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1. 发明申请

US20090215191A1 Optical Sensor For Detecting Chemical Reaction Activity 失效
标题翻译：用于检测化学反应活性的光学传感器
公开(公告)号：US20090215191A1
公开(公告)日：2009-08-27
申请号：US12087691
申请日：2007-01-10
申请人： Michael J. Sailor , Manuel M. Orosco , Claudia Pacholski , Gordon M. Miskelly
发明人： Michael J. Sailor , Manuel M. Orosco , Claudia Pacholski , Gordon M. Miskelly
IPC分类号： G01N21/55 , G01N21/01 , C12M1/34
CPC分类号： G01N33/552 , Y10S435/808 , Y10S435/973 , Y10S436/805
摘要： The invention provides an optical sensor for detecting chemical reaction activity, including, e.g., enzyme activity and catalytic or reactive molecule activity. An optical sensor of the invention includes a porous photonic film that produces a predetermined spectral reflectance response. In preferred embodiments, the film has a chemical coating (such as a hydrophobic layer) within its pores with an affinity for the reaction product(s) of the catalytic or otherwise reactive analyte A coating can also act as a protective layer in preferred embodiment. A thin substrate susceptible to reaction by at least one analyte of interest is on the surface of the thin film to block pores of the thin film. A method of detecting chemical reaction activity of the invention exposes the optical sensor to an analyte of interest, such as an enzyme or otherwise catalytic or reactive molecule. The optical sensor is subjected to light and the reflectivity spectrum of the optical sensor is monitored for a change indicative of reaction activity. Monitoring can include observation for a visible change or data acquisition via instruments such as a spectrometer for monitoring for a change in interferometric reflectance spectra.
摘要翻译：本发明提供了一种用于检测化学反应活性的光学传感器，包括例如酶活性和催化或反应性分子活性。本发明的光学传感器包括产生预定光谱反射响应的多孔光子膜。在优选的实施方案中，膜在其孔内具有对催化或其它反应性分析物的反应产物具有亲和性的化学涂层（例如疏水层）。在优选实施方案中，涂层也可以用作保护层。易受至少一种感兴趣的分析物反应的薄基材在薄膜的表面上，以阻挡薄膜的孔。检测本发明的化学反应活性的方法将光学传感器暴露于感兴趣的分析物，例如酶或其它催化或反应性分子。对光学传感器进行光照射，并且监测光学传感器的反射光谱以表明反应活性。监测可以包括通过诸如用于监测干涉反射光谱变化的光谱仪等仪器进行可见变化或数据采集的观察。

2. 发明授权

US07759129B2 Optical sensor for detecting chemical reaction activity 失效
标题翻译：用于检测化学反应活性的光学传感器
公开(公告)号：US07759129B2
公开(公告)日：2010-07-20
申请号：US12087691
申请日：2007-01-10
申请人： Michael J. Sailor , Manuel M. Orosco , Claudia Pacholski , Gordon M. Miskelly
发明人： Michael J. Sailor , Manuel M. Orosco , Claudia Pacholski , Gordon M. Miskelly
IPC分类号： G01N21/00
CPC分类号： G01N33/552 , Y10S435/808 , Y10S435/973 , Y10S436/805
摘要： The invention provides an optical sensor for detecting chemical reaction activity, including, e.g., enzyme activity and catalytic or reactive molecule activity. An optical sensor of the invention includes a porous photonic film that produces a predetermined spectral reflectance response. In preferred embodiments, the film has a chemical coating (such as a hydrophobic layer) within its pores with an affinity for the reaction product(s) of the catalytic or otherwise reactive analyte A coating can also act as a protective layer in preferred embodiment. A thin substrate susceptible to reaction by at least one analyte of interest is on the surface of the thin film to block pores of the thin film. A method of detecting chemical reaction activity of the invention exposes the optical sensor to an analyte of interest, such as an enzyme or otherwise catalytic or reactive molecule. The optical sensor is subjected to light and the reflectivity spectrum of the optical sensor is monitored for a change indicative of reaction activity. Monitoring can include observation for a visible change or data acquisition via instruments such as a spectrometer for monitoring for a change in interferometric reflectance spectra.
摘要翻译：本发明提供了一种用于检测化学反应活性的光学传感器，包括例如酶活性和催化或反应性分子活性。本发明的光学传感器包括产生预定光谱反射响应的多孔光子膜。在优选的实施方案中，膜在其孔内具有对催化或其它反应性分析物的反应产物具有亲和性的化学涂层（例如疏水层）。在优选实施方案中，涂层也可以用作保护层。易受至少一种感兴趣的分析物反应的薄基材在薄膜的表面上，以阻挡薄膜的孔。检测本发明的化学反应活性的方法将光学传感器暴露于感兴趣的分析物，例如酶或其它催化或反应性分子。对光学传感器进行光照射，并且监测光学传感器的反射光谱以表明反应活性。监测可以包括通过诸如用于监测干涉反射光谱变化的光谱仪等仪器进行可见变化或数据采集的观察。

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