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1. 发明申请

WO2011046623A3 HIV-1 ANTIBODIES 审中-公开
标题翻译： HIV-1抗体
公开(公告)号：WO2011046623A3
公开(公告)日：2011-11-03
申请号：PCT/US2010002770
申请日：2010-10-18
申请人： UNIV DUKE , CAPRISA CT FOR THE AIDS PROGRAMME OF RES IN SOUTH AFRICA , HAYNES BARTON F , LIAO HUA-XIN , MOODY M ANTHONY , MORRIS LYNN , ABDOOL KARIM SALIM SAFURDEEN
发明人： HAYNES BARTON F , LIAO HUA-XIN , MOODY M ANTHONY , MORRIS LYNN , ABDOOL KARIM SALIM SAFURDEEN
IPC分类号： C07K16/10 , A61K39/42 , A61P31/18 , C07K14/16 , C12N15/13
CPC分类号： C07K16/1063 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： The present invention relates, in general, to HIV-I antibodies and, in particular, to broadly neutralizing HIV-I antibodies that target the gp41 membrane-proximal external region (MPER).
摘要翻译：本发明一般涉及HIV-1抗体，特别涉及广泛中和靶向gp41膜近端外部区域（MPER）的HIV-1抗体。

2. 发明申请

WO2011046623A2 HIV-1 ANTIBODIES 审中-公开
标题翻译： HIV-1抗体
公开(公告)号：WO2011046623A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/002770
申请日：2010-10-18
申请人： DUKE UNIVERSITY , CAPRISA (CENTRE FOR THE AIDS PROGRAMME OF RESEARCH IN SOUTH AFRICA) , HAYNES, Barton, F. , LIAO, Hua-Xin , MOODY, M., Anthony , MORRIS, Lynn , ABDOOL KARIM, Salim, Safurdeen
发明人： HAYNES, Barton, F. , LIAO, Hua-Xin , MOODY, M., Anthony , MORRIS, Lynn , ABDOOL KARIM, Salim, Safurdeen
IPC分类号： C07K16/10 , C07K14/16 , C12N15/13 , A61K39/42 , A61P31/18
CPC分类号： C07K16/1063 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： The present invention relates, in general, to HIV-I antibodies and, in particular, to broadly neutralizing HIV-I antibodies that target the gp41 membrane-proximal external region (MPER).
摘要翻译：本发明一般涉及HIV-1抗体，特别是涉及广泛中和靶向gp41膜近端外部区域（MPER）的HIV-1抗体。

3. 发明申请

WO0204494A3 PROCESS FOR THE SELECTION OF HIV-1 SUBTYPE C ISOLATES, SELECTED HIV-1 SUBTYPE ISOLATES, THEIR GENES AND MODIFICATIONS AND DERIVATIVES THEREOF 审中-公开
标题翻译：选择HIV-1亚型C分离株的方法，选择的HIV-1亚型分离物，其基因及其修饰及衍生物
公开(公告)号：WO0204494A3
公开(公告)日：2003-03-13
申请号：PCT/IB0101208
申请日：2001-07-09
申请人： MEDICAL RES COUNCIL , UNIV CAPE TOWN , UNIV NORTH CAROLINA , ALPHAVAX INC , WILLIAMSON CAROLYN , SWANSTROM RONALD IVAR , MORRIS LYNN , KARIM SALIM ABDOOL , JOHNSTON ROBERT EDWARD
发明人： WILLIAMSON CAROLYN , SWANSTROM RONALD IVAR , MORRIS LYNN , KARIM SALIM ABDOOL , JOHNSTON ROBERT EDWARD
IPC分类号： A61K39/00 , A61K39/21 , C07K20060101 , C07K14/16 , C12N7/02 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N7/00 , C12N2740/16034 , C12N2740/16051 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a process for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. The process for the selection of HIV subtype isolates comprises the steps of isolating viruses from recently infected subjects; generating a consensus sequence for at least part of at least one HIV gene by identifying the most common codon or amino acid among the isolated viruses; and selecting the isolated virus or viruses with a high sequence identity to the consensus sequence. HIV-1 subtype C isolates, designated Du422, Du 151 and Du 179 (assigned Accession Numbers 01032114, 00072724 and 00072725, respectively, by the European Collection of Cell Cultures) are also provided.
摘要翻译：本发明提供了选择HIV-1亚型（进化枝）C分离物，所选择的HIV-1亚型C分离株，其基因及其修饰和衍生物用于预防和治疗疫苗以产生蛋白质和多肽的方法，用于引起艾滋病毒感染或疾病的保护。选择HIV亚型分离物的过程包括从最近感染的受试者中分离病毒的步骤; 通过鉴定分离的病毒中最常见的密码子或氨基酸，产生至少一部分HIV基因的共有序列; 并选择与共有序列具有高序列同一性的分离的病毒或病毒。还提供了称为Du422，Du 151和Du 179（分别由欧洲细胞培养物集合分配的登录号01032114，00072724和00072725）的HIV-1亚型C分离物。

4. 发明授权

US08926477B2 Combined beverage holder and exercise apparatus 有权
标题翻译：组合饮料架和运动器具
公开(公告)号：US08926477B2
公开(公告)日：2015-01-06
申请号：US13424908
申请日：2012-03-20
申请人： John Morris Lynn
发明人： John Morris Lynn
IPC分类号： A63B23/16 , A63B21/045 , A63B21/02 , A63B21/04 , A63B21/00 , A63B71/06 , A63B21/005
CPC分类号： A63B23/16 , A63B21/00043 , A63B21/0055 , A63B21/025 , A63B21/0421 , A63B71/0622 , A63B2225/682
摘要： An apparatus combines a beverage holder (e.g., a mug) with a compressible device (i.e., a gripper or handgrip) that is usable as an exercise apparatus for a users hands, wrists or forearms. This dual purpose apparatus can function not only as a mug or insulator but also a squeezable exercise device whereby flexing and relaxing a user's hand, the user conditions their hands, wrists or forearms. The device may also include lights or audio. In some embodiments the handgrip may be detachably attached to the beverage container to allow the independent use of the holder and handgrip.
摘要翻译：一种装置将饮料保持器（例如，杯子）与可用作用户手，手腕或前臂的锻炼装置的可压缩装置（即，夹持器或手柄）组合。这种双用途装置不仅可以用作杯子或绝缘体，还可以起到可挤压锻炼装置的作用，从而使使用者的手弯曲和放松，使用者摆放手，手腕或前臂。该设备还可以包括灯或音频。在一些实施例中，手柄可以可拆卸地附接到饮料容器以允许独立使用保持器和手柄。

5. 发明授权

US07963692B2 Monitoring apparatus 有权
标题翻译：监控装置
公开(公告)号：US07963692B2
公开(公告)日：2011-06-21
申请号：US12380331
申请日：2009-02-26
申请人： John Morris Lynn
发明人： John Morris Lynn
IPC分类号： G04F1/00
CPC分类号： A61J7/0472 , A61J2205/20 , Y10T137/0318 , Y10T137/8326
摘要： A monitoring apparatus is disclosed for monitoring time by a color change indicator, comprising an observable fluid, a first reservoir holding at least a portion of the observable fluid, and a second reservoir abutting the first reservoir. The first reservoir is responsive to pressure on it such that a portion of the observable fluid flows into the second reservoir. The second reservoir is responsive to a lack of pressure in the first reservoir such that a portion of the observable fluid in the second reservoir reverses flow back into the first reservoir once the first reservoir is not under pressure.
摘要翻译：公开了一种监测装置，用于通过颜色变化指示器监测时间，包括可观察流体，保持可观察流体的至少一部分的第一储存器和与第一储存器邻接的第二储存器。第一储存器响应于其上的压力，使得可观察流体的一部分流入第二储存器。第二储存器响应于第一储存器中的压力不足，使得一旦第一储存器不处于压力下，第二储存器中的可观察流体的一部分反向流回第一储存器。

6. 发明申请

US20090211642A1 Monitoring apparatus 有权
标题翻译：监控装置
公开(公告)号：US20090211642A1
公开(公告)日：2009-08-27
申请号：US12380331
申请日：2009-02-26
申请人： John Morris Lynn
发明人： John Morris Lynn
IPC分类号： F17D3/00
CPC分类号： A61J7/0472 , A61J2205/20 , Y10T137/0318 , Y10T137/8326
摘要： A monitoring apparatus is disclosed for monitoring time by a color change indicator, comprising an observable fluid, a first reservoir holding at least a portion of the observable fluid, and a second reservoir abutting the first reservoir. The first reservoir is responsive to pressure on it such that a portion of the observable fluid flows into the second reservoir. The second reservoir is responsive to a lack of pressure in the first reservoir such that a portion of the observable fluid in the second reservoir reverses flow back into the first reservoir once the first reservoir is not under pressure.
摘要翻译：公开了一种监测装置，用于通过颜色变化指示器监测时间，包括可观察流体，保持可观察流体的至少一部分的第一储存器和与第一储存器邻接的第二储存器。第一储存器响应于其上的压力，使得可观察流体的一部分流入第二储存器。第二储存器响应于第一储存器中的压力不足，使得一旦第一储存器不处于压力下，第二储存器中的可观察流体的一部分反向流回第一储存器。

7. 发明申请

US20110180564A1 Timing Soap Dispenser Apparatus and Method 审中-公开
标题翻译：定时肥皂机装置及方法
公开(公告)号：US20110180564A1
公开(公告)日：2011-07-28
申请号：US13014981
申请日：2011-01-27
申请人： Terry G. Jones , John Morris Lynn
发明人： Terry G. Jones , John Morris Lynn
IPC分类号： B67D7/00 , B67D7/22 , B67D7/08 , B67D7/86 , B23P19/04 , B67D7/84
CPC分类号： A47K5/12 , B05B11/30 , G09B19/0076 , Y10T29/49826
摘要： A soap dispenser system for dispensing soap in response to a user's action, such as pumping force to a dispenser pump of a soap container. The soap container has a theme identifier device corresponding to the soap container. A supportive base detachably connects to the soap container. The base includes a receiver device for detecting the theme identifier device of the soap container when the soap connector is connected to the base. A readable data storage is connected to the receiver device. The storage contains data representing a variety of different human perceptible media, such as audio (e.g., animal, people, or musical sounds). At least one of the variety of media corresponds to the theme identifier device of the soap container. An output device delivers the media to a user of the soap container. A processor connected to the receiver device, the storage, and the output device responds to the receiver detecting the theme identifier device and dispensing action by a user to obtain soap from the container. The processor selectively controls the output device to deliver specific media (from among the variety) to the user corresponding to the theme identifier device of the soap container. The system can encourage frequent and efficacious washing. The media encourages washing for recommended wash times, for example, the system delivers 20-30 seconds (or such other period as desired for the particular embodiment) of animal sounds for entertainment and measure of recommended wash time when an animal themed soap container is used.
摘要翻译：一种肥皂分配器系统，用于响应于使用者的动作来分配肥皂，例如向肥皂容器的分配器泵抽吸力。肥皂容器具有对应于肥皂容器的主题识别装置。支撑底座可拆卸地连接到肥皂容器。底座包括一个接收器装置，用于当肥皂连接器连接到基座时，用于检测肥皂容器的主题识别装置。可读数据存储器连接到接收器设备。存储器包含表示各种不同的人类可感知媒体的数据，例如音频（例如，动物，人或音乐声音）。各种媒体中的至少一种对应于肥皂容器的主题标识符装置。输出装置将介质输送到肥皂容器的使用者。连接到接收机设备，存储器和输出设备的处理器响应于接收器检测主题标识符设备并且由用户分配动作以从容器获得肥皂。处理器选择性地控制输出设备以将特定媒体（从各种之间）传送到与肥皂容器的主题标识符设备相对应的用户。该系统可以鼓励频繁和有效的洗涤。媒体鼓励洗涤推荐的洗涤时间，例如，系统为使用动物的主题肥皂容器进行娱乐的动物声音20-30秒（或特定实施例所需的其他时期）和推荐的洗涤时间的量度。

8. 发明申请

US20080290112A1 Soap dispenser and method for helping assure clean hands 审中-公开
标题翻译：肥皂分配器和帮助确保清洁手的方法
公开(公告)号：US20080290112A1
公开(公告)日：2008-11-27
申请号：US12000318
申请日：2007-12-11
申请人： John Morris Lynn
发明人： John Morris Lynn
IPC分类号： B67D5/06 , B44B5/00 , G01N31/22 , G01C15/02
CPC分类号： A47K5/12
摘要： A method and apparatus for helping to assure cleaner hands using a soap dispenser are disclosed. The method includes marking a hand of a user with a slight indentation on their hand when they activate the dispenser, wherein the indentation lasts during the desired period of hand washing.
摘要翻译：公开了一种帮助确保使用肥皂机的清洁手的方法和装置。该方法包括当用户激活分配器时在其手上标记用户轻微缩进的手，其中在所需的洗手时间期间持续缩进。

9. 发明申请

US20130012358A1 Combined Beverage Holder and Exercise Apparatus 有权
标题翻译：组合饮料持有人和运动器材
公开(公告)号：US20130012358A1
公开(公告)日：2013-01-10
申请号：US13424908
申请日：2012-03-20
申请人： John Morris Lynn
发明人： John Morris Lynn
IPC分类号： A63B23/16 , A63B71/00 , B65D25/00
CPC分类号： A63B23/16 , A63B21/00043 , A63B21/0055 , A63B21/025 , A63B21/0421 , A63B71/0622 , A63B2225/682
摘要： An apparatus is disclosed which combines a beverage holder (e.g. a mug) with a compressible device (i.e. a gripper or handgrip) that is usable as an exercise apparatus for a users hands, wrists or forearms. This dual purpose apparatus can function not only as a mug or insulator but also a squeezable exercise device where by flexing and relaxing a user's hand the user conditions their hands, wrists or forearms. The device may also include lights or audio. In some embodiments the handgrip may be detachably attached to the beverage container to allow the independent use of the holder and handgrip.
摘要翻译：公开了一种将饮料保持器（例如杯子）与可用作用户手，手腕或前臂的运动装置的可压缩装置（即，夹持器或手柄）组合的装置。这种双用途装置不仅可以用作杯子或绝缘体，而且可以起到可挤压的锻炼装置的作用，通过使用者的手弯曲和放松，使用者摆放他们的手，手腕或前臂。该设备还可以包括灯或音频。在一些实施例中，手柄可以可拆卸地附接到饮料容器以允许独立使用保持器和手柄。

10. 发明授权

US07425900B2 Clean hands assured with signal 失效
标题翻译：用信号清洁手
公开(公告)号：US07425900B2
公开(公告)日：2008-09-16
申请号：US11098272
申请日：2005-04-04
申请人： John Morris Lynn , Kathryn Anne Newth
发明人： John Morris Lynn , Kathryn Anne Newth
IPC分类号： G08B13/14 , A47L1/06 , B67D5/06 , B65D35/00 , B44D3/00 , B43L21/00
CPC分类号： G08B21/245
摘要： A method and apparatus are disclosed for helping assure the washing of a person's hands. An easily identifiable substance is provided which may be removed by washing. A marking mechanism is coupled with or contains the easily identifiable substance and the hand of the person is then marked with the easily identifiable substance when the marking mechanism is triggered. Substantially concurrent (or somewhat delayed) with the hand being marked a signal is given off which helps assure that the person actually uses the marking mechanism. Another way to coerce use of the marking mechanism and to allow authority figures to monitor use of the marking mechanism is a information recording device which tracks use of the marking mechanism.
摘要翻译：公开了一种用于帮助确保人的手的洗涤的方法和装置。提供可以通过洗涤去除的容易识别的物质。标记机构与容易识别的物质结合或包含容易识别的物质，并且当标记机构被触发时，人的手随后被标记有容易识别的物质。给予手上标有信号的基本并发（或稍微延迟），这有助于确保人实际使用标记机制。强制使用标记机构并允许权限图来监视标记机构的使用的另一种方式是跟踪标记机构的使用的信息记录装置。

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