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1. 发明专利

IL183528D0 PROCESS FOR PREPARING ROSUVASTATIN 未知
公开(公告)号：IL183528D0
公开(公告)日：2007-09-20
申请号：IL18352807
申请日：2007-05-29
申请人： ASTRAZENECA UK LTD , BUTTERS MICHAEL , LENGER STEVEN ROBERT , MURRAY PAUL MICHAEL , SNAPE EVAN WILLIAM
IPC分类号： C07D20100101 , C07D239/36 , C07D239/42
摘要： A process for formation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, via a Heck reaction is described. Intermediates useful in the process and processes for making said intermediates are also described.

2. 发明专利

GB2528778A Process for the removal and return of a catalyst to a liquid phase medium and its use in cross-coupling reactions 未知
公开(公告)号：GB2528778A
公开(公告)日：2016-02-03
申请号：GB201511333
申请日：2013-11-28
申请人： PHOSPHONICS LTD , MURRAY PAUL MICHAEL
发明人： MURRAY PAUL MICHAEL , WILKES ROBIN , NORTH CHRISTOPHER
IPC分类号： B01J31/06 , B01J31/16 , B01J31/24 , C07B37/04 , C07B43/00 , C08G77/385 , C08G77/388 , C08G77/392 , C08G77/395
摘要： A process for the selective removal of a component from a liquid phase and subsequently returning the component to a liquid phase is disclosed. A novel compound of formula (I) [SUP]-[[L]-[G]]a (I) in which L is a linking group, G is an aryl group having a leaving group LG selected from Cl, Br, I, sulfonate such as triflate, a diazo group, a nitrile, an ester and an alkoxy group and substituent Q is selected from H, NR2, OR, C02R, F, Cl, N02 CN and SUP is a support having a plurality of groups -[L]-[G] bound to the support is contacted with the liquid phase to bind the component to the compound I thereby forming a captured component which is separated from and may be returned to the liquid phase. The compound I is especially useful in binding homogeneous catalysts to remove it from a reaction medium and selectively returning the catalyst to the reaction medium at a later stage. The compound is particularly useful for cross-coupling reactions, for example in Suzuki reactions.

3. 发明专利

IL193264D0 PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS 未知
公开(公告)号：IL193264D0
公开(公告)日：2009-02-11
申请号：IL19326408
申请日：2008-08-05
申请人： ASTRAZENECA UK LTD , UBE INDUSTRIES , MURRAY PAUL MICHAEL , NISHINO SHIGEYOSHI , VAZ LUIS MANUEL , AINGE DEBRA , HARADA KATSUMASA , YOSHII KIYOTAKA
IPC分类号： C07D20100101
摘要： A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2′-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2′-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2′-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2′-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.

4. 发明专利

IL188201D0 PROCESSES FOR THE MANUFACTURE OF ROSUVASTATIN AND INTERMEDIATES 未知
公开(公告)号：IL188201D0
公开(公告)日：2008-03-20
申请号：IL18820107
申请日：2007-12-17
申请人： ASTRAZENECA UK LTD , BUTTERS MICHAEL , CRABB JEFFREY NORMAN , LENGER STEVEN ROBERT , MURRAY PAUL MICHAEL , SNAPE EVAN WILLIAM , COX DAVID KENNETH
IPC分类号： C07D20100101 , C07D239/30 , C07D239/36 , C07D239/42
摘要： A process for the manufacture of a compound of formula (V), useful for making rosuvastatin, by a stereoselective aldol reaction is described. Novel intermediates and processes to make them are also described.

5. 发明专利

IL183528A PROCESS FOR PREPARING ROSUVASTATIN 未知
公开(公告)号：IL183528A
公开(公告)日：2012-02-29
申请号：IL18352807
申请日：2007-05-29
申请人： ASTRAZENECA UK LTD , BUTTERS MICHAEL , LENGER STEVEN ROBERT , MURRAY PAUL MICHAEL , SNAPE EVAN WILLIAM
发明人： BUTTERS MICHAEL , LENGER STEVEN ROBERT , MURRAY PAUL MICHAEL , SNAPE EVAN WILLIAM
IPC分类号： C07D239/36 , C07D239/42
摘要： A process for formation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, via a Heck reaction is described. Intermediates useful in the process and processes for making said intermediates are also described.

6. 发明申请

WO2010146395A1 PYRAZINE CARBOXAMIDES AS INHIBITORS OF DGAT1 审中-公开
标题翻译：作为DGAT1的抑制剂的吡嗪类羧酰胺
公开(公告)号：WO2010146395A1
公开(公告)日：2010-12-23
申请号：PCT/GB2010/051003
申请日：2010-06-17
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BIRCH, Alan Martin , BUTLIN, Roger John , CAMPBELL, Leonie , GREEN, Clive , LEACH, Andrew , MURRAY, Paul Michael , RYBERG, Per Olof , WARING, Michael James
发明人： BIRCH, Alan Martin , BUTLIN, Roger John , CAMPBELL, Leonie , GREEN, Clive , LEACH, Andrew , MURRAY, Paul Michael , RYBERG, Per Olof , WARING, Michael James
IPC分类号： C07D241/24 , C07D401/12 , C07D413/10 , A61K31/4965 , A61K31/497 , A61P3/10
CPC分类号： C07D241/24 , C07D401/12 , C07D413/10
摘要： DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, r is 0 or 1 and X 1 is linear (1-3C)alkyl; q is 0 or 1 and X 1 is fluoro, chloro or (1-3C)alkyl; Y 1 is selected from fluoro, chloro, bromo, cyano, (1-3C)alkyl and (1-2C)alkoxy; n is 0, 1 or 2 and Y 2 is fluoro, chloro or (1-3C)alkyl; p is 0, 1 or 2 and Y 3 is (1-3C)alkyl or forms a (3-5C)cycloalkyl ring; Z is carboxy or - CONHSO 2 Me or CONRbRc wherein Rb and Rc are independently selected, for example, from hydrogen and (1-4C)alkyl or Rb and Rc are linked so as to form a morpholine ring or a (4-6C)heterocyclic ring and when Z is CONRbRc the Rb and Rc groups may be optionally substituted by carboxy.
摘要翻译：与药物组合物一起描述式（I）的DGAT-1抑制剂化合物，其药学上可接受的盐和前药与制备它们的方法及其用于治疗例如肥胖症的用途，其中例如r为0 或1和X1是直链（1-3C）烷基; q是0或1，X 1是氟，氯或（1-3C）烷基; Y1选自氟，氯，溴，氰基，（1-3C）烷基和（1-2C）烷氧基; n为0,1或2，Y2为氟，氯或（1-3C）烷基; p为0,1或2，Y 3为（1-3C）烷基或形成（3-5C）环烷基环; Z是羧基或-CONHSO 2 Me或其中R b和R c独立地选自氢和（1-4C）烷基或R b和R c连接形成吗啉环或（4-6C ）杂环，并且当Z是R 1 CONR b R c时，R b和R c基团可以任选被羧基取代。

7. 发明申请

WO2007102352A3 PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS 审中-公开
标题翻译：制备二苯并噻吩化合物的方法
公开(公告)号：WO2007102352A3
公开(公告)日：2008-01-10
申请号：PCT/JP2007053700
申请日：2007-02-21
申请人： ASTRAZENECA UK LTD , UBE INDUSTRIES , MURRAY PAUL MICHAEL , VAZ LUIS-MANUEL , AINGE DEBRA , HARADA KATSUMASA , NISHINO SHIGEYOSHI , YOSHII KIYOTAKA
发明人： MURRAY PAUL MICHAEL , VAZ LUIS-MANUEL , AINGE DEBRA , HARADA KATSUMASA , NISHINO SHIGEYOSHI , YOSHII KIYOTAKA
IPC分类号： C07D281/18 , C07C205/00 , C07C209/00
CPC分类号： C07D281/18 , C07C319/18 , C07D281/16 , C07C323/62
摘要： A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2'-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2'-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2'-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2'-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.
摘要翻译：二苯并硫氮杂化合物适宜地通过在酸性催化剂的存在下使2-氨基-2'-羧基 - 二苯硫醚化合物进行脱水缩合反应来制备; 2-氨基-2'-羧基二苯硫醚化合物通过在低级脂族酯溶剂中还原2-硝基-2'-羧基 - 二苯硫醚化合物来适当地制备; 2-硝基-2'-羧基二苯硫醚化合物可通过硝基苯化合物与硫代水杨酸化合物在低级脂族醇和水的混合物中反应来制备。

8. 发明申请

WO2006067456A2 CHEMICAL PROCESS 审中-公开
标题翻译：化学工艺
公开(公告)号：WO2006067456A2
公开(公告)日：2006-06-29
申请号：PCT/GB2005004999
申请日：2005-12-22
申请人： ASTRAZENECA UK LTD , BUTTERS MICHAEL , LENGER STEVEN ROBERT , MURRAY PAUL MICHAEL , SNAPE EVAN WILLIAM
发明人： BUTTERS MICHAEL , LENGER STEVEN ROBERT , MURRAY PAUL MICHAEL , SNAPE EVAN WILLIAM
IPC分类号： C07D239/36 , C07D239/42
CPC分类号： C07D239/36 , C07D239/42
摘要： A process for formation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, (A chemical formula should be inserted here - please see paper copy enclosed herewith) I via a Heck reaction is described. Intermediates useful in the process and processes for making said intermediates are also described.
摘要翻译：描述了通过Heck反应形成式（I）化合物或其药学上可接受的盐的方法（应在此插入化学式 - 请参见随附的I文件）I。还描述了用于制备所述中间体的方法和方法中的中间体。

9. 发明申请

WO1992016923A1 FLIGHT SIMULATOR 审中-公开
标题翻译：飞行模拟器
公开(公告)号：WO1992016923A1
公开(公告)日：1992-10-01
申请号：PCT/GB1991002088
申请日：1991-11-26
申请人： REDIFFUSION SIMULATION LIMITED , MURRAY, Paul, Michael
发明人： REDIFFUSION SIMULATION LIMITED
IPC分类号： G09B09/32
CPC分类号： G09B9/30 , G09B9/14 , G09B9/46
摘要： A vehicle simulator in which a first motion platform (35) is driven in translation and rotation from a datum position. A simulator user station is positioned on the first motion platform, the user station defining a predetermined eyepoint position and a predetermined field of view from the eyepoint position relative to the user station. A display surface (37) is mounted on a second motion (38) platform so as to lie within the field of view, and the second motion platform (38) is driven to maintain a predetermined positional relationship between the eyepoint position and the display surface (37). An image is projected to be viewed from the eyepoint position via the display surface (37). The display surface is substantially spherical and the second motion platform (38) is driven, in response to translations of the eyepoint position, so that the location of the eyepoint position relative to the centre of the spherical display surface (37) is substantially constant and, in response to rotations of the first motion platform (35) about the eyepoint position, so that the second motion platform (38) is maintained substantially stationary. The display surface (45) extends to a perimeter that is outside the predetermined field of view for any possible rotations of the first motion system (35) about the eyepoint position.

10. 发明申请

WO2007007119A1 PROCESSES FOR THE MANUFACTURE OF ROSUVASTATIN AND INTERMEDIATES 审中-公开
标题翻译：罗维沙星和中间体的制备方法
公开(公告)号：WO2007007119A1
公开(公告)日：2007-01-18
申请号：PCT/GB2006/003543
申请日：2006-07-03
申请人： ASTRAZENECA UK LIMITED , BUTTERS, Michael , COX, David, Kenneth , CRABB, Jeffrey, Norman , LENGER, Steven, Robert , MURRAY, Paul, Michael , SNAPE, Evan, William
发明人： BUTTERS, Michael , COX, David, Kenneth , CRABB, Jeffrey, Norman , LENGER, Steven, Robert , MURRAY, Paul, Michael , SNAPE, Evan, William
IPC分类号： C07D239/42 , C07D239/36 , C07D239/30
CPC分类号： C07D239/30 , C07D239/36 , C07D239/42
摘要： A process for the manufacture of a compound of formula (V), useful for making rosuvastatin, by a stereoselective aldol reaction is described. Novel intermediates and processes to make them are also described.
摘要翻译：描述了通过立体选择性醛醇反应制备可用于制备瑞舒伐他汀的式（V）化合物的方法。还描述了新的中间体和制备它们的方法。

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