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1. 发明申请

WO0224635A2 AMINOALCOHOL DERIVATIVES 审中-公开
标题翻译：氨基醇衍生物
公开(公告)号：WO0224635A2
公开(公告)日：2002-03-28
申请号：PCT/JP0108155
申请日：2001-09-19
申请人： FUJISAWA PHARMACEUTICAL CO , SAKURAI MINORU , WASHIZUKA KENICHI , HAMASHIMA HITOSHI , TOMISHIMA YASUYO , IMANISHI MASASHI , NAKAJIMA YUTAKA , OHTAKE HIROAKI , KORADA SATORU , MURATA MASAYOSHI , KAYAKIRI HIROSHI , FUJII NAOAKI , TANIGUCHI KIYOSHI
发明人： SAKURAI MINORU , WASHIZUKA KENICHI , HAMASHIMA HITOSHI , TOMISHIMA YASUYO , IMANISHI MASASHI , NAKAJIMA YUTAKA , OHTAKE HIROAKI , KORADA SATORU , MURATA MASAYOSHI , KAYAKIRI HIROSHI , FUJII NAOAKI , TANIGUCHI KIYOSHI
IPC分类号： A61K31/167 , A61K31/17 , A61K31/18 , A61K31/216 , A61K31/327 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/421 , A61K31/426 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/472 , A61K31/498 , A61P1/00 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P13/00 , A61P13/02 , C07C53/18 , C07C231/02 , C07C231/08 , C07C231/10 , C07C233/36 , C07C233/43 , C07C233/62 , C07C233/75 , C07C233/80 , C07C235/56 , C07C273/02 , C07C275/40 , C07C275/42 , C07C275/54 , C07C303/38 , C07C311/08 , C07D207/34 , C07D207/40 , C07D207/416 , C07D209/08 , C07D209/18 , C07D209/40 , C07D209/42 , C07D209/88 , C07D213/40 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/38 , C07D215/40 , C07D215/48 , C07D215/50 , C07D217/18 , C07D217/22 , C07D217/26 , C07D231/14 , C07D231/56 , C07D233/90 , C07D235/06 , C07D235/08 , C07D235/16 , C07D237/28 , C07D241/20 , C07D241/42 , C07D241/44 , C07D249/08 , C07D261/14 , C07D261/18 , C07D261/20 , C07D263/18 , C07D263/34 , C07D277/28 , C07D277/56 , C07D295/215 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/82 , C07D333/36 , C07D333/38 , C07D333/66 , C07D333/70 , C07D487/04 , A61K31/395
CPC分类号： C07D207/416 , C07C233/43 , C07C233/62 , C07C233/80 , C07C235/56 , C07C275/40 , C07C275/42 , C07C275/54 , C07C311/08 , C07C2601/10 , C07C2601/14 , C07C2602/10 , C07D207/34 , C07D209/08 , C07D209/18 , C07D209/40 , C07D209/42 , C07D209/88 , C07D213/40 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/38 , C07D215/40 , C07D215/48 , C07D215/50 , C07D217/22 , C07D217/26 , C07D231/14 , C07D231/56 , C07D233/90 , C07D235/06 , C07D235/08 , C07D235/16 , C07D237/28 , C07D241/20 , C07D241/42 , C07D241/44 , C07D249/08 , C07D261/14 , C07D261/18 , C07D261/20 , C07D263/34 , C07D277/28 , C07D277/56 , C07D295/215 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/82 , C07D333/36 , C07D333/38 , C07D333/66 , C07D333/70 , C07D487/04 , Y02P20/55
摘要： The present invention relates to a compound formula (I) wherein X1 is bond or -O-CH2-, (II) or (III) R is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s), and B is hydrogen; halogen; lower alkyl; lower alkoxycarbonyl; cyclo(lower)alkyl; or a heterocyclic group, naphthyl, 1,2,3,4-tetrahydronaphthyl, benzyl or phenyl, each of which may be substituted with one or two substituent(s), or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiures or urinary incontinence.
摘要翻译：本发明涉及其中X 1为键或-O-CH 2 - ，（II）或（III）R 1为氢或氨基保护基的化合物（I），a为苯基，吲哚基或咔唑基，各自为可以被一个或两个取代基取代，B是氢; 卤素; 低级烷基低级烷氧基羰基; 环（低级）烷基; 或杂环基，萘基，1,2,3,4-四氢萘基，苄基或苯基，其各自可以被一个或两个取代基取代，或其盐。本发明的化合物（I）及其药学上可接受的盐可用于预防和/或治疗感染或尿失禁。

2. 发明申请

WO1997040357A1 AUTOMATIC EXTRACTING EQUIPMENT AND AUTOMATIC CONCENTRATION MEASURING EQUIPMENT FOR COMPONENT SUBSTANCE IN LIQUID SAMPLE 审中-公开
标题翻译：自动提取设备和液体样品中组分物质的自动浓度测量设备
公开(公告)号：WO1997040357A1
公开(公告)日：1997-10-30
申请号：PCT/JP1997001366
申请日：1997-04-18
申请人： DAINIPPON SEIKI CO., LTD. , FUJISAWA YAKUHIN KOGYO CO., LTD. , SAWADA, Naotaka , BABA, Akiyoshi , SAITO, Katsuhiko , HOSOKAWA, Yasumasa , MIYOSHI, Hajime , NISHIMURA, Shintaro , MURATA, Masayoshi
发明人： DAINIPPON SEIKI CO., LTD. , FUJISAWA YAKUHIN KOGYO CO., LTD.
IPC分类号： G01N01/10
CPC分类号： G01N35/025 , G01N2035/0405 , G01N2035/1025
摘要： Equipment, which can automatically perform a series of operations in solvent extraction when subjecting component substances contained in liquid samples to solvent extraction and measuring concentrations of the component substances, attain reduction of an operator's labor and time and make effective use of space. An automatic extracting equipment comprises a table holding a plurality of sample tubes, a table holding a plurality of containers for extraction and a plurality of containers for storage, a sample dispensing unit for sucking liquid samples from the sample tubes to discharge the same into the containers for extraction, a solvent dispensing unit for discharging an organic solvent into the containers for extraction, a shaker for transferring target component substances, in liquid samples contained in the containers for extraction, into the organic solvent, and a separation liquid dispensing unit for sucking sample separation liquids separated in the containers for extraction to discharge the same into the containers for storage.
摘要翻译：设备，当对液体样品中所含的组分物质进行溶剂萃取和测量组分物质的浓度时，可以自动执行溶剂萃取中的一系列操作，减少操作人员的劳动和时间并有效利用空间。一种自动提取设备，包括：一个容纳多个样品管的工作台;一个容纳多个容器的工作台;多个用于存放的容器;一个样品分配单元，用于从样品管抽出液体样品，用于提取的溶剂分配单元，用于将有机溶剂排放到用于萃取的容器中，将用于萃取的容器中所含的液体样品中的目标成分物质转移到有机溶剂中的振动器，以及用于吸取样品的分离液分配单元分离液体在容器中分离，用于萃取，以将其排放到容器中进行储存。

3. 发明申请

WO1992015584A1 PROCESS FOR PRODUCING TRICYCLIC COMPOUND OR SALT THEREOF 审中-公开
标题翻译：生产三聚体化合物或其盐的方法
公开(公告)号：WO1992015584A1
公开(公告)日：1992-09-17
申请号：PCT/JP1992000215
申请日：1992-02-27
申请人： FUZISAWA PHARMACEUTICAL CO., LTD. , WAKUNAGA PHARMACEUTICAL CO., LTD. , TSUTSUMI, Hideo , TERASAWA, Takeshi , BARRETT, David , MURATA, Masayoshi , SAKANE, Kazuo , YAZAKI, Akira , INOUE, Satoshi
发明人： FUZISAWA PHARMACEUTICAL CO., LTD. , WAKUNAGA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D471/06
CPC分类号： C07D471/06 , Y02P20/55
摘要： A compound represented by general formula (I), which is useful as an intermediate for the production of a clinically excellent synthetic antibacterial, a salt thereof, and a process for producing the same. In said formula, R1 represents hydrogen or a carboxyl protective group, R2 represents hydrogen or lower alkyl, X1 represents hydrogen or halogen, X2 represents halogen, X5a represents hydrogen or halogen, A represents methylene, =CH-COOR4, etc., and B represents methylene or carbonyl, provided that A and B should not be methylene groups at the same time.

4. 发明申请

WO2002024635A3 AMINOALCOHOL DERIVATIVES 审中-公开
公开(公告)号：WO2002024635A3
公开(公告)日：2002-03-28
申请号：PCT/JP2001/008155
申请日：2001-09-19
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , SAKURAI, Minoru , WASHIZUKA, Kenichi , HAMASHIMA, Hitoshi , TOMISHIMA, Yasuyo , IMANISHI, Masashi , NAKAJIMA, Yutaka , OHTAKE, Hiroaki , KORADA, Satoru , MURATA, Masayoshi , KAYAKIRI, Hiroshi , FUJII, Naoaki , TANIGUCHI, Kiyoshi
发明人： SAKURAI, Minoru , WASHIZUKA, Kenichi , HAMASHIMA, Hitoshi , TOMISHIMA, Yasuyo , IMANISHI, Masashi , NAKAJIMA, Yutaka , OHTAKE, Hiroaki , KORADA, Satoru , MURATA, Masayoshi , KAYAKIRI, Hiroshi , FUJII, Naoaki , TANIGUCHI, Kiyoshi
IPC分类号： C07C275/40
摘要： The present invention relates to a compound formula (I) wherein X 1 is bond or -O-CH 2 -, (II) or (III) R 1 is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s), and B is hydrogen; halogen; lower alkyl; lower alkoxycarbonyl; cyclo(lower)alkyl; or a heterocyclic group, naphthyl, 1,2,3,4-tetrahydronaphthyl, benzyl or phenyl, each of which may be substituted with one or two substituent(s), or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiures or urinary incontinence.

5. 发明申请

WO1996015109A1 ENDOTHELIN ANTAGONISTS 审中-公开
标题翻译：内皮素拮抗剂
公开(公告)号：WO1996015109A1
公开(公告)日：1996-05-23
申请号：PCT/JP1995002306
申请日：1995-11-13
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , HEMMI, Mitsue +hf , NEYA, Masahiro , ZENKOH, Tatsuya , SAWADA, Hitoshi , KASAHARA, Chiyoshi , MURATA, Masayoshi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD. , HEMMI, Mitsue +hf , HEMMI, Keiji +di
IPC分类号： C07D209/20
CPC分类号： C07D405/12 , C07D209/20 , C07D317/60 , C07D409/12
摘要： A compound of formula (I), in which: R is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R is hydrogen, hydroxy or protected hydroxy; R is lower alkyl, aryl, ar(lower)alkyl or optionally substituted heterocyclic(lower)alkyl; R is carboxy, protected carboxy or lower alkylsufonylcarbamoyl; R is hydrogen or lower alkyl; R is hydrogen or heterocyclic group; A is a single bond or lower alkylene, and Ar is optionally substituted aryl, or pharmaceutically acceptable salts thereof, having endothelin antagonistic activity.
摘要翻译：式（I）化合物，其中：R 1为低级烷基，环（低级）烷基，任选取代的芳基，任选取代的杂环基，环（低级）烷基（低级）烷基或芳（低级）烷基 ; R 2是氢，羟基或保护的羟基; R 3是低级烷基，芳基，芳（低级）烷基或任选取代的杂环（低级）烷基; R 4是羧基，保护的羧基或低级烷基磺酰基氨基甲酰基; R 5是氢或低级烷基; R 6是氢或杂环基; A是单键或低级亚烷基，Ar是具有内皮素拮抗活性的任选取代的芳基或其药学上可接受的盐。

6. 发明申请

WO1995010520A1 3-PYRROLIDINYLTHIO-CARBAPENEM DERIVATIVES AND THEIR ANTIMICROBAL ACTIVITY 审中-公开
标题翻译： 3-吡咯烷二恶唑衍生物及其抗微生物活性
公开(公告)号：WO1995010520A1
公开(公告)日：1995-04-20
申请号：PCT/JP1994001588
申请日：1994-09-27
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MURATA, Masayoshi , TSUTSUMI, Hideo , MATSUDA, Keiji , HATTORI, Kohji , NAKAJIMA, Takashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D477/20
CPC分类号： C07D477/20 , Y02P20/55
摘要： A compound of formula (I), in which R is carboxy, etc., R is hydroxy(lower)alkyl, etc., R is hydrogen or lower alkyl, R is 2(or 3)-methylpyridin-4-ylmethyl, etc., and R is hydrogen or imino-protective group, or pharmaceutically acceptable salts thereof, which is useful as an antimicrobial agent.
摘要翻译：式（I）化合物，其中R 1是羧基等，R 2是羟基（低级）烷基等，R 3是氢或低级烷基，R 4是2 （或3） - 甲基吡啶-4-基甲基等，R 5是可用作抗微生物剂的氢或亚氨基保护基或其药学上可接受的盐。

7. 发明申请

WO1992002521A1 1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID COMPOUNDS 审中-公开
标题翻译： 1-氨基甲酰基[3.2.0] HEPT-2-环己基-2-羧酸化合物
公开(公告)号：WO1992002521A1
公开(公告)日：1992-02-20
申请号：PCT/JP1991000997
申请日：1991-07-25
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MURATA, Masayoshi , CHIBA, Toshiyuki , TSUTSUMI, Hideo , YAMADA, Akira , HATTORI, Kohji
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D477/00
CPC分类号： C07D477/14
摘要： A compound of formula (I) in which R is carboxy, protected carboxy or carboxylato, R is hydroxy(lower)alkyl or protected hydroxy-(lower)alkyl, R is axetidinyl, pyrrolidinyl, imidazolinyl, tetrahydropyrimidinyl, piperidyl, 1,1-di(lower)alkylpiperidinio, 3-(lower)-alkyl-1-(2-imidazolinio), 3-[hydroxy-(lower)alkyl]-1-(2-imidazolinio) or 3-(lower)alkyl-1,4,5,6-tetrahydro-1-pyrimidinio; wherein each heterocyclic group may be substituted by one or more suitable substituent(s), R is hydrogen or lower alkyl, and A is lower alkylene, provided that when R is lower alkylpyrrolidinyl, then R is hydrogen, or a pharmaceutically acceptable salt thereof, which is useful as an antimicrobial agent.
摘要翻译：式（I）的化合物，其中R 1是羧基，被保护的羧基或羧基，R 2是羟基（低级）烷基或被保护的羟基 - （低级）烷基，R 3是肟基，吡咯烷基，咪唑啉基，四氢嘧啶基，哌啶基，1,1-二（低级）烷基哌啶基，3-（低级）烷基-1-（2-咪唑啉基），3- [羟基 - （低级）烷基] -1-（2-咪唑啉鎓）或 3-（低级）烷基-1,4,5,6-四氢-1- pyrimidinio; 其中每个杂环基团可以被一个或多个合适的取代基取代，R 10是氢或低级烷基，A是低级亚烷基，条件是当R 3是低级烷基吡咯烷基时，R 10是氢或其药学上可接受的盐，其可用作抗微生物剂。

8. 发明申请

WO1995027694A1 PROCESS FOR PRODUCING 'alpha','beta'-DISUBSTITUTED ALCOHOL DERIVATIVE 审中-公开
标题翻译：生产α，β - 衍生的醇醇衍生物的方法
公开(公告)号：WO1995027694A1
公开(公告)日：1995-10-19
申请号：PCT/JP1995000656
申请日：1995-04-05
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MURATA, Masayoshi , TSUTSUMI, Hideo , OHTAKE, Hiroaki , YONISHI, Satoshi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07C69/16
CPC分类号： C07D209/18 , C07B53/00 , C07C67/31 , C07C231/12 , C07C235/30 , C07C235/34 , C07C2601/14 , C07D307/54 , C07D333/24
摘要： A process for producing an alpha , beta -disubstituted alcohol derivative according to the reaction scheme, which is more excellent than the conventional reduction process in the selectivity for an anti -form, thus being industrially advantageous. In (1), R represents hydrogen or an organic group; R represents optionally substituted carbamoyl; R represents an organic group; and A and Q represent each lower alkylene or a single bond.
摘要翻译：根据反应方案制备α，β-二取代醇衍生物的方法，其比在常规还原方法中对于反式选择性更优异，因此在工业上是有利的。在（1）中，R 1表示氢或有机基团; R 2表示任选取代的氨基甲酰基; R 3表示有机基团; A和Q表示低级亚烷基或单键。

9. 发明申请

WO1992006978A1 1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID COMPOUNDS 审中-公开
标题翻译： 1-氨基甲酰基[3.2.0] HEPT-2-环己基-2-羧酸化合物
公开(公告)号：WO1992006978A1
公开(公告)日：1992-04-30
申请号：PCT/JP1991001394
申请日：1991-10-14
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MURATA, Masayoshi , CHIBA, Toshiyuki , TSUTSUMI, Hideo , HATTORI, Kohji , KURODA, Satoru , OHTAKA, Hiroaki , SHIRAI, Fumiyuki
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D477/00
CPC分类号： C07D477/14
摘要： 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds of formula (a), in which R is carboxy, COO or protected carboxy, R is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R is hydrogen or lower alkyl, Z is a group of formulae (b) or (c), wherein R is hydrogen; lower alkyl or lower alkenyl, each of which is optionally substituted by the group consisting of lower alkoxy, carbamoyl, hydroxy, halogen, mono(or di)(lower)alkylcarbamoyl, mono(or di)(lower)alkenylcarbamoyl, mono(or bis)[hydroxy(lower)alkyl]carbamoyl, optionally substituted cyclic-aminocarbonyl, acylamino, ureido, optionally substituted heterocyclic-carbonylamino, carbamoyloxy, mono(or di)(lower)alkylcarbamoyloxy, lower alkylthio, halo(lower)alkylthio, optionally substituted heterocyclicthio, optionally substituted heterocyclic group, optionally substituted aryl, and acyl; R is hydrogen or lower alkyl, and R is lower alkyl, or pharmaceutically acceptable salts thereof, which is useful as an antimicrobial agent.
摘要翻译：式（a）的1-氮杂双环[3.2.0]庚-2-烯-2-羧酸化合物，其中R 1是羧基，COO - 或被保护的羧基，R 2是羟基（低级）烷基或被保护的羟基（低级）烷基，R 8是氢或低级烷基，Z是式（b）或（c）的基团，其中R 3是氢; 羟基，卤素，单（或二）（低级）烷基氨基甲酰基，单（或二）（低级）烯基氨基甲酰基，单（或双（低级））链烯基氨基甲酰基，）（羟基（低级）烷基]氨基甲酰基，任选取代的环氨基羰基，酰氨基，脲基，任选取代的杂环 - 羰基氨基，氨基甲酰氧基，单（或二）（低级）烷基氨基甲酰氧基，低级烷硫基，卤（低级）烷硫基，任选取代的杂环硫，任选取代的杂环基，任选取代的芳基和酰基; R 9是氢或低级烷基，R 10是可用作抗微生物剂的低级烷基或其药学上可接受的盐。

10. 发明申请

WO1993021186A1 SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译：作为抗微生物剂的取代的3-吡咯烷基硫代碳酸酯
公开(公告)号：WO1993021186A1
公开(公告)日：1993-10-28
申请号：PCT/JP1993000469
申请日：1993-04-09
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MURATA, Masayoshi , TSUTSUMI, Hideo , MATSUDA, Keiji , HATTORI, Kohji , NAKAJIMA, Takashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D477/00
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D477/20 , Y02P20/55
摘要： A compound of formula (I), in which R is carboxy or protected carboxy, R is 1-hydroxyethyl, R is methyl, R is optionally substituted pyridyl(lower)alkyl, optionally N-substituted 2-oxopiperazin-1-yl-(lower)alkyl, optionally substituted imidazol-1-yl(C2-C3)alkyl, optionally substituted imidazol-5-yl(lower)alkyl, optionally substituted imidazol-2-yl-(lower)alkyl, optionally substituted pyrazol-4-(or 5-)yl(lower)alkyl, optionally substituted pyrazol-1-ylethyl, optionally substituted triazolyl(lower)alkyl, optionally substituted pyrimidinyl(lower)-alkyl, optionally substituted dihydropyrimidinyl(lower)alkyl, or optionally substituted (2,3-dihydroimidazo-[1,2-b]pyrazol-1-yl)ethyl, and R is hydrogen or imino-protective group, and pharmaceutically acceptable salts thereof, which have antimicrobial activity.
摘要翻译：式（I）化合物，其中R 1为羧基或被保护的羧基，R 2为1-羟基乙基，R 3为甲基，R 4为任选取代的吡啶基（低级）烷基，任选地 N-取代的2-氧代哌嗪-1-基 - （低级）烷基，任意取代的咪唑-1-基（C 2 -C 3）烷基，任意取代的咪唑-5-基（低级）烷基，任意取代的咪唑-2-基 - （低级）烷基，任选取代的吡唑-4-（或5-）基（低级）烷基，任选取代的吡唑-1-基乙基，任选取代的三唑基（低级）烷基，任选取代的嘧啶基（低级） - 烷基，任选取代的二氢嘧啶基（低级）烷基或任选取代的（2,3-二氢咪唑并[1,2-b]吡唑-1-基）乙基，R 5为氢或亚氨基保护基，及其药学上可接受的盐，其中具有抗菌活性。

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