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1. 发明申请

US20120034651A1 Akt activity specifically inhibiting polypeptide 有权
标题翻译： Akt活性特异性抑制多肽
公开(公告)号：US20120034651A1
公开(公告)日：2012-02-09
申请号：US10583058
申请日：2004-12-14
申请人： Masayuki Noguchi , Futoshi Okada , Makoto Hiromura
发明人： Masayuki Noguchi , Futoshi Okada , Makoto Hiromura
IPC分类号： C12P21/06 , C12N15/63 , C07H21/04 , C07K7/08 , C07K16/18 , C12N5/02 , C07K14/435
CPC分类号： C07K14/4703 , A61K38/00 , C07K7/08 , C07K14/47 , C07K16/40
摘要： The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like. The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the sequence listing) that contain an amino acid sequence corresponding to any of the position of amino acid residue 10-24 of human TCL1, amino acid residue 8-22 of human TCL1B, amino acid residue 5-19 of human MTCP1, and amino acid residue 9-24 of mouse or rat TCL1; and the derivatives. Further, the present invention includes DNA encording the polypeptide (SEQ ID NO: 2, 4, 6, 8 or 10 of the sequence listing), and the antibodies specifically binding to the polypeptides. The polypeptide of the present invention can be used for an inhibitor of Akt activity, an antitumor agent, or the like.
摘要翻译：本发明提供特异性抑制Akt（蛋白激酶B）活性的多肽，其DNA，其抗体，Akt活性抑制剂或抗肿瘤剂等的活性。多肽包含多肽（序列表的SEQ ID NO：1,3,5,7和9），其含有对应于人TCL1的氨基酸残基10-24的任何位置的氨基酸序列，氨基酸残基人类TCL1B 8-22，人类MTCP1的5-19氨基酸残基，小鼠或大鼠TCL1的氨基酸残基9-24; 和衍生品。此外，本发明包括根据多肽的DNA（序列表的SEQ ID NO：2,4,6,8或10）和与多肽特异性结合的抗体。本发明的多肽可用于Akt活性抑制剂，抗肿瘤剂等。

2. 发明授权

US08440630B2 Akt activity specifically inhibiting polypeptide 有权
标题翻译： Akt活性特异性抑制多肽
公开(公告)号：US08440630B2
公开(公告)日：2013-05-14
申请号：US10583058
申请日：2004-12-14
申请人： Masayuki Noguchi , Futoshi Okada , Makoto Hiromura
发明人： Masayuki Noguchi , Futoshi Okada , Makoto Hiromura
IPC分类号： A61K38/10 , A61K38/16 , A61P35/00 , A61P35/02 , G01N33/574
CPC分类号： C07K14/4703 , A61K38/00 , C07K7/08 , C07K14/47 , C07K16/40
摘要： The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like. The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the sequence listing) that contain an amino acid sequence corresponding to any of the position of amino acid residue 10-24 of human TCL1, amino acid residue 8-22 of human TCL1B, amino acid residue 5-19 of human MTCP1, and amino acid residue 9-24 of mouse or rat TCL1; and the derivatives. Further, the present invention includes DNA encording the polypeptide (SEQ ID NO: 2, 4, 6, 8 or 10 of the sequence listing), and the antibodies specifically binding to the polypeptides. The polypeptide of the present invention can be used for an inhibitor of Akt activity, an antitumor agent, or the like.
摘要翻译：本发明提供特异性抑制Akt（蛋白激酶B）活性的多肽，其DNA，其抗体，Akt活性抑制剂或抗肿瘤剂等的活性。多肽包含多肽（序列表的SEQ ID NO：1,3,5,7和9），其含有对应于人TCL1的氨基酸残基10-24的任何位置的氨基酸序列，氨基酸残基人类TCL1B 8-22，人类MTCP1的5-19氨基酸残基，小鼠或大鼠TCL1的氨基酸残基9-24; 和衍生品。此外，本发明包括根据多肽的DNA（序列表的SEQ ID NO：2,4,6,8或10）和与多肽特异性结合的抗体。本发明的多肽可用于Akt活性抑制剂，抗肿瘤剂等。

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