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1. 发明申请

WO2015138702A1 IMPROVED MEASUREMENT OF BODY FLUID VOLUMES 审中-公开
标题翻译：改善身体体液量的测量
公开(公告)号：WO2015138702A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020140
申请日：2015-03-12
申请人： PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL , MOLITORIS, Bruce, A. , WANG, Exing , SANDOVAL, Ruben, M.
发明人： MOLITORIS, Bruce, A. , WANG, Exing , SANDOVAL, Ruben, M.
IPC分类号： G01N33/49 , A61K49/10 , A61B5/145 , A61B5/1455
CPC分类号： A61K49/0054 , A61B5/1451 , A61B5/14546 , A61B5/201 , A61B5/4875 , A61B5/4881 , A61K49/0041
摘要： The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV-TVPV.
摘要翻译：本发明一般涉及动物受试者体液体积的测量。感兴趣的体液体积包括细胞外液体积（ECFV），总血管血浆体积（TVPV）和间质液体体积（IFV）。这些方法对于患有肾功能衰竭的受试者尤其是肾透析患者特别有益。可以通过施用第一分子来测量ECFV，所述第一分子是血管系统的血管壁的非代谢和可渗透的，其中第一分子分布在总血管空间以及间质空间内。 TVPV可以通过施用第二分子来测量，所述第二分子是非代谢的并且不渗透血管系统的血管壁，其中第二分子仅分布在血管空间内。然后可以使用IFV = ECFV-TVPV等式计算IFV。

2. 发明申请

WO2006113724A1 METHOD AND APPARATUS FOR KIDNEY FUNCTION ANALYSIS 审中-公开
标题翻译：用于KIDNEY功能分析的方法和装置
公开(公告)号：WO2006113724A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/014576
申请日：2006-04-18
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , YU, Weiming , MOLITORIS, Bruce, A. , SANDOVAL, Ruben, M.
发明人： YU, Weiming , MOLITORIS, Bruce, A. , SANDOVAL, Ruben, M.
IPC分类号： A61K51/00
CPC分类号： A61K49/0004 , A61K49/0032 , A61K49/0041 , A61K49/0043 , A61K49/0054
摘要： A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio. The apparatus includes a number of finger receiving apertures, a light generation circuit, a light detection circuit, a pulse counting circuit, and a user interface.
摘要翻译：提供了一种用于确定与动物有关的生理数据的方法和装置，例如肾脏诊断数据。该方法包括将第一和第二分子的混合物注射到动物（例如人类患者）中，确定分子的分子比例，以及基于分子比确定生理数据。该装置包括多个手指接收孔，光产生电路，光检测电路，脉冲计数电路和用户接口。

3. 发明申请

WO2009140026A3 RENAL FUNCTION ANALYSIS METHOD AND APPARATUS 审中-公开
标题翻译：肾功能分析方法和装置
公开(公告)号：WO2009140026A3
公开(公告)日：2010-01-21
申请号：PCT/US2009040994
申请日：2009-04-17
申请人： PHARMACOPHOTONICS LLC D B A FA , WANG EXING , MEIER DANIEL , BUNCH ROBERT , MOLITORIS BRUCE , SANDOVAL RUBEN , RUBIN MATTHEW
发明人： WANG EXING , MEIER DANIEL , BUNCH ROBERT , MOLITORIS BRUCE , SANDOVAL RUBEN , RUBIN MATTHEW
IPC分类号： A61K49/00 , A61B5/00 , A61B5/20
CPC分类号： A61B5/201 , A61B1/00154 , A61B1/00165 , A61B5/0071 , A61B5/0084 , A61B5/412 , A61B5/6852 , A61K49/0017 , A61M5/007
摘要： A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
摘要翻译：用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。将荧光分子引入哺乳动物受试者的血液中。在一段时间内，测量报告物和标记荧光分子的强度。计算比例以确定受试者的肾脏的健康状况。该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。

4. 发明申请

WO2007047430A8 METHOD OF TREATING ACUTE FAILURE WITH THROMBOMODULIN VARIANT 审中-公开
标题翻译：治疗急性缺血性脑血管病变变化的方法
公开(公告)号：WO2007047430A8
公开(公告)日：2008-04-10
申请号：PCT/US2006040069
申请日：2006-10-12
申请人： LILLY CO ELI , UNIV INDIANA RES & TECH CORP , GRINNELL BRIAN WILLIAM , MCKINNEY THURMAN DWIGHT , MOLITORIS BRUCE A
发明人： GRINNELL BRIAN WILLIAM , MCKINNEY THURMAN DWIGHT , MOLITORIS BRUCE A
IPC分类号： A61K38/17 , A61P13/12
CPC分类号： A61K38/1709
摘要： The present invention provides a method for preventing and/or treating subjects with acute renal failure caused by a variety of conditions. The method comprises administering to the subject soluble thrombomodulin. In conjunction with standard of care, soluble thrombomodulin will reduce tissue injury and subsequent morbidity and mortality.
摘要翻译：本发明提供一种预防和/或治疗由各种病症引起的急性肾功能衰竭的方法。该方法包括向受试者施用可溶性血栓调节蛋白。结合护理标准，可溶性血栓调节蛋白可以减少组织损伤及随后的发病率和死亡率。

5. 发明申请

WO2010127136A2 MEASUREMENT OF BODY FLUID VOLUMES 审中-公开
标题翻译：体液流量测量
公开(公告)号：WO2010127136A2
公开(公告)日：2010-11-04
申请号：PCT/US2010032997
申请日：2010-04-29
申请人： PHARMACOPHOTONICS INC , MOLITORIS BRUCE A , WANG EXING , SANDOVAL RUBEN M JR
发明人： MOLITORIS BRUCE A , WANG EXING , SANDOVAL RUBEN M JR
IPC分类号： A61K49/00
CPC分类号： A61K49/0054 , A61K49/0043
摘要： The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV = ECFV - TVPV.
摘要翻译：本发明一般涉及动物受试者体液体积的测量。感兴趣的体液体积包括细胞外液体积（ECFV），总血管血浆体积（TVPV）和间质液体体积（IFV）。这些方法对于患有肾功能衰竭的受试者尤其是肾透析患者特别有益。可以通过施用第一分子来测量ECFV，所述第一分子是血管系统的血管壁的非代谢和可渗透的，其中第一分子分布在总血管空间以及间质空间内。 TVPV可以通过施用第二分子来测量，所述第二分子是非代谢的并且不渗透血管系统的血管壁，其中第二分子仅分布在血管空间内。然后可以使用等式IFV = ECFV-TVPV来计算IFV。

6. 发明申请

WO2009140026A2 RENAL FUNCTION ANALYSIS METHOD AND APPARATUS 审中-公开
标题翻译：肾功能分析方法和装置
公开(公告)号：WO2009140026A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/040994
申请日：2009-04-17
申请人： PHARMACOPHOTONICS, LLC D/B/A FAST DIAGNOSTICS , WANG, Exing , MEIER, Daniel , BUNCH, Robert , MOLITORIS, Bruce , SANDOVAL, Ruben , RUBIN, Matthew
发明人： WANG, Exing , MEIER, Daniel , BUNCH, Robert , MOLITORIS, Bruce , SANDOVAL, Ruben , RUBIN, Matthew
IPC分类号： A61K49/00 , A61B5/20 , A61B5/00
CPC分类号： A61B5/201 , A61B1/00154 , A61B1/00165 , A61B5/0071 , A61B5/0084 , A61B5/412 , A61B5/6852 , A61K49/0017 , A61M5/007
摘要： A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
摘要翻译：用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。将荧光分子引入哺乳动物受试者的血液中。在一段时间内，测量报告物和标记荧光分子的强度。计算比例以确定受试者的肾脏的健康状况。该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。

7. 发明申请

WO2008073884A2 METHOD OF TREATING ACUTE RENAL FAILURE WITH THROMBOMODULIN VARIANTS 审中-公开
标题翻译：治疗急性肾功能衰竭与肝细胞生成素变化的方法
公开(公告)号：WO2008073884A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/086965
申请日：2007-12-10
申请人： ELI LILLY AND COMPANY , INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , GRINNELL, Brian, William , JONES, Bryan, Edward , MOLITORIS, Bruce, A.
发明人： GRINNELL, Brian, William , JONES, Bryan, Edward , MOLITORIS, Bruce, A.
CPC分类号： C07K14/7455 , A61K38/00
摘要： The present invention provides a method for preventing and/or treating subjects with acute renal failure caused by a variety of conditions. The method comprises administering to the subject soluble thrombomodulin which does not activate Protein C. In conjunction with standard of care, soluble thrombomodulin that does not activate Protein C will prevent or reduce acute kidney injury and subsequent morbidity and mortality.
摘要翻译：本发明提供一种预防和/或治疗由各种病症引起的急性肾功能衰竭的方法。该方法包括向受试者施用不激活蛋白C的可溶性血栓调节蛋白。结合护理标准，不激活蛋白C的可溶性血栓调节蛋白将预防或减少急性肾损伤及随后的发病率和死亡率。

8. 发明申请

WO2010144336A3 METHODS FOR TREATING CHRONIC KIDNEY DISEASE 审中-公开
标题翻译：治疗慢性寄生虫病的方法
公开(公告)号：WO2010144336A3
公开(公告)日：2011-02-03
申请号：PCT/US2010037565
申请日：2010-06-07
申请人： QUARK PHARMACEUTICALS INC , US DEPT OF VETERANS AFFAIRS WASHINGTON DC , FEINSTEIN ELENA , ADAMSKY SVETLANA , ERLICH SHAI , MOLITORIS BRUCE
发明人： FEINSTEIN ELENA , ADAMSKY SVETLANA , ERLICH SHAI , MOLITORIS BRUCE
IPC分类号： A61K31/7088 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1135 , C12N2310/14 , C12N2310/321 , C12N2310/343 , C12N2310/3521
摘要： The present invention relates to methods for treating chronic kidney disease (CKD) including methods for preventing or delaying onset of CKD and methods for preventing exacerbation and progression of CKD. In particular embodiments, the invention provides methods for treating a subject at risk of developing CKD comprising administering to the subject a composition comprising a) a therapeutically effective amount of at least one oligonucleotide compound which inhibits the expression of a human target gene associated with the kidney disease; and b) a pharmaceutically acceptable excipient or carrier, or mixtures thereof, thereby reducing the risk of CKD in the subject.
摘要翻译：本发明涉及治疗慢性肾脏疾病（CKD）的方法，包括预防或延缓CKD发病的方法以及预防CKD加重和进展的方法。在具体实施方案中，本发明提供了治疗患有CKD风险的受试者的方法，包括向受试者施用组合物，该组合物包含：a）治疗有效量的至少一种寡核苷酸化合物，其抑制与肾相关的人靶基因的表达疾病; 和b）药学上可接受的赋形剂或载体或其混合物，从而降低受试者中CKD的风险。

9. 发明申请

WO2010127136A3 MEASUREMENT OF BODY FLUID VOLUMES 审中-公开
公开(公告)号：WO2010127136A3
公开(公告)日：2010-11-04
申请号：PCT/US2010/032997
申请日：2010-04-29
申请人： PHARMACOPHOTONICS, INC. , MOLITORIS, Bruce A. , WANG, Exing , SANDOVAL, Ruben M., Jr.
发明人： MOLITORIS, Bruce A. , WANG, Exing , SANDOVAL, Ruben M., Jr.
IPC分类号： A61B5/00
摘要： The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV = ECFV - TVPV.

10. 发明申请

WO2008067491A3 MATERIALS AND METHODS FOR TREATING DISEASES CAUSED BY GENETIC DISORDERS USING AMINOGLYCOSIDES AND DERIVATIVES THEREOF WHICH EXHIBIT LOW NEPHROTOXICITY 审中-公开
公开(公告)号：WO2008067491A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/085974
申请日：2007-11-29
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , MOLITORIS, Bruce, A. , BEDWELL, David, M. , SANDOVAL, Ruben, M.
发明人： MOLITORIS, Bruce, A. , BEDWELL, David, M. , SANDOVAL, Ruben, M.
IPC分类号： A01N43/04 , A61K31/70
摘要： Various aspects related to the preparation of congeners of the aminoglycosides gentamicin such as the congener C2 and using this compound or derivatives thereof and pharmaceutically active salts to treat diseases that involve genetic mutations which introduce a missense or premature stop codon into a gene. Still other aspects include treating human or animal patients with the gentamicin congener C2 and derivatives and pharmaceutical salt thereof to overcome, or to at least mitigate, the symptoms of disease and disorders such as some forms of Becker's or Duchenne muscular dystrophy, Hurler's Syndrome and Cystic Fibrosis that have as their etiology the presence of a premature stop codon in a gene whose proper expression is necessary for good health.

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