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1. 发明授权

US09682991B2 Tricyclic compounds for use as kinase inhibitors 有权
公开(公告)号：US09682991B2
公开(公告)日：2017-06-20
申请号：US13519872
申请日：2010-12-31
申请人： Joaquín Pastor Fernández , Francisco Javier Ramos Lima , Ana Isabel Hernandez Higueras , Sonia Martínez González , Jose Ignacio Martín Hernando , Carl-Gustave Pierre Saluste , Esther Gonzalez Cantalapiedra , Carmen Blanco Aparicio , Antonio Rodríguez Hergueta , Ana Maria Garcia Collazo , Antonio Salgado Serrano , Beatriz Noya Marino
发明人： Joaquín Pastor Fernández , Francisco Javier Ramos Lima , Ana Isabel Hernandez Higueras , Sonia Martínez González , Jose Ignacio Martín Hernando , Carl-Gustave Pierre Saluste , Esther Gonzalez Cantalapiedra , Carmen Blanco Aparicio , Antonio Rodríguez Hergueta , Ana Maria Garcia Collazo , Antonio Salgado Serrano , Beatriz Noya Marino
IPC分类号： C07D491/14 , C07D487/14
CPC分类号： C07D491/14 , C07D487/14
摘要： There is provided compounds of formula (I), wherein R1, R2, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).

2. 发明授权

US09651022B2 Manufacturing method of wind turbine blades of variable length 有权
公开(公告)号：US09651022B2
公开(公告)日：2017-05-16
申请号：US13534685
申请日：2012-06-27
申请人： Ion Arocena De La Rua , Eneko Sanz Pascual , Maria Garcia Fernandez Aviles , Raquel Aguilar Melendez
发明人： Ion Arocena De La Rua , Eneko Sanz Pascual , Maria Garcia Fernandez Aviles , Raquel Aguilar Melendez
IPC分类号： F03D1/06
CPC分类号： F03D1/0675 , F05B2230/601 , F05B2240/302 , F05B2240/313 , Y02E10/721 , Y02P70/523 , Y10T29/49336
摘要： A method of manufacturing wind turbine blades of variable length with connection elements with the rotor hub. The method includes providing and using enlarged manufacturing molds having a common zone of a predetermined length and, at least, an adaptive zone arranged with the length needed for manufacturing the blades with a desired length, particularly the length required for optimizing the annual energy production (AEP) of a predetermined wind turbine model in a predetermined site.

3. 发明授权

US09198664B2 Tissue ligation devices and controls therefor 有权
标题翻译：组织结扎装置及其控制
公开(公告)号：US09198664B2
公开(公告)日：2015-12-01
申请号：US12752873
申请日：2010-04-01
申请人： Gregory W. Fung , Russell A. Seiber , Eduardo Sager , Gary H. Miller , Maria Garcia , Ryan Douglas Helmuth , Arnold M. Escano , Douglas Todd Ellison , William E. Cohn
发明人： Gregory W. Fung , Russell A. Seiber , Eduardo Sager , Gary H. Miller , Maria Garcia , Ryan Douglas Helmuth , Arnold M. Escano , Douglas Todd Ellison , William E. Cohn
IPC分类号： A61B17/04 , A61B17/12 , A61B17/06 , A61B17/00 , A61B17/34 , A61B19/00
CPC分类号： A61B17/12013 , A61B17/0469 , A61B17/0487 , A61B17/06114 , A61B2017/00243 , A61B2017/003 , A61B2017/00331 , A61B2017/00557 , A61B2017/00867 , A61B2017/0475 , A61B2017/0496 , A61B2017/3445 , A61B2090/037 , A61B2090/0811
摘要： Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess-suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.
摘要翻译：这里描述了用于关闭一个或多个组织的装置，以及用于控制这些装置的手柄。通常，这里描述的装置包括圈套环组件，其中圈套环组件包括圈套和缝合线环以及用于控制圈套环组件的手柄。在一些变型中，圈套环组件可以包括保持构件，其可以将缝合线环可释放地连接到圈套。在其他变型中，装置包括一个或多个减小力的缝合线锁，以帮助防止缝合线环从圈套圈组件中无意中脱离。在其他变体中，超缝合管理功能。这里描述的手柄可以被配置为从缝合线环去除多余的缝合线，并且还可以被配置为从缝合环组件释放缝线环。

4. 发明申请

US20130065881A1 Tricyclic Compounds for Use as Kinase Inhibitors 有权
标题翻译：用作激酶抑制剂的三环化合物
公开(公告)号：US20130065881A1
公开(公告)日：2013-03-14
申请号：US13519872
申请日：2010-12-31
申请人： Joaquin Pastor Fernandez , Francisco Javier Ramos Lima , Ana Isabel Hernandez Higueras , Sonia Martinez Gonzalez , Jose Ignacio Martin Hernando , Carl-Gustave Pierre Saluste , Esther Gonzalez Cantalapiedra , Carmen Blanco Aparicio , Antonio Rodriguez Hergueta , Ana Maria Garcia Collazo , Antonio Salgado Serrano , Beatriz Noya Marino
发明人： Joaquin Pastor Fernandez , Francisco Javier Ramos Lima , Ana Isabel Hernandez Higueras , Sonia Martinez Gonzalez , Jose Ignacio Martin Hernando , Carl-Gustave Pierre Saluste , Esther Gonzalez Cantalapiedra , Carmen Blanco Aparicio , Antonio Rodriguez Hergueta , Ana Maria Garcia Collazo , Antonio Salgado Serrano , Beatriz Noya Marino
IPC分类号： C07D498/14 , C07D487/04 , A61K31/5025 , C07D519/00 , A61K31/55 , A61P35/00 , A61P9/00 , A61P37/02 , A61P31/12 , A61P29/00 , A61P3/00 , A61P5/00 , A61P25/00 , A61P11/00 , A61P37/08 , A61P17/06 , A61P19/08 , A61P25/28 , A61P9/10 , A61P3/10 , A61P1/16 , A61K31/5383
CPC分类号： C07D491/14 , C07D487/14
摘要： There is provided compounds of formula (I), wherein R1, R2, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).
摘要翻译：提供式（I）化合物，其中R 1，R 2，R 3和R 4具有在说明书中给出的含义（和哪些化合物任选地如说明书所示取代）和其药学上可接受的酯，酰胺，溶剂化物或其盐，哪些化合物可用于治疗其中期望和/或需要抑制蛋白质或脂质激酶（例如PIM家族激酶，例如PIM-1，PIM-2和/或PIM-3）的疾病，以及特别是在治疗癌症或增殖性疾病方面。还提供了包含式（I）化合物的组合。

5. 发明申请

US20080241677A1 Sealed Terminals For Batteries 审中-公开
标题翻译：电池密封端子
公开(公告)号：US20080241677A1
公开(公告)日：2008-10-02
申请号：US12090259
申请日：2006-11-10
申请人： Jose Maria Garcia Alberola
发明人： Jose Maria Garcia Alberola
IPC分类号： H01M2/02
CPC分类号： H01M2/305 , H01M2/06
摘要： The invention relates to sealed terminals for batteries of the type that are used as connection terminals in the electrical circuitry of a motor vehicle. The inventive terminals comprise an outer truncated-cone-shaped part, an inner part which is equipped with a ring labyrinth and stepped zones which are provided between said two parts. The terminals are characterised by the inclusion of at least one peripheral ring having a lower wall which is perpendicular to the axis of the terminal and having a smaller diameter than the stepped zone.
摘要翻译：本发明涉及用作机动车辆的电路中的连接端子的类型的电池的密封端子。本发明的端子包括外截锥形部分，设置有环形迷宫的内部部分和设置在所述两部分之间的阶梯区域。端子的特征在于包括至少一个具有下壁的外围环，所述下壁垂直于端子的轴线并具有比阶梯区更小的直径。

6. 发明申请

US20080221210A1 Thyroid Receptor Agonists 审中-公开
标题翻译：甲状腺受体激动剂
公开(公告)号：US20080221210A1
公开(公告)日：2008-09-11
申请号：US10593928
申请日：2005-03-22
申请人： Ana Maria Garcia Collazo , Thomas Anders Wilson Norin , Neerai Garg , Anton Joakim Lofstedt , Tomas Fredrik Hansson , Lars Jesper Hallberg , Peter Brandt
发明人： Ana Maria Garcia Collazo , Thomas Anders Wilson Norin , Neerai Garg , Anton Joakim Lofstedt , Tomas Fredrik Hansson , Lars Jesper Hallberg , Peter Brandt
IPC分类号： A61K31/216 , C07C229/36 , A61P9/00 , A61K31/197
CPC分类号： C07C59/64 , C07C217/76 , C07C235/34 , C07C235/52 , C07C323/25 , C07C2601/02 , C07C2601/04 , C07C2601/14
摘要： The invention provides compounds of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition mediated by a thyroid receptor. Formula (I), wherein R1, R2, n, Y, Y′, R3, R4, W and R5 are as defined in the specification.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯，酰胺，溶剂化物或其盐，包括这种酯或酰胺的盐，以及这种酯，酰胺或盐的溶剂合物。本发明还提供了这样的化合物在治疗或预防由甲状腺受体介导的病症中的用途。式（I）其中R 1，R 2，n，Y，Y'，R 3，R 4， SUP>，W和R 5如说明书中所定义。

7. 发明授权

US07377983B2 Prevention of deposits on ceramics 有权
公开(公告)号：US07377983B2
公开(公告)日：2008-05-27
申请号：US11251432
申请日：2005-10-14
申请人： Carl William Erkenbrecher, Jr. , John Mark Longoria , Richard Alan Reynolds , Jennifer C. Julian , Malcolm DeLeo , Maria Garcia Ochomogo
发明人： Carl William Erkenbrecher, Jr. , John Mark Longoria , Richard Alan Reynolds , Jennifer C. Julian , Malcolm DeLeo , Maria Garcia Ochomogo
IPC分类号： B08B3/00
CPC分类号： C11D3/042 , C11D1/004 , C11D1/008 , C11D1/62 , C11D1/94 , C11D3/2082 , C11D3/2086 , C11D3/48 , C11D11/0052
摘要： A method to prevent deposits on a ceramic surface comprising: (1) pretreating the surface by applying an aqueous solution containing from about 200 ppm to about 1000 ppm by weight of an amphoteric fluorosurfactant, and (2) periodically applying an aqueous maintenance solution comprising from about 1 ppm to about 200 ppm of at least one of an amphoteric or cationic fluorosurfactant or a mixture thereof, from about 5 ppm to about 100 ppm of a sequestering acid, and from about 2.5 ppm to about 200 ppm of a quaternary ammonium biocide compound, wherein all concentrations are by weight of aqueous solution is disclosed.

8. 发明申请

US20070173409A1 Metabolic and nutritional activator for plants 审中-公开
标题翻译：植物代谢和营养激活剂
公开(公告)号：US20070173409A1
公开(公告)日：2007-07-26
申请号：US11698600
申请日：2007-01-26
申请人： Jose Maria Garcia-Mina Freire , Fabrice Houdusse , Angel Ma Zamarreno , Esther Cassanova
发明人： Jose Maria Garcia-Mina Freire , Fabrice Houdusse , Angel Ma Zamarreno , Esther Cassanova
IPC分类号： A01N59/04 , A01N3/02
CPC分类号： C05F11/10 , A01N37/36
摘要： This invention relates to a new formulation activating the absorption of mineral nutrients by plants. Consequently, it has also an effect on the metabolization of these mineral compounds by the plant. These formulations that have been discovered with this property activating nutrient absorption have as main component the compounds represented by general formula I CH3-S—CH2-CH2—CH(OR1)—COR2 I where R1 is selected from the group formed by hydrogen, alkyl rests, (preferably methyl or ethyl), and aryl: while R2 is selected from the group formed by hydroxyl, amides, alkyl rest esters (preferably methyl or ethyl), or aryl. When the rest is hydroxyl, acid salts with monovalent cations, preferably Na+ and K+, polyvalent cations, preferably Cu++ and Fe+++, and electropositive organic compounds such as amines (e.g., ethanolamine) are also considered.
摘要翻译：本发明涉及一种激活植物对矿物营养素吸收的新配方。因此，它也对植物对这些矿物质的代谢产生影响。已知用这种性质激活营养吸收的这些制剂作为主要成分，由通式I表示的化合物<？in-line-formula description =“In-line Formulas”end =“lead”？> CH 3 -S- CH 2 -CH 2 -CH（OR 1） - COR 2 I <？in-line-formula description =“在线公式其中R 1选自氢，烷基，烷基（优选甲基或乙基）和芳基所组成的基团：其中R 1，R 2，选自由羟基，酰胺，烷基休止酯（优选甲基或乙基）或芳基形成的基团。当其余为羟基时，具有一价阳离子，优选Na +和K +，多价阳离子，优选Cu ++， SUP> +++ ，还考虑了正电性有机化合物如胺（如乙醇胺）。

9. 发明申请

US20070120037A1 Support system for auxiliary power unit 有权
标题翻译：辅助动力装置支撑系统
公开(公告)号：US20070120037A1
公开(公告)日：2007-05-31
申请号：US11499384
申请日：2006-08-04
申请人： Jose Martinez Rueda , Jose Rojo Carrion , Jose Sen Pacios , Juan Melian Brinquis , Nicolas Saint , David Calvo , Steffan Thomas , Antonio Gavilan , Maria Garcia Patino
发明人： Jose Martinez Rueda , Jose Rojo Carrion , Jose Sen Pacios , Juan Melian Brinquis , Nicolas Saint , David Calvo , Steffan Thomas , Antonio Gavilan , Maria Garcia Patino
IPC分类号： F16M5/00
CPC分类号： B64D41/00 , B64D27/26 , B64D2041/002 , Y02T50/44
摘要： Support system for auxiliary power unit which sustains an auxiliary power unit (1) of an aircraft to a fixed structure (2) belonging to a compartment of the auxiliary power unit (6) of said aircraft, made in a high mechanical strength material, and with high resistance to ignition, which comprises at least three fittings (3, 4, 5) of a substantially cylindrical shape, said fittings (3, 4, 5) being able to be hollow, and each one of them presenting a first end (7) comprising means of attachment of the support system (8) to the fixed structure (2) and a second end (9) comprising means of securing of the support system (8) which are joined to the auxiliary power unit (1) in the periphery of the extension of said auxiliary power unit (1), with at least a first forward fitting (4) and a second forward fitting (5) being located in the forward part of the auxiliary power unit (1), and at least one rear fitting (3) being located in the rear part of the auxiliary power unit (1).
摘要翻译：辅助动力单元的支撑系统，其将飞机的辅助动力单元（1）维持在属于所述飞行器的辅助动力单元（6）的隔室中的固定结构（2），其由高机械强度材料制成，以及具有高耐点火性，其包括至少三个基本上圆柱形形状的配件（3,4,5），所述配件（3,4,5）能够是中空的，并且它们中的每一个具有第一端（ 7）包括将支撑系统（8）连接到固定结构（2）的装置和包括固定支撑系统（8）的装置的第二端（9），所述支撑系统（8）被连接到辅助动力单元（1）所述辅助动力单元（1）的延伸部的周边至少具有位于辅助动力单元（1）的前部的第一前部配件（4）和第二前部配件（5），并且至少一个后配件（3）位于辅助件的后部动力装置（1）。

10. 发明申请

US20070107226A1 Methods of forming an article, such as an item of jewelry 审中-公开
标题翻译：形成物品的方法，如首饰项目
公开(公告)号：US20070107226A1
公开(公告)日：2007-05-17
申请号：US11593805
申请日：2006-11-07
申请人： Michael Araujo , Jennifer Ashworth , Maria Garcia , Michael Gayton
发明人： Michael Araujo , Jennifer Ashworth , Maria Garcia , Michael Gayton
IPC分类号： A44C27/00
CPC分类号： A44C27/00 , A44C25/001 , Y10T29/49588
摘要： An improved method of forming an article of jewelry includes the steps of: providing an elongated arbor (20) having an oval-shaped transverse cross-section for a portion of its longitudinal extent; providing a length of tubular stock (21); winding the stock about the arbor; cutting the wound stock at such locations and at such angles as to form two substantially-identical members (23, 23), each member having a first end (24) and a second end (25); removing the members from the arbor; arranging the members such that the first end of one of the members is arranged proximate the first end of the other of the members, and such that the second end of one of the members is arranged proximate the second end of the other of the members; inserting connecting pins (26,30) into the marginal end portions of the members adjacent the first and second ends; and soldering the connecting pins and members together to form the article.
摘要翻译：形成首饰制品的改进方法包括以下步骤：为其纵向范围的一部分提供具有椭圆形横截面的细长心轴（20）; 提供长度的管状原料（21）; 围绕乔木缠绕股票; 在这些位置和角度切割伤口原料以形成两个基本相同的构件（23,23），每个构件具有第一端（24）和第二端（25）; 从乔木中取出成员; 安排成员使得其中一个构件的第一端靠近其中一个构件的第一端设置，并且使得其中一个构件的第二端靠近另一个构件的第二端设置; 将连接销（26,30）插入邻近第一和第二端的构件的边缘端部; 并将连接销和构件焊接在一起以形成制品。

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