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1. 发明申请

WO2006047249A1 ANTI-IL-22RA ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开
标题翻译：抗IL-22RA抗体和结合合作伙伴及其在炎症中的使用方法
公开(公告)号：WO2006047249A1
公开(公告)日：2006-05-04
申请号：PCT/US2005/037821
申请日：2005-10-21
申请人： ZYMOGENETICS, INC. , XU, Wenfeng , KINDSVOGEL, Wayne, R. , CHANDRASEKHER, Yasmin, A. , DILLON, Stacey, R. , LEHNER, Joyce, M. , SIADAK, Anthony, W. , SIVAKUMAR, Pallavur, V. , MOORE, Margaret, D.
发明人： XU, Wenfeng , KINDSVOGEL, Wayne, R. , CHANDRASEKHER, Yasmin, A. , DILLON, Stacey, R. , LEHNER, Joyce, M. , SIADAK, Anthony, W. , SIVAKUMAR, Pallavur, V. , MOORE, Margaret, D.
IPC分类号： C07K16/28 , C07K14/715
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译：本发明涉及阻断，抑制，减少，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。

2. 发明申请

WO2004085475A3 ANTI-IL-20 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开
标题翻译：抗IL-20抗体和结合合作伙伴及其在炎症中的使用方法
公开(公告)号：WO2004085475A3
公开(公告)日：2005-07-14
申请号：PCT/US2004008955
申请日：2004-03-24
申请人： ZYMOGENETICS INC , XU WENFENG , KINDSVOGEL WAYNE , CHANDRASEKHER YASMIN A , DILLON STACEY R , LEHNER JOYCE M , SIADAK ANTHONY W , SIVAKUMAR PALLAVUR V , MOORE MARGARET D
发明人： XU WENFENG , KINDSVOGEL WAYNE , CHANDRASEKHER YASMIN A , DILLON STACEY R , LEHNER JOYCE M , SIADAK ANTHONY W , SIVAKUMAR PALLAVUR V , MOORE MARGARET D
IPC分类号： C07K14/54 , C07K14/715 , C07K16/24 , C07K16/28 , A61P37/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-20 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. The present invention includes anti-IL-20 and anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
摘要翻译：本发明涉及阻断，抑制，降低，拮抗或中和IL-20多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。本发明包括抗IL-20和抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-20的方法。

3. 发明申请

WO2004085476A3 ANTI-IL-22RA ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开
标题翻译：抗IL-22RA抗体和结合合作伙伴及其在炎症中的使用方法
公开(公告)号：WO2004085476A3
公开(公告)日：2005-03-31
申请号：PCT/US2004008956
申请日：2004-03-24
申请人： ZYMOGENETICS INC , XU WENFENG , KINDSVOGEL WAYNE , CHANDRASEKHER YASMIN A , DILLON STACEY R , LEHNER JOYCE M , SIADAK ANTHONY W , SIVAKUMAR PALLAVUR V , MOORE MARGARET D
发明人： XU WENFENG , KINDSVOGEL WAYNE , CHANDRASEKHER YASMIN A , DILLON STACEY R , LEHNER JOYCE M , SIADAK ANTHONY W , SIVAKUMAR PALLAVUR V , MOORE MARGARET D
IPC分类号： C07K14/54 , C07K14/715 , C07K16/24 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译：本发明涉及阻断，抑制，减少，拮抗或中和IL-22，IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA（zcytor11）是IL-20和IL-22的常见受体。本发明包括抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。

4. 发明申请

WO2004085475A2 ANTI-IL-20 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开
标题翻译：抗IL-20抗体和结合合作伙伴及其在炎症中的使用方法
公开(公告)号：WO2004085475A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/008955
申请日：2004-03-24
申请人： ZYMOGENETICS, INC. , XU, Wenfeng , KINDSVOGEL, Wayne , CHANDRASEKHER, Yasmin, A. , DILLON, Stacey, R. , LEHNER, Joyce, M. , SIADAK, Anthony, W. , SIVAKUMAR, Pallavur, V. , MOORE, Margaret, D.
发明人： XU, Wenfeng , KINDSVOGEL, Wayne , CHANDRASEKHER, Yasmin, A. , DILLON, Stacey, R. , LEHNER, Joyce, M. , SIADAK, Anthony, W. , SIVAKUMAR, Pallavur, V. , MOORE, Margaret, D.
IPC分类号： C07K16/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-20 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. The present invention includes anti-IL-20 and anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
摘要翻译：本发明涉及阻断，抑制，降低，拮抗或中和IL-20多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。本发明包括抗IL-20和抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-20的方法。

5. 发明申请

WO2009082624A3 ANTAGONISTS OF IL-17A, IL-17F, AND IL-23 AND METHODS OF USING THE SAME 审中-公开
标题翻译： IL-17A，IL-17F和IL-23的拮抗剂及其使用方法
公开(公告)号：WO2009082624A3
公开(公告)日：2009-10-29
申请号：PCT/US2008086292
申请日：2008-12-10
申请人： ZYMOGENETICS INC , LEWIS KATHERINE E , BRENDER TY M , YI EUGENE C , THOMPSON PENNY J , STEVENS BRENDA L , MABRY III GEORGE ROBERT , PRESNELL SCOTT R , MOORE MARGARET D , GUERRA-LEWIS PATRICIA I
发明人： LEWIS KATHERINE E , BRENDER TY M , YI EUGENE C , THOMPSON PENNY J , STEVENS BRENDA L , MABRY III GEORGE ROBERT , PRESNELL SCOTT R , MOORE MARGARET D , GUERRA-LEWIS PATRICIA I
IPC分类号： C07K16/00 , A61K39/395 , A61P37/00
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23p19 or both IL-17 and IL-23p19. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease. In particular, antibodies and antibody fragments that have superior neutralizing potency for the IL-17A/F heterodimer, and bispecific molecules that combine this superior anti-IL-17A antibody with anti-IL-23A antibodies are disclosed.
摘要翻译：本发明涉及阻断，抑制，减少，拮抗或中和IL-17，IL-23p19或IL-17和IL-23p19的活性。 IL-17和IL-23是参与炎症过程和人类疾病的细胞因子。具体而言，公开了对IL-17A / F异源二聚体具有优异的中和效力的抗体和抗体片段，以及将该优异的抗IL-17A抗体与抗IL-23A抗体组合的双特异性分子。

6. 发明申请

WO2008025031A1 TREATMENT OF GRAFT-VERSUS-HOST DISEASE 审中-公开
标题翻译：治疗遗传性疾病
公开(公告)号：WO2008025031A1
公开(公告)日：2008-02-28
申请号：PCT/US2007/076892
申请日：2007-08-27
申请人： ZYMOGENETICS, INC. , HOSKEN, Nancy , BYRNES-BLAKE, Kelly , BENDER, Ty , HUBER, Monica , MOORE, Margaret, D. , RENE, Shirley , RIXON, Mark, W. , UNDERWOOD, Sara , WAGGIE, Kimberly, S.
发明人： HOSKEN, Nancy , BYRNES-BLAKE, Kelly , BENDER, Ty , HUBER, Monica , MOORE, Margaret, D. , RENE, Shirley , RIXON, Mark, W. , UNDERWOOD, Sara , WAGGIE, Kimberly, S.
IPC分类号： A61K38/17 , A61K39/395 , A61P37/06
CPC分类号： C07K16/2866 , A61K38/1793 , A61K2039/505 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Methods for treating graft-versus-host disease, methods for reducing symptoms of graft-versus-host disease, and methods of reducing the severity of graft-versus-host disease in a patient are disclosed. The methods comprise administering to the patient a therapeutically effective amount of an IL-27 antagonist in combination with a pharmaceutically acceptable vehicle. IL-27 antagonists include soluble IL-27RA proteins and antagonists that comprise an antigen-binding site of an antibody.
摘要翻译：公开了治疗移植物抗宿主病的方法，用于减少移植物抗宿主病的症状的方法以及降低患者中移植物抗宿主病严重程度的方法。所述方法包括向患者施用治疗有效量的IL-27拮抗剂与药学上可接受的载体。 IL-27拮抗剂包括可溶性IL-27RA蛋白和包含抗体的抗原结合位点的拮抗剂。

7. 发明申请

WO2008025033A3 USE OF IL-27 ANTAGONISTS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF APLASTIC ANEMIA 审中-公开
标题翻译：用于治疗APLASTIC ANEMIA的药物的制造的IL-27拮抗剂的使用
公开(公告)号：WO2008025033A3
公开(公告)日：2008-07-31
申请号：PCT/US2007076899
申请日：2007-08-27
申请人： ZYMOGENETICS INC , HOSKEN NANCY , BYRNES-BLAKE KELLY , BENDER TY , HUBER MONICA , MOORE MARGARET D , RENE SHIRLEY , RIXON MARK W , UNDERWOOD SARA
发明人： HOSKEN NANCY , BYRNES-BLAKE KELLY , BENDER TY , HUBER MONICA , MOORE MARGARET D , RENE SHIRLEY , RIXON MARK W , UNDERWOOD SARA
IPC分类号： A61K38/00 , A61K9/00 , A61K39/00
CPC分类号： A61K9/0019 , A61K38/1793 , A61K2039/505 , C07K16/2866 , C07K2319/30 , A61K2300/00
摘要： Methods of treating aplastic anemia in a patient and of increasing blood cell production in a patient having aplastic anemia are disclosed. The methods comprise administering to the patient a therapeutically effective amount of an IL-27 antagonist in combination with a pharmaceutically acceptable vehicle. IL-27 antagonists include soluble IL-27RA proteins and antagonists that comprise an antigen-binding site of an antibody.
摘要翻译：公开了治疗再生障碍性贫血患者的再生障碍性贫血的治疗方法和增加血细胞生成的方法。所述方法包括向患者施用治疗有效量的IL-27拮抗剂与药学上可接受的载体。 IL-27拮抗剂包括可溶性IL-27RA蛋白和包含抗体的抗原结合位点的拮抗剂。

8. 发明申请

WO2007030803A2 TRIMERIZING POLYPEPTIDES 审中-公开
标题翻译：调整多糖
公开(公告)号：WO2007030803A2
公开(公告)日：2007-03-15
申请号：PCT/US2006035225
申请日：2006-09-11
申请人： ZYMOGENETICS INC , MOORE MARGARET D , FOX BRIAN A
发明人： MOORE MARGARET D , FOX BRIAN A
IPC分类号： C12N15/63
CPC分类号： C12N15/62 , A61K38/00 , C07K14/005 , C07K14/705 , C07K2319/03 , C07K2319/81 , C12N2740/10022 , C12N2740/13022
摘要： The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.
摘要翻译：本发明涉及三聚蛋白的制备方法，其包括用编码包含ZymoZipper（ZZ）结构域和异源蛋白质的融合蛋白的表达载体转化或转染的宿主细胞。在一个实施方案中，异源蛋白质是膜蛋白，融合蛋白中包含的异源蛋白质的部分是该蛋白质的细胞外结构域，并且所得的融合蛋白质是可溶的。在本发明的另一个实施方案中，ZZ结构域衍生自病毒包膜蛋白的跨膜（TM）亚基或其它含有病毒基因组的七重复重复基因。该方法可用于产生同型和异三聚体蛋白质。本发明还包括本方法中使用的DNA分子，表达载体和宿主细胞以及通过本发明方法产生的融合蛋白。

9. 发明申请

WO2005087810A3 DIMERIC FUSION PROTEINS AND MATERIALS AND METHODS FOR PRODUCING THEM 审中-公开
标题翻译：二聚体融合蛋白和生产它们的材料和方法
公开(公告)号：WO2005087810A3
公开(公告)日：2005-11-10
申请号：PCT/US2005007590
申请日：2005-03-08
申请人： ZYMOGENETICS INC , MOORE MARGARET D , FOX BRIAN A
发明人： MOORE MARGARET D , FOX BRIAN A
IPC分类号： C07H21/04 , C07K14/49 , C07K14/705 , C07K14/725 , C07K14/74 , C12N15/62 , C12P21/02 , C12P21/04
CPC分类号： C07K14/7051 , C07K14/49 , C07K14/70539 , C07K2319/00 , C07K2319/30 , C12N15/62 , C12P21/02
摘要： Polypeptide fusions, dimeric fusion proteins, and materials and methods for making them are disclosed. One of the polypeptide fusions consists of a non-immunoglobulin polypeptide, a polypeptide linker, a dimerizing domain, and, optionally, a linking polypeptide. Another of the polypeptide fusions consists of a non-immunoglobulin polypeptide, a polypeptide linker, and a second dimerizing domain.
摘要翻译：披露了多肽融合蛋白，二聚融合蛋白，以及制备它们的材料和方法。多肽融合体之一由非免疫球蛋白多肽，多肽接头，二聚体结构域和任选的连接多肽组成。另一种多肽融合物由非免疫球蛋白多肽，多肽接头和第二个二聚化结构域组成。

10. 发明申请

WO2005052000A3 ANTI-IL-20 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开
标题翻译：抗IL-20抗体和结合的伙伴以及炎症中使用的方法
公开(公告)号：WO2005052000A3
公开(公告)日：2005-10-27
申请号：PCT/US2004039071
申请日：2004-11-19
申请人： ZYMOGENETICS INC , XU WENFENG , KINDSVOGEL WAYNE R , CHEN ZHI , HUGHES STEVEN D , CHANDRASEKHER YASMIN A , DILLON STACEY R , LEHNER JOYCE M , SIADAK ANTHONY W , SIVAKUMAR PALLAVUR V , MOORE MARGARET D
发明人： XU WENFENG , KINDSVOGEL WAYNE R , CHEN ZHI , HUGHES STEVEN D , CHANDRASEKHER YASMIN A , DILLON STACEY R , LEHNER JOYCE M , SIADAK ANTHONY W , SIVAKUMAR PALLAVUR V , MOORE MARGARET D
IPC分类号： A61K38/00 , A61K38/20 , C07K14/54 , C07K14/715 , C07K16/24 , C07K16/28 , C12P21/04
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/20 , A61K47/60 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
摘要翻译：本发明涉及阻断IL-20多肽分子的活性。 IL-20是参与炎症过程和人类疾病的细胞因子。 IL-20RA / IL-20RB是IL-20的常见受体。本发明包括抗IL-20抗体和结合配偶体，以及使用此类抗体和结合配偶体来拮抗IL-20的方法。

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