search. A primary synchronization code (PSC) correlation peak location on a received signal is selected. A common pilot channel (CPICH) correlation value is determined by non-coherent integration of a local signal created based on a first cell ID on the cell identification list to the received signal. If the CPICH correlation value is greater than a noise threshold, thus indicating that the first cell ID is a newly found cell ID, or if a last cell ID in the cell identification list is reached, an additional determination is made as to whether there is more than one cell ID on the list having the same timing.
摘要翻译：公开了一种用于在多小区无线通信系统中执行功率有效的小区搜索的方法和装置。具有存储器的存储器的无线发送/接收单元（WTRU）被用于执行小区搜索，所述存储器存储优先排序的先前排名最广的小区标识（ID）的小区标识列表。选择接收信号上的主同步码（PSC）相关峰位置。公共导频信道（CPICH）相关值通过基于小区识别列表上基于第一小区ID创建的本地信号与接收信号的非相干积分来确定。如果CPICH相关值大于噪声阈值，则表示第一小区ID是新发现的小区ID，或者如果到达小区识别列表中的最后一个小区ID，则进一步确定是否存在列表上的多个单元格ID具有相同的时序。

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