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1. 发明申请

US20120049568A1 System For Securing a Truck Bed Cover 失效
标题翻译：用于固定卡车底盖的系统
公开(公告)号：US20120049568A1
公开(公告)日：2012-03-01
申请号：US12872924
申请日：2010-08-31
申请人： Mark A. Wolf , Robert A. Wolf
发明人： Mark A. Wolf , Robert A. Wolf
IPC分类号： B60P7/04
CPC分类号： B60J7/10
摘要： A system for securing a truck bed cover includes a pair of vertical side rails clamped to the bed railing of a pickup truck. A first one of a pair of horizontal side rails is attached along the front side of the truck bed and the second one of the pair of horizontal side rails is attachable via a latching mechanism along the rear. The cover is attached along respective front and rear edges to each of the horizontal side rails, and is attachable along respective side edges to the vertical side rails, preferably, using a hook-and-loop fastener. Tensioning devices are employed to keep the cover taut and even on both sides.
摘要翻译：用于固定卡车厢盖的系统包括一对夹在皮卡车的床栏杆上的垂直侧轨。一对水平侧轨道中的第一个沿着卡车车厢的前侧安装，一对水平侧轨道中的第二个可沿着后部经由一个闩锁机构固定。盖子沿着相应的前后边缘连接到每个水平侧轨道，并且可以沿着相应的侧边缘附接到垂直侧轨道，优选地使用钩环紧固件。张紧装置用于保持盖子紧紧并且甚至两侧。

2. 发明申请

US20110312931A1 GLYCINE TRANSPORTER-1 INHIBITORS, METHODS OF MAKING THEM, AND USES THEREOF 有权
标题翻译：甘氨酸转运蛋白-1抑制剂，其制备方法及其用途
公开(公告)号：US20110312931A1
公开(公告)日：2011-12-22
申请号：US13151992
申请日：2011-06-02
申请人： Christopher L. CIOFFI , Mark A. WOLF , Peter R. GUZZO , Shuang LIU , Kashinath SADALAPURE , Visweswaran PARTHASARATHY , Jun-Ho MAENG
发明人： Christopher L. CIOFFI , Mark A. WOLF , Peter R. GUZZO , Shuang LIU , Kashinath SADALAPURE , Visweswaran PARTHASARATHY , Jun-Ho MAENG
IPC分类号： A61K31/496 , C07D403/12 , C07D401/04 , C07D405/04 , C07D405/14 , C07D401/12 , C07D487/08 , A61K31/495 , A61K31/454 , A61K31/4995 , A61P25/18 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/24 , A61P3/10 , A61P3/04 , A61P3/00 , A61P25/04 , A61P25/30 , A61P25/34 , A61P25/08 , A61P25/14 , A61P25/06 , A61P27/02 , C07D295/26
CPC分类号： C07D295/26 , C07D205/04 , C07D207/48 , C07D211/58 , C07D213/71 , C07D233/84 , C07D241/04 , C07D249/04 , C07D309/14 , C07D313/04 , C07D405/12 , C07D487/08
摘要： The compounds of the present invention are represented by the following formula (I): wherein the substituents R1, R2, R3, R4, (R5)m, R6, A, X, and Y are as defined herein. The compounds are useful in methods of treating a disorder which is created by or is dependent upon inhibiting GlyT-1.
摘要翻译：本发明的化合物由下式（I）表示：其中取代基R 1，R 2，R 3，R 4，（R 5）m，R 6，A，X和Y如本文所定义。该化合物可用于治疗由抑制GlyT-1产生或依赖于其的依赖性疾病的方法。

3. 发明申请

US20110224156A1 Propionic Acids, Propionic Acid Esters, and Related Compounds 有权
标题翻译：丙酸，丙酸酯和相关化合物
公开(公告)号：US20110224156A1
公开(公告)日：2011-09-15
申请号：US13042657
申请日：2011-03-08
申请人： Mark A. Wolf , Keith D. Barnes
发明人： Mark A. Wolf , Keith D. Barnes
IPC分类号： A61K31/7024 , A61P25/18 , C07C323/52 , C07C327/34 , C07D241/08 , C07C271/20 , C07D213/56 , C07H15/04 , A61K31/70 , A61K31/198 , A61K31/225 , A61K31/215 , A61K31/4965 , A61K31/27 , A61K31/44 , A61K31/422 , C07D413/12 , A61K31/426 , C07D277/06
CPC分类号： C07D241/08 , C07C323/58 , C07C323/59 , C07C327/22 , C07D213/56 , C07D263/44 , C07D277/06 , C07D413/12 , C07H13/12
摘要： The invention relates to propionic acids, propionic acid esters, and related compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of Central Nervous System (CNS).
摘要翻译：本发明涉及丙酸，丙酸酯和相关化合物，含有这些化合物的药物组合物，以及使用这些化合物治疗各种疾病或病症的方法，包括但不限于中枢神经系统的疾病和/或病症（CNS）。

4. 发明授权

US07608627B2 6-azaindole compound 失效
标题翻译： 6-氮杂吲哚化合物
公开(公告)号：US07608627B2
公开(公告)日：2009-10-27
申请号：US11547308
申请日：2005-04-04
申请人： Yoshiaki Horiguchi , Hiroshi Imoto , Mark A. Wolf
发明人： Yoshiaki Horiguchi , Hiroshi Imoto , Mark A. Wolf
IPC分类号： A61K31/407 , A61P3/10 , A61P37/06 , C07D471/04
CPC分类号： C07D471/04
摘要： A compound represented by the formula wherein R1, R2, R3 and R6 are the same or different and each is a hydrogen atom or a substituent; one of R4 and R5 is a hydrogen atom and the other is a group represented by the formula: —C(═X)—R7 wherein X is N—O—R8 or N—NH—R9 wherein R8 and R9 are the same or different and each is a hydrogen atom or a group bonded via a carbon atom; and R7 is a hydrogen atom or a substituent, and the like and a salt thereof have a superior IκB kinase inhibitory activity, and useful as pharmaceutical agents such as agents for preventing or treating diabetes and the like.
摘要翻译：由下式表示的化合物，其中R 1，R 2，R 3和R 6相同或不同，各自为氢原子或取代基; R4和R5之一是氢原子，另一个是由下式表示的基团-C（-X）-R7，其中X是NO-R8或N-NH-R9，其中R8和R9相同或不同，各自为氢原子或通过碳原子键合的基团; 和R7是氢原子或取代基等，其盐具有优异的IkappaB激酶抑制活性，可用作药物，例如用于预防或治疗糖尿病的药物等。

5. 发明申请

US20080064715A1 6-Azaindole Compound 失效
标题翻译： 6-Azaindole化合物
公开(公告)号：US20080064715A1
公开(公告)日：2008-03-13
申请号：US11547308
申请日：2005-04-04
申请人： Yoshiaki Horiguchi , Hiroshi Imoto , Mark A. Wolf
发明人： Yoshiaki Horiguchi , Hiroshi Imoto , Mark A. Wolf
IPC分类号： A61K31/407 , A61P3/10 , A61P37/06 , C07D471/04
CPC分类号： C07D471/04
摘要： A compound represented by the formula wherein R1, R2, R3 and R6 are the same or different and each is a hydrogen atom or a substituent; one of R4 and R5 is a hydrogen atom and the other is a group represented by the formula: —C(═X)—R7 wherein X is N—O—R8 or N—NH—R9 wherein R8 and R9 are the same or different and each is a hydrogen atom or a group bonded via a carbon atom; and R7 is a hydrogen atom or a substituent, and the like and a salt thereof have a superior IκB kinase inhibitory activity, and useful as pharmaceutical agents such as agents for preventing or treating diabetes and the like.
摘要翻译：由下式表示的化合物其中R 1，R 2，R 3和R 6是相同或不同的各自为氢原子或取代基; R 4和R 5之一是氢原子，另一个是由下式表示的基团-C（-X）-R 7， SUP>其中X是NOR 8或N-NH-R 9，其中R 8和R 9是相同或不同，各自为氢原子或通过碳原子键合的基团; R 7是氢原子或取代基等，其盐具有优异的IkappaB激酶抑制活性，可用作糖尿病等的预防或治疗剂等药剂。

6. 发明授权

US09045445B2 Glycine transporter-1 inhibitors, methods of making them, and uses thereof 有权
标题翻译：甘氨酸转运蛋白-1抑制剂，其制备方法及其应用
公开(公告)号：US09045445B2
公开(公告)日：2015-06-02
申请号：US13151992
申请日：2011-06-02
申请人： Christopher L. Cioffi , Mark A. Wolf , Peter R. Guzzo , Shuang Liu , Kashinath Sadalapure
发明人： Christopher L. Cioffi , Mark A. Wolf , Peter R. Guzzo , Shuang Liu , Kashinath Sadalapure
IPC分类号： A61K31/496 , C07D403/12 , C07D295/26 , C07D205/04 , C07D207/48 , C07D211/58 , C07D213/71 , C07D233/84 , C07D241/04 , C07D249/04 , C07D309/14 , C07D313/04 , C07D405/12 , C07D487/08
CPC分类号： C07D295/26 , C07D205/04 , C07D207/48 , C07D211/58 , C07D213/71 , C07D233/84 , C07D241/04 , C07D249/04 , C07D309/14 , C07D313/04 , C07D405/12 , C07D487/08
摘要： The compounds of the present invention are represented by the following formula (I): wherein the substituents R1, R2, R3, R4, (R5)m, R6, A, X, and Y are as defined herein. The compounds are useful in methods of treating a disorder which is created by or is dependent upon inhibiting GlyT-1.
摘要翻译：本发明的化合物由下式（I）表示：其中取代基R 1，R 2，R 3，R 4，（R 5）m，R 6，A，X和Y如本文所定义。该化合物可用于治疗由抑制GlyT-1产生或依赖于其的依赖性疾病的方法。

7. 发明授权

US08815905B2 Propionic acids, propionic acid esters, and related compounds 有权
标题翻译：丙酸，丙酸酯和相关化合物
公开(公告)号：US08815905B2
公开(公告)日：2014-08-26
申请号：US13042657
申请日：2011-03-08
申请人： Mark A. Wolf , Keith D. Barnes
发明人： Mark A. Wolf , Keith D. Barnes
IPC分类号： A61K31/4406 , A61P25/18 , A61P25/30 , C07D211/80 , C07D401/12 , C07D403/12 , C07C323/52 , C07C327/34 , C07C271/20 , C07D241/08 , C07D213/56 , C07D413/12 , C07D277/06 , A61K31/7024 , A61K31/198 , A61K31/422 , A61K31/426
CPC分类号： C07D241/08 , C07C323/58 , C07C323/59 , C07C327/22 , C07D213/56 , C07D263/44 , C07D277/06 , C07D413/12 , C07H13/12
摘要： The invention relates to propionic acids, propionic acid esters, and related compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of Central Nervous System (CNS).
摘要翻译：本发明涉及丙酸，丙酸酯和相关化合物，含有这些化合物的药物组合物，以及使用这些化合物治疗各种疾病或病症的方法，包括但不限于中枢神经系统的疾病和/或病症（CNS）。

8. 发明申请

US20080119502A1 VINCA DERIVATIVES 失效
公开(公告)号：US20080119502A1
公开(公告)日：2008-05-22
申请号：US11854186
申请日：2007-09-12
申请人： Mark A. WOLF , Peter R. GUZZO , Ian L. SCOTT
发明人： Mark A. WOLF , Peter R. GUZZO , Ian L. SCOTT
IPC分类号： A61K31/437 , C07D471/16 , A61P35/00
CPC分类号： C07D519/00
摘要： The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.

9. 发明授权

US08128149B1 System for securing a truck bed cover 失效
标题翻译：用于固定卡车厢盖的系统
公开(公告)号：US08128149B1
公开(公告)日：2012-03-06
申请号：US12872924
申请日：2010-08-31
申请人： Mark A. Wolf , Robert A. Wolf
发明人： Mark A. Wolf , Robert A. Wolf
IPC分类号： B60P7/02
CPC分类号： B60J7/10
摘要： A system for securing a truck bed cover includes a pair of vertical side rails clamped to the bed railing of a pickup truck. A first one of a pair of horizontal side rails is attached along the front side of the truck bed and the second one of the pair of horizontal side rails is attachable via a latching mechanism along the rear. The cover is attached along respective front and rear edges to each of the horizontal side rails, and is attachable along respective side edges to the vertical side rails, preferably, using a hook-and-loop fastener. Tensioning devices are employed to keep the cover taut and even on both sides.
摘要翻译：用于固定卡车厢盖的系统包括一对夹在皮卡车的床栏杆上的垂直侧轨。一对水平侧轨道中的第一个沿着卡车车厢的前侧安装，一对水平侧轨道中的第二个可沿着后部经由一个闩锁机构固定。盖子沿着相应的前后边缘连接到每个水平侧轨道，并且可以沿着相应的侧边缘附接到垂直侧轨道，优选地使用钩环紧固件。张紧装置用于保持盖子紧紧并且甚至两侧。

10. 发明授权

US08039453B2 Vinca derivatives 失效
标题翻译：长春花衍生物
公开(公告)号：US08039453B2
公开(公告)日：2011-10-18
申请号：US11854186
申请日：2007-09-12
申请人： Mark A. Wolf , Peter R. Guzzo , Ian L Scott
发明人： Mark A. Wolf , Peter R. Guzzo , Ian L Scott
IPC分类号： A61K31/33 , C07D487/22
CPC分类号： C07D519/00
摘要： The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.
摘要翻译：本发明涉及长春花生物碱的衍生物。还公开了含有这些化合物的药物组合物以及各种条件的制备和处理方法。

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