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1. 发明申请

WO1998010091A1 PROCESS FOR PREPARING OPTICALLY ACTIVE ISOMERS OF 2-HALO-2-FLUOROCYCLOPROPANECARBOXYLIC ACIDS 审中-公开
标题翻译：制备2-卤代-2-氟代环戊烷羧酸的光学活性异构体的方法
公开(公告)号：WO1998010091A1
公开(公告)日：1998-03-12
申请号：PCT/JP1997003112
申请日：1997-09-05
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED , DAIICHI PHARMACEUTICAL COMPANY, LIMITED. , WAKITA, Ryuhei , KUDO, Junko , ISHII, Takeshi , MITSUDA, Satoshi , IMURA, Akihiro
发明人： SUMITOMO CHEMICAL COMPANY, LIMITED , DAIICHI PHARMACEUTICAL COMPANY, LIMITED.
IPC分类号： C12P41/00
CPC分类号： C12P41/005 , C12P7/40
摘要： A process for preparing a particular optically active isomer of a 2-halo-2-fluorocyclopropanecarboxylic acid from a 2-halo-2-fluorocyclopropanecarboxylic ester comprising a mixture of optically active isomers. The process is characterized by asymmetrically hydrolyzing a 2-halo-2-fluorocyclopropanecarboxylic ester represented by general formula (1), (wherein X represents a chlorine, bromine, or iodine atom; R represents a lower alkyl group; and * represents an asymmetric carbon atom), using an esterase having a capability of asymmetrically hydrolyzing the ester.
摘要翻译：由2-卤代-2-氟环丙烷羧酸酯制备2-卤-2-氟环丙烷羧酸的特定旋光异构体的方法，该方法包括旋光异构体的混合物。该方法的特征在于不对称地水解由通式（1）表示的2-卤代-2-氟环丙烷羧酸酯，其中X表示氯，溴或碘原子; R表示低级烷基; *表示不对称碳原子），使用具有不对称水解酯的能力的酯酶。

2. 发明申请

WO1994000488A1 ANTI-HIV PEPTIDE OR PEPTIDE DERIVATIVE 审中-公开
标题翻译：抗艾滋病毒肽或肽衍生物
公开(公告)号：WO1994000488A1
公开(公告)日：1994-01-06
申请号：PCT/JP1993000836
申请日：1993-06-22
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , KUMAGAI, Kazuo , IKUTA, Kazuyoshi , OHKI, Koji , MITSUDA, Satoshi
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07K07/10
CPC分类号： C07K14/70514 , A61K38/00
摘要： A peptide or a peptide derivative represented by the following sequence (1), or a peptide or a peptide derivative wherein at least one amino acid in the sequence (1) is a D-amino acid, and a dimer thereof. In the sequence (1): R1-Asp Thr Ser Glu Asp Glu Val Ile Glu Lys Ile Leu Lys Asn Cys(R2) Lys Ile Gln Ile Glu Leu Asp Pro X Phe Glu Asn-R3, R1 represents hydrogen, a cysteine residue or an N-terminus-modifying group; R2 represents hydrogen or a cysteine-modifying group; R3 represents hydroxy, a cysteine residue or a C-terminus-modifying group; and X represents a tyrosine residue or a valine residue. The peptide or peptide derivative inhibits the infection with human immunodeficiency virus (HIV) and the formation of multinucleated giant cells after the infection with HIV, thus being usable for treating and preventing acquired immunodeficiency syndrome.
摘要翻译：由以下序列（1）表示的肽或肽衍生物或其中序列（1）中的至少一个氨基酸为D-氨基酸的肽或肽衍生物及其二聚体。在序列（1）中：R1-Asp Thr Ser Glu Asp Glu Val Ile Glu Lys Ile Leu Lys Asn Cys（R2）Lys Ile Gln Ile Glu Leu Asp Pro X Phe Glu Asn-R3，R1代表氢，半胱氨酸残基或 N末端修饰基团; R2代表氢或半胱氨酸修饰基团; R3表示羟基，半胱氨酸残基或C-末端修饰基团; X表示酪氨酸残基或缬氨酸残基。肽或肽衍生物在HIV感染后抑制人免疫缺陷病毒（HIV）的感染和多核巨细胞的形成，因此可用于治疗和预防后天免疫缺陷综合征。

3. 发明申请

WO1987006269A1 PROCESS FOR PREPARING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLIC ACIDS 审中-公开
标题翻译：制备光学活性环丙烷羧酸的方法
公开(公告)号：WO1987006269A1
公开(公告)日：1987-10-22
申请号：PCT/JP1987000244
申请日：1987-04-16
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED , NISHIZAWA, Kanji , MITSUDA, Satoshi , KOMAKI, Ryohei , SUGIMOTO, Masako , SUGIKI, Chiaki , OGAMI, Yasutaka , SONODA, Kazumi , KISHIMOTO, Fumitaka
发明人： SUMITOMO CHEMICAL COMPANY, LIMITED
IPC分类号： C12P41/00
CPC分类号： C12P41/005 , C07C51/09 , C12P7/40 , C07C61/37 , C07C61/40
摘要： A process for preparing optically active cyclopropanecarboxylic acids represented by formula (I), (wherein X represents a chlorine atom, a bromine atom, a methyl group or a trifluoromethyl group, and R' represents a hydrogen atom or a metal ion) or their salts. The process comprises asymmetrically hydrolyzing a cyclopropanecarboxylic acid ester represented by formula (II), (wherein X is as defined above and R represents a C1 - C4 alkyl group or a halogen atom-substituted C1 - C4 alkyl group) with a microorganism or an esterase derived therefrom.

4. 发明申请

WO1984004543A1 PROCESS FOR PREPARING OPTICALLY ACTIVE BENZYL ALCOHOL COMPOUNDS 审中-公开
标题翻译：制备光学活性苯甲醇化合物的方法
公开(公告)号：WO1984004543A1
公开(公告)日：1984-11-22
申请号：PCT/JP1984000225
申请日：1984-05-01
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED , MITSUDA, Satoshi , MATSUO, Noritada , HIROHARA, Hideo
发明人： SUMITOMO CHEMICAL COMPANY, LIMITED
IPC分类号： C12P13/00
CPC分类号： C12P13/007 , C12P13/004 , C12P41/004
摘要： Process for preparing optically active alpha-cyanobenzyl alcohol compounds represented by formula (I), rich in an (S)-enantiomer useful as intermediates for synthesizing insecticidal pyrethroids, which comprises asymmetrically hydrolyzing (R,S)-alpha-cyanobenzyl alcohol esters of formula (II), using esterase of microorganism origin.

5. 发明申请

WO1984003714A1 PROCESS FOR BIOCHEMICAL OPTICAL RESULUTION OF CYCLOPENTENOLONE DERIVATIVE 审中-公开
标题翻译：环戊烯酮衍生物的生物化学光学结果的方法
公开(公告)号：WO1984003714A1
公开(公告)日：1984-09-27
申请号：PCT/JP1983000086
申请日：1983-03-18
申请人： SUMITOMO CHEMICAL CO. LTD. , MITSUDA, Satoshi , HIROHARA, Hideo
发明人： SUMITOMO CHEMICAL CO. LTD.
IPC分类号： C12P07/26
CPC分类号： C12P41/004 , C12P7/26
摘要： A process for biochemical optical resolution of 4-hydroxy-3-methyl-2-(2'-propynyl)-2-cyclopentenone, which comprises allowing esterase produced by microorganism or esterase of animal pancreas to act on an organic saturated or unsaturated C1 - C18 carboxylic acid ester of ( 9E)-4-hydroxy-3-methyl-2-(2'-propynyl)-2-cyclopentenone to effect asymmetric hydrolisis for obtaining optically active 4-hydroxy-3-methyl-2(2'-propynyl)-2-cyclopentenone and its enantiomer. This process is simple in comparison with a conventional process of optical resolution according to an organic synthetic chemistry principle and does not require expensive optically active reagents, thus being industrially quite advantageous.

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