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1. 发明公开

EP0290558A1 ANTIFOLATE AGENTS 失效
标题翻译：抗叶酸介质。
公开(公告)号：EP0290558A1
公开(公告)日：1988-11-17
申请号：EP87907792.0
申请日：1987-11-30
申请人： STEVENS, Malcolm Francis Graham , GRIFFIN, Roger John , MEEK, Michelle Anne
发明人： STEVENS, Malcolm Francis Graham , GRIFFIN, Roger John , MEEK, Michelle Anne
IPC分类号： A61K31 , A61P17 , A61P31 , A61P33 , A61P35 , A61P43 , C07D239
CPC分类号： C07D239/48
摘要： Des 2,4 -diamino-5-pyrimidines sous forme de base libre ou d'un acide d'adjonction acide de cette base sont représentés par la formule structurelle (I), où R1 représente un alkoxy, un aralkoxy ou un groupe amino mono substitué ou dit substitué, R2 représente un groupe nitro et R3 représente un groupe alkyl. Ces composés servent d'agents antifolate et sont utiles dans le traitement thérapeutique, par exemple comme agents antitumoraux, comme agents antipsoriasiques, comme agents antibactériens, comme agents trypanocides et comme agents antipaludéens. Des préparations pharmaceutiques comprenant ces composés pour leur administration à des mammifères et des procédés de préparations des composés sont décrits. Des nouveaux composés particulièrement utiles, notamment pour une thérapie antitumorale, sont représentés par la formule structurelle IA, où n est égal à 1-6; R1 représente un hydrogène ou un alkyl; R4, R5, et R6, qui peuvent être identiques ou différents ,représentent chacun un hydrogène, un alkyl, un alkoxyl, un halo, un nitro, un perfluoroalkyle, un groupe de la formule -CO2Ra, où Ra représente un hydrogène, un alkyl ou un alkoxyalkyl, ou un groupe de la formule -CONRbRc, où Rb et Rc qui peuvent être identiques ou différents représentent chacun un alkyl ; et R3 représente un alkyl.

2. 发明专利

GB2204867A ANTIFOLATE PYRIMIDINE COMPOUNDS 未知
公开(公告)号：GB2204867A
公开(公告)日：1988-11-23
申请号：GB8728018
申请日：1987-11-30
申请人： STEVENS MALCOLM FRANCIS GRAHAM , GRIFFIN ROGER JOHN , MEEK MICHELLE ANNE
发明人： STEVENS MALCOLM FRANCIS GRAHAM , GRIFFIN ROGER JOHN , MEEK MICHELLE ANNE
IPC分类号： A61K31/505 , A61P17/00 , A61P31/04 , A61P33/02 , A61P35/00 , A61P43/00 , C07D239/48

3. 发明专利

GB2204867B ANTIFOLIATE PYRIMIDINE COMPOUNDS 未知
公开(公告)号：GB2204867B
公开(公告)日：1991-05-29
申请号：GB8728018
申请日：1987-11-30
申请人： STEVENS MALCOLM FRANCIS GRAHAM , GRIFFIN ROGER JOHN , MEEK MICHELLE ANNE
发明人： STEVENS MALCOLM FRANCIS GRAHAM , GRIFFIN ROGER JOHN , MEEK MICHELLE ANNE
IPC分类号： A61K31/505 , A61P17/00 , A61P31/04 , A61P33/02 , A61P35/00 , A61P43/00 , C07D239/48

4. 发明申请

WO2011005943A1 COMPOSITIONS CONTAINING BENEFIT AGENT DELIVERY PARTICLES 审中-公开
标题翻译：含有有益效果的成分颗粒的组合物
公开(公告)号：WO2011005943A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/041344
申请日：2010-07-08
申请人： THE PROCTER & GAMBLE COMPANY , MEEK, Michelle , SOUTER, Philip Frank , FERNANDEZ PRIETO, Susana , SMETS, Johan , KULKARNI, Mohan Gopalkrishna , SHUKLA, Parshuram Gajanan , BOTE, Aruna Narayan , JADHAV, Arun Savalaram
发明人： MEEK, Michelle , SOUTER, Philip Frank , FERNANDEZ PRIETO, Susana , SMETS, Johan , KULKARNI, Mohan Gopalkrishna , SHUKLA, Parshuram Gajanan , BOTE, Aruna Narayan , JADHAV, Arun Savalaram
IPC分类号： C11D3/22 , C11D17/00
CPC分类号： C11D3/505 , C11D3/001 , C11D3/0036 , C11D3/226 , C11D3/386 , C11D3/38618 , C11D3/38663 , C11D3/3956 , C11D3/42 , C11D11/0017 , C11D17/0013 , C11D17/0039 , C11D17/043
摘要： The present disclosure relates to compositions containing benefit agent delivery particles containing at least one benefit agent and at least one cellulosic polymer. The disclosure further relates to compositions containing benefit agent delivery particles and processes for making and using such compositions. The disclosure further relates to methods of imparting a benefit delivery capability to a cleaning composition.
摘要翻译：本公开内容涉及含有有益剂递送颗粒的组合物，其含有至少一种有益试剂和至少一种纤维素聚合物。本公开还涉及含有有益剂递送颗粒的组合物以及制备和使用这些组合物的方法。本公开还涉及赋予清洁组合物的益处递送能力的方法。

5. 发明申请

WO2010090915A1 DETERGENT COMPOSITION 审中-公开
标题翻译：洗涤剂组合物
公开(公告)号：WO2010090915A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/022155
申请日：2010-01-27
申请人： THE PROCTER & GAMBLE COMPANY , SOUTER, Philip, Frank , SOMERVILLE ROBERTS, Nigel, Patrick , MEEK, Michelle , BAEZ CHAVEZ, Jose, David , BAHARI, Mohammed, Badrulhisham
发明人： SOUTER, Philip, Frank , SOMERVILLE ROBERTS, Nigel, Patrick , MEEK, Michelle , BAEZ CHAVEZ, Jose, David , BAHARI, Mohammed, Badrulhisham
IPC分类号： C11D3/386 , C11D17/00 , C11D3/39 , C11D3/395
CPC分类号： C11D3/38672 , C11D3/386 , C11D3/3902 , C11D3/3935 , C11D17/0039
摘要： An automatic dishwashing detergent composition comprising by weight of the composition: a) at least 9% of coated bleach particles the particles having a coating comprising at least 5% by weight of the particle of an efflorescent material; b) at least 0.5% of granulates containing active enzyme wherein the granulates comprise efflorescent material.
摘要翻译：一种自动餐具洗涤剂组合物，其包含以下组合物的重量：a）至少9％的包衣漂白剂颗粒，该颗粒具有包含至少5重量％的风化材料颗粒的涂层; b）至少0.5％的含有活性酶的颗粒，其中颗粒包含风化材料。

6. 发明申请

WO2011100410A2 CLEANING COMPOSITION COMPRISING AMYLASE VARIANTS WITH HIGH STABILITY IN THE PRESENCE OF A CHELATING AGENT 审中-公开
标题翻译：清洁组合物包含在粘合剂存在下具有高稳定性的氨基酸变体
公开(公告)号：WO2011100410A2
公开(公告)日：2011-08-18
申请号：PCT/US2011/024321
申请日：2011-02-10
申请人： THE PROCTER & GAMBLE COMPANY , MEEK, Michelle , SOUTER, Phillip, Frank , BEWICK, Lindsay, Suzanne , SVENDSEN, Allan , JOHANSEN, Annette, Helle , BJOERNVAD, Mads, Eskelund , RASMUSSEN, Frank, Winther , SKJOET, Michael , LARSEN, Eskildsen, Signe , OEBRO, Jens , KAASGAARD, Svend , BEIER, Lars
发明人： MEEK, Michelle , SOUTER, Phillip, Frank , BEWICK, Lindsay, Suzanne , SVENDSEN, Allan , JOHANSEN, Annette, Helle , BJOERNVAD, Mads, Eskelund , RASMUSSEN, Frank, Winther , SKJOET, Michael , LARSEN, Eskildsen, Signe , OEBRO, Jens , KAASGAARD, Svend , BEIER, Lars
IPC分类号： C11D3/33
CPC分类号： C11D3/386 , C11D3/33 , C11D3/361 , C12N9/2417 , C12Y302/01001
摘要： The present invention relates to cleaning compositions comprising variants of an alpha-amylase having improved stability to chelating agents relative to its parent enzyme and cleaning processes comprising such compositions.
摘要翻译：本发明涉及包含相对于其母体酶对螯合剂具有改善的稳定性的α-淀粉酶变体和包含这些组合物的清洁方法的清洁组合物。

7. 发明申请

WO2011005932A1 COMPOSITIONS CONTAINING BENEFIT AGENT DELIVERY PARTICLES 审中-公开
标题翻译：含有有益效果的成分颗粒的组合物
公开(公告)号：WO2011005932A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/041329
申请日：2010-07-08
申请人： THE PROCTER & GAMBLE COMPANY , MEEK, Michelle , SOUTER, Phillip, Frank , FERNANDEZ PRIETO, Susana , SMETS, Johan , KULKARNI, Mohan, Gopalkrishna , SHUKLA, Parshuram, Gajanan , BOTE, Aruna, Narayan , JADHAV, Arun, Savalaram
发明人： MEEK, Michelle , SOUTER, Phillip, Frank , FERNANDEZ PRIETO, Susana , SMETS, Johan , KULKARNI, Mohan, Gopalkrishna , SHUKLA, Parshuram, Gajanan , BOTE, Aruna, Narayan , JADHAV, Arun, Savalaram
IPC分类号： C11D17/00 , C11D3/22
CPC分类号： C11D17/0039 , C11D3/226 , C11D3/38672 , C11D3/3935 , C11D3/40 , C11D3/505 , C11D17/0013
摘要： The present disclosure relates to benefit agent delivery particles containing at least one benefit agent and at least one cellulosic polymer. The disclosure further relates to fabric care compositions containing benefit agent delivery particles and processes for making and using such compositions. The disclosure further relates to methods of imparting a benefit delivery capability to a fabric care composition.
摘要翻译：本公开涉及包含至少一种有益试剂和至少一种纤维素聚合物的有益剂递送颗粒。本公开还涉及含有有益剂递送颗粒的织物护理组合物以及制备和使用这些组合物的方法。本公开进一步涉及向织物护理组合物赋予益处递送能力的方法。

8. 发明申请

WO2009102854A1 CLEANING COMPOSITIONS 审中-公开
标题翻译：清洁组合物
公开(公告)号：WO2009102854A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/033897
申请日：2009-02-12
申请人： THE PROCTER & GAMBLE COMPANY , MEEK, Michelle , SOUTER, Philip, Frank , GARRETT, Garry, Steven , SAUNDERS, Charles, Winston , REEDER, Nancy, L. , SONG, Brian, Xiaoging , KEITH, Brian, Lee
发明人： MEEK, Michelle , SOUTER, Philip, Frank , GARRETT, Garry, Steven , SAUNDERS, Charles, Winston , REEDER, Nancy, L. , SONG, Brian, Xiaoging , KEITH, Brian, Lee
IPC分类号： C11D3/386 , C11D1/72 , C11D3/28 , C11D3/16 , C11D3/34
CPC分类号： C11D3/38618 , C11D1/72 , C11D1/721 , C11D1/722 , C11D3/166 , C11D3/28 , C11D3/33 , C11D3/349 , C11D3/38663 , C11D3/38672 , C11D3/43 , C11D17/043
摘要： The present application relates to nil phosphate and nil borate cleaning compositions comprising a protease cleaning system and a wetting agent, and processes for making and using such compositions. Such compositions offer improved enzyme stability in product and a consumer desirable cleaning profile.
摘要翻译：本申请涉及包括蛋白酶清洁系统和润湿剂的无磷酸盐和无硼酸盐清洁组合物，以及制备和使用这些组合物的方法。这样的组合物提供了产品中的酶稳定性和消费者期望的清洁轮廓。

9. 发明申请

WO1988004293A1 ANTIFOLATE AGENTS 审中-公开
标题翻译：防腐剂
公开(公告)号：WO1988004293A1
公开(公告)日：1988-06-16
申请号：PCT/GB1987000859
申请日：1987-11-30
申请人： STEVENS, Malcolm, Francis, Graham , GRIFFIN, Roger, John , MEEK, Michelle, Anne
IPC分类号： C07D239/48
CPC分类号： C07D239/48
摘要： 2,4-Diamino-5-phenylpyrimidines in the form of the free base or an acid addition salt thereof having structural formula (I), wherein R1 is an alkoxy, aralkoxy or a mono-substituted or disubstituted amino group, R2 is a nitro group, and R3 is an alkyl group. The compounds act as antifolate agents and are useful for therapeutic treatment, for example as antitumour agents, antipsoriatic agents, antibacterial agents, antitrypanosomal agents and antimalarial agents. Pharmaceutical preparations comprising these compounds for administration to mammals, and methods for preparing the compounds, are disclosed. Particularly useful new compounds, especially for antitumour therapy, have structural formula (IA), in which n is 1-6; R 1 represents hydrogen or alkyl; R4, R5 and R6, which may be identical or different, each represent hydrogen, alkyl, alkoxy, halo, nitro, perfluoroalkyl, a group of formula -CO2Ra wherein Ra represents hydrogen, alkyl or alkoxyalkyl, or a group of formula -CONRbRc wherein Rb and Rc which may be identical or different each represent alkyl; and R3 represents alkyl.

10. 发明申请

WO2011109366A1 COMPOSITION COMPRISING SUBSTITUTED CELLULOSIC POLYMER AND AMYLASE 审中-公开
标题翻译：包含取代的纤维素聚合物和淀粉酶的组合物
公开(公告)号：WO2011109366A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/026649
申请日：2011-03-01
申请人： THE PROCTER & GAMBLE COMPANY , MEEK, Michelle , SOUTER, Philip, Frank , LANT, Neil, Joseph , BROOKER, Alan, Thomas , SOMERVILLE ROBERTS, Nigel, Patrick
发明人： MEEK, Michelle , SOUTER, Philip, Frank , LANT, Neil, Joseph , BROOKER, Alan, Thomas , SOMERVILLE ROBERTS, Nigel, Patrick
IPC分类号： C11D3/00 , C11D7/06 , C11D3/22 , C11D3/386
CPC分类号： C11D3/3905 , C11D3/38609 , C11D3/392 , C11D3/3942 , C11D3/3945 , C11D17/06
摘要： The present invention relates to a solid particulate laundry detergent composition comprising: (a) substituted cellulosic polymer comprising carboxymethyl substituent groups, and having a degree of substitution (DS) of at least 0.55, and having a degree of blockiness (DB) of at least 0.35, and having a DS+DB is in the range of from 1.05 to 2.00; (b) amylase with greater than 90% identity to the AA560 alpha amylase endogenous to Bacillus sp. DSM 12649 and comprising: (i) mutations at one or more of positions 9, 149, 182, 186, 202, 257, 295, 299, 323, 339 and 345; and (ii) mutations at four or more of positions 118, 183, 184, 195, 320 and 458; and (c) laundry detergent ingredients.
摘要翻译：本发明涉及一种固体颗粒衣物洗涤剂组合物，其包含：（a）包含羧甲基取代基的取代纤维素聚合物，并且具有至少0.55的取代度（DS）至少为0.55，并且具有至少 0.35，DS + DB为1.05〜2.00的范围; （b）与芽孢杆菌属内源的AA560α淀粉酶具有大于90％同一性的淀粉酶。 DSM 12649，其包含：（i）位置9,149,182,186,202,257,295,29,323,339和345中的一个或多个的突变; 和（ii）位置118,183,184,195,320和458中的四个或更多个的突变; 和（c）衣物洗涤剂成分。

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