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1. 发明公开

EP0649435A4 MEMBRANE-ASSOCIATED IMMUNOGENS OF MYCOBACTERIA. 失效
标题翻译：膜相关分枝杆菌的免疫原性蛋白。
公开(公告)号：EP0649435A4
公开(公告)日：1996-12-27
申请号：EP93916768
申请日：1993-06-28
申请人： KAPOOR ARCHANA , MUNSHI ANIL
发明人： KAPOOR ARCHANA , MUNSHI ANIL
IPC分类号： C12N15/09 , A61K39/00 , A61K39/04 , A61P31/04 , C07H21/04 , C07K14/195 , C07K14/35 , C07K14/41 , C07K19/00 , C12N9/14 , C12N15/31 , C12P21/02 , C12R1/32 , C07K15/04 , C07K14/00 , C12N15/55
CPC分类号： C07K14/35 , A61K39/00 , C07K2319/00 , C07K2319/40 , C12N9/14
摘要： Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA, constructed in pBR322 vector, and screened with sera collected from tuberculosis patients. The BCG DNA insert of one of the recombinants, pMBB51A, which expressed an antigen of Mr 90 kD, was sequenced completely and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was identified. This gene was identified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. In addition, the well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. Also, the promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

2. 发明授权

EP0649435B1 MEMBRANE-ASSOCIATED IMMUNOGENS OF MYCOBACTERIA 失效
标题翻译：分枝杆菌的膜相关免疫原性蛋白
公开(公告)号：EP0649435B1
公开(公告)日：2006-04-05
申请号：EP93916768.0
申请日：1993-06-28
申请人： KAPOOR, Archana , MUNSHI, Anil
发明人： KAPOOR, Archana , MUNSHI, Anil
IPC分类号： C07K14/00 , C12N9/14 , C12N15/31 , C12N15/55 , A61K39/04 , C07K14/35
CPC分类号： C07K14/35 , A61K39/00 , C07K2319/00 , C07K2319/40 , C12N9/14 , Y02A50/472
摘要： Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA, constructed in pBR322 vector, and screened with sera collected from tuberculosis patients. The BCG DNA insert of one of the recombinants, pMBB51A, which expressed an antigen of Mr 90 kD, was sequenced completely and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was identified. This gene was identified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. In addition, the well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. Also, the promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

3. 发明公开

EP0649435A1 MEMBRANE-ASSOCIATED IMMUNOGENS OF MYCOBACTERIA 失效
标题翻译：膜相关分枝杆菌的免疫原性蛋白。
公开(公告)号：EP0649435A1
公开(公告)日：1995-04-26
申请号：EP93916768.0
申请日：1993-06-28
申请人： KAPOOR, Archana , MUNSHI, Anil
发明人： KAPOOR, Archana , MUNSHI, Anil
IPC分类号： C12N15 , A61K39 , A61P31 , C07H21 , C07K14 , C07K19 , C12N9 , C12P21 , C12R1
CPC分类号： C07K14/35 , A61K39/00 , C07K2319/00 , C07K2319/40 , C12N9/14 , Y02A50/472
摘要： Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA, constructed in pBR322 vector, and screened with sera collected from tuberculosis patients. The BCG DNA insert of one of the recombinants, pMBB51A, which expressed an antigen of Mr 90 kD, was sequenced completely and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was identified. This gene was identified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. In addition, the well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. Also, the promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

4. 发明专利

AU689075B2 Membrane-associated immunogens of mycobacteria 未知
公开(公告)号：AU689075B2
公开(公告)日：1998-03-26
申请号：AU4651193
申请日：1993-06-28
申请人： KAPOOR ARCHANA , MUNSHI ANIL
发明人： KAPOOR ARCHANA , MUNSHI ANIL
IPC分类号： C12N15/09 , A61K39/00 , A61K39/04 , A61P31/04 , C07H21/04 , C07K14/195 , C07K14/35 , C07K14/41 , C07K19/00 , C12N9/14 , C12N15/31 , C12P21/02 , C12R1/32 , C07K15/04 , C07K13/00 , C12N15/55
摘要： Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA and screened with sera collected from tuberculosis patients. The BCG DNA expressed an antigen of Mr 90 kD, and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was indentified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. The well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. The promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

5. 发明专利

AU4651193A Membrane-associated immunogens of mycobacteria 未知
公开(公告)号：AU4651193A
公开(公告)日：1994-01-24
申请号：AU4651193
申请日：1993-06-28
申请人： KAPOOR ARCHANA , MUNSHI ANIL
发明人： KAPOOR ARCHANA , MUNSHI ANIL
IPC分类号： C12N15/09 , A61K39/00 , A61K39/04 , A61P31/04 , C07H21/04 , C07K14/195 , C07K14/35 , C07K14/41 , C07K19/00 , C12N9/14 , C12N15/31 , C12P21/02 , C12R1/32 , C07K15/04 , C07K13/00 , C12N15/55
摘要： Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA and screened with sera collected from tuberculosis patients. The BCG DNA expressed an antigen of Mr 90 kD, and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was indentified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. The well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. The promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

6. 发明专利

DE69334002T2 未知
公开(公告)号：DE69334002T2
公开(公告)日：2007-04-19
申请号：DE69334002
申请日：1993-06-28
申请人： KAPOOR ARCHANA , MUNSHI ANIL
发明人： KAPOOR ARCHANA , MUNSHI ANIL
IPC分类号： C07K14/00 , C12N15/09 , A61K39/00 , A61K39/04 , A61P31/04 , C07H21/04 , C07K14/195 , C07K14/35 , C07K14/41 , C07K19/00 , C12N9/14 , C12N15/31 , C12N15/55 , C12P21/02 , C12R1/32
摘要： Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA and screened with sera collected from tuberculosis patients. The BCG DNA expressed an antigen of Mr 90 kD, and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was indentified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. The well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. The promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

7. 发明专利

AT322502T 未知
公开(公告)号：AT322502T
公开(公告)日：2006-04-15
申请号：AT93916768
申请日：1993-06-28
申请人： KAPOOR ARCHANA , MUNSHI ANIL
发明人： KAPOOR ARCHANA , MUNSHI ANIL
IPC分类号： C12N15/09 , A61K39/00 , A61K39/04 , A61P31/04 , C07H21/04 , C07K14/195 , C07K14/35 , C07K14/41 , C07K19/00 , C12N9/14 , C12N15/31 , C12P21/02 , C12R1/32 , C07K14/00 , C12N15/55
摘要： Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA and screened with sera collected from tuberculosis patients. The BCG DNA expressed an antigen of Mr 90 kD, and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was indentified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. The well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. The promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

8. 发明专利

DE69334002D1 未知
公开(公告)号：DE69334002D1
公开(公告)日：2006-05-18
申请号：DE69334002
申请日：1993-06-28
申请人： KAPOOR ARCHANA , MUNSHI ANIL
发明人： KAPOOR ARCHANA , MUNSHI ANIL
IPC分类号： C07K14/00 , C12N15/09 , A61K39/00 , A61K39/04 , A61P31/04 , C07H21/04 , C07K14/195 , C07K14/35 , C07K14/41 , C07K19/00 , C12N9/14 , C12N15/31 , C12N15/55 , C12P21/02 , C12R1/32
摘要： Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA and screened with sera collected from tuberculosis patients. The BCG DNA expressed an antigen of Mr 90 kD, and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was indentified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. The well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. The promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

9. 发明申请

WO1994000493A1 MEMBRANE-ASSOCIATED IMMUNOGENS OF MYCOBACTERIA 审中-公开
标题翻译：膜结缔组织免疫球蛋白
公开(公告)号：WO1994000493A1
公开(公告)日：1994-01-06
申请号：PCT/US1993006080
申请日：1993-06-28
申请人： KAPOOR, Archana , MUNSHI, Anil
IPC分类号： C07K15/04
CPC分类号： C07K14/35 , A61K39/00 , C07K2319/00 , C07K2319/40 , C12N9/14 , Y02A50/472
摘要： Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA, constructed in pBR322 vector, and screened with sera collected from tuberculosis patients. The BCG DNA insert of one of the recombinants, pMBB51A, which expressed an antigen of Mr 90 kD, was sequenced completely and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was identified. This gene was identified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. In addition, the well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. Also, the promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.
摘要翻译：已经分离了编码四种新型免疫决定蛋白抗原的核酸，其为结核分枝杆菌疫苗株。从pBR322载体构建的来自牛分枝杆菌BCG DNA的基因组文库中分离这些基因作为免疫反应性重组克隆，并用结核病患者的血清进行筛选。鉴定了表达90kD前列腺素抗原的重组体pMBB51A的BCG DNA插入片段，并且编码编码分子量为79kD的推定蛋白质的761个氨基酸的ORF。鉴定该基因编码牛分枝杆菌BCG的膜结合离子动力ATP酶。这里描述的方法可用于鉴定分枝杆菌的免疫原。此外，良好表征的牛分枝杆菌BCG抗原可用于预防，诊断和治疗结核病。 79 kD抗原也可用于设计针对不同病原体的重组疫苗。 79kD膜相关多肽的序列也可用于开发用于检测分枝杆菌的基于特异性PCR扩增的诊断程序。此外，79kD抗原的启动子可用于在分枝杆菌中表达同源和/或异源抗原。

10. 发明申请

WO9962315A3 METHOD FOR ALTERING THE ACTIVITY OF PROTEINS OF THE PKA SIGNALING PATHWAY 审中-公开
标题翻译：改变PKA信号通路蛋白活性的方法
公开(公告)号：WO9962315A3
公开(公告)日：2000-05-04
申请号：PCT/GB9901680
申请日：1999-05-27
申请人： LAURAS AS , JONES ELIZABETH LOUISE , HANSSON VIDAR , LEVY FINN OLAV , MUSTELIN THOMAS , SKAALHEGG BJOERN STEEN , SUNDVOLD VIBEKE , TASKEN KJETIL , VANG TORKEL , ALTMAN AMNON , MUNSHI ANIL
发明人： HANSSON VIDAR , LEVY FINN OLAV , MUSTELIN THOMAS , SKAALHEGG BJOERN STEEN , SUNDVOLD VIBEKE , TASKEN KJETIL , VANG TORKEL , ALTMAN AMNON , MUNSHI ANIL
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/52 , C12P19/18 , C12Q1/02 , C12N9/12 , C12N15/12 , C12N15/85
CPC分类号： C12N9/1051 , A61K38/1709 , C12N15/52 , C12P19/18
摘要： The invention relates to methods of altering the activity of the PKA signaling pathway by altering, preferably inhibiting, the extent of phosphorylation of PKA substrates or downstream kinase substrates, particularly by the use of modified substrates, gene sequences encoding such modified substrates, vectors and host cells containing the gene sequence, inhibitors of substrate phosphorylation and use of the gene sequence, protein or inhibitors to alter the PKA signaling pathway, for example in treating immunosuppressive disorders or proliferative diseases.
摘要翻译：本发明涉及通过改变，优选地抑制PKA底物或下游激酶底物的磷酸化程度，特别是通过使用修饰的底物，编码这种修饰的底物的基因序列，载体和宿主来改变PKA信号通路的活性的方法包含基因序列的细胞，底物磷酸化的抑制剂和基因序列的使用，蛋白质或抑制剂改变PKA信号通路，例如在治疗免疫抑制障碍或增殖性疾病中。

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