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1. 发明申请

WO2005021538A1 NOVEL CHELATING AGENTS AND CHELATES AND THEIR USE 审中-公开
标题翻译：新型戒烟药剂及其使用及其使用
公开(公告)号：WO2005021538A1
公开(公告)日：2005-03-10
申请号：PCT/FI2004/000502
申请日：2004-08-27
申请人： WALLAC OY , HOVINEN, Jari , MUKKALA, Veli-Matti , HAKALA, Harri , PEURALAHTI, Jari
发明人： HOVINEN, Jari , MUKKALA, Veli-Matti , HAKALA, Harri , PEURALAHTI, Jari
IPC分类号： C07D405/04
CPC分类号： G01N33/587 , C07D405/04 , C07D405/14 , C07F9/65586 , G01N33/582
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译：本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。

2. 发明申请

WO2003076939A1 DISSOCIATIVE FLUORESCENCE ENHANCEMENT ASSAY 审中-公开
标题翻译：分散荧光增强测定
公开(公告)号：WO2003076939A1
公开(公告)日：2003-09-18
申请号：PCT/FI2003/000145
申请日：2003-02-28
申请人： WALLAC OY , HEMMILÄ, Ilkka , BLOMBERG, Kaj , MUKKALA, Veli-Matti , HAKALA, Harri
发明人： HEMMILÄ, Ilkka , BLOMBERG, Kaj , MUKKALA, Veli-Matti , HAKALA, Harri
IPC分类号： G01N33/542
CPC分类号： G01N33/542 , C12Q1/682 , G01N21/64 , G01N33/582 , Y10S436/80 , Y10T436/108331 , Y10T436/15 , Y10T436/200833 , C12Q2527/125 , C12Q2563/107
摘要： The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a ß-diketone of formula (I) wherein R 1 is an aryl, optionally mono- or multi-substituted, and R 2 is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms. The invention further relates to a bioaffinity assay using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection comprising the use of said enhancement solution.
摘要翻译：本发明涉及使用镧系元素离子或其螯合物作为标记物和解离荧光增强作为检测工具的测定技术的增强方案，其中所述增强溶液包含式I的β-二酮，其中R 1是芳基，或多取代的，R2是具有2至9个碳原子的直链或支链烷基，被四个或多个氟原子取代。本发明还涉及使用镧系元素离子或其螯合物作为标记和解离荧光增强作为检测工具的生物亲和力测定，其包括使用所述增强溶液。

3. 发明申请

WO1989008263A1 A NOVEL SPECTROFLUOROMETRIC METHOD AND COMPOUNDS THAT ARE OF VALUE FOR THE METHOD 审中-公开
标题翻译：一种新的方法和方法的价值的方法和化合物
公开(公告)号：WO1989008263A1
公开(公告)日：1989-09-08
申请号：PCT/SE1989000073
申请日：1989-02-22
申请人： WALLAC OY , MUKKALA, Veli-Matti , SUND, Christian , KWIATKOWSKI, Marek
发明人： WALLAC OY
IPC分类号： G01N33/58
CPC分类号： C07D239/26 , C07D213/22 , C07D239/30 , C07F5/003 , C07F9/58 , G01N33/533
摘要： A spectrofluorometric method for the detection of target structures by the use of two or more fluorescent lanthanide chelate probes for specifically marking each of said structures. The probes used differ with respect to their excitation or emission wavelength maxima. Also disclosed are certain lanthanide chelates that can be used in the method, either for synthesizing the probes or to be used directly as probes. The chelating ligand of these novel probes comprises two heterocyclic rings (preferably pyridyl) linked together so that jointly they can coordinate (chelate) one metal ion. The bridge linking the two rings together permits electron delocalization between the rings. Attached to their 6-positions the two rings carry chelating groups having heteroatoms (N, O or S) that participate in the chelation of the metal ion. Preferably the chelating groups at the 6-positions are -CH2N(CH2COOH)2, -CH2N(CH2CH2COOH)2, (a) or (b).
摘要翻译：用于通过使用两种或多种荧光镧系元素螯合探针来检测靶结构的分光荧光法，用于特别标记每个所述结构。使用的探针在其激发或发射波长最大值方面不同。还公开了可用于该方法的某些镧系元素螯合物，用于合成探针或直接用作探针。这些新型探针的螯合配体包含两个连接在一起的杂环（优选吡啶基），因此它们可共同配合（螯合）一种金属离子。将两个环连接在一起的桥允许环之间的电子离域化。附着在它们的6位上，两个环带有具有参与金属离子螯合的杂原子（N，O或S）的螯合基团。优选6位上的螯合基团是-CH 2 N（CH 2 COOH）2，-CH 2 N（CH 2 CH 2 COOH）2，（a）或（b）。

4. 发明申请

WO2009030819A1 LUMINESCENT LANTHANIDE (III) CHELATES, CHELATING AGENTS AND CONJUGATES DERIVED THEREOF 审中-公开
标题翻译：光泽兰（III）烟囱，火柴及其衍生物
公开(公告)号：WO2009030819A1
公开(公告)日：2009-03-12
申请号：PCT/FI2008/050494
申请日：2008-09-05
申请人： WALLAC OY , PEURALAHTI, Jari , HOVINEN, Jari , KETOLA, Janne , JAAKKOLA, Lassi , MUKKALA, Veli-Matti , LIITTI, Päivi
发明人： PEURALAHTI, Jari , HOVINEN, Jari , KETOLA, Janne , JAAKKOLA, Lassi , MUKKALA, Veli-Matti , LIITTI, Päivi
IPC分类号： C07D405/14 , C07D409/14 , G01N33/52 , G01N33/58
CPC分类号： C07D405/14 , C07D409/14 , G01N33/533 , G01N33/543 , G01N33/582
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained. The chelates described herein compris - a lanthanide ion, Ln 3+ - chromophoric moiety - a chelating part, and - a reactive group.
摘要翻译：本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。本文描述的螯合物包括镧系元素离子，Ln 3+发色部分 - 螯合部分和 - 反应性基团。

5. 发明申请

WO1984003698A1 COMPOUND 审中-公开
标题翻译：复合
公开(公告)号：WO1984003698A1
公开(公告)日：1984-09-27
申请号：PCT/SE1984000089
申请日：1984-03-13
申请人： LKB-PRODUKTER AB , WALLAC, Oy , MIKOLA, Heikki , MUKKALA, Veli-Matti , HEMMILÄ, Ilkka
发明人： LKB-PRODUKTER AB , WALLAC, Oy
IPC分类号： C07C161/04
CPC分类号： G01N33/533 , C07F9/3817 , G01N2458/40 , Y10S435/968 , Y10T436/13
摘要： Compound having structure (I), where R is a direct chain or branched alkylene group comprising 2-8 carbon atoms; n and m are 0 or 1, Y is a carboxylic or phosphonic acid, and X is an active funcitional group which permits covalent coupling to a bio-organic molecule.

6. 发明申请

WO2009115644A1 LANTHANIDE(III) CHELATES COMPRISING BETA-DIKETONES AND CONJUGATES DERIVED THEREOF 审中-公开
标题翻译：（III）包含β-二酮和其衍生物的螯合物
公开(公告)号：WO2009115644A1
公开(公告)日：2009-09-24
申请号：PCT/FI2009/050208
申请日：2009-03-18
申请人： WALLAC OY , HOVINEN, Jari , MUKKALA, Veli-Matti
发明人： HOVINEN, Jari , MUKKALA, Veli-Matti
IPC分类号： C07D255/02 , C07D257/00 , C07D257/02 , C07C49/15 , C09K11/77 , C09K11/07 , G01N33/53 , C07F5/00
CPC分类号： C09K11/06 , C07D257/02 , C09K2211/1007 , C09K2211/1029 , C09K2211/1092 , C09K2211/182 , G01N33/532
摘要： This invention relates to luminescent lanthanide(III) chelates based on β-diketones comprising an azacycloalkane backbone and biomolecule conjugates and solid supports comprising these chelates. In contrast to lanthanide chelates based on monomeric β-diketones as well as lanthanide(III) chelates based on acyclic azaalkanes including several β-diketone subunits, the molecules of the present technology are luminescent even in the absence of additional chelators such as phosphine oxides.
摘要翻译：本发明涉及基于包含氮杂环烷烃主链和生物分子缀合物的β-二酮的发光镧系元素（III）螯合物和包含这些螯合物的固体载体。与基于单体β-二酮的镧系元素螯合物以及基于包括几个β-二酮亚基的无环氮烷烃的镧系元素（III）螯合物相反，即使在不存在另外的螯合剂如氧化膦的情况下，本技术的分子也是发光的。

7. 发明申请

WO9815830A3 HOMOGENOUS LUMINESCENCE ENERGY TRANSFER ASSAYS 审中-公开
标题翻译：均质发光能量转移测定
公开(公告)号：WO9815830A3
公开(公告)日：1998-06-18
申请号：PCT/FI9700560
申请日：1997-09-19
申请人： WALLAC OY , HEMMILAE ILKKA ANTERO , HURSKAINEN PERTTI JUHANI , BLOMBERG KAJ RUNAR , MUKKALA VELI-MATTI , TAKALO HARRI JUHA , KOVANEN SATU ANNELI , WEBB STUART ALAN
发明人： HEMMILAE ILKKA ANTERO , HURSKAINEN PERTTI JUHANI , BLOMBERG KAJ RUNAR , MUKKALA VELI-MATTI , TAKALO HARRI JUHA , KOVANEN SATU ANNELI , WEBB STUART ALAN
IPC分类号： C12Q1/68 , G01N21/64 , G01N21/78 , G01N33/542 , G01N33/543 , G01N33/573 , G01N33/574 , G01N33/68 , G01N33/74 , G01N33/76
CPC分类号： G01N21/6408 , C12Q1/6818 , G01N21/6428 , G01N33/542 , G01N33/573 , G01N33/57434 , G01N33/6869 , G01N33/743 , G01N33/76 , G01N2021/6441 , G01N2458/40
摘要： The invention relates to improvements of energy-transfer based homogeneous assays, which use time-resolved fluorometry in detection. The specific improvements relate to the type of lanthanide chelate labels used as energy donors, optimized energy acceptors for defined assays, the way energy transfer is measured using optimized filters and time windows, ways to correct all possible interferences derived from samples, use the assay for multi-component analysis and development of simplified assay protocols. 00000
摘要翻译：本发明涉及基于能量转移的均相测定的改进，其在检测中使用时间分辨的荧光测定法。具体的改进涉及用作能量供体的镧系螯合物标签的类型，用于定义测定的优化的能量受体，使用优化的过滤器和时间窗测量能量转移的方式，校正来自样品的所有可能的干扰的方法，多组分分析和开发简化的测定方案。 00000

8. 发明申请

WO1993011433A1 LUMINESCENT LANTHANIDE CHELATES 审中-公开
标题翻译：光泽兰花
公开(公告)号：WO1993011433A1
公开(公告)日：1993-06-10
申请号：PCT/FI1991000373
申请日：1991-12-05
申请人： WALLAC OY , TAKALO, Harri , MUKKALA, Veli-Matti
发明人： WALLAC OY
IPC分类号： G01N33/533
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , G01N33/533
摘要： The compounds of this invention are lanthanide chelates comprising three heterocyclic rings covalently coupled to each other (either one 2,6-pyridylene and two five-membered unsaturated heterocyclic ring moieties or two 2,6-pyridylene and one five-membered unsaturated heterocyclic ring moiety) and two chelating groups so seated that they together chelate the same lanthanide ion even in aqueous solutions. Optionally these lanthanide chelates also contain a reactive group for coupling to biologically active molecules. The new chelates of our invention find applications in those areas that are classical for lanthanide chelates. Moreover, these compounds are useful as probes in time-resolved fluorescence microscopy, cytometry, multilabelling techniques and process controls in industry.
摘要翻译：本发明的化合物是包含三个彼此共价偶联的杂环的镧系元素螯合物（一个2,6-亚吡啶基和两个五元不饱和杂环环部分或两个2,6-亚吡啶基和一个五元不饱和杂环部分）和两个如此坐下的螯合基团，即使在水溶液中它们一起螯合相同的镧系元素离子。任选地，这些镧系螯合物还含有用于与生物活性分子偶联的反应性基团。本发明的新螯合物可用于那些经典镧系螯合物的领域。此外，这些化合物可用作时间分辨荧光显微镜，细胞计数，多标签技术和工业过程控制中的探针。

9. 发明申请

WO2009068751A1 TRANSPORTER ASSAY 审中-公开
标题翻译：运输工具测定
公开(公告)号：WO2009068751A1
公开(公告)日：2009-06-04
申请号：PCT/FI2008/050696
申请日：2008-11-27
申请人： WALLAC OY , FRANG, Heini , HOVINEN, Jari , MUKKALA, Veli-Matti , HURSKAINEN, Pertti , HEMMILÄ, Ilkka
发明人： FRANG, Heini , HOVINEN, Jari , MUKKALA, Veli-Matti , HURSKAINEN, Pertti , HEMMILÄ, Ilkka
IPC分类号： G01N33/58
CPC分类号： G01N33/542 , G01N2333/705 , Y10T436/143333
摘要： This invention concerns a non-radioactive homogenous proximity assay for cellular transport system. The assay format disclosed here takes advantageous of the fact that ABC transporters have two similar ATP binding sites, and thus allowing two ATP molecules to bind simultaneously to these adjacent sites.
摘要翻译：本发明涉及用于细胞运输系统的非放射性同源邻近测定法。这里公开的测定格式有利于ABC转运蛋白具有两个相似的ATP结合位点，因此允许两个ATP分子同时结合到这些相邻位点。

10. 发明申请

WO2007082996A1 NEUTRAL LABELING REACTANTS AND CONJUGATES DERIVED THEREOF 审中-公开
标题翻译：中性标记物及其衍生物
公开(公告)号：WO2007082996A1
公开(公告)日：2007-07-26
申请号：PCT/FI2007/050019
申请日：2007-01-16
申请人： WALLAC OY , HOVINEN, Jari , PEURALAHTI, Jari , MUKKALA, Veli-Matti , BLOMBERG, Kaj
发明人： HOVINEN, Jari , PEURALAHTI, Jari , MUKKALA, Veli-Matti , BLOMBERG, Kaj
IPC分类号： C07C237/06 , C07C331/28 , C07J7/00 , C07C237/04 , C07C229/16 , G01N33/533 , G01N33/58
CPC分类号： C07C229/76 , A61K49/085 , A61K49/10 , A61K49/103 , A61K51/0478 , C07C251/60 , C07C331/28 , G01N33/533
摘要： This invention concerns novel neutral labeling reactants. The novel reactants are deri- vatives of diethylenetriaminepentaacetic acid (DTPA) diamides, wherein a suitable group is linked to the molecule allowing introduction of the said neutral chelate to bioactive molecules.
摘要翻译：本发明涉及新的中性标记反应物。新型反应物是二亚乙基三胺五乙酸（DTPA）二酰胺的衍生物，其中合适的基团与分子连接，允许将所述中性螯合物引入生物活性分子。

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