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1. 发明申请

WO0214480A9 DECELLULARIZED TISSUE ENGINEERED CONSTRUCTS AND TISSUES 审中-公开
标题翻译：细致的组织工程结构和组织
公开(公告)号：WO0214480A9
公开(公告)日：2003-03-27
申请号：PCT/US0125628
申请日：2001-08-16
申请人： UNIV DUKE , MITCHELL SHANNON , KOH JENNIFER , NIKLASON LAURA E , PRABHAKAR VIKAS
发明人： MITCHELL SHANNON , KOH JENNIFER , NIKLASON LAURA E , PRABHAKAR VIKAS
IPC分类号： A61L27/38 , C12N5/00 , C12N5/06 , A61L27/28 , A61L27/50
CPC分类号： A61L27/3839 , A61L27/3691 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/90
摘要： New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct bz growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can bu used immediatley or stored unitl needed. The decellularized construct can be used for further tissue eingineering, which may include seeding the construct with cells obtained from the intended receipient of hte construct. During any of the growth phases required for production of the construct, the developing construct maz be subjected to various tissue engineering steps such as applciation of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization. The decellularized, engineered native tissue may then be subjected to further tissue engineering steps.
摘要翻译：公开了用于生产组织工程化构建体和工程化天然组织的新方法。所述方法包括在体外产生组织工程化构建体bz在体外培养细胞，然后使构建体脱细胞化以产生主要由细胞外基质组分组成的脱细胞化构建体。该构造可以使用immediatley或存储unitl所需。脱细胞构建体可用于进一步的组织排卵，其可以包括用从hTE构建体的预期接收体获得的细胞接种构建体。在生产构件所需的任何生长阶段期间，显影构件都经受各种组织工程步骤，例如包括脉动力的机械刺激的应用。所述方法还包括通过从动物或人收集组织来产生工程化的天然组织，在组织上执行一个或多个组织工程步骤，以及对组织进行脱细胞化。然后可以将脱细胞化的工程化天然组织进行进一步的组织工程步骤。

2. 发明申请

WO0214480A2 DECELLULARIZED TISSUE ENGINEERED CONSTRUCTS AND TISSUES 审中-公开
标题翻译：去细胞化的组织工程结构和组织
公开(公告)号：WO0214480A2
公开(公告)日：2002-02-21
申请号：PCT/US0125628
申请日：2001-08-16
申请人： UNIV DUKE , MITCHELL SHANNON , KOH JENNIFER , NIKLASON LAURA E , PRABHAKAR VIKAS
发明人： MITCHELL SHANNON , KOH JENNIFER , NIKLASON LAURA E , PRABHAKAR VIKAS
IPC分类号： A61L27/38 , C12N5/00 , C12N5/06 , A61L27/28 , A61L27/50
CPC分类号： A61L27/3839 , A61L27/3691 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/90
摘要： New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct bz growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can bu used immediatley or stored unitl needed. The decellularized construct can be used for further tissue eingineering, which may include seeding the construct with cells obtained from the intended receipient of hte construct. During any of the growth phases required for production of the construct, the developing construct maz be subjected to various tissue engineering steps such as applciation of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization. The decellularized, engineered native tissue may then be subjected to further tissue engineering steps.
摘要翻译：公开了生产组织工程构建体和工程化天然组织的新方法。所述方法包括在基底上体外生成组织工程化构建体，然后使该构建体去细胞化以产生主要由细胞外基质组分组成的脱细胞构建体。该构造可以使用立即数或所需的存储单元。脱细胞构建体可以用于进一步的组织工程化，其可以包括用从hte构建体的预期接收体获得的细胞接种构建体。在生产该构建体所需的任何生长阶段期间，发育中的构建体可以经受各种组织工程步骤，例如应用包括脉动力的机械刺激。所述方法还包括通过从动物或人获取组织来制造工程化天然组织，在组织上进行一个或多个组织工程步骤，并使组织脱细胞化。然后，脱细胞的工程化天然组织可以进行进一步的组织工程步骤。

3. 发明申请

WO2002014480A3 DECELLULARIZED TISSUE ENGINEERED CONSTRUCTS AND TISSUES 审中-公开
公开(公告)号：WO2002014480A3
公开(公告)日：2002-02-21
申请号：PCT/US2001/025628
申请日：2001-08-16
申请人： DUKE UNIVERSITY , MITCHELL, Shannon , KOH, Jennifer , NIKLASON, Laura, E. , PRABHAKAR, Vikas
发明人： MITCHELL, Shannon , KOH, Jennifer , NIKLASON, Laura, E. , PRABHAKAR, Vikas
IPC分类号： C12N5/06
摘要： New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct bz growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can bu used immediatley or stored unitl needed. The decellularized construct can be used for further tissue eingineering, which may include seeding the construct with cells obtained from the intended receipient of hte construct. During any of the growth phases required for production of the construct, the developing construct maz be subjected to various tissue engineering steps such as applciation of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization. The decellularized, engineered native tissue may then be subjected to further tissue engineering steps.

4. 发明申请

WO2012015670A1 STENT GRAFT SYSTEM AND METHOD OF USE 审中-公开
标题翻译： STENT GRAFT系统及其使用方法
公开(公告)号：WO2012015670A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/044892
申请日：2011-07-21
申请人： MEDTRONIC VASCULAR INC. , WEIDMAN, Jenna , MITCHELL, Shannon , KIEHL, Andrew
发明人： WEIDMAN, Jenna , MITCHELL, Shannon , KIEHL, Andrew
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/067 , A61F2002/075 , A61F2220/0041 , A61F2220/005 , A61F2220/0075 , A61F2230/0013
摘要： A stent graft system and method of use including a stent graft system with a first stent graft component and a second stent graft component. A first tubular graft of the first stent graft component has an integral first body and first leg, with the first body defining a first crown opening and a first substantially elliptical opening. The second body of the second stent graft component is disposed in the first body of the first stent graft component with the second leg of the second stent graft component disposed through the first substantially elliptical opening of the first stent graft component with the perimeter of the first elliptical opening of the first stent graft component in contact with the second body of the second stent graft component.
摘要翻译：一种支架移植系统和使用方法，包括具有第一支架移植物组件和第二支架移植物组件的支架移植物系统。第一支架移植物部件的第一管状移植物具有整体的第一主体和第一支腿，第一主体限定第一冠部开口和第一基本上椭圆形的开口。第二支架移植物部件的第二主体设置在第一支架移植物部件的第一主体中，第二支架移植部件的第二支腿通过第一支架移植部件的第一基本上椭圆形的开口设置，与第二支架移植物组件的第二主体接触的第一覆膜支架部件的椭圆形开口。

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