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1. 发明申请

WO2007090081A2 ANALYSIS OF MYCOPHENOLIC ACID IN SALIVA USING LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY 审中-公开
标题翻译：使用液相色谱仪测定沙门氏菌中的MYCOPHENOLIC酸的分析
公开(公告)号：WO2007090081A2
公开(公告)日：2007-08-09
申请号：PCT/US2007061214
申请日：2007-01-29
申请人： RHODE ISLAND EDUCATION , AKHLAGHI FATEMEH , MENDONZA ANISHA E
发明人： AKHLAGHI FATEMEH , MENDONZA ANISHA E
IPC分类号： G01N33/50
CPC分类号： G01N33/9493 , G01N30/7233 , Y10T436/11 , Y10T436/142222 , Y10T436/143333
摘要： A method for mass spectrometric analysis of a saliva sample possibly containing mycophenolic acid or its metabolites mycophenolic acid phenyl glucuronide (MPAG) or mycophenolic acid acyl-glucuronide (Acyl-MPAG), including the steps: (a) providing a saliva sample containing one or more drug or metabolites; (b) deproteinating the sample; (c) separating the one or more drug or metabolites from the saliva sample; and (d) analyzing the one or more drug or metabolites using a mass spectrometer. The sample containing one or more MPA or metabolites is obtained from in an oral fluid based biological samples i.e. whole saliva or saliva obtained by chemical or mechanical stimulation or from specific salivary glands. The size of the sample contains one or more MPA or metabolites is at least about 100 microL. A kit for use in mass spectrometric analysis of a sample may contain one or more MPA or metabolites from saliva samples, comprising: (a) reagents for deproteinating of the saliva sample, including internal standards; (b) reagents for separating the one or more MPA or metabolites from the saliva sample; (c) reagents for analyzing the one or MPA or metabolites using a mass spectrometer; (d) a solution of one or more MPA or metabolites' in saliva samples; and (e) instructions for analyzing the one or more MPA or saliva using a mass spectrometer. The kit includes (a) mobile phase solutions; (b) a chromatography column; and (c) a quality control specimen.
摘要翻译：可能含有霉酚酸或其代谢物霉酚酸苯基葡糖苷酸（MPAG）或霉酚酸酰基葡糖苷酸（Acyl-MPAG）的唾液样品的质谱分析方法，包括以下步骤：（a）提供含有一种或多种更多的药物或代谢物; （b）剥离样品; （c）从唾液样品中分离出一种或多种药物或代谢物; 和（d）使用质谱仪分析一种或多种药物或代谢物。含有一种或多种MPA或代谢物的样品是从基于口腔液体的生物样品，即通过化学或机械刺激获得的全唾液或唾液或从特定的唾液腺得到的。样品的大小含有一种或多种MPA或代谢物至少约100微升。用于样品的质谱分析的试剂盒可以含有一种或多种来自唾液样品的MPA或代谢物，其包括：（a）用于唾液样品的去蛋白试剂，包括内标; （b）用于从唾液样品中分离一种或多种MPA或代谢物的试剂; （c）使用质谱仪分析一种或MPA或代谢物的试剂; （d）唾液样品中一种或多种MPA或代谢物的溶液; 和（e）使用质谱仪分析一种或多种MPA或唾液的说明。试剂盒包括（a）流动相溶液; （b）色谱柱; 和（c）质量控制标本。

2. 发明申请

WO2008121096A1 MONITORING CYCLOSPORINE IN SALIVA 审中-公开
标题翻译：在SALIVA监测CYCLOSPORINE
公开(公告)号：WO2008121096A1
公开(公告)日：2008-10-09
申请号：PCT/US2006/018961
申请日：2006-05-17
申请人： THE BOARD OF GOVERNORS FOR HIGHER EDUCATION , AKHLAGHI, Fatemeh , MENDONZA, Anisha, E.
发明人： AKHLAGHI, Fatemeh , MENDONZA, Anisha, E.
IPC分类号： A61B5/00
CPC分类号： G01N33/9493 , A61K38/13 , G01N1/38
摘要： A method of monitoring cyclosporine in saliva comprising steps of freezing and thawing said saliva sample; sonicating said saliva sample; and adding said saliva sample to a solvent and water mixture to determine the concentration of cyclosporine in said saliva. Quantification thereby is sensitive with a lower limit of quantification of 1 ng/ml. Cyclosporine concentration in saliva is be correlat with that in blood, allowing a less-evasive determination of blood cyclosporine concentration.
摘要翻译：一种监测唾液中环孢菌素的方法，包括冷冻和解冻所述唾液样品的步骤; 超声处理唾液样品; 并将所述唾液样品加入到溶剂和水混合物中以确定所述唾液中环孢菌素的浓度。因此定量灵敏，定量下限为1 ng / ml。唾液中的环孢菌素浓度与血液中的环孢菌素浓度相关，允许较少回避测定血液环孢菌素浓度。

3. 发明申请

WO2007090081A3 ANALYSIS OF MYCOPHENOLIC ACID IN SALIVA USING LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2007090081A3
公开(公告)日：2007-08-09
申请号：PCT/US2007/061214
申请日：2007-01-29
申请人： THE BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS , AKHLAGHI, Fatemeh , MENDONZA, Anisha, E.
发明人： AKHLAGHI, Fatemeh , MENDONZA, Anisha, E.
IPC分类号： G01N33/00 , C12Q1/24
摘要： A method for mass spectrometric analysis of a saliva sample possibly containing mycophenolic acid or its metabolites mycophenolic acid phenyl glucuronide (MPAG) or mycophenolic acid acyl-glucuronide (Acyl-MPAG), including the steps: (a) providing a saliva sample containing one or more drug or metabolites; (b) deproteinating the sample; (c) separating the one or more drug or metabolites from the saliva sample; and (d) analyzing the one or more drug or metabolites using a mass spectrometer. The sample containing one or more MPA or metabolites is obtained from in an oral fluid based biological samples i.e. whole saliva or saliva obtained by chemical or mechanical stimulation or from specific salivary glands. The size of the sample contains one or more MPA or metabolites is at least about 100 microL. A kit for use in mass spectrometric analysis of a sample may contain one or more MPA or metabolites from saliva samples, comprising: (a) reagents for deproteinating of the saliva sample, including internal standards; (b) reagents for separating the one or more MPA or metabolites from the saliva sample; (c) reagents for analyzing the one or MPA or metabolites using a mass spectrometer; (d) a solution of one or more MPA or metabolites' in saliva samples; and (e) instructions for analyzing the one or more MPA or saliva using a mass spectrometer. The kit includes (a) mobile phase solutions; (b) a chromatography column; and (c) a quality control specimen.

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