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1. 发明申请

US20060188578A1 Hyaluronic acid nanoparticles 审中-公开
标题翻译：透明质酸纳米粒子
公开(公告)号：US20060188578A1
公开(公告)日：2006-08-24
申请号：US10561548
申请日：2004-06-17
申请人： Maria Jose Fernandez , Maria Fuente Freire , Maria Seijo Rey
发明人： Maria Jose Fernandez , Maria Fuente Freire , Maria Seijo Rey
IPC分类号： A61K31/728 , A61K9/14
CPC分类号： A61K9/5161 , A61K9/0014 , A61K9/0019 , A61K9/5192 , A61K47/36 , C08J3/14 , C08J2305/08 , C08L5/08
摘要： The invention relates to hyaluronic acid nanoparticles for the administration of at least one active ingredient. The inventive nanoparticles comprise hyaluronic acid in salt form a positively-charged polymer, a polyanionic salt and at least one active ingredient. The method of obtaining the aforementioned nanoparticles comprises the following steps consisting in: preparing an aqueous solution of a hyaluronic acid salt, preparing an aqueous solution of a cationic polymer, adding a polyanionic salt to the solution of the hyaluronic acid salt, and stir-mixing said solutions such as to produce the nanoparticles, the active ingredient being dissolved in one of the initial solutions or in the suspension of nanoparticles obtained in order to be absorbed on the nanoparticles. The invention also relates to pharmaceutical and cosmetic compositions comprising the above-mentioned nanoparticles.
摘要翻译：本发明涉及用于施用至少一种活性成分的透明质酸纳米颗粒。本发明的纳米颗粒包含盐形式的透明质酸，带正电荷的聚合物，聚阴离子盐和至少一种活性成分。获得上述纳米颗粒的方法包括以下步骤：制备透明质酸盐的水溶液，制备阳离子聚合物的水溶液，将聚阴离子盐加入到透明质酸盐的溶液中，并搅拌混合所述溶液例如产生纳米颗粒，活性成分溶解在初始溶液之一或为了被吸收在纳米颗粒上而获得的纳米颗粒的悬浮液中。本发明还涉及包含上述纳米颗粒的药物和化妆品组合物。

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