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1. 发明申请

WO2005007000A1 METHOD AND APPARATUS FOR TREATMENT OF TISSUE ADJACENT A BODILY CONDUIT WITH A COMPRESSION BALLOON 审中-公开
标题翻译：用于治疗组织相似物的方法和装置具有压缩性气囊的体液
公开(公告)号：WO2005007000A1
公开(公告)日：2005-01-27
申请号：PCT/US2004/014768
申请日：2004-05-11
申请人： CELSION CORPORATION , MON, John
发明人： MON, John
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/04 , A61B18/1492 , A61B18/1815 , A61B18/22 , A61B2017/00274 , A61B2017/22051 , A61B2018/00547 , A61B2018/044
摘要： An apparatus for treatment of tissue within a body requiring thermotherapy includes a catheter to be inserted into a bodily conduit, an energy-emitting source disposed within the catheter, a compression balloon surrounding the energy-emitting source where the compression balloon has an inflated diameter that is greater than that of the bodily conduit in a relaxed state and an outside surface of the balloon is coated with one of gene modifiers and drug or medication, and means for activating the energy-emitting source to radiate energy to heat the drug-coated compression balloon and tissue to be treated whereby the heated drug-coated compression balloon effectively delivers the one of the gene modifiers and drug or medication to a target area of the diseased tissue. In addition, methods for using the above apparatus to treat diseased tissue are disclosed.
摘要翻译：一种用于治疗需要热疗的身体内的组织的装置，包括插入身体导管中的导管，设置在导管内的能量发射源，围绕能量发射源的压缩气囊，其中压缩气囊具有膨胀直径，大于处于松弛状态的身体管道，并且球囊的外表面涂覆有基因修饰剂和药物或药物之一，以及用于激活能量发射源以辐射能量以加热药物包被的压缩的装置气球和组织，由此加热的药物包被的压缩气囊将基因修饰剂和药物或药物中的一种有效地递送到患病组织的靶区域。此外，公开了使用上述装置来治疗患病组织的方法。

2. 发明申请

WO2003070298A3 METHOD AND APPARATUS TREATING TISSUE ADJACENT A BODILY CONDUIT WITH THERMOCOMPRESSION AND DRUGS 审中-公开
公开(公告)号：WO2003070298A3
公开(公告)日：2003-08-28
申请号：PCT/US2003/004512
申请日：2003-02-19
申请人： CELSION CORPORATION , MON, John , FENN, Alan, J.
发明人： MON, John , FENN, Alan, J.
IPC分类号： A61B18/04
摘要： A method and apparatus (100) of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source (110) heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43 °C for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source (110) activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy- emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.

3. 发明申请

WO2004034925A2 THERMOTHERAPY METHOD FOR TREATMENT AND PREVENTION OF CANCER IN MALE AND FEMALE PATIENTS AND COSMETIC ABLATION OF TISSUE 审中-公开
标题翻译：用于治疗和预防男性和女性患者的癌症和组织化学吸收的热保护方法
公开(公告)号：WO2004034925A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/026681
申请日：2003-08-27
申请人： CELSION CORPORATION , FENN, Alan, J. , MON, John
发明人： FENN, Alan, J. , MON, John
IPC分类号： A61F
CPC分类号： A61N5/02
摘要： A method for treating cancerous or benign conditions of a body or organ employs selective irradiation of the body tissue with energy. The method includes the steps of monitoring temperatures of the skin surface adjacent the body, positioining at least one energy applicator around the body, delivering energy to the at least one energy applicator to selectively irradiate the body tissue with energy and treat at least one of cancerous and benign conditions of the body, adjusting the level of power to be delivered to the at least one energy applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the at least one energy applicator, determining total energy delivered to the at least one energy applicator, and completing the treatment when the desired total energy dose has been delivered by the at least one energy applicator to the body.
摘要翻译：用于治疗身体或器官的癌症或良性病症的方法使用能量选择性地照射身体组织。该方法包括以下步骤：监测邻近身体的皮肤表面的温度，使身体周围的至少一个能量施加器定位，向至少一个能量施加器输送能量以选择性地用能量照射身体组织，并且治疗癌症中的至少一种以及身体的良性状态，基于所监测的皮肤温度，调整在治疗期间被输送到至少一个能量施加器的功率水平，监测传送到至少一个能量施加器的能量，确定传递给所述至少一个能量施加器的总能量至少一个能量施加器，并且当所述至少一个能量施加器被递送到所述身体时，完成所述治疗。

4. 发明申请

WO2004026098A2 METHOD FOR ADMINISTERING THERMOTHERAPY TO PREVENT THE GROWTH OF TUMORS 审中-公开
标题翻译：用于管理热保护以预防肿瘤生长的方法
公开(公告)号：WO2004026098A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/028898
申请日：2003-09-16
申请人： CELSION CORPORATION , FENN, Alan, J. , MON, John
发明人： FENN, Alan, J. , MON, John
IPC分类号： A61B
CPC分类号： A61B18/18 , A61B8/06 , A61B8/12 , A61B18/1815 , A61B18/24 , A61B2017/00022 , A61B2017/00092 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00547 , A61B2018/1861 , A61B2090/378 , A61M25/04 , A61M25/1011 , A61M29/02 , A61M2205/3368 , A61N5/04 , A61N5/045 , A61N7/02 , A61N2005/067
摘要： In order to reduce blood flow thereby accumulating additional equivalent thermal dose following the step of heating an organ or appendage by irradiating microwaves at the organ or appendage, the step of compressing the organ or aplpendage following the heating step is added to thertherapy treatment. In a preferred embodiment, the organ is the prostate and periodic prostate compression is employed to reduce the prostate blood flow thereby allowing chemotherapy, thermosensitive liposome-encapsulated chemotherapy, or gene therapy to accumulate in the prostate region during thermotherapy. Doppler ultrasound imaging may be used to measure tumor blood flow rate and then serve as real-time feedback to assist in adjusting the amount of balloon catheter inflation and to assess damage to the tumor vasculature during the treatment.
摘要翻译：为了减少血液流动，从而在通过在器官或附属物上照射微波加热器官或附属物的步骤后积累额外的等效热剂量，将加热步骤之后的器官或物质的压缩步骤加入到治疗治疗中。在优选的实施方案中，器官是前列腺，并且使用周期性前列腺压缩来减少前列腺血流量，从而允许化疗，热敏脂质体包封的化学疗法或基因治疗在热疗期间在前列腺区积累。多普勒超声成像可用于测量肿瘤血流速率，然后作为实时反馈，以协助调整球囊导管充气量，并评估治疗期间对肿瘤脉管系统的损伤。

5. 发明申请

WO2004022159A1 MONOPOLE PHASED ARRAY THERMOTHERAPY APPLICATOR FOR DEEP TUMORS 审中-公开
标题翻译： OPOPLE阵列热应激剂适用于深部肿瘤
公开(公告)号：WO2004022159A1
公开(公告)日：2004-03-18
申请号：PCT/US2003/026964
申请日：2003-08-29
申请人： CELSION CORPORATION , FENN, Alan, J. , MON, John , SMITH, Dennis
发明人： FENN, Alan, J. , MON, John , SMITH, Dennis
IPC分类号： A61N1/40
CPC分类号： A61N1/403
摘要： A monopole phased array thermotherapy applicator radiating radiofrequency energy for inducing a temperature rise in a target within a body includes a plurality of monopole elements for transmitting electric-field radiation; a metallic waveguide with an RF reflecting ground plane surface with a plurality of circular holes for mounting the monopole elements where the metallic waveguide forms an aperture for receiving a body to be treated; a waveform generator providing a source of electric field coupled to each monopole radiation element through a respective phase and power weighting network; at least one electric field probe positioned on a skin surface of the body for detecting electric field radiation from the plurality of monopole elements; and a controller circuit coupled to the electric field probe received feedback signals to adjust the phase and power delivered to the plurality of monopole elements so that one or more adaptive nulls are formed on the surface of the body and a focus is formed at the target tissue to be treated with thermotherapy.
摘要翻译：辐射射频能量的单极相控阵热疗器施加在体内的靶内引起温度升高，包括用于传输电场辐射的多个单极子元件; 具有RF反射接地平面表面的金属波导，具有用于安装单极元件的多个圆形孔，其中金属波导形成用于接收待处理物体的孔; 波形发生器，通过相应的相位和功率加权网络提供耦合到每个单极辐射元件的电场源; 位于所述主体的皮肤表面上的至少一个电场探针，用于检测来自所述多个单极元件的电场辐射; 以及耦合到电场探针的控制器电路接收的反馈信号以调节传递到多个单极子元件的相位和功率，使得在身体的表面上形成一个或多个自适应零点，并且在目标组织处形成焦点用热疗治疗。

6. 发明申请

WO2006102471A2 APPARATUS AND METHOD FOR PRE-CONDITIONING/FIXATION AND TREATMENT OF DISEASES WITH HEAT ACTIVATION/RELEASE WITH THERMOACTIVATED DRUGS AND GENE PRODUCTS 审中-公开
标题翻译：用热激活药物和基因产物预热/固定和治疗具有热激活/释放的疾病的装置和方法
公开(公告)号：WO2006102471A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/010505
申请日：2006-03-22
申请人： CELSION CORPORATION , MON, John
发明人： MON, John
CPC分类号： A61B18/1477 , A61B18/18 , A61B2018/143 , A61B2218/002 , A61K41/0052 , A61N7/02
摘要： An apparatus and method for administering focused energy to a body using either a single energy applicator or multiple energy applicators to supply heat prior to, concurrently with and/or after delivery of a drug, gene and/or viral vector. A multi-modality treatment using a localized, focused and/or regional heating apparatus, which supplies heat to a defined area of a patient's body. The apparatus is used heat is used to pretreat a specific body site, to activate thermoactivated drugs, genes, or viral vectors, and/or to deliver drugs, genes, or viral vectors to the specific body site. The heating apparatus is provided with one or more variable and adjustable probes and one or more delivery ports heat the specific treatment site and to deliver the thermoactivated drugs and genes to the specific treatment site. Each probe may optionally be provided with one or more temperature sensors to allow for the temperature in the specific treatment site and the surrounding tissue to be properly regulated. The use of the apparatus and method allow for the heat conditioning of a specific treatment site and for the delivery or activation of a drug, gene, or viral vector limited to only the specific treatment site, allowing for a more accurate treatment of diseased tissue without damaging healthy tissue. In addition, this method is uniquely used with non invasive technologies to help determine on a real time basis the completion of the treatment. #699718
摘要翻译：一种用于使用单一能量施加器或多个能量施加器向身体施加聚焦能量以在药物，基因和/或病毒载体递送之前，同时和/或之后提供热量的装置和方法。使用局部，聚焦和/或区域加热装置的多方式治疗，其将热量提供给患者身体的限定区域。使用该装置用于预处理特定身体部位，激活热激活的药物，基因或病毒载体，和/或将药物，基因或病毒载体递送至特定身体部位。加热装置设置有一个或多个可变和可调的探针和一个或多个输送端口加热特定的处理部位并将热激活的药物和基因输送到特定的治疗部位。每个探针可以可选地设置有一个或多个温度传感器，以允许适当调节特定治疗部位和周围组织中的温度。使用该装置和方法允许特定治疗部位的加热调节和仅限于仅特定治疗部位的药物，基因或病毒载体的递送或激活，从而允许对患病组织进行更准确的治疗而无需破坏健康组织。此外，该方法独特地用于非侵入性技术，以帮助实时确定治疗的完成。＃699718

7. 发明申请

WO2004034925A3 THERMOTHERAPY METHOD FOR TREATMENT AND PREVENTION OF CANCER IN MALE AND FEMALE PATIENTS AND COSMETIC ABLATION OF TISSUE 审中-公开
标题翻译：热疗法治疗和预防男性和女性患者的癌症以及组织的化学清除
公开(公告)号：WO2004034925A3
公开(公告)日：2004-10-28
申请号：PCT/US0326681
申请日：2003-08-27
申请人： CELSION CORP , FENN ALAN J , MON JOHN
发明人： FENN ALAN J , MON JOHN
IPC分类号： A61F20060101 , A61F2/00 , A61N5/02
CPC分类号： A61N5/02
摘要： A method for treating cancerous or benign conditions of a body or organ employs selective irradiation of the body tissue with energy. The method includes the steps of monitoring temperatures of the skin surface adjacent the body, positioining at least one energy applicator around the body, delivering energy to the at least one energy applicator to selectively irradiate the body tissue with energy and treat at least one of cancerous and benign conditions of the body, adjusting the level of power to be delivered to the at least one energy applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the at least one energy applicator, determining total energy delivered to the at least one energy applicator, and completing the treatment when the desired total energy dose has been delivered by the at least one energy applicator to the body.
摘要翻译：用于治疗身体或器官的癌症或良性病症的方法利用能量选择性照射身体组织。该方法包括以下步骤：监测邻近身体的皮肤表面的温度，将围绕身体的至少一个能量施加器定位，将能量输送到至少一个能量施加器以选择性地用能量照射身体组织并且治疗癌症和身体的良性状况，基于所监测的皮肤温度来调整在治疗期间要递送到至少一个能量施用器的功率水平，监测输送到至少一个能量施用器的能量，确定输送到至少一个能量施用器的总能量至少一个能量施加器，并且当期望的总能量剂量已经由至少一个能量施加器递送到身体时完成治疗。

8. 发明申请

WO2004007020A2 THERMOTHERAPY METHOD FOR TREATMENT AND PREVENTION OF BREAST CANCER AND CANCER IN OTHER ORGANS 审中-公开
标题翻译：治疗和预防其他器官乳腺癌和癌症的热疗方法
公开(公告)号：WO2004007020A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/021655
申请日：2003-07-11
申请人： CELSION CORPORATION , FENN, Alan, J. , MON, John
发明人： FENN, Alan, J. , MON, John
IPC分类号： A61N5/02
CPC分类号： A61N5/02

9. 发明申请

WO2006102471A3 APPARATUS AND METHOD FOR PRE-CONDITIONING/FIXATION AND TREATMENT OF DISEASES WITH HEAT ACTIVATION/RELEASE WITH THERMOACTIVATED DRUGS AND GENE PRODUCTS 审中-公开
标题翻译：用热激活药物和基因产物预热/固定和治疗具有热激活/释放的疾病的装置和方法
公开(公告)号：WO2006102471A3
公开(公告)日：2007-08-23
申请号：PCT/US2006010505
申请日：2006-03-22
申请人： CELSION CORP , MON JOHN
发明人： MON JOHN
IPC分类号： A61K41/00
CPC分类号： A61B18/1477 , A61B18/18 , A61B2018/143 , A61B2218/002 , A61K41/0052 , A61N7/02
摘要： An apparatus and method for administering focused energy to a body using either a single energy applicator or multiple energy applicators to supply heat prior to, concurrently with and/or after delivery of a drug, gene and/or viral vector. A multi-modality treatment using a localized, focused and/or regional heating apparatus, which supplies heat to a defined area of a patient's body. The apparatus is used heat is used to pretreat a specific body site, to activate thermoactivated drugs, genes, or viral vectors, and/or to deliver drugs, genes, or viral vectors to the specific body site. The heating apparatus is provided with one or more variable and adjustable probes and one or more delivery ports heat the specific treatment site and to deliver the thermoactivated drugs and genes to the specific treatment site. Each probe may optionally be provided with one or more temperature sensors to allow for the temperature in the specific treatment site and the surrounding tissue to be properly regulated. The use of the apparatus and method allow for the heat conditioning of a specific treatment site and for the delivery or activation of a drug, gene, or viral vector limited to only the specific treatment site, allowing for a more accurate treatment of diseased tissue without damaging healthy tissue. In addition, this method is uniquely used with non invasive technologies to help determine on a real time basis the completion of the treatment. #699718
摘要翻译：一种用于使用单一能量施加器或多个能量施加器向身体施加聚焦能量以在药物，基因和/或病毒载体递送之前，同时和/或之后提供热量的装置和方法。使用局部，聚焦和/或区域加热装置的多方式治疗，其将热量提供给患者身体的限定区域。使用该装置用于预处理特定身体部位，激活热激活的药物，基因或病毒载体，和/或将药物，基因或病毒载体递送至特定身体部位。加热装置设置有一个或多个可变和可调的探针和一个或多个输送端口加热特定的处理部位并将热激活的药物和基因输送到特定的治疗部位。每个探针可以可选地设置有一个或多个温度传感器，以允许适当调节特定治疗部位和周围组织中的温度。使用该装置和方法允许特定治疗部位的加热调节和仅限于仅特定治疗部位的药物，基因或病毒载体的递送或激活，从而允许对患病组织进行更准确的治疗而无需破坏健康组织。此外，该方法独特地用于非侵入性技术，以帮助实时确定治疗的完成。＃699718

10. 发明申请

WO2004026098A3 METHOD FOR ADMINISTERING THERMOTHERAPY TO PREVENT THE GROWTH OF TUMORS 审中-公开
标题翻译：管理热疗以预防肿瘤生长的方法
公开(公告)号：WO2004026098A3
公开(公告)日：2004-06-24
申请号：PCT/US0328898
申请日：2003-09-16
申请人： CELSION CORP , FENN ALAN J , MON JOHN
发明人： FENN ALAN J , MON JOHN
IPC分类号： A61B18/20 , A61B20060101 , A61B17/00 , A61B17/22 , A61B18/00 , A61B18/04 , A61B18/12 , A61B18/18 , A61B18/24 , A61B19/00 , A61F2/00 , A61F2/958 , A61M29/02 , A61M31/00 , A61N5/00 , A61N5/02 , A61N5/04 , A61N5/067 , A61N7/02
CPC分类号： A61B18/18 , A61B8/06 , A61B8/12 , A61B18/1815 , A61B18/24 , A61B2017/00022 , A61B2017/00092 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00547 , A61B2018/1861 , A61B2090/378 , A61M25/04 , A61M25/1011 , A61M29/02 , A61M2205/3368 , A61N5/04 , A61N5/045 , A61N7/02 , A61N2005/067
摘要： In order to reduce blood flow thereby accumulating additional equivalent thermal dose following the step of heating an organ or appendage by irradiating microwaves at the organ or appendage, the step of compressing the organ or aplpendage following the heating step is added to thertherapy treatment. In a preferred embodiment, the organ is the prostate and periodic prostate compression is employed to reduce the prostate blood flow thereby allowing chemotherapy, thermosensitive liposome-encapsulated chemotherapy, or gene therapy to accumulate in the prostate region during thermotherapy. Doppler ultrasound imaging may be used to measure tumor blood flow rate and then serve as real-time feedback to assist in adjusting the amount of balloon catheter inflation and to assess damage to the tumor vasculature during the treatment.
摘要翻译：为了减少血流从而在通过在器官或附属器处照射微波来加热器官或附器的步骤之后累积额外的等效热剂量，在加热步骤之后加入器官或附件的步骤被加入到治疗处理中。在一个优选的实施方案中，器官是前列腺，并且采用周期性前列腺压缩来减少前列腺血流，由此允许化疗，热敏脂质体包裹的化疗或基因疗法在热疗期间在前列腺区域积聚。多普勒超声成像可用于测量肿瘤血流速率，然后用作实时反馈以帮助调整球囊导管膨胀量并评估治疗期间对肿瘤脉管系统的损伤。

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