专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07700118B2 Molecular differences between species of the M. tuberculosis complex 有权
标题翻译：结核分枝杆菌菌种之间的分子差异
公开(公告)号：US07700118B2
公开(公告)日：2010-04-20
申请号：US12049063
申请日：2008-03-14
申请人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
发明人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
IPC分类号： A61K39/04 , A61K39/205 , A61K39/00
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tubercuosis to attenuate the pathogenic bacteria.
摘要翻译：在分枝杆菌分离株中鉴定了特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.tb相比在BCG中存在的许多缺失。这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。可将经删除的序列重新引入BCG以提高疫苗接种的效力。或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。

2. 发明授权

US07188567B1 Gas generation system 失效
标题翻译：气体发生系统
公开(公告)号：US07188567B1
公开(公告)日：2007-03-13
申请号：US10130191
申请日：2000-11-10
申请人： John R. Italiane , James M. Styner , Andrew C. Nguyen , Gary S. Gregg , Gary F. Holland , Michael A. Wilson
发明人： John R. Italiane , James M. Styner , Andrew C. Nguyen , Gary S. Gregg , Gary F. Holland , Michael A. Wilson
IPC分类号： C06D5/00
CPC分类号： C06D5/06 , B60R21/264 , B60R2021/2633
摘要： A gas generator (24; 140) may be used in an inflatable member system (20) which includes an inflatable member (22) expandable from a stowed condition to a deployed condition. The generator may include a flexible container (30; 150) within the inflatable member, a gas generant (28; 148), initially located within the flexible container, and an initiator (34). A propagating member (60; 142) may be located within the container to permit the initiator to initiate the generant upon triggering of the initiator to inflate the inflatable member from stowed to deployed conditions. A sustainer (44; 152; 156) may be provided to sustain the gas generation and may be positioned within a generator housing upstream of the propagating member or at or adjacent the downstream end of the propagating member.
摘要翻译：气体发生器（24; 140）可以用在可膨胀构件系统（20）中，该系统包括从收起状态扩展到展开状态的可膨胀构件（22）。发生器可以包括可充气构件内的柔性容器（30; 150），最初位于柔性容器内的气体发生剂（28; 148）和起动器（34）。传播构件（60; 142）可以位于容器内，以允许引发器在触发引发器时起动发生器，以使可充气构件从收起的状态充满到展开状态。可以提供维持器（44; 152; 156）以维持气体产生并且可以位于传播构件上游的发生器壳体内，或位于传播构件的下游端处或邻近传播构件的下游端。

3. 发明授权

US06291190B1 Molecular differences between species of the M. tuberculosis complex 失效
标题翻译：结核分枝杆菌菌种之间的分子差异
公开(公告)号：US06291190B1
公开(公告)日：2001-09-18
申请号：US09318191
申请日：1999-05-25
申请人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
发明人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
IPC分类号： G01N3353
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletions are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tuberculosis to attenuate the pathogenic bacteria.
摘要翻译：在分枝杆菌分离物中鉴定特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.bb相比在BCG中存在的许多缺失。这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。可将经删除的序列重新引入BCG以提高疫苗接种的效力。或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。

4. 发明授权

US5278462A Threshold crossover detector with improved digital noise rejection 失效
标题翻译：具有改进的数字噪声抑制的阈值交叉检测器
公开(公告)号：US5278462A
公开(公告)日：1994-01-11
申请号：US873253
申请日：1992-04-24
申请人： Michael A. Wilson
发明人： Michael A. Wilson
IPC分类号： H03K5/08 , H03K5/1536 , H03K5/153
CPC分类号： H03K5/08 , H03K5/1536
摘要： The detector applies an analog input signal through respectively positive and negative offset voltages to the inputs of two comparators, one of which produces a first output signal as the input signal passes beyond a predetermined minimum voltage in the positive going direction, and the other of which produces a second output signal when the input voltage exceeds a minimum predetermined value in a negative going direction. The input signal is also applied directly to the input of a third comparator the output of which produces a third signal each time the input signal crosses over zero voltage in a positive going direction. The first and second comparator output signals are applied to the reset and set terminals, respectively, of a first flip flop. The output of this first flip flop, and the output of the third comparator are applied through an AND gate to the set terminal of a second flip flop. The second flip flop produces at its output a digital signal precisely at the time that a signal is produced at the output of the third comparator, provided the outputs of the first and second comparators have been successively generated in the cycle of the input voltage immediately preceding the output signal of the third comparator.
摘要翻译：检测器通过分别的正和负偏移电压将模拟输入信号施加到两个比较器的输入端，其中一个输入信号随着输入信号在正向上超过预定最小电压而产生第一输出信号，另一个当输入电压在负方向上超过最小预定值时产生第二输出信号。输入信号也直接施加到第三比较器的输入，第三比较器的输出在每次输入信号在正向运行方向上跨过零电压时产生第三信号。第一和第二比较器输出信号分别施加到第一触发器的复位和设置端子。该第一触发器的输出和第三比较器的输出通过与门施加到第二触发器的设定端。第二触发器在其输出处产生数字信号，在第三比较器的输出处产生信号时，只要第一和第二比较器的输出在紧接着的输入电压的周期中连续生成第三比较器的输出信号。

5. 发明授权

US4909549A Composition and process for inflating a safety crash bag 失效
标题翻译：充气安全碰撞袋的组成和过程
公开(公告)号：US4909549A
公开(公告)日：1990-03-20
申请号：US278848
申请日：1988-12-02
申请人： Donald R. Poole , Michael A. Wilson
发明人： Donald R. Poole , Michael A. Wilson
IPC分类号： B60R21/26 , B60R21/30 , B64D25/02 , C06D5/00 , C06D5/06
CPC分类号： C06D5/06 , B60R21/30
摘要： Composition and process for inflating an automobile or aircraft safety crash bag comprising igniting a pyrotechnic composition to generate a gas which is admixed with air by means of an aspirating venturi which results in substantially non-toxic products which are thereafter utilized to inflate said crash bag.

6. 发明授权

US5984591A Thrust slot air conveyor having a varying slot angle 失效
标题翻译：推力槽空气输送机具有变化的槽角度
公开(公告)号：US5984591A
公开(公告)日：1999-11-16
申请号：US129970
申请日：1998-08-06
申请人： Brian K. Hilbish , Michael A. Wilson
发明人： Brian K. Hilbish , Michael A. Wilson
IPC分类号： B65G51/03 , B65G51/02
CPC分类号： B65G51/03 , B65G51/035 , B65G2201/0247
摘要： An air conveyor includes guides for stabilizing articles during conveyance and a plenum with apertures for providing pressurized air. In the preferred embodiment, the air conveyor also includes opposed spacers defining passages having a closed end and an open end. The passages are in fluid communication with the apertures of the plenum for directing streams of pressurized air through the open ends at the articles in a downstream direction to propel the articles. In another embodiment, channels defined in support structure for the guides form part of passageways for directing streams of pressurized air at an inclined and downstream angle to propel the articles. The guides are removable to allow the conveyor to be adapted to different sized and shaped articles. The air conveyor may also include an additional plenum and additional opposed spacers associated with the plenum for propelling the articles downstream. The angle of the slots can be larger for creating an article-to-article separation or smaller for creating a contiguous article flow.
摘要翻译：空气输送机包括用于在输送期间稳定物品的引导件和具有用于提供加压空气的孔的增压室。在优选实施例中，空气输送机还包括限定具有封闭端和开口端的通道的相对间隔件。通道与增压室的孔流体连通，用于在下游方向引导加压空气流通过物品处的开口端，以推进物品。在另一个实施例中，限定在用于引导件的支撑结构中的通道形成用于以倾斜和下游角度引导加压空气流的通道的一部分，以推进物品。引导件是可拆卸的，以允许输送机适应不同尺寸和成形的物品。空气输送机还可以包括附加的增压室和与增压室相关联的附加的相对间隔件，用于将物品推进下游。狭缝的角度可以更大，用于创建物品到物品的分离或更小以创建连续的物品流。

7. 发明授权

US5872703A System and method for regulating power in tank circuits having a bridge configuration 失效
标题翻译：具有桥式结构的油箱回路调节功率的系统和方法
公开(公告)号：US5872703A
公开(公告)日：1999-02-16
申请号：US918242
申请日：1997-08-25
申请人： Martin A. Williams , Austin L. Widener , Michael A. Wilson
发明人： Martin A. Williams , Austin L. Widener , Michael A. Wilson
IPC分类号： H02M3/337 , H02M3/335
CPC分类号： H02M3/3376
摘要： A system for regulating an alternating current voltage source has a pair of P-channel MOSFETs and a pair of N-channel MOSFETs in a bridge configuration with an inductor-capacitor tank there between. A processor in conjunction with a feedback circuit regulates the energy transferred to the tank by modulating the pulse width of signals that are output from the processor and which are used as inputs to the gates of the MOSFETs. By increasing or decreasing the pulse widths transmitted to the various gates of the MOSFETs, the processor increases or decreases the energy transferred to the tank. The feedback circuit is connected between the tank and the processor so that the processor can compare the feedback voltage from the tank to a threshold level in the processor and modify the pulse widths at the output of the processor accordingly.
摘要翻译：用于调节交流电压源的系统具有一对P沟道MOSFET和一对桥式配置的N沟道MOSFET，其间具有电感器 - 电容器箱。与反馈电路结合的处理器通过调制从处理器输出的信号的脉冲宽度并且将其用作MOSFET的栅极的输入来调节传输到储存器的能量。通过增加或减少传输到MOSFET的各种栅极的脉冲宽度，处理器增加或减少传输到罐的能量。反馈电路连接在储罐和处理器之间，使得处理器可以将来自储罐的反馈电压与处理器中的阈值水平进行比较，并相应地修改处理器输出端的脉冲宽度。

8. 发明授权

US5866842A Low temperature autoigniting propellant composition 失效
标题翻译：低温自燃推进剂组成
公开(公告)号：US5866842A
公开(公告)日：1999-02-02
申请号：US683286
申请日：1996-07-18
申请人： Kimberly A. Wilson , Michael A. Wilson , Donald R. Poole , Gary F. Holland
发明人： Kimberly A. Wilson , Michael A. Wilson , Donald R. Poole , Gary F. Holland
IPC分类号： C06B31/28 , C06B31/32 , C06B33/04 , C06C9/00 , C06B45/10 , C06B35/00
CPC分类号： C06B31/28 , C06B31/32 , C06B33/04 , C06C9/00
摘要： A low temperature autoigniting composition for use in a mobile occupant restraint system comprising, a low temperature melting oxidizer and a fuel, wherein the low temperature autoigniting composition autoignites in the temperature range of about 130.degree. C. to about 175.degree. C. In a preferred embodiment, the composition comprises a low temperature melting oxidizer, a fuel, and a catalyst, wherein the composition autoignites in the temperature range of about 130.degree. C. to about 150.degree. C. Preferably, the oxidizer comprises about 20 to about 70 percent by weight of the composition, the fuel comprises about 10 to about 50 percent by weight of the composition, and the catalyst comprises about 2 to about 50 percent by weight of the composition. The autoignition propellants of the invention are designed to function at low temperatures and before heat damage to an airbag deployment mechanism can occur, for example, during a fire.
摘要翻译：一种用于移动乘员约束系统的低温自发组合物，其包括低温熔化氧化剂和燃料，其中所述低温自燃组合物在约130℃至约175℃的温度范围内自燃。在优选的组合物包含低温熔化氧化剂，燃料和催化剂，其中组合物在约130℃至约150℃的温度范围内自发结晶。优选地，氧化剂包含约20至约70％的组合物的重量，燃料占组合物重量的约10至约50％，催化剂占组合物重量的约2％至约50％。本发明的自燃推进剂被设计成在低温下起作用，并且在例如在火灾期间可能发生对气囊展开机构的热损伤之前。

9. 发明授权

US5545272A Thermally stable gas generating composition 失效
标题翻译：热稳定气体发生组合物
公开(公告)号：US5545272A
公开(公告)日：1996-08-13
申请号：US517564
申请日：1995-08-21
申请人： Donald R. Poole , Gary F. Holland , Nicholas A. Wolf , Michael A. Wilson
发明人： Donald R. Poole , Gary F. Holland , Nicholas A. Wolf , Michael A. Wilson
IPC分类号： C06B31/32 , C06D5/06 , C06B31/56
CPC分类号： C06D5/06 , C06B31/32
摘要： There is provided a gas generating composition consisting essentially of a mixture of nitroguanidine and phase stabilized ammonium nitrate. When the ammonium nitrate is phase stabilized with from about 7% to about 20%, by weight, of a potassium salt, the mixture is structurally and volumetrically stable over typical automotive operating temperatures and has a melting temperature in excess of 100.degree. C. The mixture generates large volumes of nitrogen and carbon dioxide when ignited with minimal generation of solids or toxic gases and is particularly useful as an inflating medium for automobile airbags.
摘要翻译：提供了一种主要由硝基胍和相稳定的硝酸铵的混合物组成的气体发生组合物。当硝酸铵以约7％至约20％重量的钾盐进行相稳定时，该混合物在典型的汽车操作温度下在结构和体积上是稳定的并且具有超过100℃的熔融温度。当以最小量的固体或有毒气体点燃时，混合物产生大量的氮和二氧化碳，并且特别用作汽车安全气囊的充气介质。

10. 发明授权

US4722134A Process of producing superconducting bar magnets 失效
标题翻译：生产超导棒磁铁的工艺
公开(公告)号：US4722134A
公开(公告)日：1988-02-02
申请号：US823757
申请日：1986-01-29
申请人： Michael A. Wilson
发明人： Michael A. Wilson
IPC分类号： H01F6/00 , H01L39/14 , H01L39/24
CPC分类号： H01L39/14 , H01F6/00 , Y10T29/49014
摘要： A bar magnet is provided comprising a billet of superconducting material in a superconducting condition and having an established magnetic field. The bar magnet is formed by exposing the billet of superconducting material to a magnetic field of the desired extent and shape while the superconducting material is above its critical temperature. While being exposed to the magnetic field, the billet of superconducting material is lowered to its critical temperature so as to stabilize the intensity and pattern of the field. The magnetic field is them removed from the billet of material and the billet maintained at or below the critical temperature.
摘要翻译：提供一种棒状磁体，其包括超导状态的超导材料坯体并且具有确定的磁场。棒状磁体通过将超导材料的坯料暴露于所需程度和形状的磁场而形成，同时超导材料高于其临界温度。在暴露于磁场的同时，超导材料的坯料降低到其临界温度，以稳定场强的强度和图案。磁场是从材料坯料中除去的，而钢坯保持在临界温度以下。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式