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    • 4. 发明授权
    • Chlorine dioxide treatment for biological tissue
    • 二氧化氯处理生物组织
    • US08703106B2
    • 2014-04-22
    • US13601623
    • 2012-08-31
    • Barry Keven SperonelloLinda HratkoFrank S. CastellanaAndrew Patrick FullMarcos Gomez
    • Barry Keven SperonelloLinda HratkoFrank S. CastellanaAndrew Patrick FullMarcos Gomez
    • A61K33/20A61M37/00A61Q11/00A61P31/00A61K8/20
    • A61K33/20
    • Methods for administration of a substantially non-cytotoxic chlorine dioxide composition to whiten a tooth surface are provided. The method comprises contacting a surface of a tooth with an efficacious amount of a composition comprising chlorine dioxide to provide an efficacious amount of chlorine dioxide to the tooth surface, wherein the contacting step comprises one or more of: i) contacting the tooth surface iteratively with at least two, substantially contiguous applications of a substantially non-cytotoxic composition comprising chlorine dioxide; ii) irrigating the tooth surface using an irrigation device that delivers a substantially non-cytotoxic composition comprising chlorine dioxide, or iii) irrigating the tooth surface using an irrigation device that comprises a chlorine dioxide composition comprising a cytotoxic amount of oxy-chlorine anions; and an oxy-chlorine anion barrier, wherein the irrigation devices delivers a substantially oxy-chlorine anion free chlorine dioxide composition to the tooth surface.
    • 提供了用于施用基本上非细胞毒性的二氧化氯组合物以使牙齿表面变白的方法。 该方法包括使牙齿的表面与有效量的包含二氧化氯的组合物接触以向牙齿表面提供有效量的二氧化氯,其中所述接触步骤包括以下中的一种或多种:i)将牙齿表面与 包含二氧化氯的基本上非细胞毒性组合物的至少两个基本连续的应用; ii)使用提供包含二氧化氯的基本上非细胞毒性组合物的冲洗装置冲洗牙齿表面,或iii)使用包括含有细胞毒性量的氧 - 氯阴离子的二氧化氯组合物的冲洗装置冲洗牙齿表面; 和氧 - 氯阴离子屏障,其中所述冲洗装置将基本上无氯 - 阴离子的二氧化氯组合物递送到所述牙齿表面。