专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009136382A3 ANTIBODIES TO RECEPTOR OF ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF 审中-公开
公开(公告)号：WO2009136382A3
公开(公告)日：2009-11-12
申请号：PCT/IB2009/051915
申请日：2009-05-08
申请人： ABBOTT GMBH & CO. KG , Abbott Laboratories , GU, Jijie , HSIEH, Chung-Ming , WU, Zhen , DIGIAMMARINO, Enrico L. , LUO, Feng , FOX, Gerard B. , HARLAN, John E. , SCHMIDT, Martin , LOEBBERT, Ralf , MUELLER, Reinhold , EBERT, Ulrich , NIMMRICH, Volker
发明人： GU, Jijie , HSIEH, Chung-Ming , WU, Zhen , DIGIAMMARINO, Enrico L. , LUO, Feng , FOX, Gerard B. , HARLAN, John E. , SCHMIDT, Martin , LOEBBERT, Ralf , MUELLER, Reinhold , EBERT, Ulrich , NIMMRICH, Volker
IPC分类号： C12N15/12 , C12N5/00 , C12N7/00
摘要： The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid β and advanced glycation-end-products.

2. 发明申请

WO2007039256A3 BINDING DOMAINS OF PROTEINS OF THE REPULSIVE GUIDANCE MOLECULE (RGM) PROTEIN FAMILY AND FUNCTIONAL FRAGMENTS THEREOF, AND THEIR USE 审中-公开
标题翻译：装订排斥性引导分子（RGM）蛋白质家族蛋白质的和域的功能片段，以及它们的用途
公开(公告)号：WO2007039256A3
公开(公告)日：2007-07-05
申请号：PCT/EP2006009497
申请日：2006-09-29
申请人： ABBOTT GMBH & CO KG , MUELLER BERNHARD K , SCHAFFAR GREGOR , MUELLER REINHOLD
发明人： MUELLER BERNHARD K , SCHAFFAR GREGOR , MUELLER REINHOLD
IPC分类号： C07K14/475 , A61K39/395 , A61P25/00 , C07K14/71 , C07K16/28
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K2317/34
摘要： The invention concerns the identification and use of neogenin receptor-binding domains of members of the repulsive guidance molecule (RGM) protein family as well as polypeptide fragments derived therefrom. The inventive domains, i.e. peptide fragments are suited as agents for the active or passive immunization of individuals as well as diagnostic and therapeutic agents for use with diseases or pathological conditions in whose origin or progression, a member of the RGM family and a cellular receptor assigned to this molecule are involved. The invention also concerns monoclonal and polyclonal antibodies directed against the inventive binding domains and against the polypeptides derived therefrom, and to method for producing the inventive domains, polypeptides and antibodies.
摘要翻译：本发明涉及狂犬病指导分子（RGM）蛋白家族的成员的Neogenin受体结合结构域的鉴定和用途以及由其衍生的多肽片段。本发明的结构域或肽片段是作为个人的主动或被动免疫，以及用于在疾病或疾病状态，其发展或过程中RGM家族的成员和所分配的该分子的细胞受体的参与使用的诊断剂和治疗剂的一种手段是有用的。本发明还涉及针对根据本发明的结合结构域并针对由其衍生的多肽的单克隆和多克隆抗体以及用于生产根据本发明的结构域，多肽和抗体的方法。

3. 发明申请

WO2006020933A3 DUAL LABELED FLUORESCENT PROBES 审中-公开
公开(公告)号：WO2006020933A3
公开(公告)日：2006-02-23
申请号：PCT/US2005/028859
申请日：2005-08-12
申请人： STRATAGENE CALIFORNIA , SORGE, Joseph , MUELLER, Reinhold , PADMABANDU, Gothami
发明人： SORGE, Joseph , MUELLER, Reinhold , PADMABANDU, Gothami
IPC分类号： C07H21/02 , C07H21/04 , C12P19/34 , C12Q1/68
摘要： The present invention relates to probes useful for the detection and measurement of target nucleic acids, as well as compositions and kits containing such probes. The probes of the present invention include an interactive pair of labels, as well as a hairpin sequence that does not hybridize to a target nucleic acid. According to the present invention, the probe generates a detectable signal indicative of a presence of a target nucleic acid. The detectable signal emitted by one of the pair of labels is substantially constant upon binding of the probe to target nucleic acid, and the detectable signal increases by at least (2) fold upon cleavage of the probe between the pair of labels.

4. 发明申请

WO2004061132A1 COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE DETECTION 审中-公开
标题翻译：用于多核苷酸检测的组合物和方法
公开(公告)号：WO2004061132A1
公开(公告)日：2004-07-22
申请号：PCT/US2003/038501
申请日：2003-12-05
申请人： STRATAGENE , SORGE, Joseph, A. , SUN, Gulan , MUELLER, Reinhold, Dietrich
发明人： SORGE, Joseph, A. , SUN, Gulan , MUELLER, Reinhold, Dietrich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C07H21/00 , C07H21/02 , C12Q2565/101 , C12Q2545/114 , C12Q2525/161
摘要： The present invention relates to compositions comprising probes for the detection of a target polynucleotide, and methods for detecting the amount of a target polynucleotide using the subject composition. In particular, the subject method involves the use of both target-hybridizing probes and non-target-hybridizing probes, where the probes generate a detectable signal (e.g., detectable by FRET) for the target polynucleotide detection.
摘要翻译：本发明涉及包含用于检测靶多核苷酸的探针的组合物，以及使用该主题组合物检测靶多核苷酸的量的方法。特别地，本发明方法涉及使用靶 - 杂交探针和非靶杂交探针，其中探针产生可检测的信号（例如可通过FRET检测）用于靶多核苷酸检测。

5. 发明申请

WO0215975A3 DEVICE FOR IRRADIATING TISSUE 审中-公开
标题翻译：装置进行照射组织
公开(公告)号：WO0215975A3
公开(公告)日：2002-04-25
申请号：PCT/DE0103167
申请日：2001-08-18
申请人： MUELLER REINHOLD G , ACHTERBERG NILS
发明人： MUELLER REINHOLD G , ACHTERBERG NILS
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1084

6. 发明申请

WO0123390A3 AZEPINOINDOLE DERIVATIVES, THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译： AZEPINOINDOL衍生物及其制备和应用
公开(公告)号：WO0123390A3
公开(公告)日：2001-12-27
申请号：PCT/EP0009024
申请日：2000-09-15
申请人： BASF AG , LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
发明人： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
IPC分类号： A61K31/55 , A61P3/10 , A61P9/10 , A61P11/00 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C07D487/06
CPC分类号： C07D487/06
摘要： The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.
摘要翻译：本发明涉及式（I）化合物及其互变异构形式，可能的对映体和非对映体形式，及其前药，其制备和用途，其值具有说明书中给出的含义。

7. 发明申请

WO2008064292A3 NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NGR) AND USES THEREOF 审中-公开
公开(公告)号：WO2008064292A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/085349
申请日：2007-11-21
申请人： ABBOTT LABORATORIES , MEZLER, Mario , MOELLER, Achim , MUELLER, Reinhold , MUELLER, Bernhard K. , GHAYUR, Tariq , BARLOW, Eve H. , SCHMIDT, Martin , MEYER, Axel , TEUSCH, Nicole
发明人： MEZLER, Mario , MOELLER, Achim , MUELLER, Reinhold , MUELLER, Bernhard K. , GHAYUR, Tariq , BARLOW, Eve H. , SCHMIDT, Martin , MEYER, Axel , TEUSCH, Nicole
IPC分类号： A61K39/395
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.

8. 发明申请

WO2005059159A3 DNA POLYMERASE COMPOSITIONS FOR QUANTITATIVE PCR AND METHODS THEREOF 审中-公开
标题翻译：用于定量PCR的DNA聚合酶组合物及其方法
公开(公告)号：WO2005059159A3
公开(公告)日：2008-01-24
申请号：PCT/US2004041899
申请日：2004-12-13
申请人： STRATAGENE CALIFORNIA , SORGE JOSEPH A , MUELLER REINHOLD DIETRICH , PADMABANDU GOTHAMI , ROELOFS NICK , HOGREFE HOLLY H
发明人： SORGE JOSEPH A , MUELLER REINHOLD DIETRICH , PADMABANDU GOTHAMI , ROELOFS NICK , HOGREFE HOLLY H
IPC分类号： C12N9/12 , C07H21/02 , C07H21/04 , C12N1/21 , C12N9/22 , C12N15/03 , C12P19/34 , C12P21/06 , C12Q20060101 , C12Q1/68
CPC分类号： C12N9/1276 , C07H21/04 , C12N9/1252 , C12Q1/6869 , C12Q2535/101 , C12Q2521/101
摘要： The invention relates to the generation and characterization of Archaeal DNA polymerase mutants with deficient 3'-5' exonuclease activity and reduced base analog detection activity. The invention further provides for Archaeal DNA polymerase mutants with deficient 3'-5' exonuclease activity and reduced base analog detection activity containing additional mutations that modulate other DNA polymerase activities including DNA polymerization or reverse transcriptase activity. The invention also discloses methods and applications of DNA polymerases with efficient 3'-5' exonuclease activity and reduced base analog detection activity.
摘要翻译：本发明涉及具有缺乏3'-5'核酸外切酶活性和降低的碱基类似物检测活性的古菌DNA聚合酶突变体的产生和表征。本发明进一步提供具有缺乏3'-5'核酸外切酶活性的古菌DNA聚合酶突变体和降低的碱基类似物检测活性，其含有调节其它DNA聚合酶活性（包括DNA聚合或逆转录酶活性）的其它突变。本发明还公开了具有有效3'-5'核酸外切酶活性和降低的碱基类似物检测活性的DNA聚合酶的方法和应用。

9. 发明申请

WO0157038A9 HETEROCYCLIC COMPOUNDS AND THEIR USE AS PARP INHIBITORS 审中-公开
标题翻译：杂环化合物和它们作为PARP抑制剂
公开(公告)号：WO0157038A9
公开(公告)日：2001-09-20
申请号：PCT/EP0100790
申请日：2001-01-25
申请人： BASF AG , LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
发明人： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I), wherein; either A or A represents CONH2, and the other radical A or A represents hydrogen, chlorine, fluorine, bromine, iodine C1-C6 alkyl, OH, nitro, CF3, CN, NR R , NH-CO-R , O-C1-C4 alkyl; X can represent N and C-R ; X , independent of X , can represent N and C-R ; R can represent hydrogen, C1-C6 alkyl, C1-C4 alkyl-phenyl, phenyl; B can represent an unsaturated, saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring having a maximum of 15 carbon atoms, an unsaturated, saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring having a maximum of 14 carbon atoms and 0 to 5 nitrogen atoms, 0 to 2 oxygen atoms or 0 to 2 sulfur atoms, which can each still be substituted with an R and a maximum of 3 of the same or different radicals R , and; R , R , R , R -R have the meanings as cited in Claim No. 1. The invention also relates to the tautomeric forms, and possible enantiomeric and diastereomeric forms of said compounds, to the prodrugs thereof and to their use as PARP inhibitors.
摘要翻译：本发明涉及式（I）化合物式中A <1>或A <2>是CONH 2，另一基团A <2>或A <1>为氢，氯，氟，溴，碘，C1-C6 烷基，OH，硝基，CF 3，CN，NR <11> - [R <12>，NH-CO-R <13>，O-C 1 -C 4烷基，并且X <1>可以是N和CR <2> 和X <2>可以是独立的X <1>，N和CR <2>和C 1 -C 4 - 烷基 - 苯基，R <2>是氢，C1-C6烷基的苯基，和B是不饱和，饱和或部分不饱和的单 - ，最多15个碳原子，不饱和的二环或三环的环，饱和或部分不饱和的单 - ，具有最大14个碳原子和0至5个氮原子，0〜2个氧原子和0〜二环或三环环可以指2个硫原子，每个的又带有R <4>和最多3组相同或不同的基团R <5>可以被取代，并且R <1>，R <4>，R <5>，R <11> - [R <13>的含义如权利要求1和互变异构形式在指示物，可能的对映体和非对映形式，以及它们的前体药物，以及它们作为PARP抑制剂的用途。

10. 发明申请

WO2006020933A2 DUAL LABELED FLUORESCENT PROBES 审中-公开
标题翻译：双标签荧光探针
公开(公告)号：WO2006020933A2
公开(公告)日：2006-02-23
申请号：PCT/US2005028859
申请日：2005-08-12
申请人： STRATAGENE CALIFORNIA , SORGE JOSEPH , MUELLER REINHOLD , PADMABANDU GOTHAMI
发明人： SORGE JOSEPH , MUELLER REINHOLD , PADMABANDU GOTHAMI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q1/686 , C12Q2525/301 , C12Q2521/301 , C12Q2565/101
摘要： The present invention relates to probes useful for the detection and measurement of target nucleic acids, as well as compositions and kits containing such probes. The probes of the present invention include an interactive pair of labels, as well as a hairpin sequence that does not hybridize to a target nucleic acid. According to the present invention, the probe generates a detectable signal indicative of a presence of a target nucleic acid. The detectable signal emitted by one of the pair of labels is substantially constant upon binding of the probe to target nucleic acid, and the detectable signal increases by at least (2) fold upon cleavage of the probe between the pair of labels.
摘要翻译：本发明涉及可用于检测和测量靶核酸的探针，以及含有这种探针的组合物和试剂盒。本发明的探针包括互补的标记物对，以及不与靶核酸杂交的发夹序列。根据本发明，探针产生指示靶核酸存在的可检测信号。在将该探针与靶核酸结合后，由该对标记中的一个发射的可检测信号基本上是恒定的，并且当探针在该对标记之间切割时，可检测信号增加至少（2）倍。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式