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1. 发明申请

US20090281353A1 Use of dimethyl disulfide for methionine production in microoragnisms 有权
标题翻译：二甲基二硫化物用于微生物中的甲硫氨酸生产
公开(公告)号：US20090281353A1
公开(公告)日：2009-11-12
申请号：US11988971
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
发明人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
IPC分类号： C12P13/12 , C07C323/03 , C12N1/21 , C12N15/31 , C12Q1/68 , C12N9/00
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，DeltametF生物体或DeltametE AmetH生物体，例如谷氨酸棒状杆菌或大肠杆菌的突变体可以使用甲基封端的硫化物源，例如二甲基二硫醚（DMDS）作为硫和甲基，绕过MetH / MetE和MetF活性的需要，需要还原硫酸盐，用于合成甲硫氨酸。该专利中还描述的是涉及MetY（也称为MetZ）作为将甲基封端的硫化物源例如DMDS掺入甲硫氨酸的酶的数据。谷氨酸棒状病毒的DeltametF DeltametB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基两者的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过量产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

2. 发明授权

US08399214B2 Use of dimethyl disulfide for methionine production in microoraganisms 有权
标题翻译：用二甲基二硫化物在微生物激素中生产甲硫氨酸
公开(公告)号：US08399214B2
公开(公告)日：2013-03-19
申请号：US11988971
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
发明人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
IPC分类号： C12P1/00
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，一种有机蛋白（MetF）生物体或一种具有谷氨酸棒状杆菌或大肠杆菌的突变体的MetE生物体可以使用例如二甲基二硫醚（DMDS）的甲基封端硫化物源作为硫和甲基，绕过MetH / MetE和MetF活性的需要，需要还原硫酸盐，用于合成甲硫氨酸。该专利中还描述的是涉及MetY（也称为MetZ）作为将甲基封端的硫化物源例如DMDS掺入甲硫氨酸的酶的数据。 A＆Dgr; metF＆Dgr;谷氨酸棒杆菌的metB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过量产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

3. 发明授权

US5651652A Breakaway tamperproof fastener 失效
标题翻译：防爆防拆扣
公开(公告)号：US5651652A
公开(公告)日：1997-07-29
申请号：US715786
申请日：1996-09-19
申请人： David J. Williams , Mark K. Williams
发明人： David J. Williams , Mark K. Williams
IPC分类号： B65D55/06 , F16B19/00
CPC分类号： B65D55/06 , Y10S411/908 , Y10S411/913
摘要： An elongate fastener that may not be removed without destruction is provided for insertion in adjacent cooperating holes defined in box structures and their closure elements to maintain closure. The fastener defines a head, larger than the hole to carry the fastener, that structurally carries a peripherally extending tab to aid manual manipulation. The head structurally connects an elongate perpendicularly extending body that fits in the cooperating holes and is formed by spaced peripheral webs that carry barb-like fasteners in their end portions distal from the head that allow insertion of the body through a hole by deformation, but thereafter expand responsive to retentent memory to prevent removal. The interconnection of the body and head is weaker in tensile strength than the material on either side of the interconnection so that the head may be removed from the body by manual manipulation of the peripheral tab, without the use of tools, to allow opening of the box structure.
摘要翻译：提供可以不被破坏而被移除的细长紧固件，用于插入在盒结构及其闭合元件中限定的相邻配合孔中以保持封闭。紧固件限定了一个头部，大于该孔以承载紧固件，其结构上携带有外围延伸的接片以辅助手动操作。头部结构上连接细长的垂直延伸的主体，其配合在协作孔中，并且由间隔开的周边腹板形成，所述周边腹板在远离头部的端部中承载倒钩形紧固件，允许身体通过变形插入孔，但此后扩展响应于保持内存以防止删除。身体和头部的互连的拉伸强度弱于互连任一侧上的材料，使得头部可以通过手动操纵周边突片而从身体移除，而不使用工具，以允许打开盒结构。

4. 外观设计

USD417062S Apron for order pickers 失效
公开(公告)号：USD417062S
公开(公告)日：1999-11-30
申请号：US102311
申请日：1999-03-22
申请人： Mark K. Williams
设计人： Mark K. Williams

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