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1. 发明申请

WO2012109470A2 MUTANT LUCIFERASES 审中-公开
标题翻译：突变的LUCIFERASES
公开(公告)号：WO2012109470A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024526
申请日：2012-02-09
申请人： UNIVERSITY OF MASSACHUSETTS , MILLER, Stephen C. , MOFFORD, David , HARWOOD, Katryn
发明人： MILLER, Stephen C. , MOFFORD, David , HARWOOD, Katryn
IPC分类号： C12N9/02 , C12N15/53 , C12N15/85 , C12Q1/66
CPC分类号： C12Q1/66 , A01K2267/0393 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/30 , C07K2319/31 , C07K2319/50 , C12N9/0069 , C12Y113/12007
摘要： Described are mutant luciferases, nucleic acids that encode them, cells and animals expressing them, methods of use thereof, and kits.
摘要翻译：描述了突变型萤光素酶，编码它们的核酸，表达它们的细胞和动物，其使用方法和试剂盒。

2. 发明申请

WO2009036351A3 ACTIVATIBLE DYES 审中-公开
公开(公告)号：WO2009036351A3
公开(公告)日：2009-03-19
申请号：PCT/US2008/076268
申请日：2008-09-12
申请人： UNIVERSITY OF MASSACHUSETTS , MILLER, Stephen C.
发明人： MILLER, Stephen C.
IPC分类号： C09B19/00 , C09B67/00 , C11D3/40 , C11D3/395
摘要： Novel, activatable dyes, such as photoactivatable dyes, e.g., oxazine dyes, are described. Some of the dyes are targeting dyes that can, e.g., target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes rapidly turn on their fluorescence and emit light, such as near-IR light with spatial and temporal precision.

3. 发明申请

WO2008109463A3 RED-SHIFTED LUCIFERASE 审中-公开
公开(公告)号：WO2008109463A3
公开(公告)日：2008-11-20
申请号：PCT/US2008055536
申请日：2008-02-29
申请人： UNIV MASSACHUSETTS , MILLER STEPHEN C
发明人： MILLER STEPHEN C
IPC分类号： C12Q1/68 , C07D265/38 , C07H21/04 , C07K16/46 , G01N33/53
CPC分类号： C07F9/906 , C07F9/80
摘要： The compositions described herein shift the light output of luciferases to the near-IR by resonance energy transfer to a targetable near-IR fluorophore.
摘要翻译：本文所述的组合物通过共振能量转移至可靶向的近红外荧光团将萤光素酶的光输出转移至近红外。

4. 发明申请

WO2011008689A1 METHOD TO SECURE AN ELASTIC COMPONENT IN A VALVE 审中-公开
标题翻译：安全阀中弹性部件的方法
公开(公告)号：WO2011008689A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/041698
申请日：2010-07-12
申请人： NAVILYST MEDICAL, INC. , MILLER, Stephen, C.
发明人： MILLER, Stephen, C.
IPC分类号： A61M1/00
CPC分类号： A61M39/24 , A61M1/3653 , A61M1/3659 , A61M39/22 , A61M2039/242 , A61M2039/2426
摘要： A valve comprises a flexible member including a slit formed on a central portion thereof and a first housing defining a first lumen extending therethrough, the first housing including a first contacting surface adapted, when the slit of the flexible member is aligned with the first lumen, to contact a first side of the flexible member the first housing defining a relief area extending about a perimeter of the first contacting surface radially outside the central portion relative to a longitudinal axis of the first lumen in combination with a second housing adapted to mate with the first housing with a second lumen defined by the second housing aligned with the first lumen and separated therefrom by the flexible member, the second housing including a second contacting surface.
摘要翻译：阀包括柔性构件，其包括形成在其中心部分上的狭缝和限定延伸穿过其中的第一腔的第一壳体，所述第一壳体包括第一接触表面，当柔性构件的狭缝与第一管腔对准时，与柔性构件的第一侧接触，第一壳体限定相对于第一内腔的纵向轴线径向地围绕第一接触表面的周边延伸的减压区域，第二壳体适于与第一壳体配合第一壳体，具有由第二壳体限定的第二腔体，与第一腔体对准并且通过柔性构件与第一腔室分离，第二壳体包括第二接触表面。

5. 发明申请

WO2010088146A1 POWER INJECTION VALVE 审中-公开
标题翻译：动力注射阀
公开(公告)号：WO2010088146A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/021740
申请日：2010-01-22
申请人： NAVILYST MEDICAL, INC. , MILLER, Stephen C.
发明人： MILLER, Stephen C.
IPC分类号： A61M5/307
CPC分类号： A61M39/22 , A61M39/24 , A61M2039/027 , A61M2039/242
摘要： A device for transferring fluids between an internal structure in a living body and an exterior thereof, comprises a housing including a pressure activated lumen extending to a distal end opening to a power injection lumen that extends to a distal port configured for connection t a fluid conduit extending to a target structure within the body and a pressure activated valve extending across the pressure activated lumen and controlling fluid flow therethrough, the pressure activated valve opening to permit fluid flow therethrough into the power injection lumen when a fluid pressure differential thereacross is at least a first predetermined threshold level and remaining sealed when the fluid pressure differential thereacross is less than the first threshold level in combination with a proximal port coupled to the housing for movement between a first position in which a proximal end of the power injection lumen opens to the proximal port and a second position in which a proximal end of the pressure activated lumen opens to the proximal port.
摘要翻译：一种用于在活体内部结构和其外部之间传送流体的装置，包括壳体，该壳体包括延伸到动力注射腔的远端开口的压力活化腔，其延伸至构造成连接的远端口，到主体内的目标结构，以及压力激活的阀，其延伸穿过压力激活的腔并且控制通过其中的流体流动，压力激活的阀开口，以允许流体流过动力注射腔，当其中的流体压力差异为至少第一预定的阈值水平并且当其相交的流体压差小于第一阈值水平时保持密封，其结合耦合到壳体的近端口，用于在第一位置和第二位置之间移动，在第一位置中，动力注射腔的近端与近端口以及第二位置，其中的近端压力激活的管腔通向近端口。

6. 发明申请

WO2009036351A2 ACTIVATIBLE DYES 审中-公开
标题翻译：活化染料
公开(公告)号：WO2009036351A2
公开(公告)日：2009-03-19
申请号：PCT/US2008076268
申请日：2008-09-12
申请人： UNIV MASSACHUSETTS , MILLER STEPHEN C
发明人： MILLER STEPHEN C
IPC分类号： C09B19/00 , C09B67/00 , C11D3/395 , C11D3/40
CPC分类号： C09B19/00 , A61K49/0028 , C09B5/60 , G01N33/5005
摘要： Novel, activatable dyes, such as photoactivatable dyes, e.g., oxazine dyes, are described. Some of the dyes are targeting dyes that can, e.g., target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes rapidly turn on their fluorescence and emit light, such as near-IR light with spatial and temporal precision.
摘要翻译：描述了新颖的可活化染料，如可光活化染料，例如恶嗪染料。一些染料是靶向染料，其可以例如靶向生物分子，诸如多肽，蛋白质或核酸。一旦激活，例如通过辐照，新型染料迅速打开其荧光并发射光，例如具有空间和时间精度的近红外光。

7. 发明申请

WO2008109463A2 RED-SHIFTED LUCIFERASE 审中-公开
标题翻译：红变红细胞
公开(公告)号：WO2008109463A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/055536
申请日：2008-02-29
申请人： UNIVERSITY OF MASSACHUSETTS , MILLER, Stephen, C.
发明人： MILLER, Stephen, C.
IPC分类号： C07F9/80
CPC分类号： C07F9/906 , C07F9/80
摘要： The compositions described herein shift the light output of luciferases to the near-IR by resonance energy transfer to a targetable near-IR fluorophore.
摘要翻译：本文所述的组合物通过共振能量转移将荧光素酶的光输出转移到近红外到可靶向近红外荧光团。

8. 发明申请

WO2008109459A1 LUCIFERINS 审中-公开
标题翻译：荧光素
公开(公告)号：WO2008109459A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/055531
申请日：2008-02-29
申请人： UNIVERSITY OF MASSACHUSETTS , MILLER, Stephen C.
发明人： MILLER, Stephen C.
IPC分类号： C07D277/62 , C12Q1/66 , G01N33/53
CPC分类号： C12Q1/66 , C07D277/62 , C07D277/68
摘要： Novel luciferins, methods of making luciferins, and uses of the same are disclosed.
摘要翻译：公开了新的萤光素，制备荧光素的方法及其用途。

9. 发明申请

WO2008014034A1 LUER FITTING FOR POWER INJECTABLE PICC 审中-公开
标题翻译：用于电力注入PICC的LUER配件
公开(公告)号：WO2008014034A1
公开(公告)日：2008-01-31
申请号：PCT/US2007/068330
申请日：2007-05-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , MILLER, Stephen C.
发明人： MILLER, Stephen C.
IPC分类号： A61M39/10
CPC分类号： A61M39/10 , A61M25/0612 , A61M2039/1033 , A61M2205/58
摘要： A fitting for connecting a catheter to a fluid conduit, comprises a housing defining a lumen extending therethrough from a distal end adapted for attachment to a catheter and a proximal end releasably connectable to a second fitting in combination with a wing extending from the housing away from an axis of the lumen, a portion of the housing opposite the wing being substantially rounded and free of projections away from the axis, a radially outermost lateral edge of a first surface of the wing being rounded wherein, when in a desired position, the first surface faces the skin.
摘要翻译：用于将导管连接到流体导管的配件包括：壳体，其限定从适于附接到导管的远端延伸穿过的内腔，以及可释放地连接到第二配件的近端，所述近端与从所述外壳延伸远离的壳体组合所述腔的轴线，与所述翼相对的壳体的一部分基本上是圆形的且没有远离所述轴线的突起，所述机翼的第一表面的径向最外侧的边缘是圆形的，其中当处于所需位置时，所述第一表面面向皮肤。

10. 发明申请

WO2012109470A3 MUTANT LUCIFERASES 审中-公开
公开(公告)号：WO2012109470A3
公开(公告)日：2012-11-08
申请号：PCT/US2012024526
申请日：2012-02-09
申请人： UNIV MASSACHUSETTS , MILLER STEPHEN C , MOFFORD DAVID , HARWOOD KATRYN
发明人： MILLER STEPHEN C , MOFFORD DAVID , HARWOOD KATRYN
IPC分类号： C12N9/02 , C12N15/53 , C12N15/85 , C12Q1/66
CPC分类号： C12Q1/66 , A01K2267/0393 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/30 , C07K2319/31 , C07K2319/50 , C12N9/0069 , C12Y113/12007
摘要： Described are mutant luciferases, nucleic acids that encode them, cells and animals expressing them, methods of use thereof, and kits.
摘要翻译：描述了突变荧光素酶，编码它们的核酸，表达它们的细胞和动物，其使用方法和试剂盒。

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