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1. 发明公开

EP2340309A2 NEUTRAL NANOTRANSPORTERS 审中-公开
标题翻译： NEUTRALE NANOTRANSPORTER
公开(公告)号：EP2340309A2
公开(公告)日：2011-07-06
申请号：EP09789352.3
申请日：2009-09-22
申请人： Rxi Pharmaceuticals Corporation , Khvorova, Anastasia , Salomon, William , Kamens, Joanne , Samarsky, Dmitry , Woolf, Tod M. , Miller, Michelle , Bulock, Karen G.
发明人： KHVOROVA, Anastasia , SALOMON, William , KAMENS, Joanne , SAMARSKY, Dmitry , WOOLF, Tod, M. , MILLER, Michelle , BULOCK, Karen, G.
IPC分类号： C12N15/113 , A61K31/7088
CPC分类号： C12N15/1136 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/3515 , C12N2310/3519 , C12N2310/3521 , C12N2320/32 , C12N2320/51 , C12N2320/53
摘要： The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.
摘要翻译：本发明涉及具有最小双链区域的RNAi构建体及其在基因沉默中的用途。与本发明相关的RNAi构建体包括8-14个核苷酸的双链区域和各种化学修饰，并且在基因沉默中是非常有效的。

2. 发明申请

WO2002081497A3 ανβ3 INTEGRIN-BINDING POLYPEPTIDE MONOBODIES AND THEIR USE 审中-公开
公开(公告)号：WO2002081497A3
公开(公告)日：2002-10-17
申请号：PCT/US2002/010763
申请日：2002-04-04
申请人： UNIVERSITY OF ROCHESTER , KOIDE, Shohei , DEWHURST, Stephen , KOIDE, Akiko , RICHARDS, Julie , MILLER, Michelle
发明人： KOIDE, Shohei , DEWHURST, Stephen , KOIDE, Akiko , RICHARDS, Julie , MILLER, Michelle
IPC分类号： A61K38/00
摘要： The present invention relates to a polypeptide monobody which includes a modified acid sequence and renders the polypeptide monobody able to bind selectively to ανβ3 integrin. Fusion proteins and conjugates which include the polypeptide monobody, as well as compositions containing the polypeptide monobody, fusion proteins, or conjugates are also disclosed. Uses thereof include: treating or preventing an ανβ3 integrin-mediated disease or disorder, inhibiting ανβ3 integrin activity, treating a cancerous or precancerous condition, imaging tissues using positron emission tomography or magnetic resonance imaging, assessing the metastatic characteristics of a tumor, and delivering DNA to a cell.

3. 发明申请

WO2010033248A3 NEUTRAL NANOTRANSPORTERS 审中-公开
标题翻译：中性纳米转运体
公开(公告)号：WO2010033248A3
公开(公告)日：2010-06-17
申请号：PCT/US2009005251
申请日：2009-09-22
申请人： RXI PHARMACEUTICALS CORP , KHVOROVA ANASTASIA , SALOMON WILLIAM , KAMENS JOANNE , SAMARSKY DMITRY , WOOLF TOD M , MILLER MICHELLE , BULOCK KAREN G
发明人： KHVOROVA ANASTASIA , SALOMON WILLIAM , KAMENS JOANNE , SAMARSKY DMITRY , WOOLF TOD M , MILLER MICHELLE , BULOCK KAREN G
IPC分类号： C12N15/113 , A61K31/7088
CPC分类号： C12N15/1136 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/3515 , C12N2310/3519 , C12N2320/32 , C12N2320/51 , C12N2310/3521
摘要： Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified polynucleotides and fat mixtures. Methods of using the neutral lipid formulations are also provided.
摘要翻译：根据本发明提供了用于核酸递送的中性脂质制剂。中性脂质制剂包括疏水改性的多核苷酸和脂肪混合物。还提供了使用中性脂质制剂的方法。

4. 发明申请

WO2010033248A2 NEUTRAL NANOTRANSPORTERS 审中-公开
标题翻译：中性NANOTRANSPORTERS
公开(公告)号：WO2010033248A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/005251
申请日：2009-09-22
申请人： RXI PHARMACEUTICALS CORPORATION , KHVOROVA, Anastasia , SALOMON, William , KAMENS, Joanne , SAMARSKY, Dmitry , WOOLF, Tod, M. , MILLER, Michelle , BULOCK, Karen, G.
发明人： KHVOROVA, Anastasia , SALOMON, William , KAMENS, Joanne , SAMARSKY, Dmitry , WOOLF, Tod, M. , MILLER, Michelle , BULOCK, Karen, G.
IPC分类号： C12N15/113 , A61K31/7088
CPC分类号： C12N15/1136 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/3515 , C12N2310/3519 , C12N2310/3521 , C12N2320/32 , C12N2320/51 , C12N2320/53
摘要： Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified polynucleotides and fat mixtures. Methods of using the neutral lipid formulations are also provided.
摘要翻译：根据本发明提供用于核酸递送的中性脂质制剂。中性脂质制剂包括疏水改性的多核苷酸和脂肪混合物。还提供了使用中性脂质制剂的方法。

5. 发明申请

WO2006130692A3 FUNCTIONALITY DISABLE AND RE-ENABLE FOR PROGRAMMABLE CALCULATORS 审中-公开
标题翻译：可编程计数器的功能禁用和重启
公开(公告)号：WO2006130692A3
公开(公告)日：2009-04-16
申请号：PCT/US2006021122
申请日：2006-06-01
申请人： TEXAS INSTRUMENTS INC , MILLER MICHELLE A , FELTZ DOUGLAS W , VONBERG GARY C
发明人： MILLER MICHELLE A , FELTZ DOUGLAS W , VONBERG GARY C
IPC分类号： G06F15/02
CPC分类号： G06F15/02 , G06F15/16
摘要： A handheld calculator with disable/re-enable capability. The calculator includes a keypad (12), a display screen (11), and circuitry internal to the calculator (10). The circuitry includes a microprocessor, a storage unit for storing data and programs for execution by the microprocessor to implement calculator functions. The storage unit has stored therein a disable/re-enable program that recognizes a first predetermined calculator event and in response thereto disables one or more programs, and that recognizes a second predetermined calculator event and in response thereto re-enables the disabled program. The invention allows Apps, programs and additional information that may be embedded within the Apps and programs in a calculator or other handheld calculating device to be rendered temporarily inaccessible within a relatively short period of time, and then to be restored to the calculator, again, in a relatively short period of time.
摘要翻译：具有禁用/重新启用功能的手持计算器。计算器包括键盘（12），显示屏（11）和计算器（10）内部的电路。电路包括微处理器，用于存储用于由微处理器执行以实现计算器功能的数据和程序的存储单元。存储单元在其中存储有识别第一预定计算器事件的禁用/重新启用程序，并且响应于此禁用一个或多个程序，并且识别第二预定计算器事件，并响应于此，重新启用禁用的程序。本发明允许在计算器或其他手持式计算设备中嵌入应用程序和程序内的应用程序，程序和附加信息在相对短的时间段内暂时不可访问，然后再次恢复到计算器，在相对较短的时间内。

6. 发明申请

WO2005042630A2 TWO COMPONENT CURABLE COMPOSITIONS 审中-公开
标题翻译：两种组分可固化的组合物
公开(公告)号：WO2005042630A2
公开(公告)日：2005-05-12
申请号：PCT/EP2004052765
申请日：2004-11-03
申请人： HUNTSMAN ADV MAT SWITZERLAND , MILLER MICHELLE
发明人： MILLER MICHELLE
IPC分类号： C08J3/20 , C08K3/34 , C08L63/00 , C08K3/00
CPC分类号： C08K3/346 , B82Y30/00 , C08K2201/011 , C08L63/00
摘要： A two component reactive composition is described. Each component, before they are mixed together, contains a filler having thin platelet structure, e.g. a nanoclay, and a further filler that interacts with the platelets. The individual components can have a filler loading that makes them flowable and therefore the components can readily be mixed together for ready dispensing. When the components are mixed thoroughly together, the resulting resin may have a viscosity higher than that of the individual components. The loading of the filler is preferably chosen so that the resulting blended resin is capable of being applied on to a vertical surface without experiencing significant slump. The viscosity of the mixed material can be up to 5 to 10 times or more than that of the individual components before mixing. The composition can be used in. adhesives, modelling pastes, coatings, sealants, putties , mastics, stopping compounds, caulking materials, encapsulants and surface coatings, e.g. paints.
摘要翻译：描述了双组分反应性组合物。各组分在它们混合在一起之前含有具有薄片结构的填料，例如，纳米粘土以及与血小板相互作用的另外的填充剂。各个组件可以具有填充物负载，使得它们可以流动，并且因此组件可以容易地混合在一起以便随时分配。当组分充分混合在一起时，所得树脂的粘度可能高于各组分的粘度。优选选择填料的填充量，使得所得混合树脂能够施加到垂直表面上而不会经历显着的坍塌。在混合之前，混合材料的粘度可以高达各个组分的粘度的5至10倍或更多。该组合物可以用于粘合剂，模塑膏，涂料，密封剂，油灰，胶粘剂，停止化合物，填缝材料，包封剂和表面涂料，涂料。

7. 发明申请

WO2009018609A1 HEPATITIS C ANTIVIRAL COMPOSITIONS AND METHODS 审中-公开
标题翻译： HEPATITIS C抗病毒组合物和方法
公开(公告)号：WO2009018609A1
公开(公告)日：2009-02-12
申请号：PCT/AU2008/001130
申请日：2008-08-04
申请人： BIOTROM LIMITED , EWART, Gary, Dinneen , LUSCOMBE, Carolyn, Anne , MILLER, Michelle
发明人： EWART, Gary, Dinneen , LUSCOMBE, Carolyn, Anne , MILLER, Michelle
IPC分类号： A61K31/155 , A61K31/167 , A61K31/18 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/435 , A61P31/14
CPC分类号： C07C279/22 , A61K31/155 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/435 , A61K31/4418 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K38/212 , A61K45/06 , C07C311/08 , C07D213/69 , C07D231/12 , C07D307/54 , C07D333/24 , A61K2300/00
摘要： The present invention relates to novel compositions having anti-viral activity and in particular it relates to synergistic compositions active against Hepatitis C virus (HCV). The invention also relates to methods for retarding, reducing or otherwise inhibiting HCV growth and/or functional activity.
摘要翻译：本发明涉及具有抗病毒活性的新型组合物，特别涉及对丙型肝炎病毒（HCV）有活性的协同组合物。本发明还涉及用于延缓，减少或以其它方式抑制HCV生长和/或功能活性的方法。

8. 发明申请

WO02081497A2 alpha nu beta 3 INTEGRIN-BINDING POLYPEPTIDE MONOBODIES AND THEIR USE 审中-公开
标题翻译： alpha nu beta 3 INTEGRIN-BINDING POLYPEPTIDE MONOBODIES AND THEE USE
公开(公告)号：WO02081497A2
公开(公告)日：2002-10-17
申请号：PCT/US0210763
申请日：2002-04-04
申请人： UNIV ROCHESTER , KOIDE SHOHEI , DEWHURST STEPHEN , KOIDE AKIKO , RICHARDS JULIE , MILLER MICHELLE
发明人： KOIDE SHOHEI , DEWHURST STEPHEN , KOIDE AKIKO , RICHARDS JULIE , MILLER MICHELLE
IPC分类号： C07K14/78 , C07K16/00 , C07K16/28 , C07K
CPC分类号： C07K16/00 , A61K51/088 , A61K2039/505 , C07K14/78 , C07K16/2848 , C07K2317/34
摘要： The present invention relates to a polypeptide monobody which includes a modified acid sequence and renders the polypeptide monobody able to bind selectively to alpha nu beta 3 integrin. Fusion proteins and conjugates which include the polypeptide monobody, as well as compositions containing the polypeptide monobody, fusion proteins, or conjugates are also disclosed. Uses thereof include: treating or preventing an alpha nu beta 3 integrin-mediated disease or disorder, inhibiting alpha nu beta 3 integrin activity, treating a cancerous or precancerous condition, imaging tissues using positron emission tomography or magnetic resonance imaging, assessing the metastatic characteristics of a tumor, and delivering DNA to a cell.
摘要翻译：本发明涉及一种多肽单体，其包含修饰的酸序列，并使多肽单体能够选择性结合αnββ整联蛋白。还公开了包含多肽单体的融合蛋白和缀合物，以及含有多肽单体，融合蛋白或缀合物的组合物。其用途包括：治疗或预防αnββ整联蛋白介导的疾病或病症，抑制αnββ整联蛋白活性，治疗癌症或癌前病症，使用正电子发射断层扫描或磁共振成像成像组织，评估转移特征肿瘤，并将DNA递送至细胞。

9. 发明申请

WO2006130692A2 FUNCTIONALITY DISABLE AND RE-ENABLE FOR PROGRAMMABLE CALCULATORS 审中-公开
标题翻译：可编程计数器的功能禁用和重启
公开(公告)号：WO2006130692A2
公开(公告)日：2006-12-07
申请号：PCT/US2006/021122
申请日：2006-06-01
申请人： TEXAS INSTRUMENTS INCORPORATED , MILLER, Michelle, A. , FELTZ, Douglas, W. , VONBERG, Gary, C.
发明人： MILLER, Michelle, A. , FELTZ, Douglas, W. , VONBERG, Gary, C.
CPC分类号： G06F15/02 , G06F15/16
摘要： A handheld calculator with disable/re-enable capability. The calculator includes a keypad (12), a display screen (11), and circuitry internal to the calculator (10). The circuitry includes a microprocessor, a storage unit for storing data and programs for execution by the microprocessor to implement calculator functions. The storage unit has stored therein a disable/re-enable program that recognizes a first predetermined calculator event and in response thereto disables one or more programs, and that recognizes a second predetermined calculator event and in response thereto re-enables the disabled program. The invention allows Apps, programs and additional information that may be embedded within the Apps and programs in a calculator or other handheld calculating device to be rendered temporarily inaccessible within a relatively short period of time, and then to be restored to the calculator, again, in a relatively short period of time.
摘要翻译：具有禁用/重新启用功能的手持计算器。计算器包括键盘（12），显示屏（11）和计算器（10）内部的电路。电路包括微处理器，用于存储用于由微处理器执行以实现计算器功能的数据和程序的存储单元。存储单元在其中存储有识别第一预定计算器事件的禁用/重新启用程序，并且响应于此禁用一个或多个程序，并且识别第二预定计算器事件，并响应于此，重新启用禁用的程序。本发明允许在计算器或其他手持式计算设备中嵌入应用程序和程序内的应用程序，程序和附加信息在相对短的时间段内暂时不可访问，然后再次恢复到计算器，在相对较短的时间内。

10. 发明申请

WO2005042630A3 TWO COMPONENT CURABLE COMPOSITIONS 审中-公开
公开(公告)号：WO2005042630A3
公开(公告)日：2005-05-12
申请号：PCT/EP2004/052765
申请日：2004-11-03
申请人： HUNTSMAN ADVANCED MATERIALS (SWITZERLAND) GmbH , MILLER, Michelle
发明人： MILLER, Michelle
IPC分类号： C08J3/20
摘要： A two component reactive composition is described. Each component, before they are mixed together, contains a filler having thin platelet structure, e.g. a nanoclay, and a further filler that interacts with the platelets. The individual components can have a filler loading that makes them flowable and therefore the components can readily be mixed together for ready dispensing. When the components are mixed thoroughly together, the resulting resin may have a viscosity higher than that of the individual components. The loading of the filler is preferably chosen so that the resulting blended resin is capable of being applied on to a vertical surface without experiencing significant slump. The viscosity of the mixed material can be up to 5 to 10 times or more than that of the individual components before mixing. The composition can be used in. adhesives, modelling pastes, coatings, sealants, putties , mastics, stopping compounds, caulking materials, encapsulants and surface coatings, e.g. paints.

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