专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005013090A3 SYSTEMS AND METHODS FOR BIOPOLYMER ENGINEERING 审中-公开
标题翻译：生物聚合物工程系统与方法
公开(公告)号：WO2005013090A3
公开(公告)日：2006-04-13
申请号：PCT/US2004024752
申请日：2004-07-30
申请人： DNA TWOPOINTO INC , GUSTAFSSON CLAES , GOVINDARAJAN SRIDHAR , MINSHULL JEREMY STEPHEN
发明人： GUSTAFSSON CLAES , GOVINDARAJAN SRIDHAR , MINSHULL JEREMY STEPHEN
IPC分类号： C07K16/10 , C07K16/46 , G01N20060101 , G06F20060101 , G06F19/16 , G06F19/18 , G06F19/24 , G01N33/00 , G01N33/48
CPC分类号： G06F19/18 , C07K16/1027 , C07K16/461 , C07K2317/76 , G06F19/16 , G06F19/24
摘要： Methods, computer systems, and computer program products for biopolymer engineering. A variant set for a biopolymer of interest is constructed by identifying, using a plurality of rules, a plurality of positions in the biopolymer of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space. A variant set comprising a plurality of variants of the biopolymer of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.
摘要翻译：方法，计算机系统和生物聚合物工程的计算机程序产品。通过使用多个规则来识别感兴趣的生物聚合物中的多个位置，并且对于多个位置中的每个相应位置，通过识别相应位置的替换来构建用于感兴趣的生物聚合物的变体。多个位置中的各个位置的多个位置和替换共同限定生物聚合物序列空间。选择包含感兴趣的生物聚合物的多个变体的变体组。测量变体集中全部或部分变体的属性。序列活性关系在（i）由变体组表示的感兴趣的生物聚合物的一个或多个位置处的一个或多个取代和（ii）针对变体集中的全部或部分变体测量的性质之间建模。变体集被重新定义为包括在基于序列活动关系的函数选择的多个位置中的替换的变体。

2. 发明申请

WO2003068955A3 STREPTOMYCES AVERMITILIS GENE DIRECTING THE RATIO OF B2:B1 AVERMECTINS 审中-公开
公开(公告)号：WO2003068955A3
公开(公告)日：2003-08-21
申请号：PCT/IB2003/000348
申请日：2003-01-31
申请人： PFIZER PRODUCTS INC. , STUTZMAN-ENGWALL, Kim, Jonelle , GUSTAFSSON, Claes, Eric, Daniel , KREBBER, Anke , RAILLARD, Sun, Ai , MINSHULL, Jeremy, Stephen , KIM, Seran , CHEN, Yan
发明人： STUTZMAN-ENGWALL, Kim, Jonelle , GUSTAFSSON, Claes, Eric, Daniel , KREBBER, Anke , RAILLARD, Sun, Ai , MINSHULL, Jeremy, Stephen , KIM, Seran , CHEN, Yan
IPC分类号： C12N1/21
摘要： The present invention relates to polynucleotide comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

3. 发明申请

WO2005012877A2 SYSTEMS AND METHODS FOR ANTIBODY ENGINEERING 审中-公开
标题翻译：用于抗体工程的系统和方法
公开(公告)号：WO2005012877A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/024751
申请日：2004-07-30
申请人： DNA TWOPOINTO INC. , GUSTAFSSON, Claes , GOVINDARAJAN, Sridhar , MINSHULL, Jeremy, Stephen
发明人： GUSTAFSSON, Claes , GOVINDARAJAN, Sridhar , MINSHULL, Jeremy, Stephen
IPC分类号： G01N
CPC分类号： G06F19/18 , C07K16/1027 , C07K16/461 , C07K2317/76 , G06F19/16 , G06F19/24
摘要： Methods, computer systems, and computer program products for antibody engineering. A variant set for an antibody of interest is constructed by identifying, using a plurality of roles, a plurality of positions in the antibody of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define an antibody sequence space. A variant set comprising a plurality of variants of the antibody of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the antibody of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.
摘要翻译：方法，计算机系统和抗体工程的计算机程序产品。通过使用多个角色来识别感兴趣抗体中的多个位置，并且对于多个位置中的每个相应位置，通过识别相应位置的替换来构建用于感兴趣抗体的变体。多个位置中的各个位置的多个位置和替换共同限定抗体序列空间。选择包含感兴趣的抗体的多个变体的变体组。测量变体集中全部或部分变体的属性。在（i）由变体组表示的感兴趣抗体的一个或多个位置处的一个或多个取代和（ii）针对变体组中全部或部分变体测量的性质的序列活性关系进行建模。变体集被重新定义为包括在基于序列活动关系的函数选择的多个位置中的替换的变体。

4. 发明申请

WO2005012877A3 SYSTEMS AND METHODS FOR ANTIBODY ENGINEERING 审中-公开
标题翻译：用于抗体工程的系统和方法
公开(公告)号：WO2005012877A3
公开(公告)日：2006-04-06
申请号：PCT/US2004024751
申请日：2004-07-30
申请人： DNA TWOPOINTO INC , GUSTAFSSON CLAES , GOVINDARAJAN SRIDHAR , MINSHULL JEREMY STEPHEN
发明人： GUSTAFSSON CLAES , GOVINDARAJAN SRIDHAR , MINSHULL JEREMY STEPHEN
IPC分类号： C07K16/10 , C07K16/46 , G01N20060101 , G06F20060101 , G06F19/16 , G06F19/18 , G06F19/24 , G01N33/00 , G01N33/48
CPC分类号： G06F19/18 , C07K16/1027 , C07K16/461 , C07K2317/76 , G06F19/16 , G06F19/24
摘要： Methods, computer systems, and computer program products for antibody engineering. A variant set for an antibody of interest is constructed by identifying, using a plurality of roles, a plurality of positions in the antibody of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define an antibody sequence space. A variant set comprising a plurality of variants of the antibody of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the antibody of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.
摘要翻译：方法，计算机系统和抗体工程的计算机程序产品。通过使用多个角色来鉴定感兴趣的抗体中的多个位置，并且对于多个位置中的每个相应位置，通过识别相应位置的替换来构建用于感兴趣抗体的变体。多个位置中的各个位置的多个位置和替换共同限定抗体序列空间。选择包含感兴趣抗体的多个变体的变体集合。测量变体集中全部或部分变体的属性。在（i）由变体组表示的感兴趣抗体的一个或多个位置处的一个或多个取代和（ii）针对变体组中的全部或部分变体测量的性质之间建立序列活性关系。变体集被重新定义为包括基于序列活动关系的函数而选择的多个位置中的替换的变体。

5. 发明申请

WO2003068955A2 STREPTOMYCES AVERMITILIS GENE DIRECTING THE RATIO OF B2:B1 AVERMECTINS 审中-公开
标题翻译：表达B2基因比例的方差分析基因
公开(公告)号：WO2003068955A2
公开(公告)日：2003-08-21
申请号：PCT/IB2003/000348
申请日：2003-01-31
申请人： PFIZER PRODUCTS INC. , STUTZMAN-ENGWALL, Kim, Jonelle , GUSTAFSSON, Claes, Eric, Daniel , KREBBER, Anke , RAILLARD, Sun, Ai , MINSHULL, Jeremy, Stephen , KIM, Seran , CHEN, Yan
发明人： STUTZMAN-ENGWALL, Kim, Jonelle , GUSTAFSSON, Claes, Eric, Daniel , KREBBER, Anke , RAILLARD, Sun, Ai , MINSHULL, Jeremy, Stephen , KIM, Seran , CHEN, Yan
IPC分类号： C12N15/00
CPC分类号： C12N9/88 , C12P17/181 , C12P19/623
摘要： The present invention relates to polynucleotide comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
摘要翻译：本发明涉及包含编码aveC基因产物的核苷酸序列的多核苷酸，该多核苷酸分子可用于改变在阿维菌素的发酵培养物中产生的2:1级阿凡曼菌素的比例或量。本发明还涉及其中aveC基因已经失活或突变以改变所产生的2:1类阿维菌素的比例或量的阿维链霉菌的载体，宿主细胞和突变株。

6. 发明申请

WO2005013090A2 SYSTEMS AND METHODS FOR BIOPOLYMER ENGINEERING 审中-公开
标题翻译：生物聚合物工程系统与方法
公开(公告)号：WO2005013090A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/024752
申请日：2004-07-30
申请人： DNA TWOPOINTO INC. , GUSTAFSSON, Claes , GOVINDARAJAN, Sridhar , MINSHULL, Jeremy, Stephen
发明人： GUSTAFSSON, Claes , GOVINDARAJAN, Sridhar , MINSHULL, Jeremy, Stephen
IPC分类号： G06F
CPC分类号： G06F19/18 , C07K16/1027 , C07K16/461 , C07K2317/76 , G06F19/16 , G06F19/24
摘要： Methods, computer systems, and computer program products for biopolymer engineering. A variant set for a biopolymer of interest is constructed by identifying, using a plurality of rules, a plurality of positions in the biopolymer of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space. A variant set comprising a plurality of variants of the biopolymer of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.
摘要翻译：方法，计算机系统和生物聚合物工程的计算机程序产品。通过使用多个规则来识别感兴趣的生物聚合物中的多个位置，并且对于多个位置中的每个相应位置，通过识别相应位置的替代来构建用于感兴趣的生物聚合物的变体。多个位置中的各个位置的多个位置和替换共同限定生物聚合物序列空间。选择包含感兴趣的生物聚合物的多个变体的变体组。测量变体集中全部或部分变体的属性。在（i）由变体组表示的感兴趣的生物聚合物的一个或多个位置处的一个或多个取代和（ii）针对变体组中的全部或部分变体测量的特性的序列活性关系进行建模。变体集被重新定义为包括基于序列活动关系的函数而选择的多个位置中的替换的变体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式