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1. 发明申请

WO2011069528A1 LYOPHILIZATION OF NUCLEIC ACIDS IN LACTATE-CONTAINING SOLUTIONS 审中-公开
标题翻译：在含有LACTAT的溶液中的核酸的分解
公开(公告)号：WO2011069528A1
公开(公告)日：2011-06-16
申请号：PCT/EP2009/008803
申请日：2009-12-09
申请人： CUREVAC GMBH , MUTZKE, Thorsten , KETTERER, Thomas , VON DER MÜLBE, Florian
发明人： MUTZKE, Thorsten , KETTERER, Thomas , VON DER MÜLBE, Florian
IPC分类号： C12N15/10 , A61K48/00
CPC分类号： C12N15/1003 , C12N1/04
摘要： The present invention is directed to the lyophilization of nucleic acids in lactate-containing solutions or formulations. The present invention is particularly suitable for enhancing and improving storage and shipping capabilities of nucleic acids for multiple purposes. The present invention is furthermore directed to methods of lyophilization suitable to prepare such inventive lyophilized nucleic acids, to the use of such lyophilized nucleic acids in the preparation of pharmaceutical compositions, to first and second medical indications using such lyophilized nucleic acids and to kits, particularly to kit of parts, comprising such lyophilized nucleic acids.
摘要翻译：本发明涉及在含乳酸的溶液或制剂中冻干核酸。本发明特别适用于增强和改进用于多个目的的核酸的储存和运输能力。本发明还涉及适用于制备这种本发明的冻干核酸的冷冻干燥方法，使用这种冻干核酸在制备药物组合物中，使用这种冻干核酸的第一和第二种医学适应症以及试剂盒，特别是包含这样的冻干核酸的试剂盒。

2. 发明申请

WO2011069587A1 LYOPHILIZATION OF NUCLEIC ACIDS IN LACTATE-CONTAINING SOLUTIONS 审中-公开
标题翻译：在含有LACTAT的溶液中的核酸的分解
公开(公告)号：WO2011069587A1
公开(公告)日：2011-06-16
申请号：PCT/EP2010/006789
申请日：2010-11-08
申请人： CUREVAC GMBH , MUTZKE, Thorsten , KETTERER, Thomas , VON DER MÜLBE, Florian
发明人： MUTZKE, Thorsten , KETTERER, Thomas , VON DER MÜLBE, Florian
IPC分类号： C12N15/10 , A61K48/00
CPC分类号： C12N15/1003 , C12N1/04
摘要： The present invention is directed to the lyophilization of nucleic acids in a lactate-containing solution or formulation. The present invention is particularly suitable for enhancing and improving storage and shipping capabilities of nucleic acids for multiple purposes. The present invention is furthermore directed to methods of lyophilization suitable to prepare such inventive lyophilized nucleic acids, to the use of a lactate-containing solution or formulation for the preparation of such lyophilized nucleic acids or the use of a solution containing at least one nucleic acid (sequence) and (free) lactate for lyophilization of at least one nucleic acid (sequence), to the use of such lyophilized nucleic acids in the preparation of pharmaceutical compositions, to first and second medical indications using such lyophilized nucleic acids and to kits, particularly to kit of parts, comprising such lyophilized nucleic acids.
摘要翻译：本发明涉及在含乳酸的溶液或制剂中冻干核酸。本发明特别适用于增强和改进用于多个目的的核酸的储存和运输能力。本发明还涉及适于制备本发明的冻干核酸的冷冻干燥方法，使用含乳酸盐的溶液或制剂用于制备这种冻干核酸或使用含有至少一种核酸的溶液（序列）和（游离）乳酸盐，用于冻干至少一种核酸（序列），使用这样的冻干核酸在药物组合物的制备中，使用这种冻干核酸的第一和第二种医学适应症和试剂盒，特别是包含这种冻干核酸的试剂盒。

3. 发明申请

WO2011069586A1 MANNOSE-CONTAINING SOLUTION FOR LYOPHILIZATION, TRANSFECTION AND/OR INJECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：含有核酸的柠檬酸化，转运和/或注射的含有含水溶液
公开(公告)号：WO2011069586A1
公开(公告)日：2011-06-16
申请号：PCT/EP2010/006788
申请日：2010-11-08
申请人： CUREVAC GMBH , MUTZKE, Thorsten
发明人： MUTZKE, Thorsten
IPC分类号： C12N15/87 , C12N15/11
CPC分类号： A61K31/7088 , A61K39/0011 , A61K47/12 , A61K47/26 , A61K48/00 , A61K2039/53 , C12N15/87
摘要： The present invention is directed to (the use of) a solution containing at least one nucleic acid (sequence) and free mannose for lyophilization, transfection and/or injection, particularly of RNA and mRNA. The inventive solution exhibits a positive effect on stabilization of the nucleic acid (sequence) during lyophilization and storage but also leads to a considerable increase of the transfection efficiency of a nucleic acid. It thus also increases in vivo expression of a protein encoded by such a nucleic acid upon increased transfection rate. The present invention is furthermore directed to a method of lyophilization using the mannose-containing solution, to pharmaceutical compositions, vaccines, kits, first and second medical uses applying such a mannose-containing solution and/or a nucleic acid (sequence) lyophilized or resuspended with such a solution.
摘要翻译：本发明涉及包含至少一种核酸（序列）和游离甘露糖的溶液（使用）用于冻干，转染和/或注射，特别是RNA和mRNA的溶液。本发明溶液对冷冻干燥和储存期间核酸（序列）的稳定性具有积极作用，但也导致核酸转染效率的显着增加。因此，在增加转染率的同时，它也增加了由这种核酸编码的蛋白质的体内表达。本发明还涉及使用含甘露糖的溶液，药物组合物，疫苗，试剂盒，应用这种含甘露糖的溶液和/或冻干或重悬浮的核酸（序列）的第一和第二医疗用途的冻干方法。用这样的解决方案。

4. 发明申请

WO2008077592A1 METHOD FOR PURIFYING RNA ON A PREPARATIVE SCALE BY MEANS OF HPLC 审中-公开
标题翻译：通过HPLC纯化准备量的RNA的方法
公开(公告)号：WO2008077592A1
公开(公告)日：2008-07-03
申请号：PCT/EP2007/011294
申请日：2007-12-20
申请人： CUREVAC GMBH , KETTERER, Thomas , VON DER MÜLBE, Florian , REIDEL, Ladislaus , MUTZKE, Thorsten
发明人： KETTERER, Thomas , VON DER MÜLBE, Florian , REIDEL, Ladislaus , MUTZKE, Thorsten
IPC分类号： C12N15/10
CPC分类号： C12N15/101
摘要： The application describes a method for the preparative purification of RNA, which method is distinguished in that the RNA is purified by means of HPLC using a porous reversed phase as the stationary phase. The use of the porous reversed phase in this HPLC method is also described.
摘要翻译：本申请描述了RNA的制备纯化方法，其特征在于通过使用多孔反相作为固定相的HPLC纯化RNA。还描述了在该HPLC方法中使用多孔反相。

5. 发明申请

WO2011069529A1 MANNOSE-CONTAINING SOLUTION FOR LYOPHILIZATION, TRANSFECTION AND/OR INJECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：含有核酸的柠檬酸化，转运和/或注射的含有含水的溶液
公开(公告)号：WO2011069529A1
公开(公告)日：2011-06-16
申请号：PCT/EP2009/008804
申请日：2009-12-09
申请人： CUREVAC GMBH , MUTZKE, Thorsten
发明人： MUTZKE, Thorsten
IPC分类号： C12N15/87 , C12N15/11
CPC分类号： A61K31/7088 , A61K39/0011 , A61K47/12 , A61K47/26 , A61K48/00 , A61K2039/53 , C12N15/87
摘要： The present invention is directed to (the use of) a solution containing at least one nucleic acid (sequence) and free mannose for lyophilization, transfection and/or injection, particularly of RNA and mRNA. The inventive solution exhibits a positive effect on stabilization of the nucleic acid (sequence) during lyophilization and storage but also leads to a considerable increase of the transfection efficiency of a nucleic acid. It thus also increases in vivo expression of a protein encoded by such a nucleic acid upon increased transfection rate. The present invention is furthermore directed to a method of lyophilization using the mannose-containing solution, to pharmaceutical compositions, vaccines, kits, first and second medical indications applying such a mannose-containing solution and/or a nucleic acid (sequence) lyophilized or resuspended with such a solution.
摘要翻译：本发明涉及包含至少一种核酸（序列）和游离甘露糖的溶液（用于）冻干，转染和/或注射，特别是RNA和mRNA的溶液（的用途）。本发明溶液对冷冻干燥和储存期间核酸（序列）的稳定性具有积极作用，但也导致核酸转染效率的显着增加。因此，在增加转染率的同时，它也增加了由这种核酸编码的蛋白质的体内表达。本发明还涉及使用含甘露糖的溶液，药物组合物，疫苗，试剂盒，应用这种含甘露糖的溶液和/或冻干或重悬浮的核酸（序列）的第一和第二医疗适应症的冻干方法。用这样的解决方案。

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