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1. 发明申请

WO1994026909A1 HERBICIDE RESISTANT PLANTS 审中-公开
标题翻译：抗除草剂植物
公开(公告)号：WO1994026909A1
公开(公告)日：1994-11-24
申请号：PCT/IB1994000096
申请日：1994-05-06
申请人： CIBA-GEIGY JAPAN LIMITED , JAPAT LTD. , WARD, Eric, R. , VOLRATH, Sandra , KOIZUMI, Shinichi , TADA, Sachiyo , MORI, Ichiro , IWASAKI, Genji
发明人： CIBA-GEIGY JAPAN LIMITED , JAPAT LTD.
IPC分类号： C12N15/60
CPC分类号： C12N9/88 , C12N15/8278 , C12Q1/527
摘要： Disclosed are plants, plant tissue and plant seed, whose growth and development are tolerant of, or resistant to various imidazole and triazole herbicidal compounds, at levels which normally are inhibitory to the plants. The tolerance or resistance is conferred by an altered imidazoleglycerol phosphate dehydratase (IGPD). Plant genes encoding wild-type and altered IGPD, purified plant IGPD, methods of isolating IGPD from plants, and methods of using both purified IGPD and IGPD-encoding genes are also disclosed.
摘要翻译：公开了植物，植物组织和植物种子，其生长发育对各种咪唑和三唑除草化合物具有耐受性或耐受性，其水平通常对植物具有抑制作用。耐受性或抗性由改变的咪唑磷酸脱水酶（IGPD）赋予。还公开了编码野生型和改变的IGPD的植物基因，纯化植物IGPD，从植物分离IGPD的方法，以及使用纯化的IGPD和IGPD编码基因的方法。

2. 发明申请

WO2004034985A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2004034985A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/032625
申请日：2003-10-15
申请人： SMITHKLINE BEECHAM CORPORATION , BURGESS, Joelle, L. , CALLAHAN, John, F. , HAMAJIMA, Toshihiro , IDA, Satoru , TANG, Jun , MORI, Ichiro
发明人： BURGESS, Joelle, L. , CALLAHAN, John, F. , HAMAJIMA, Toshihiro , IDA, Satoru , TANG, Jun , MORI, Ichiro
IPC分类号： A61K
CPC分类号： C07D401/12 , C07D215/54 , C07D405/12
摘要： 3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate YAK3 activity.
摘要翻译：本文描述了可用作YAK3抑制剂的3-羧基喹啉衍生物。所述发明还包括制备这种3-羧基喹啉衍生物的方法以及使用它们治疗由不适当的YAK3活性介导的疾病的方法。

3. 发明申请

WO1992019629A1 TRIAZOLE COMPOUNDS 审中-公开
标题翻译：三唑化合物
公开(公告)号：WO1992019629A1
公开(公告)日：1992-11-12
申请号：PCT/JP1992000485
申请日：1992-04-17
申请人： CIBA-GEIGY (JAPAN) LIMITED , JAPAT LTD. , MORI, Ichiro , IWASAKI, Genji , SCHEIDEGGER, Alfred , KOIZUMI, Shinichi , HAYAKAWA, Kenji , MANO, Junichi
发明人： CIBA-GEIGY (JAPAN) LIMITED , JAPAT LTD.
IPC分类号： C07F09/6518
CPC分类号： A01N57/24 , A01N57/16 , C07F9/6518 , Y02P20/55
摘要： This invention relates to a novel triazole compound represented by formula (1) wherein R1 represents a hydrogen atom or a group A which is a protective group or is C1-C4-alkyl; X and Y jointly represent a carbonyl group together with the carbon atom to which they are bonded, or X and Y each independently represent a hydrogen atom or a -OR2 group, wherein R2 represents a hydrogen atom, a lower alkyl group, an acetyl group, a benzyl group or a silyl group represented by -SiR'3 (wherein R' represents an alkyl group); and Z represents a -CH2PO(OR3)2 or -CH2OPO(OR3)2 group wherein R3 represents a hydrogen atom, a lower alkyl group, a benzyl group, a phenyl group, a cyanoethyl group, an allyl group, a CH2OH group, a COOR5 group, or an alkali metal, alkaline earth metal, ammonium, organic ammonium, trialkylsulphonium, trialkylsulfoxonium, phosphonium or amidinium cation; n is 0 or 1; and R5 is a C1-C6-alkyl group, a process for preparing the same, a composition containing the same, as well as, application of the compound in the technical fields of herbicide or microbicides.
摘要翻译：本发明涉及由式（1）表示的新颖的三唑化合物，其中R 1表示氢原子或作为保护基团的基团A或C 1 -C 4 - 烷基; X和Y共同表示与它们所键合的碳原子一起的羰基，或者X和Y各自独立地表示氢原子或-OR 2基团，其中R 2表示氢原子，低级烷基，乙酰基，由-SiR'3（其中R'表示烷基）表示的苄基或甲硅烷基; Z表示-CH 2 PO（OR 3）2或-CH 2 OPO（OR 3）2基，其中R 3表示氢原子，低级烷基，苄基，苯基，氰基乙基，烯丙基，CH 2 OH基， COOR 5基团，或碱金属，碱土金属，铵，有机铵，三烷基锍，三烷基锍鎓，鏻或脒鎓阳离子; n为0或1; R5为C1-C6烷基，其制备方法，含有该化合物的组合物，以及该化合物在除草剂或杀微生物剂的技术领域的应用。

4. 发明申请

WO2004034985A3 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2004034985A3
公开(公告)日：2004-09-10
申请号：PCT/US0332625
申请日：2003-10-15
申请人： SMITHKLINE BEECHAM CORP , BURGESS JOELLE L , CALLAHAN JOHN F , HAMAJIMA TOSHIHIRO , IDA SATORU , TANG JUN , MORI ICHIRO
发明人： BURGESS JOELLE L , CALLAHAN JOHN F , HAMAJIMA TOSHIHIRO , IDA SATORU , TANG JUN , MORI ICHIRO
IPC分类号： A61K20060101 , A61K31/47 , C07D215/54 , C07D401/12 , C07D405/12 , C07D453/02
CPC分类号： C07D401/12 , C07D215/54 , C07D405/12
摘要： 3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate YAK3 activity.
摘要翻译：本文描述了可用作YAK3抑制剂的3-羧基喹啉衍生物。所述的发明还包括制备这种3-羧基喹啉衍生物的方法以及使用该3-羧基喹啉衍生物的方法来治疗由不适当的YAK3活性介导的疾病。

5. 发明申请

WO2004037314A2 TOPICAL PATCH PREPARATION KIT CONTAINING A DELAYED-TYPE HYPERSENSITIVITY INDUCER 审中-公开
标题翻译：具有延迟型超敏性感应器的主题配对准备套件
公开(公告)号：WO2004037314A2
公开(公告)日：2004-05-06
申请号：PCT/US0330758
申请日：2003-09-29
申请人： TEIKOKU PHARMA USA INC , SHUDO JUTARO , MORI ICHIRO
发明人： SHUDO JUTARO , MORI ICHIRO
IPC分类号： A61F13/00 , A61K9/70 , A61K31/04 , A61K47/06 , A61K49/00 , A61M20060101 , A61M37/00 , A61M
CPC分类号： A61K9/7015
摘要： Elevated temperature storage stable fluid compositions of a delayed-type hypersensitivity inducer, e.g., DNCB, and methods for using the same are provided. In many embodiments, the subject compositions are present in a sealed container and housed together with an unloaded topical patch preparation, e.g., in a kit format. In using the subject compositions, the fluid composition is applied to an unloaded topical patch preparation, which preparation is then topically applied. The present invention finds use in a variety of applications where the administration of a delayed-type hypersensitivity inducer is desired, and is particularly suited for use in the treatment of HIV associated disease conditions, e.g., AIDS.
摘要翻译：提供了延迟型超敏感诱导剂例如DNCB的高温储存稳定的液体组合物及其使用方法。在许多实施方案中，本发明组合物存在于密封容器中，并与未加载的局部贴剂制剂一起包装，例如以试剂盒形式。在使用主题组合物时，将流体组合物施用于卸载的局部贴剂制剂，然后将该制剂局部施用。本发明可用于期望延迟型超敏反应诱导剂的施用的多种应用，并且特别适合用于治疗HIV相关疾病病症，例如艾滋病。

6. 发明申请

WO2002072081A1 TOPICAL PATCH PREPARATION CONTAINING A DELAYED-TYPE HYPERSENSITIVITY INDUCER AND METHODS FOR USING THE SAME 审中-公开
标题翻译：包含延迟型超灵敏度感应器的主题配方及其使用方法
公开(公告)号：WO2002072081A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/005641
申请日：2002-02-22
申请人： TEIKOKU PHARMA USA, INC. , SHUDO, Jutaro , MORI, Ichiro
发明人： SHUDO, Jutaro , MORI, Ichiro
IPC分类号： A61K31/04
CPC分类号： A61K9/7061 , A61F2013/0296 , A61K31/04 , Y02A50/409
摘要： Topical patch preparations that contain a delayed-type hypersensitivity inducer, e.g., 1-dichloro-2,4-dinitrobenzene (DNCB), and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel composition includes the delayed-type hypersensitivity inducer, a water-soluble polymer gel, water and a water holding agent. In using the subject topical patch preparations, the topical patch preparations are applied to a skin surface of a subject and maintained at the site of application for a period of time sufficient for an effective amount of the delayed-type hypersensitivity inducer to be administered to the subject, where this maintenance period typically does not exceed about 60 minutes. The subject invention finds use in a variety of applications where the administration of a delayed-type hypersensitivity inducer is desired, and is particularly suited for use in the treatment of HIV associated disease conditions, e.g., AIDS.
摘要翻译：提供含有延迟型超敏感诱导物例如1-二氯-2,4-二硝基苯（DNCB）的局部贴剂制剂及其使用方法。本发明的局部贴剂制剂由存在于载体上的粘合凝胶组合物组成，其中粘合性凝胶组合物包含延迟型超敏感诱导剂，水溶性聚合物凝胶，水和保水剂。在使用本发明的局部贴剂制剂时，将局部贴剂制剂施用于受试者的皮肤表面并保持在施用部位一段时间，足以将有效量的延迟型超敏反应诱导剂施用于该维护期通常不超过约60分钟。本发明可用于期望延迟型超敏反应诱导剂的施用的多种应用，并且特别适合用于治疗HIV相关疾病病症，例如艾滋病。

7. 发明申请

WO2004037314A3 PATCH AND KIT CONTAINING DELAYED-TYPE HYPERSENSITIVITY INDUCER 审中-公开
公开(公告)号：WO2004037314A3
公开(公告)日：2004-05-06
申请号：PCT/US2003/030758
申请日：2003-09-29
申请人： TEIKOKU PHARMA USA, INC. , SHUDO, Jutaro , MORI, Ichiro
发明人： SHUDO, Jutaro , MORI, Ichiro
IPC分类号： A61F13/00
摘要： Elevated temperature storage stable fluid compositions of a delayed-type hypersensitivity inducer, e.g. , DNCB, and methods for using the same are provided. In many embodiments, the subject compositions are present in a sealed container and housed together with an unloaded topical patch preparation, e.g. , in a kit format. In using the subject compositions, the fluid composition is applied to an unloaded topical patch preparation, which preparation is then topically applied. The present invention finds use in a variety of applications where the administration of a delayed-type hypersensitivity inducer is desired, and is particularly suited for use in the treatment of HIV associated disease conditions, e.g. , AIDS.

8. 发明申请

WO1995018811A1 PHOSPHONIC ACID DERIVATIVES CONTAINING A TRIAZOLE RING AS HERBICIDES 审中-公开
标题翻译：含有作为除草剂的三唑环的磷酸衍生物
公开(公告)号：WO1995018811A1
公开(公告)日：1995-07-13
申请号：PCT/IB1995000004
申请日：1995-01-03
申请人： JAPAT LTD. , CIBA-GEIGY JAPAN LIMITED , MORI, Ichiro , KIMURA, Yoko , MATSUNAGA, Shinichiro , NAKANO, Toshihito , O'SULLIVAN, Anthony, Cornelius
发明人： JAPAT LTD. , CIBA-GEIGY JAPAN LIMITED
IPC分类号： C07F09/6518
CPC分类号： C07F9/65583 , A01N57/24 , C07F9/6518 , C07F9/65586
摘要： A triazole of formula (I) in which the meanings of the radicals are described in claim 1, have good pre- and post-emergence selective herbicidal and growth-regulating properties. They are suitable as active substances in weed killers and in compositions for inhibiting plant-growth.
摘要翻译：式（I）的三唑，其中自由基的含义在权利要求1中描述，具有良好的芽前和芽后选择性除草和生长调节性质。它们适合作为除草剂和抑制植物生长的组合物中的活性物质。

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