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1. 发明申请

WO2011127045A2 METHOD AND APPARATUS FOR WOUND SEALANT APPLICATION 审中-公开
标题翻译：封闭式密封应用的方法和装置
公开(公告)号：WO2011127045A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/031235
申请日：2011-04-05
申请人： NEOMEND, INC. , CASSINGHAM, Charles Vaughn , MEZGER, William Jerome
发明人： CASSINGHAM, Charles Vaughn , MEZGER, William Jerome
IPC分类号： A61M5/178 , A61M5/28 , A61M5/142 , A61B17/03
CPC分类号： A61B17/00491 , A61B2017/00495 , A61B2017/00544 , A61B2017/00548
摘要： Devices and methods are disclosed for delivering sealing compound to a wound in animals, including humans. Such wound sealing is important after deep skin penetrating lacerations or subsequent to internal wounds. The apparatus utilize an aerosol dispensing system that both mixes and applies a multi-part sealant compound. The aerosol system includes a plurality of sealant component chambers, a source of pressurized gas, an aerosol mixing head, a pressure regulator, a pneumatic switch, and a component pumping mechanism. The aerosol system, either a reusable or a disposable device, is further provided with a system that keeps dry components from liquid components and then automatically mixes the liquid and dry components prior to application. The system provides for easy control over the application, inexpensive manufacture, and simplified preparation, thus minimizing the time needed for application and enhancing the potential outcomes of the patient.
摘要翻译：公开了用于将密封化合物递送到包括人在内的动物的伤口的装置和方法。这种伤口密封在深层皮肤穿透撕裂或内部伤口后很重要。该装置利用气溶胶分配系统，其混合并施加多部分密封剂化合物。气溶胶系统包括多个密封剂组分室，加压气体源，气溶胶混合头，压力调节器，气动开关和部件泵送机构。气溶胶系统（可重复使用的或一次性的设备）还具有将干燥组分保持在液体组分中并在施用之前自动混合液体和干燥组分的系统。该系统提供了对应用的便利控制，廉价的制造和简化的准备，从而最小化了应用所需的时间并增加了患者的潜在结果。

2. 发明申请

WO2011127020A2 SYSTEMS, DEVICES, METHODS FOR DELIVERING HYDROGEL COMPOSITIONS WITH SELF-PURGING TO PREVENT CLOGGING 审中-公开
标题翻译：系统，装置，用于自给自足的水凝胶组合物的预防方法
公开(公告)号：WO2011127020A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/031192
申请日：2011-04-05
申请人： NEOMEND, INC. , BARKER, Peter , MEZGER, William Jerome
发明人： BARKER, Peter , MEZGER, William Jerome
IPC分类号： A61M5/145 , A61M5/178 , A61M39/22
CPC分类号： A61B17/00491 , A61B17/12186 , A61B2017/00495 , A61B2017/00942 , A61M5/003 , A61M35/003
摘要： A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.
摘要翻译：通过将经受选择性施加的施加压力P（A）的分离的第一和第二液体组分输送到用于混合和排出的出口路径中来形成水凝胶组合物。当中断P（A）的施加时，液体冲洗剂被自动地输送到出口路径中，经受基本上恒定地施加的清除压力P（P），以从出口路径连续冲洗剩余的水凝胶组合物。

3. 发明申请

WO2011127020A3 SYSTEMS, DEVICES, METHODS FOR DELIVERING HYDROGEL COMPOSITIONS WITH SELF-PURGING TO PREVENT CLOGGING 审中-公开
标题翻译：系统，装置，用于自给自足的水凝胶组合物的预防方法
公开(公告)号：WO2011127020A3
公开(公告)日：2012-03-08
申请号：PCT/US2011031192
申请日：2011-04-05
申请人： NEOMEND INC , BARKER PETER , MEZGER WILLIAM JEROME
发明人： BARKER PETER , MEZGER WILLIAM JEROME
IPC分类号： A61M5/145 , A61M5/178 , A61M39/22
CPC分类号： A61B17/00491 , A61B17/12186 , A61B2017/00495 , A61B2017/00942 , A61M5/003 , A61M35/003
摘要： A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.
摘要翻译：通过将经受选择性施加的施加压力P（A）的分离的第一和第二液体组分输送到用于混合和排出的出口路径中来形成水凝胶组合物。当中断P（A）的施加时，液体冲洗剂被自动地输送到出口路径中，经受基本上恒定地施加的清除压力P（P），以从出口路径连续冲洗剩余的水凝胶组合物。

4. 发明申请

WO2008112071A1 SYSTEMS, METHODS, AND COMPOSITIONS FOR PREVENTION OF TISSUE ADHESION 审中-公开
标题翻译：用于预防组织粘连的系统，方法和组合物
公开(公告)号：WO2008112071A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/002349
申请日：2008-02-22
申请人： NEOMEND, INC. , CASSINGHAM, Charles, Vaughn , MEZGER, William, Jerome
发明人： CASSINGHAM, Charles, Vaughn , MEZGER, William, Jerome
IPC分类号： A61M31/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61L31/041 , A61L31/06 , A61L31/148 , C08L71/02
摘要： A blended electrophilic material with a first component having a functionality of at least three and a second component having a functionality of two is mixed with a nucleophilic material. The blended electrophilic material cross-links with the nucleophilic material to form a non- liquid, three dimensional structure which can applied, e.g., as an adhesion barrier.
摘要翻译：将具有至少三官能度的第一组分和官能度为2的第二组分的混合亲电材料与亲核材料混合。混合的亲电材料与亲核材料交联以形成可应用于例如粘附屏障的非液体三维结构。

5. 发明申请

WO2011127045A3 METHOD AND APPARATUS FOR WOUND SEALANT APPLICATION 审中-公开
标题翻译：封闭式密封应用的方法和装置
公开(公告)号：WO2011127045A3
公开(公告)日：2012-02-23
申请号：PCT/US2011031235
申请日：2011-04-05
申请人： NEOMEND INC , CASSINGHAM CHARLES VAUGHN , MEZGER WILLIAM JEROME
发明人： CASSINGHAM CHARLES VAUGHN , MEZGER WILLIAM JEROME
IPC分类号： A61M5/178 , A61B17/03 , A61M5/142 , A61M5/28
CPC分类号： A61B17/00491 , A61B2017/00495 , A61B2017/00544 , A61B2017/00548
摘要： Devices and methods are disclosed for delivering sealing compound to a wound in animals, including humans. Such wound sealing is important after deep skin penetrating lacerations or subsequent to internal wounds. The apparatus utilize an aerosol dispensing system that both mixes and applies a multi-part sealant compound. The aerosol system includes a plurality of sealant component chambers, a source of pressurized gas, an aerosol mixing head, a pressure regulator, a pneumatic switch, and a component pumping mechanism. The aerosol system, either a reusable or a disposable device, is further provided with a system that keeps dry components from liquid components and then automatically mixes the liquid and dry components prior to application. The system provides for easy control over the application, inexpensive manufacture, and simplified preparation, thus minimizing the time needed for application and enhancing the potential outcomes of the patient.
摘要翻译：公开了用于将密封化合物递送到包括人在内的动物的伤口的装置和方法。这种伤口密封在深层皮肤穿透撕裂或内部伤口后很重要。该装置利用气溶胶分配系统，其混合并施加多部分密封剂化合物。气溶胶系统包括多个密封剂组分室，加压气体源，气溶胶混合头，压力调节器，气动开关和部件泵送机构。气溶胶系统（可重复使用的或一次性的设备）还具有将干燥的组分从液体组分中保持的系统，然后在施用之前自动混合液体和干燥组分。该系统提供了对应用的便利控制，廉价的制造和简化的准备，从而最小化应用所需的时间并增强患者的潜在结果。

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