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1. 发明申请

WO2009067221A2 MICROEMULSION CONTAINING INDOLOCARBAZOLE COMPOUND AND DOSAGE FORMS CONTAINING THE SAME 审中-公开
标题翻译：含有吲哚考虑的化合物的微乳液和含有它的剂型
公开(公告)号：WO2009067221A2
公开(公告)日：2009-05-28
申请号：PCT/US2008/012942
申请日：2008-11-20
申请人： CEPHALON, INC. , DRAGER, Anthony, S. , MCINTYRE, Bradley, T. , PATEL, Piyush, R.
发明人： DRAGER, Anthony, S. , MCINTYRE, Bradley, T. , PATEL, Piyush, R.
IPC分类号： A61K9/107 , A61K31/55
CPC分类号： A61K31/55 , A61K9/1075 , A61K9/143 , A61K9/1611 , A61K9/2077 , A61K9/4858 , A61K9/4866 , A61K47/14 , A61K47/34
摘要： The invention described herein provides a pharmaceutical composition and oral dosage forms containing the same, having high concentrations of solubilized indolocarbazole compounds as the active ingredient in microemulsion form. The invention also provides a process for increasing the solubilized concentration of indolocarbazole compounds such as lestaurtinib using the addition of water in combination with a hydrophilic component as part of the microemulsion formation process.
摘要翻译：本文描述的本发明提供了含有该组合物和口服剂型的药物组合物和口服剂型，其具有高浓度的溶解的吲哚咔唑化合物作为微乳液形式的活性成分。本发明还提供了一种使用与亲水性组分一起加入水作为微乳液形成过程的一部分来增加吲哚咔唑化合物如赖链霉素的溶解浓度的方法。

2. 发明申请

WO2008002493A3 PHARMACEUTICAL MEASURING AND DISPENSING CUP 审中-公开
公开(公告)号：WO2008002493A3
公开(公告)日：2008-01-03
申请号：PCT/US2007/014623
申请日：2007-06-22
申请人： CEPHALON, INC. , MCINTYRE, Bradley, T. , PATEL, Piyush, R.
发明人： MCINTYRE, Bradley, T. , PATEL, Piyush, R.
IPC分类号： G01F19/00
摘要： A measuring and diluting cup for preparing pharmaceutical doses is provided. The cup comprises an upstanding body having an open mouth and a hollow interior bounded by a sidewall. The cup also has a pharmaceutical measuring compartment. The pharmaceutical measuring compartment is opposite the open mouth and forms a bottom of the hollow interior. The cup also has a diluent measuring compartment which is adjacent the open mouth. The pharmaceutical measuring compartment captures a measured volume Smaller than the volume of the diluent measuring compartment, and the pharmaceutical measuring compartment opens to the diluent measuring compartment. The upstanding body is substantially cylindrical and the pharmaceutical measuring compartment has a Cylindrical or conical region concentric with the upstanding body. The pharmaceutical measuring compartment has a smaller diameter than the upstanding body.

3. 发明申请

WO2005051958A2 PARTICLE-FORMING COMPOSITIONS CONTAINING FUSED PYRROLOCARBAZOLES 审中-公开
标题翻译：含有熔融吡咯烷酮的颗粒形成组合物
公开(公告)号：WO2005051958A2
公开(公告)日：2005-06-09
申请号：PCT/US2004/037928
申请日：2004-11-12
申请人： CEPHALON, INC. , McINTYRE, Bradley, T. , DICKASON, Dave , PATEL, Piyush, R.
发明人： McINTYRE, Bradley, T. , DICKASON, Dave , PATEL, Piyush, R.
IPC分类号： C07D498/22
CPC分类号： A61K31/55 , A61K31/403 , A61K31/5513 , C07D498/22
摘要： A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into suspended particles, thereby forming a stable suspension that provides greatly improved bioavailability of orally administered fused pyrrolocarbazole compounds.
摘要翻译：公开了一种非水性，形成颗粒的，熔融的含有咯咯唑的组合物。当与水性介质接触时，颗粒形成组合物自发地分散到悬浮颗粒中，从而形成稳定的悬浮液，其提供口服给药的熔融吡咯并咔唑化合物的极大改善的生物利用度。

4. 发明申请

WO2009067221A3 MICROEMULSION CONTAINING INDOLOCARBAZOLE COMPOUND AND DOSAGE FORMS CONTAINING THE SAME 审中-公开
标题翻译：含有吲哚并咔唑化合物的微乳液和含有该化合物的剂型
公开(公告)号：WO2009067221A3
公开(公告)日：2009-09-24
申请号：PCT/US2008012942
申请日：2008-11-20
申请人： CEPHALON INC , DRAGER ANTHONY S , MCINTYRE BRADLEY T , PATEL PIYUSH R
发明人： DRAGER ANTHONY S , MCINTYRE BRADLEY T , PATEL PIYUSH R
IPC分类号： A61K9/107 , A61K31/55
CPC分类号： A61K31/55 , A61K9/1075 , A61K9/143 , A61K9/1611 , A61K9/2077 , A61K9/4858 , A61K9/4866 , A61K47/14 , A61K47/34
摘要： The invention described herein provides a pharmaceutical composition and oral dosage forms containing the same, having high concentrations of solubilized indolocarbazole compounds as the active ingredient in microemulsion form. The invention also provides a process for increasing the solubilized concentration of indolocarbazole compounds such as lestaurtinib using the addition of water in combination with a hydrophilic component as part of the microemulsion formation process.
摘要翻译：本文所述的发明提供了药物组合物和含有其的口服剂型，其具有高浓度的溶解的吲哚并咔唑化合物作为微乳剂形式的活性成分。本发明还提供了一种通过加入与亲水性组分结合的水作为微乳液形成过程的一部分来提高吲哚并咔唑化合物如来他替尼的溶解浓度的方法。

5. 发明申请

WO2008002493A2 PHARMACEUTICAL MEASURING AND DISPENSING CUP 审中-公开
标题翻译：药物测量和分配杯
公开(公告)号：WO2008002493A2
公开(公告)日：2008-01-03
申请号：PCT/US2007014623
申请日：2007-06-22
申请人： CEPHALON INC , MCINTYRE BRADLEY T , PATEL PIYUSH R
发明人： MCINTYRE BRADLEY T , PATEL PIYUSH R
IPC分类号： G01F19/00
CPC分类号： B01F15/0441 , A61J7/0046 , B01F13/002 , B01F13/0098 , B01F15/00512 , G01F19/00
摘要： ABSTRACT A measuring and diluting cup for preparing pharmaceutical doses is provided. The cup comprises an upstanding body having an open mouth and a hollow interior bounded by a sidewall. The cup also has a pharmaceutical measuring compartment. The pharmaceutical measuring compartment is opposite the open mouth and forms a bottom of the hollow interior. The cup also has a diluent measuring compartment which is adjacent the open mouth. The pharmaceutical measuring compartment captures a measured volume Smaller than the volume of the diluent measuring compartment, and the pharmaceutical measuring compartment opens to the diluent measuring compartment. The upstanding body is substantially cylindrical and the pharmaceutical measuring compartment has a Cylindrical or conical region concentric with the upstanding body. The pharmaceutical measuring compartment has a smaller diameter than the upstanding body.
摘要翻译：摘要提供了一种用于制备药物剂量的测量和稀释杯。杯子包括具有开口的直立体和由侧壁界定的中空的内部。杯子还有一个药物测量室。药物测量室与开口相对，形成中空内部的底部。杯子还具有邻近开口的稀释剂测量室。药物测量室捕获测量体积小于稀释剂测量室的体积，并且药物测量室通向稀释剂测量室。直立体基本上是圆柱形的，并且药物测量室具有与直立身体同心的圆柱形或圆锥形区域。药物测量室的直径小于直立身体。

6. 发明申请

WO2005051958A3 PARTICLE-FORMING COMPOSITIONS CONTAINING FUSED PYRROLOCARBAZOLES 审中-公开
标题翻译：含有熔融吡咯烷酮的颗粒形成组合物
公开(公告)号：WO2005051958A3
公开(公告)日：2006-01-12
申请号：PCT/US2004037928
申请日：2004-11-12
申请人： CEPHALON INC , DICKASON DAVE , MCINTYRE BRADLEY T , PATEL PIYUSH R
发明人： DICKASON DAVE , MCINTYRE BRADLEY T , PATEL PIYUSH R
IPC分类号： A61K31/403 , A61K31/55 , A61K31/5513 , C07D498/22
CPC分类号： A61K31/55 , A61K31/403 , A61K31/5513 , C07D498/22
摘要： A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into suspended particles, thereby forming a stable suspension that provides greatly improved bioavailability of orally administered fused pyrrolocarbazole compounds.
摘要翻译：公开了一种非水性，形成颗粒的，熔融的含有咯咯唑的组合物。当与水性介质接触时，颗粒形成组合物自发地分散到悬浮颗粒中，从而形成稳定的悬浮液，其提供口服给药的熔融吡咯并咔唑化合物的极大改善的生物利用度。

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