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1. 发明申请

WO2012016180A2 LIQUEFACTION BIOMASS PROCESSING WITH HEAT RECOVERY 审中-公开
标题翻译：热回收液化生物质工艺
公开(公告)号：WO2012016180A2
公开(公告)日：2012-02-02
申请号：PCT/US2011/045958
申请日：2011-07-29
申请人： PURDUE RESEARCH FOUNDATION , LADISCH, Michael, R. , MOSIER, Nathan , KIM, Youngmi , ROOYEN, Justin van
发明人： LADISCH, Michael, R. , MOSIER, Nathan , KIM, Youngmi , ROOYEN, Justin van
IPC分类号： C12P7/10
CPC分类号： C08B1/00 , C12N1/22 , C12P7/10 , C12P19/02 , C12P19/14 , Y02E50/16 , Y02E50/17 , Y02P20/124 , Y02P20/59
摘要： Described are processes that include the non-enzymatic, hydrolytic liquefaction of lignocellulosic biomass to form digest slurries and heat recovery from such digest slurries. Due to enhanced flow properties of the digest slurries such heat recovery can be efficiently conducted in spiral, plate and frame or other heat exchanger designs, with the recovered heat going to unit operations of the process such as heating incoming pretreatment media for the liquefaction. Processes can also involve additional hydrolytic digestion of some or all of the initial slurry components with enzyme and/or additional heat recovery from the initial slurry by direct contact heat exchange in which a portion of the digest slurry liquids is flashed to vapor and that vapor is condensed onto incoming lignocellulosic biomass to the process. Processes as described can be integrated into ethanol manufacture by fermentation of sugars from the digested compositions.
摘要翻译：描述了包括木质纤维素生物质的非酶促水解液化以形成消化浆液和从这种消化浆液回收热量的过程。由于消化浆料的流动性能增强，所以热回收可以在螺旋，板式和框架或其他热交换器设计中有效地进行，其中回收的热量进入过程的单元操作，例如加热用于液化的进入预处理介质。方法还可以包括用酶进行一些或全部初始浆液组分的附加水解消化和/或通过直接接触热交换从初始浆液中额外回收热量，其中一部分消化浆液液体闪蒸成蒸气并且蒸气是冷凝到进入的木质纤维素生物质上进行该过程。所描述的方法可以通过发酵来自消化组合物的糖而整合到乙醇生产中。

2. 发明申请

WO2006119318A3 METHODS FOR INCREASING THE YIELD OF FERMENTABLE SUGARS FROM PLANT STOVER 审中-公开
标题翻译：从植物油中增加可食用糖的方法
公开(公告)号：WO2006119318A3
公开(公告)日：2007-03-08
申请号：PCT/US2006016887
申请日：2006-05-02
申请人： PURDUE RESEARCH FOUNDATION , VERMERRIS WILLEM E , LADISCH MICHAEL R , MOSIER NATHAN S
发明人： VERMERRIS WILLEM E , LADISCH MICHAEL R , MOSIER NATHAN S
IPC分类号： C13K1/02 , C12P7/08
CPC分类号： C12P7/10 , C12P19/02 , C13K1/02 , Y02E50/16
摘要： Methods for increasing yield of fermentable sugars from plant stover are provided. The methods include using plants homozygous for two brown midrib mutations, bm1 and bm3. The methods also include using plants homozygous for a mutation in a gene that results in reduced cinnamyl alcohol dehydrogenase activity, and a mutation in a gene that results in reduced 5- hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity. The methods also include using transgenic plants that have reduced cinnamyl alcohol dehydrogenase activity and reduced 5- hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity in comparison with wild-type plants.
摘要翻译：提供了从植物秸秆提高可发酵糖产量的方法。这些方法包括使用纯合的两个棕色中间变异突变bm1和bm3的植物。所述方法还包括使用纯合于基因中的突变的植物，其导致肉桂醇脱氢酶活性降低，以及导致5-羟基环戊醛/ 5-羟基络菲基醇O-甲基转移酶活性降低的基因突变。该方法还包括与野生型植物相比，使用具有降低的肉桂醇脱氢酶活性的转基因植物和降低的5-羟基己醛/ 5-羟基络合醇O-甲基转移酶活性。

3. 发明申请

WO2006119318A2 METHODS FOR INCREASING THE YIELD OF FERMENTABLE SUGARS FROM PLANT STOVER 审中-公开
标题翻译：从植物油中增加可食用糖的方法
公开(公告)号：WO2006119318A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016887
申请日：2006-05-02
申请人： PURDUE RESEARCH FOUNDATION , VERMERRIS, Willem, E. , LADISCH, Michael, R. , MOSIER, Nathan, S.
发明人： VERMERRIS, Willem, E. , LADISCH, Michael, R. , MOSIER, Nathan, S.
IPC分类号： C13K1/02 , C12P7/08
CPC分类号： C12P7/10 , C12P19/02 , C13K1/02 , Y02E50/16
摘要： Methods for increasing yield of fermentable sugars from plant stover are provided. The methods include using plants homozygous for two brown midrib mutations, bm1 and bm3. The methods also include using plants homozygous for a mutation in a gene that results in reduced cinnamyl alcohol dehydrogenase activity, and a mutation in a gene that results in reduced 5- hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity. The methods also include using transgenic plants that have reduced cinnamyl alcohol dehydrogenase activity and reduced 5- hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity in comparison with wild-type plants.
摘要翻译：提供了从植物秸秆提高可发酵糖产量的方法。这些方法包括使用纯合的两个棕色中间变异突变bm1和bm3的植物。所述方法还包括使用纯合于基因中的突变的植物，其导致肉桂醇脱氢酶活性降低，以及导致5-羟基环戊醛/ 5-羟基络菲基醇O-甲基转移酶活性降低的基因突变。该方法还包括与野生型植物相比，使用具有降低的肉桂醇脱氢酶活性的转基因植物和降低的5-羟基己醛/ 5-羟基络合醇O-甲基转移酶活性。

4. 发明申请

WO2012016189A1 BIOMASS LIQUEFACTION PROCESSES, AND USES OF SAME 审中-公开
标题翻译：生物量液化过程及其用途
公开(公告)号：WO2012016189A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045973
申请日：2011-07-29
申请人： PURDUE RESEARCH FOUNDATION , LADISCH, Michael, R. , MOSIER, Nathan , KIM, Youngmi
发明人： LADISCH, Michael, R. , MOSIER, Nathan , KIM, Youngmi
IPC分类号： C07C55/02 , C12N9/42 , C12P7/08
CPC分类号： C12P7/14 , C12N1/22 , C12P7/10 , C12P17/04 , C12P19/02 , C12P19/14 , C12P2201/00 , C12Y302/01004 , Y02E50/16
摘要： Described are processes for the liquefaction of lignocellulosic biomass under the digestive action of dicarboxylic acid(s). Such digests can exhibit enhanced flowability, reduced volume, and significant biomass conversion to dissolved components, and can in some embodiments be further liquefied by contact with an enzyme. Products resultant of these steps can be used for their sugar content to manufacture biofuels or other products.
摘要翻译：描述了在二羧酸的消化作用下液化木质纤维素生物质的方法。这样的消化可以表现出增强的流动性，减小的体积和显着的生物质转化成溶解的组分，并且在一些实施方案中可以通过与酶的接触进一步液化。这些步骤的产物可用于其糖含量以制造生物燃料或其它产品。

5. 发明申请

WO2005093045A2 CELL CONCENTRATION AND PATHOGEN RECOVERY 审中-公开
标题翻译：细胞浓度和病原体恢复
公开(公告)号：WO2005093045A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/008759
申请日：2005-03-15
申请人： PURDUE RESEARCH FOUNDATION , LIU, Xingya , STEWART, Amanda, C. , CHEN, Wan-Tzu , MOSIER, Nathan, S. , HUANG, Tom , LADISCH, Michael, R. , BWATWA, Jeremiah , HENDRICKSON, Richard, L.
发明人： LIU, Xingya , STEWART, Amanda, C. , CHEN, Wan-Tzu , MOSIER, Nathan, S. , HUANG, Tom , LADISCH, Michael, R. , BWATWA, Jeremiah , HENDRICKSON, Richard, L.
IPC分类号： C12N5/00
CPC分类号： G01N1/4005 , C12Q1/24 , G01N33/02 , G01N2001/4016 , G01N2015/0088
摘要： Methods and kits for the isolation of organisms. Such methods and kits are particularly useful for concentrating and recovering viable organisms from food material. The recovered organisms are of sufficient number and purity to allow detection using a biochip device.
摘要翻译：
用于分离生物体的方法和试剂盒。这些方法和试剂盒对于从食物材料中浓缩和回收活的生物体特别有用。回收的生物体具有足够的数量和纯度以允许使用生物芯片装置进行检测。

6. 发明申请

WO2012016180A3 LIQUEFACTION BIOMASS PROCESSING WITH HEAT RECOVERY 审中-公开
标题翻译：采用热回收的液化生物质处理
公开(公告)号：WO2012016180A3
公开(公告)日：2012-06-07
申请号：PCT/US2011045958
申请日：2011-07-29
申请人： PURDUE RESEARCH FOUNDATION , LADISCH MICHAEL R , MOSIER NATHAN , KIM YOUNGMI , ROOYEN JUSTIN VAN
发明人： LADISCH MICHAEL R , MOSIER NATHAN , KIM YOUNGMI , ROOYEN JUSTIN VAN
IPC分类号： C12P7/06 , C12P7/10
CPC分类号： C08B1/00 , C12N1/22 , C12P7/10 , C12P19/02 , C12P19/14 , Y02E50/16 , Y02E50/17 , Y02P20/124 , Y02P20/59
摘要： Described are processes that include the non-enzymatic, hydrolytic liquefaction of lignocellulosic biomass to form digest slurries and heat recovery from such digest slurries. Due to enhanced flow properties of the digest slurries such heat recovery can be efficiently conducted in spiral, plate and frame or other heat exchanger designs, with the recovered heat going to unit operations of the process such as heating incoming pretreatment media for the liquefaction. Processes can also involve additional hydrolytic digestion of some or all of the initial slurry components with enzyme and/or additional heat recovery from the initial slurry by direct contact heat exchange in which a portion of the digest slurry liquids is flashed to vapor and that vapor is condensed onto incoming lignocellulosic biomass to the process. Processes as described can be integrated into ethanol manufacture by fermentation of sugars from the digested compositions.
摘要翻译：描述了包括木质纤维素生物质的非酶促水解液化以形成消化浆料并从这些消化浆料中热回收的方法。由于消化浆料的流动性能的提高，这种热回收可以在螺旋，板和框架或其它热交换器设计中有效地进行，回收的热量将进行到工艺的单元操作，例如加热输入的用于液化的预处理介质。方法还可以通过直接接触热交换使酶的一些或所有初始浆料组分进一步水解消化，和/或从初始浆料进一步热回收，其中将一部分消化浆料液体闪蒸至蒸气，蒸气为浓缩到进入的木质纤维素生物质上。所描述的方法可以通过从消化的组合物中发酵糖而被整合到乙醇生产中。

7. 发明申请

WO2012112546A3 METHODS AND SYSTEMS USEFUL FOR DRYING ETHANOL 审中-公开
标题翻译：用于干燥乙醇的方法和系统
公开(公告)号：WO2012112546A3
公开(公告)日：2014-04-17
申请号：PCT/US2012025042
申请日：2012-02-14
申请人： PURDUE RESEARCH FOUNDATION , ARCHER DANIELS MIDLAND CO , KIM YOUNGMI , HENDRICKSON RICHARD L , MOSIER NATHAN , LADISCH MICHAEL R , HILALY AHMAD K
发明人： KIM YOUNGMI , HENDRICKSON RICHARD L , MOSIER NATHAN , LADISCH MICHAEL R , HILALY AHMAD K
IPC分类号： C07C29/76 , B01J20/24
CPC分类号： C07C29/76 , B01J20/28004 , B01J20/28019 , B01J20/28059 , B01J20/3433 , B01J20/3458 , B01J2220/4825 , C08L3/02 , C12P7/06 , Y02E50/17 , C07C31/08
摘要： Mixtures of ethanol and water are dehydrated using starch pearls to adsorb and remove water. Vapor-phase adsorption equilibrium capacities of cassava starch pellets (tapioca pearls) having different particle sizes are disclosed, and tapioca pearl particles are shown to be surprisingly more effective for dehydrating 88 to 97% w/w feed ethanol than corn grits. The adsorption equilibrium curve and BET surface area measurement show that the adsorption capacity of tapioca pearls is a function of surface area available to water molecules. SEM images demonstrate that the particle architecture required for the adsorption and dehydration properties is that of a core- shell configuration with pre-gel starch acting as a central scaffold holding together other particles to the outer layer of the particle. The outer surface area of the pearls, populated with dry starch granules, is the main factor determining the adsorption capacity of the pearls. Tapioca pearls are shown to possess a surprisingly higher adsorption capacity than corn grits of the same particle size. Pearls of 2 mm size in diameter gave 34% higher linear adsorption equilibrium constant ( K ) than grits of 1.7 mm.
摘要翻译：用淀粉珍珠脱水乙醇和水的混合物，吸附去除水分。公开了具有不同粒度的木薯淀粉颗粒（木薯珍珠）的气相吸附平衡能力，并且显示木薯珍珠颗粒比玉米砂粒脱水88至97％w / w的进料乙醇更有效。吸附平衡曲线和BET表面积测量显示，木薯珍珠的吸附能力是水分子可用表面积的函数。 SEM图像表明，吸附和脱水性质所需的颗粒结构是核 - 壳结构的结构，其中预凝胶淀粉作为将其它颗粒保持在颗粒的外层的中心支架。珍珠的外表面积为干淀粉颗粒，是决定珍珠吸附能力的主要因素。木薯珍珠与具有相同粒度的玉米砂粒相比具有惊人的更高的吸附能力。直径2毫米的珍珠比1.7毫米的砂粒提高了34％的线性吸附平衡常数（K）。

8. 发明申请

WO2011047046A1 ETHANOL PRODUCTION FROM LIGNOCELLULOSIC BIOMASS WITH RECOVERY OF COMBUSTIBLE FUEL MATERIALS 审中-公开
标题翻译：来自具有可燃性燃料材料回收的细菌生物量的乙醇生产
公开(公告)号：WO2011047046A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052503
申请日：2010-10-13
申请人： PURDUE RESEARCH FOUNDATION , DEFENSE LIFE SCIENCES, LLC , MOSIER, Nathan , LADISCH, Michael, R. , WARNER, Jerry
发明人： MOSIER, Nathan , LADISCH, Michael, R. , WARNER, Jerry
IPC分类号： C12P7/06
CPC分类号： C12P7/10 , C10L5/445 , Y02E50/10 , Y02E50/16 , Y02E50/17 , Y02E50/30 , Y02P20/136
摘要： Described are processes for producing a product, such as ethanol, from lignocellulosic biomass, and producing a burnable fuel material from byproducts. The burnable fuel material can be burned on site to produce energy to feed back into the production process.
摘要翻译：描述了从木质纤维素生物质生产诸如乙醇的产物，以及从副产物生产可燃燃料的方法。可燃燃料材料可以在现场燃烧以产生能量以反馈到生产过程中。

9. 发明申请

WO2012112546A2 METHODS AND SYSTEMS USEFUL FOR DRYING ETHANOL 审中-公开
标题翻译：用于干燥乙醇的方法和系统
公开(公告)号：WO2012112546A2
公开(公告)日：2012-08-23
申请号：PCT/US2012/025042
申请日：2012-02-14
申请人： PURDUE RESEARCH FOUNDATION AND OFFICE OF TECHNOLOGY COMMERCIALIZATION , ARCHER DANIELS MIDLAND COMPANY , KIM, Youngmi , HENDRICKSON, Richard L. , MOSIER, Nathan , LADISCH, Michael R. , HILALY, Ahmad K.
发明人： KIM, Youngmi , HENDRICKSON, Richard L. , MOSIER, Nathan , LADISCH, Michael R. , HILALY, Ahmad K.
IPC分类号： C07C29/76 , B01J20/24
CPC分类号： C07C29/76 , B01J20/28004 , B01J20/28019 , B01J20/28059 , B01J20/3433 , B01J20/3458 , B01J2220/4825 , C08L3/02 , C12P7/06 , Y02E50/17 , C07C31/08
摘要： Mixtures of ethanol and water are dehydrated using starch pearls to adsorb and remove water. Vapor-phase adsorption equilibrium capacities of cassava starch pellets (tapioca pearls) having different particle sizes are disclosed, and tapioca pearl particles are shown to be surprisingly more effective for dehydrating 88 to 97% w/w feed ethanol than corn grits. The adsorption equilibrium curve and BET surface area measurement show that the adsorption capacity of tapioca pearls is a function of surface area available to water molecules. SEM images demonstrate that the particle architecture required for the adsorption and dehydration properties is that of a core- shell configuration with pre-gel starch acting as a central scaffold holding together other particles to the outer layer of the particle. The outer surface area of the pearls, populated with dry starch granules, is the main factor determining the adsorption capacity of the pearls. Tapioca pearls are shown to possess a surprisingly higher adsorption capacity than corn grits of the same particle size. Pearls of 2 mm size in diameter gave 34% higher linear adsorption equilibrium constant ( K ) than grits of 1.7 mm.
摘要翻译：用淀粉珍珠脱水乙醇和水的混合物，吸附去除水分。公开了具有不同粒度的木薯淀粉颗粒（木薯珍珠）的气相吸附平衡能力，并且显示木薯珍珠颗粒比玉米砂粒脱水88至97％w / w的进料乙醇更有效。吸附平衡曲线和BET表面积测量显示，木薯珍珠的吸附能力是水分子可用表面积的函数。 SEM图像表明，吸附和脱水性质所需的颗粒结构是核 - 壳结构的结构，其中预凝胶淀粉作为将其它颗粒保持在颗粒的外层的中心支架。珍珠的外表面积为干淀粉颗粒，是决定珍珠吸附能力的主要因素。木薯珍珠与具有相同粒度的玉米砂粒相比具有惊人的更高的吸附能力。直径2毫米的珍珠比1.7毫米的砂粒提高了34％的线性吸附平衡常数（K）。

10. 发明申请

WO2011047039A1 PROCESS FOR PREPARING ENRICHED GLUCAN BIOMASS MATERIALS 审中-公开
标题翻译：制备富集的葡萄糖生物质材料的方法
公开(公告)号：WO2011047039A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052495
申请日：2010-10-13
申请人： PURDUE RESEARCH FOUNDATION , BOWEN ENGINEERING CORPORATION , MOSIER, Nathan , LADISCH, Michael, R. , STATER, Brian , SPINDLER, Bradley
发明人： MOSIER, Nathan , LADISCH, Michael, R. , STATER, Brian , SPINDLER, Bradley
IPC分类号： C12P7/10
CPC分类号： C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The disclosure describes a process for the conversion of lignocellulosic biomass to ethanol utilizing a dicarboxylic acid such as maleic acid as an enzyme mimic to hydrolyze the hemicellulose and cellulose of the biomass. Controlling the condition of the maleic acid hydrolysis can selectively hydrolyze the hemicellulose giving as a result a liquid portion rich in xylose and a solid portion rich in glucan. The glucan can be further hydrolyzed to produce a glucose containing material. The sugar materials can be fermented to produce ethanol which is recovered. The dicarboxylic acid is then recovered from the residue left after the ethanol is removed from the fermentation material, and the recovered dicarboxylic acid is recycled to the beginning of the process to treat additional lignocellulosic biomass.
摘要翻译：本公开描述了使用二羧酸如马来酸将木质纤维素生物质转化为乙醇的方法，作为模拟水解模拟生物质的半纤维素和纤维素的酶。控制马来酸水解的条件可以选择性地水解半纤维素，从而得到富含木糖的液体部分和富含葡聚糖的固体部分。可以进一步水解葡聚糖以产生含葡萄糖的材料。糖材料可以发酵生产回收的乙醇。然后从从发酵材料中除去乙醇后留下的残余物中回收二羧酸，并将回收的二羧酸再循环至该方法的开始以处理另外的木质纤维素生物质。

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