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1. 发明申请

WO2010040000A3 A MULTICOMPONENT VACCINE FOR MALARIA PROVIDING LONG-LASTING IMMUNE RESPONSES AGAINST PLASMODIA 审中-公开
标题翻译：用于疟疾的多用途疫苗提供对抗原的长寿命免疫应答
公开(公告)号：WO2010040000A3
公开(公告)日：2010-08-05
申请号：PCT/US2009059284
申请日：2009-10-01
申请人： US HEALTH , UNIV NEW YORK , SCHNEERSON RACHEL , KUBLER-KIELB JOANNA , ROBBINS JOHN B , MAJADLY FATHY , MOCCA CHRISTOPHER P , KEITH JERRY , BIESOVA ZUZANA , MILLER LOUIS , NUSSENZWEIG RUTH , LIU DARRELL
发明人： SCHNEERSON RACHEL , KUBLER-KIELB JOANNA , ROBBINS JOHN B , MAJADLY FATHY , MOCCA CHRISTOPHER P , KEITH JERRY , BIESOVA ZUZANA , MILLER LOUIS , NUSSENZWEIG RUTH , LIU DARRELL
IPC分类号： A61K38/07 , A61K33/06 , A61K39/002
CPC分类号： C07K14/00 , A61K39/015 , A61K47/646
摘要： Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response to Plasmodium in a subject, comprising administering to the subject an immunogenic composition disclosed herein.
摘要翻译：公开了引起对疟原虫蛋白质的免疫应答的免疫原性缀合物。在具体实例中，疟原虫蛋白质包括性阶段表面蛋白质，环子孢子蛋白（CSP）或CSP的免疫原性部分。本文还提供了包含一种或多种所公开的免疫原性缀合物和药学上可接受的载体的免疫原性组合物。还提供了一种在受试者中引发对疟原虫的免疫应答的方法，包括向受试者施用本文公开的免疫原性组合物。

2. 发明申请

WO2008048945A3 CONJUGATES OF PLASMODIUM FALCIPARUM SURFACE PROTEINS AS MALARIA VACCINES 审中-公开
标题翻译：鳞状细胞表面蛋白质作为疟原虫疫苗的结合
公开(公告)号：WO2008048945A3
公开(公告)日：2008-07-03
申请号：PCT/US2007081440
申请日：2007-10-15
申请人： US GOV HEALTH & HUMAN SERV , SCHNEERSON RACHEL , KUBLER-KIELB JOANNA , WU YIMIN , MILLER LOUIS , MAJADLY FATHY D , ROBBINS JOHN B
发明人： SCHNEERSON RACHEL , KUBLER-KIELB JOANNA , WU YIMIN , MILLER LOUIS , MAJADLY FATHY D , ROBBINS JOHN B
IPC分类号： A61K39/015
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/55505 , A61K2039/6068 , A61K2039/6081 , C07K14/21 , C07K14/705 , C07K2319/00 , C07K2319/40
摘要： Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against Plasmodium falciparum, the most severe form of malaria. Conjugates of ookinete surface protein Pvs25 for use as a vaccine against Plasmodium vivax are also provided. Methods for preparing the conjugates, which comprise the ookinete surface protein bound onto itself or onto another protein by a linking group, are also provided.
摘要翻译：提供ookinete表面蛋白Pfs25的缀合物，其作为针对恶性疟原虫（最恶劣形式的疟疾）的疫苗是有效的。还提供了用作针对间日疟原虫的疫苗的ookinete表面蛋白Pvs25的缀合物。还提供了制备缀合物的方法，其包含通过连接基团结合到其本身或另一种蛋白质上的ookinete表面蛋白质。

3. 发明申请

WO2008048945A2 CONJUGATES OF PLASMODIUM FALCIPARUM SURFACE PROTEINS AS MALARIA VACCINES 审中-公开
标题翻译：恶性疟原虫表面蛋白与疟疾疫苗的结合
公开(公告)号：WO2008048945A2
公开(公告)日：2008-04-24
申请号：PCT/US2007/081440
申请日：2007-10-15
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SCHNEERSON, Rachel , KUBLER-KIELB, Joanna , WU, Yimin , MILLER, Louis , MAJADLY, Fathy, D. , ROBBINS, John, B.
发明人： SCHNEERSON, Rachel , KUBLER-KIELB, Joanna , WU, Yimin , MILLER, Louis , MAJADLY, Fathy, D. , ROBBINS, John, B.
IPC分类号： A61K39/015
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/55505 , A61K2039/6068 , A61K2039/6081 , C07K14/21 , C07K14/705 , C07K2319/00 , C07K2319/40 , Y02A50/412
摘要： Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against Plasmodium falciparum, the most severe form of malaria. Conjugates of ookinete surface protein Pvs25 for use as a vaccine against Plasmodium vivax are also provided. Methods for preparing the conjugates, which comprise the ookinete surface protein bound onto itself or onto another protein by a linking group, are also provided.
摘要翻译：提供了动物表面蛋白质Pfs25的偶联物，其作为针对恶性疟原虫（最严重的疟疾形式）的疫苗是有效的。还提供了用作抗间日疟原虫的疫苗的动力蛋白表面蛋白Pvs25的偶联物。还提供了用于制备缀合物的方法，所述缀合物包含通过连接基团结合到其本身或另一蛋白质上的动物表面蛋白质。

4. 发明申请

WO2002078603A2 PLASMODIUM FALCIPARUM ERYTHROCYTE BINDING PROTEIN BAEBL FOR USE AS A VACCINE 审中-公开
标题翻译：用作游离细菌的氟尿嘧啶蛋白结合蛋白BAEBL
公开(公告)号：WO2002078603A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/010071
申请日：2002-03-29
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , MAYER, Ghislaine , MILLER, Louis, H.
发明人： MAYER, Ghislaine , MILLER, Louis, H.
IPC分类号： A61K
CPC分类号： C07K14/445 , A61K39/00 , Y02A50/412
摘要： The invention relates to lasmodium falciparum Erythrocyte Binding Protein BAEBL for use as a vaccine.
摘要翻译：本发明涉及恶性疟原虫红细胞结合蛋白BAEBL用作疫苗。

5. 发明专利

CA1340963C GENE FOR ENCODING A HUMAN MALARIA VACCINE ANTIGEN 未知
公开(公告)号：CA1340963C
公开(公告)日：2000-04-18
申请号：CA597875
申请日：1989-04-26
申请人： MILLER LOUIS H , KASLOW DAVID C
发明人： MILLER LOUIS H , KASLOW DAVID C
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/015 , C07K14/44 , C07K14/445 , C07K14/705 , C12N15/30 , C07H21/04
摘要： The invention is a gene for expressing antigens for producing a human malaria vaccine. The gene includes a cloned nucleotide sequence or segment for encoding the 25kDa surface protein of zygotes and ookinetes of Plasmodium falciparum.

6. 发明专利

CA189981A TORPEDO GUARD FOR SHIPS 未知
公开(公告)号：CA189981A
公开(公告)日：1919-04-29
申请号：CA189981D
申请日：1918-11-19
申请人： MILLER LOUIS
发明人： MILLER LOUIS

7. 发明专利

CA122011A INTERLOCKING DEVICE FOR ACETYLENE GAS MACHINES 未知
公开(公告)号：CA122011A
公开(公告)日：1909-11-23
申请号：CA122011D
申请日：1909-08-26
申请人： L H MILLER ACETYLENE GAS MACHINE COMPANY , MILLER LOUIS H
发明人： MILLER LOUIS H

8. 发明申请

WO2013032819A3 RECOMMENDATION COMPONENT FOR ASSISTED ELECTRONIC INFORMATION PROCESSING 审中-公开
标题翻译：用于辅助电子信息处理的推荐组件
公开(公告)号：WO2013032819A3
公开(公告)日：2013-06-27
申请号：PCT/US2012051902
申请日：2012-08-22
申请人： CBS INTERACTIVE INC , MILLER LOUIS EDWARD
发明人： MILLER LOUIS EDWARD
IPC分类号： G06Q50/10
CPC分类号： G07F17/326
摘要： Techniques for a computer implemented game are described. A computer-implemented system may comprise a multimedia content module operative to provide multimedia content related to one or more players within a game. The computer implemented system may further comprise a game server application operative to provide player recommendations to one or more users utilizing the multimedia content received from the multimedia content module. The game server may also comprise a player ranking module operative to rank one or more players based on certain of the multimedia content and output a player ranking by corresponding player position. The game server may further comprise a player comparison module operative to receive the player ranking by position and compare the ranked players to a roster of players associated with the one or more users by corresponding position. Other embodiments are described and claimed.
摘要翻译：描述了用于计算机实现的游戏的技术。计算机实现的系统可以包括多媒体内容模块，其操作以提供与游戏中的一个或多个玩家相关的多媒体内容。计算机实现的系统还可以包括游戏服务器应用程序，用于利用从多媒体内容模块接收的多媒体内容向一个或多个用户提供玩家推荐。游戏服务器还可以包括玩家排名模块，用于基于某些多媒体内容对一个或多个玩家进行排名，并通过相应的玩家位置输出玩家排名。游戏服务器还可以包括玩家比较模块，用于通过位置接收玩家排名，并通过相应的位置将排名的玩家与与一个或多个用户相关联的玩家名单进行比较。描述和要求保护其他实施例。

9. 发明申请

WO2012078854A3 FANTASY SPORT TALENT SCOUT SYSTEM AND METHOD THEREFORE 审中-公开
公开(公告)号：WO2012078854A3
公开(公告)日：2012-06-14
申请号：PCT/US2011/063926
申请日：2011-12-08
申请人： CBS INTERACTIVE INC. , MILLER, Louis Edward
发明人： MILLER, Louis Edward
IPC分类号： G06Q50/00
摘要： Methods for a computer implemented fantasy sports game are described. A computer-implement fantasy sports game method provides data from a plurality of information sources related to one or more fantasy sports players. The data is weighted based on predetermined logic rules to produce a value associated therewith. The values are aggregated to provide a ranking of the one or more fantasy sports players. The ranked players are compared to players on a participant's roster and recommendations are made to the participant.

10. 发明申请

WO2013032812A3 AUTOPILOT SIMULATION SYSTEM AND METHOD 审中-公开
标题翻译：自动驾驶仪仿真系统和方法
公开(公告)号：WO2013032812A3
公开(公告)日：2013-04-25
申请号：PCT/US2012051878
申请日：2012-08-22
申请人： CBS INTERACTIVE INC , MILLER LOUIS EDWARD
发明人： MILLER LOUIS EDWARD
IPC分类号： G06Q50/10
CPC分类号： A63F13/67 , A63F13/828 , A63F2300/535 , A63F2300/6027 , A63F2300/69 , A63F2300/8052
摘要： A computer implemented method is described. A computer-implemented method provides determining if an extended absence flag has been triggered for a first participant. If the extended absence flag has been triggered, the computer-implemented method automatically performs one or more of a plurality of actions required to continue game play on behalf of the first participant as if the first participant was still actively involved in game play. By automatically conducting play of the first participant as if the first participant was still involved, the computer-implemented method maintains competitiveness as well as the game experience for other participants.
摘要翻译：描述了一种计算机实现的方法。计算机实现的方法提供确定是否已经为第一参与者触发了延长不存在标志。如果扩展缺席标志已被触发，则计算机实现的方法自动执行代表第一参与者继续玩游戏所需的多个动作中的一个或多个，就好像第一参与者仍然积极参与游戏。通过自动进行第一参与者的游戏，就好像第一参与者仍然参与一样，计算机实现的方法保持竞争力以及其他参与者的游戏体验。

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