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1. 发明申请

US20080194043A1 DETECTION METHODS USING TIMP1 审中-公开
标题翻译：使用TIMP1的检测方法
公开(公告)号：US20080194043A1
公开(公告)日：2008-08-14
申请号：US12052760
申请日：2008-03-21
申请人： Jon H. ASTLE , Christopher C. BURGESS , Theodore J. CATINO , Poornima DWIVEDI , Maryanne HUNTRESS , Karen Anne JOHNSON , Marcia E. LEWIS , Peter J. MAIMONIS , Gary A. MOLINO , Susan H. MYEROW , Arunthathi THIAGALINGAM , Lisa Allyn BOARDMAN , Lawrence J. BURGART , Stephen N. THIBODEAU , Sheryl BROWN-SHIMER
发明人： Jon H. ASTLE , Christopher C. BURGESS , Theodore J. CATINO , Poornima DWIVEDI , Maryanne HUNTRESS , Karen Anne JOHNSON , Marcia E. LEWIS , Peter J. MAIMONIS , Gary A. MOLINO , Susan H. MYEROW , Arunthathi THIAGALINGAM , Lisa Allyn BOARDMAN , Lawrence J. BURGART , Stephen N. THIBODEAU , Sheryl BROWN-SHIMER
IPC分类号： G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136
摘要： The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1α or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1α or TIMP1 expression is indicative of the presence of colorectal cancer. The invention further relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1α or TIMP1 nucleic acid or amino acid molecules in a clinical sample, in addition to detecting the presence of one or more additional colorectal cancer associated markers.
摘要翻译：本发明涉及用于检测个体中结肠直肠癌存在的方法，其中通过检测从患者获得的临床样品中Reg1alpha或TIMP1核酸或氨基酸分子的存在来检测结肠直肠癌，其中Reg1alpha或TIMP1 表达是指示结肠直肠癌的存在。本发明还涉及一种用于检测个体中结肠直肠癌存在的方法，其中通过检测临床样品中Reg1al或TIMP1核酸或氨基酸分子的存在来检测结肠直肠癌，另外检测一种或更多的结肠直肠癌相关标志物。

2. 发明授权

US06262334B1 Human genes and expression products: II 失效
标题翻译：人类基因和表达产物：II
公开(公告)号：US06262334B1
公开(公告)日：2001-07-17
申请号：US09385982
申请日：1999-08-30
申请人： Wilson O. Endege , Kathleen E. Steinmann , Jon H. Astle , Christopher C. Burgess , Eddie Carroll, III , Theodore J. Catino , Poornima Dwivedi , Donna M. Ford , Marcia E. Lewis , Gary A. Molino , John E. Monahan , Robert Schlegel
发明人： Wilson O. Endege , Kathleen E. Steinmann , Jon H. Astle , Christopher C. Burgess , Eddie Carroll, III , Theodore J. Catino , Poornima Dwivedi , Donna M. Ford , Marcia E. Lewis , Gary A. Molino , John E. Monahan , Robert Schlegel
IPC分类号： A01K6700
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
摘要翻译：本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体和抗体。已经发现目标核酸在肿瘤细胞，特别是结肠癌组织中是差异调节的。

3. 发明申请

US20080131889A1 Novel human genes and gene expression products: II 审中-公开
公开(公告)号：US20080131889A1
公开(公告)日：2008-06-05
申请号：US11799463
申请日：2007-04-30
申请人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam
发明人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/574
CPC分类号： C07K14/47 , A01K2217/05 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57419
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.

4. 发明授权

US07211398B2 Human genes and gene expression products: II 有权
标题翻译：人类基因和基因表达产物：II
公开(公告)号：US07211398B2
公开(公告)日：2007-05-01
申请号：US10280403
申请日：2002-10-25
申请人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam , Stephen Thibodeau , Lawrence J. Burgart , Lisa Allyn Boardman
发明人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam , Stephen Thibodeau , Lawrence J. Burgart , Lisa Allyn Boardman
IPC分类号： G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57419
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
摘要翻译：本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体和抗体。已经发现目标核酸在肿瘤细胞，特别是结肠癌组织中是差异调节的。

5. 发明授权

US5731150A IS6110 based molecular detection of mycobacterium tuberculosis 失效
标题翻译： IS6110基因分子检测结核分枝杆菌
公开(公告)号：US5731150A
公开(公告)日：1998-03-24
申请号：US551645
申请日：1995-11-01
申请人： Gurpreet S. Sandhu , Bruce C. Kline , Leslie Stockman , Glenn D. Roberts , Marcia E. Lewis
发明人： Gurpreet S. Sandhu , Bruce C. Kline , Leslie Stockman , Glenn D. Roberts , Marcia E. Lewis
IPC分类号： C12N15/09 , C12Q1/04 , C12Q1/68 , C12R1/32 , C07H21/00 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/689
摘要： The detection of the IS6110 insertion element in a clinical specimen is a rapid way of diagnosing infection by Mycobacterium tuberculosis. A reliable diagnostic test for tuberculosis based on the IS6110 DNA is described in this disclosure. A "Universal" specimen preparation protocol that eliminates live organisms and purifies nucleic acids from all types of clinical specimens is described. Two nucleic acid primers designed to amplify IS6110 DNA with high specificity in a polymerase chain reaction are also described. The amplified IS6110 DNA is identified by a restriction endonuclease and electrophoresis based assay. The identification process also renders the DNA unamplifiable in a subsequent PCR, thereby reducing the possibility of contaminating other specimens. Time, labor and cost is minimized, while user safety and test reliability are maximized. The complete DNA extraction, amplification and analysis is accomplished with ease within an 8 hour period, with a sensitivity of 92% and a specificity approaching 100%. Testing of serially obtained samples from the same patient increases the overall rate of detection to 100%.
摘要翻译：临床标本中IS6110插入元件的检测是诊断结核分枝杆菌感染的一种快速方法。本公开描述了基于IS6110 DNA的结核病的可靠诊断测试。描述了消除活生物体并从所有类型的临床标本中纯化核酸的“通用”标本制备方案。还描述了设计用于在聚合酶链反应中以高特异性扩增IS6110DNA的两个核酸引物。通过限制性内切酶和基于电泳的测定法鉴定扩增的IS6110 DNA。识别过程也使DNA在随后的PCR中不可扩增，从而降低污染其他样品的可能性。时间，人力和成本最小化，用户安全和测试可靠性最大化。完整的DNA提取，扩增和分析在8小时内容易地完成，灵敏度为92％，特异性接近100％。来自同一患者的连续获得的样品的测试将总体检测率提高到100％。

6. 发明授权

US07258973B2 Method for detecting a differentially expressed sequence 失效
标题翻译：用于检测差异表达序列的方法
公开(公告)号：US07258973B2
公开(公告)日：2007-08-21
申请号：US09907479
申请日：2001-07-17
申请人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam , Stephen Thibodeau , Lawrence J. Burgart , Lisa Allyn Boardman
发明人： Jon H. Astle , Christopher C. Burgess , Theodore J. Catino , Poornima Dwivedi , Marcia E. Lewis , Gary A. Molino , Susan H. Myerow , Arunthathi Thiagalingam , Stephen Thibodeau , Lawrence J. Burgart , Lisa Allyn Boardman
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , A01K2217/05 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57419
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
摘要翻译：本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体和抗体。已经发现目标核酸在肿瘤细胞，特别是结肠癌组织中是差异调节的。

7. 发明授权

US06262333B1 Human genes and gene expression products 失效
标题翻译：人类基因和基因表达产物
公开(公告)号：US06262333B1
公开(公告)日：2001-07-17
申请号：US09328111
申请日：1999-06-08
申请人： Wilson O. Endege , Kathleen E. Steinmann , Jon H. Astle , Christopher C. Burgess , Steven E. Bushnell , Eddie Carroll, III , Theodore J. Catino , Adnan Derti , Donna M. Ford , Marcia E. Lewis , John E. Monahan , Robert Schlegel
发明人： Wilson O. Endege , Kathleen E. Steinmann , Jon H. Astle , Christopher C. Burgess , Steven E. Bushnell , Eddie Carroll, III , Theodore J. Catino , Adnan Derti , Donna M. Ford , Marcia E. Lewis , John E. Monahan , Robert Schlegel
IPC分类号： A01K6700
CPC分类号： C07K14/47 , A61K38/00
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs. and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly colon cancer cell lines and/or tissue.
摘要翻译：本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体。和抗体。已经发现目标核酸在肿瘤细胞，特别是结肠癌细胞系和/或组织中是差异调节的。

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