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1. 发明申请

WO9909965A3 ANTI-INFLAMMATORY AGENT 审中-公开
标题翻译：抗炎剂
公开(公告)号：WO9909965A3
公开(公告)日：1999-05-20
申请号：PCT/JP9803692
申请日：1998-08-20
申请人： TAKEDA CHEMICAL INDUSTRIES LTD , ODAKA HIROYUKI , MOMOSE YU
发明人： ODAKA HIROYUKI , MOMOSE YU
IPC分类号： A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/42 , A61K31/44
CPC分类号： A61K31/4439 , A61K31/422 , A61K31/427
摘要： An anti-inflammatory agent which affects by way of a TNF- alpha inhibitory action and comprises a compound of formula (I) wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula -CO-, -CH(OH)-, or -NR - where R represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R ; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond or a salt thereof.
摘要翻译：一种通过TNF-α抑制作用起作用的抗炎剂，包含式（I）化合物，其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO - ， - CH（OH） - 或-NR 3 - 的基团，其中R 3表示可以被取代的烷基; m是0或1; n是0,1或2; X代表CH或N; A表示具有1至7个碳原子的化学键或二价脂族烃基; Q代表氧或硫; R 1表示氢或烷基; 环E可以进一步具有1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以相互结合形成化学键或其盐。

2. 发明申请

WO1997037656A1 ANTICACHECTIC COMPOSITION 审中-公开
标题翻译：防静电组合物
公开(公告)号：WO1997037656A1
公开(公告)日：1997-10-16
申请号：PCT/JP1997001148
申请日：1997-04-03
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MOMOSE, Yu , MATSUTANI, Etsuya , SOHDA, Takashi
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： A61K31/42
CPC分类号： A61K31/4439 , A61K31/422 , A61K31/427
摘要： A medicinal composition for the prophylaxis and treatment of cachexia which comprises a compound of formula (I) wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula -CO-, -CH(OH)-, or -NR - (R represents an alkyl group that may be substituted); m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulphur; R represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R ; L and M respectively represent hydrogen or may be combined with each other to form a bond, provided that when m and n are O, X represents CH, A represents a bond, Q represents sulfur, R , L and M respectively represent hydrogen, and ring E does not have further substituents, R does not represent dihydrobenzopyranyl; or a salt thereof.
摘要翻译：一种用于预防和治疗恶病质的药物组合物，其包含式（I）化合物，其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO-，-CH（OH） - 或-NR 3 - （R 3表示可被取代的烷基）的基团; m为0或1; n为0,1或2; X表示CH或N; A表示碳原子数1〜7的键或2价脂肪族烃基， Q表示氧或硫; R 1表示氢或烷基; 环E可以具有另外的1至4个取代基，其可以与R 1结合形成环; L和M分别表示氢或可以彼此结合形成键，条件是当m和n为O时，X表示CH，A表示键，Q表示硫，R 1，L和M分别表示氢和环E不具有其它取代基，R不表示二氢苯并吡喃基; 或其盐。

3. 发明申请

WO0114372A3 OXAZOLE AND THIAZOLE DERIVATIVES AS NEUROTROPHIN PRODUCTION/SECRETION PROMOTING AGENT 审中-公开
标题翻译：奥沙芬和噻唑衍生物作为神经营养因子生产/分泌促进剂
公开(公告)号：WO0114372A3
公开(公告)日：2002-03-21
申请号：PCT/JP0005681
申请日：2000-08-24
申请人： TAKEDA CHEMICAL INDUSTRIES LTD , MOMOSE YU , MURASE KATSUHITO
发明人： MOMOSE YU , MURASE KATSUHITO
IPC分类号： C07D277/20 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/662 , A61P1/00 , A61P9/00 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/24 , A61P25/28 , A61P29/00 , A61P43/00 , C07D263/32 , C07D263/34 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/32 , C07D277/40 , C07D277/54 , C07D413/00 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D521/00
CPC分类号： C07D263/34 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/32 , C07D277/40 , C07D277/54 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/14
摘要： A neurotrophin production/secretion promoting agent which comprises an azole derivative of formula (I), wherein R represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substitued, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.
摘要翻译：神经营养因子产生/分泌促进剂，其包含式（I）的唑衍生物，其中R 1表示卤素原子，可任选被取代的杂环基，可任意取代的羟基，硫醇基，可任选被取代，或可任选被取代的氨基; A表示可任意取代的酰基，可任意取代的杂环基，可任意取代的羟基，或可任意被酯化或酰胺化的羧基; B表示可任选被取代的芳族基团; X表示可任选被取代的氧原子，硫原子或氮原子; Y表示二价烃基或杂环基，或其盐; 其可用作预防或治疗神经病的药剂。

4. 发明申请

WO9803505A3 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE 审中-公开
标题翻译：杂环化合物，其生产和使用
公开(公告)号：WO9803505A3
公开(公告)日：1998-06-25
申请号：PCT/JP9702479
申请日：1997-07-17
申请人： TAKEDA CHEMICAL INDUSTRIES LTD , MOMOSE YU , MATSUTANI ETSUYA
发明人： MOMOSE YU , MATSUTANI ETSUYA
IPC分类号： C07D413/12 , C07D521/00 , A61K31/42 , A61K31/425 , C07D413/14 , C07D417/14
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12
摘要： Heterocyclic compounds represented by general formula (I) wherein R stands for an optionally substituted aromatic heterocyclic group; X stands for oxygen atom, an optionally oxidated sulfur atom, -C(=O)- or -CH(OH)-; Y stands for CH or N; m denotes an integer of 0 to 10; n denotes an integer of 1 to 5; cyclic group -NB) stands for an optionally substituted aromatic azole group; and ring A is optionally further substituted, or salts thereof. The compound (I) possesses action of inhibiting tyrosine kinase and useful as antitumor agents.

5. 发明申请

WO1997036882A1 OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE 审中-公开
标题翻译：奥沙唑衍生物，其生产和使用
公开(公告)号：WO1997036882A1
公开(公告)日：1997-10-09
申请号：PCT/JP1997001146
申请日：1997-04-02
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MOMOSE, Yu , ODAKA, Hiroyuki
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07D263/38
CPC分类号： C07D263/34 , C07D263/38 , C07D263/46 , C07D263/48 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14
摘要： A novel compound of formula (I), wherein R is a halogen atom, an optionally substituted heterocyclic, hydroxy, thiol or amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, or an optionally esterified or amidated carboxy group; B is an optionally substituted aromatic group; Y is a divalent aliphatic hydrocarbon group, or a salt thereof, which have an excellent insulin secretion-promoting and blood sugar-depressing effect, and useful in agents for diabetes.
摘要翻译：式（I）的新型化合物，其中R 1是卤素原子，任选取代的杂环，羟基，硫醇或氨基; A是任选取代的酰基，任选取代的杂环基，任选取代的羟基或任选酯化或酰胺化的羧基; B是任选取代的芳基; Y是具有优异的胰岛素分泌促进作用和降低血糖的效果的二价脂肪族烃基或其盐，可用于糖尿病药。

6. 发明申请

WO2004039365A1 AGENT FOR PREVENTING OR TREATING NEUROPATHY 审中-公开
标题翻译：用于预防或治疗神经病的药剂
公开(公告)号：WO2004039365A1
公开(公告)日：2004-05-13
申请号：PCT/JP2003/013901
申请日：2003-10-30
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MOMOSE, Yu , SAKAI, Nozomu , MAEKAWA, Tsuyoshi , HAZAMA, Masatoshi , KAWAMURA, Toru , SERA, Misayo
发明人： MOMOSE, Yu , SAKAI, Nozomu , MAEKAWA, Tsuyoshi , HAZAMA, Masatoshi , KAWAMURA, Toru , SERA, Misayo
IPC分类号： A61K31/381
CPC分类号： C07D231/12 , A61K31/402 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/4439 , A61K31/66 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07F9/4056 , C07F9/5537 , C07F9/65037 , C07F9/65067 , C07F9/65187 , C07F9/653 , C07F9/65395 , C07F9/65586 , C07F9/657181
摘要： The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula:wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s);B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group;X is a divalent acyclic hydrocarbon group;Z is -O-, -S-, -NR 2 -, -CONR 2 - or -NR 2 CO- (R 2 is a hydrogen atom or an optionally substituted alkyl group);Y is a bond or a divalent acyclic hydrocarbon group;R 1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be -O-, or a salt thereof.
摘要翻译：本发明提供了用于预防或治疗具有优异作用和低毒性的神经病的药剂。该试剂包含由下式表示的化合物：其中环A为含有2个以上氮原子的5元芳族杂环，其还可具有取代基; B为任选取代的烃基或任选取代的杂环基; X是二价无环烃基; Z是-O - ， - S - ， - NR 2， - ， - CONR 2，其中R 2是氢原子或任选取代的烷基）; Y是键或二价无环烃基; R 1是任选取代的环状基团，任选取代的氨基基团或任选取代的酰基基团，条件是当所述5元芳族杂环代表环A是咪唑，那么Z不应该是-O-或其盐。

7. 发明申请

WO1998003505A2 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE 审中-公开
标题翻译：杂环化合物，其生产和使用
公开(公告)号：WO1998003505A2
公开(公告)日：1998-01-29
申请号：PCT/JP1997002479
申请日：1997-07-17
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MOMOSE, Yu , MATSUTANI, Etsuya
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07D413/12
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12
摘要： Heterocyclic compounds represented by general formula (I) wherein R stands for an optionally substituted aromatic heterocyclic group; X stands for oxygen atom, an optionally oxidated sulfur atom, -C(=O)- or -CH(OH)-; Y stands for CH or N; m denotes an integer of 0 to 10; n denotes an integer of 1 to 5; cyclic group -NB) stands for an optionally substituted aromatic azole group; and ring A is optionally further substituted, or salts thereof. The compound (I) possesses action of inhibiting tyrosine kinase and useful as antitumor agents.
摘要翻译：由通式（I）表示的杂环化合物，其中R表示任选取代的芳族杂环基; X代表氧原子，任选氧化的硫原子，-C（= O） - 或-CH（OH） - ; Y代表CH或N; m表示0〜10的整数。 n表示1〜5的整数，环状基团-NB）表示任选取代的芳族唑基; 环A任选被进一步取代，或其盐。化合物（I）具有抑制酪氨酸激酶的作用，可用作抗肿瘤剂。

8. 发明申请

WO1996005186A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE 审中-公开
标题翻译：噻唑烷二酮衍生物及其生产和使用
公开(公告)号：WO1996005186A1
公开(公告)日：1996-02-22
申请号：PCT/JP1995001579
申请日：1995-08-09
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , SOHDA, Takashi , ODAKA, Hiroyuki , MOMOSE, Yu
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07D277/34
CPC分类号： C07D417/12 , C07D277/34
摘要： A 2,4-thiazolidinedione derivative of formula (I), wherein R is an optionally substituted hydrocarbon group or heterocyclic group which may be attached through a hydrocarbon chain; n is 0 or 1; X is CH or N; Y is a bivalent hydrocarbon group; R and R are the same or different and are a hydrogen atom, a halogen atom, an optionally substituted hydroxyl group or an optionally substituted hydrocarbon group, and either R or R and a part of Y may be linked together to form a ring; and L and M are a hydrogen atom, or L and M are linked together to form a bond; or a salt thereof. A pharmaceutical composition comprising the compound (I) and a process for producing the compound (I) are also provided.
摘要翻译：式（I）的2,4-噻唑烷二酮衍生物，其中R是可以通过烃链连接的任选取代的烃基或杂环基; n为0或1; X是CH或N; Y为二价烃基; R 1和R 2相同或不同，为氢原子，卤素原子，任选取代的羟基或任选取代的烃基，R 1或R 2和一部分的Y可以连接在一起形成环; L和M是氢原子，或L和M连接在一起形成键; 或其盐。还提供了包含化合物（I）和制备化合物（I）的方法的药物组合物。

9. 发明申请

WO1997000249A1 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE 审中-公开
标题翻译：杂环化合物，其生产和使用
公开(公告)号：WO1997000249A1
公开(公告)日：1997-01-03
申请号：PCT/JP1996001643
申请日：1996-06-14
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , SOHDA, Takashi , MATSUTANI, Etsuya , MOMOSE, Yu
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07D263/44
CPC分类号： C07D263/44 , C07D233/78 , C07D277/34 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： A heterocyclic compound represented by formula (I), wherein D stands for H or an optionally substituted hydrocarbon group; X stands for CH or N; A stands for a divalent aliphatic hydrocarbon group; R stands for an optionally substituted hydrocarbon group; Q stands for -N(R )- (R stands for hydrogen atom or a lower alkyl), O or S; Z stands for O or S; L and M independently stand for H, or they may optionally be combined with each other to form a bond; ring E may optionally be further substituted, and the substituent may optionally be combined with D to form a ring; or a salt thereof; which is useful as an antitumor agent.
摘要翻译：由式（I）表示的杂环化合物，其中D表示H或任选取代的烃基; X代表CH或N; A代表二价脂族烃基; R代表任选取代的烃基; Q表示-N（R 0） - （R 0表示氢原子或低级烷基），O或S; Z代表O或S; L和M独立地代表H，或者它们可以任选地彼此结合形成键; 环E可以任选地被进一步取代，并且取代基可以任选地与D结合形成环; 或其盐; 其作为抗肿瘤剂是有用的。

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