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1. 发明专利

IL286363D0 Benzodiazepine derivatives as rsv inhibitors 未知
公开(公告)号：IL286363D0
公开(公告)日：2021-10-31
申请号：IL28636321
申请日：2021-09-13
申请人： ENANTA PHARM INC , ZHU KAICHENG , MCGRATH KEVIN , NEGRETTI EMMANUELLI SOLYMAR , SZYMANIAK ADAM , YU JIANMING , KIM IN JONG , OR YAT SUN
发明人： ZHU KAICHENG , MCGRATH KEVIN , NEGRETTI-EMMANUELLI SOLYMAR , SZYMANIAK ADAM , YU JIANMING , KIM IN JONG , OR YAT SUN
IPC分类号： A61K45/06 , A61P31/14
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

2. 发明专利

AU1648199A Filtration apparatus 未知
公开(公告)号：AU1648199A
公开(公告)日：1999-06-28
申请号：AU1648199
申请日：1998-12-09
申请人： MCGRATH KEVIN DOUGLAS
发明人： MCGRATH KEVIN DOUGLAS
IPC分类号： B01D63/16
摘要： A filtration apparatus in which a rotating filter element is concentrically mounted in a hollow conical of cylindrical chamber. The filter element consists of a support and a membrane mounted on the support. Fluid enters the chamber through an inlet port and concentrate leaves the chamber through an outlet port. Filtrate drains through the membrane and support to a channel in the centre of the filter element. Filtration relies upon cross-flow of the fluid across the surface of the rotating filter element. This reduces the tendency of solids in the fluid to block pores of the membrane, thereby maintaining high flux and minimising the requirement for cleaning of the filter.

3. 发明专利

AU734466B2 Filtration apparatus 未知
公开(公告)号：AU734466B2
公开(公告)日：2001-06-14
申请号：AU1648199
申请日：1998-12-09
申请人： MCGRATH KEVIN DOUGLAS
发明人： MCGRATH KEVIN DOUGLAS
IPC分类号： B01D63/16 , B01D33/06 , B01D33/073
摘要： A filtration apparatus in which a rotating filter element is concentrically mounted in a hollow conical of cylindrical chamber. The filter element consists of a support and a membrane mounted on the support. Fluid enters the chamber through an inlet port and concentrate leaves the chamber through an outlet port. Filtrate drains through the membrane and support to a channel in the centre of the filter element. Filtration relies upon cross-flow of the fluid across the surface of the rotating filter element. This reduces the tendency of solids in the fluid to block pores of the membrane, thereby maintaining high flux and minimising the requirement for cleaning of the filter.

4. 发明专利

CA2245334A1 FILTRATION APPARATUS 未知
公开(公告)号：CA2245334A1
公开(公告)日：2000-02-19
申请号：CA2245334
申请日：1998-08-19
申请人： MCGRATH KEVIN DOUGLAS
发明人： MCGRATH KEVIN DOUGLAS
IPC分类号： B01D61/14 , B01D61/18 , B01D63/08 , B01D63/16 , B01D65/08 , B01D25/30
摘要： Filter apparatus (2) comprises end plates (13),(14) between which are arranged a plurality of parallel filter membrane plates (15). Feed ports (21), return ports (23), filtrate ports (22) and backflush ports (24), and seals (41),(41),(43),(44) between adjacent plates define a turbulent feed flow path across one side of the membrane to set up vibrations in the membranes to reduce clogging.

5. 发明专利

IL291834D0 Antiviral heterocyclic compounds 未知
公开(公告)号：IL291834D0
公开(公告)日：2022-06-01
申请号：IL29183422
申请日：2022-03-30
申请人： ENANTA PHARM INC , SZYMANIAK ADAM , MCGRATH KEVIN , YU JIANMING , MANN TYLER , NGUYEN LONG , ZHU KAICHENG , KIM IN JONG , OR YAT SUN
发明人： SZYMANIAK ADAM , MCGRATH KEVIN , YU JIANMING , MANN TYLER , NGUYEN LONG , ZHU KAICHENG , KIM IN JONG , OR YAT SUN
IPC分类号： A61K31/4375 , A61K31/443 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/538 , A61K45/06 , A61P31/12
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

6. 发明专利

IL291834A Antiviral heterocyclic compounds 未知
公开(公告)号：IL291834A
公开(公告)日：2022-06-01
申请号：IL29183422
申请日：2022-03-30
申请人： ENANTA PHARM INC , SZYMANIAK ADAM , MCGRATH KEVIN , YU JIANMING , MANN TYLER , NGUYEN LONG , ZHU KAICHENG , KIM IN JONG , OR YAT SUN
发明人： SZYMANIAK ADAM , MCGRATH KEVIN , YU JIANMING , MANN TYLER , NGUYEN LONG , ZHU KAICHENG , KIM IN JONG , OR YAT SUN
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

7. 发明申请

WO2008072102A3 ENHANCED CUFF SEALING FOR ENDOTRACHEAL TUBES 审中-公开
标题翻译：增强密封用于内窥镜管
公开(公告)号：WO2008072102A3
公开(公告)日：2009-05-07
申请号：PCT/IB2007053624
申请日：2007-09-07
申请人： KIMBERLY CLARK CO , MCGRATH KEVIN
发明人： MCGRATH KEVIN
IPC分类号： A61L24/00 , A61L24/04 , A61L24/08 , C09K3/12
CPC分类号： A61L24/001 , A61L24/0031 , A61L24/08 , C08L23/0892 , C08L53/00 , C08L2666/02 , C08L2666/20 , C09J133/06 , C09J153/00 , C08L2666/04
摘要： Gelling sealants that promote enhanced impermeability to medical devices is provided. The gelling sealants include various viscoelastic materials that exhibit a first viscosity upon introduction into a body cavity and a second viscosity after dwelling within the body cavity for a predetermined amount of time. The gelling sealants thicken and provide a bacterial barrier after introduction into a body cavity by adhering to the inside surfaces of the body cavity.
摘要翻译：提供了增强对医疗器械不透水性的凝胶密封剂。凝胶密封剂包括各种粘弹性材料，其在引入体腔中时呈现出第一粘度，并且在体腔内停留预定时间量后的第二粘度。凝胶密封剂通过粘附到体腔的内表面而变厚并在引入体腔后提供细菌屏障。

8. 发明申请

WO2008072102A2 ENHANCED CUFF SEALING FOR ENDOTRACHEAL TUBES 审中-公开
标题翻译：增强密封用于内窥镜管
公开(公告)号：WO2008072102A2
公开(公告)日：2008-06-19
申请号：PCT/IB2007/053624
申请日：2007-09-07
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , MCGRATH, Kevin
发明人： MCGRATH, Kevin
IPC分类号： A61L24/04 , A61L24/08
CPC分类号： A61L24/001 , A61L24/0031 , A61L24/08 , C08L23/0892 , C08L53/00 , C08L2666/02 , C08L2666/20 , C09J133/06 , C09J153/00 , C08L2666/04
摘要： Gelling sealants that promote enhanced impermeability to medical devices is provided. The gelling sealants include various viscoelastic materials that exhibit a first viscosity upon introduction into a body cavity and a second viscosity after dwelling within the body cavity for a predetermined amount of time. The gelling sealants thicken and provide a bacterial barrier after introduction into a body cavity by adhering to the inside surfaces of the body cavity.
摘要翻译：提供了增强对医疗器械不透水性的凝胶密封剂。凝胶密封剂包括各种粘弹性材料，其在引入体腔中时呈现出第一粘度，并且在体腔内停留预定时间量后的第二粘度。凝胶密封剂通过粘附到体腔的内表面而变厚并在引入体腔后提供细菌屏障。

9. 发明申请

WO2007070123A1 DETECTION OF SECRETED ASPARTYL PROTEASES FROM CANDIDA SPECIES 审中-公开
标题翻译：从坎迪达物种检测分泌的ASPARTYL蛋白质
公开(公告)号：WO2007070123A1
公开(公告)日：2007-06-21
申请号：PCT/US2006/032203
申请日：2006-08-17
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , PHILLIPS, Erica, M. , DIGAMMARINO, Enrico, L. , MCGRATH, Kevin, P.
发明人： PHILLIPS, Erica, M. , DIGAMMARINO, Enrico, L. , MCGRATH, Kevin, P.
IPC分类号： G01N33/558 , C12Q1/37
CPC分类号： G01N33/56961 , C12Q1/37 , G01N33/558
摘要： Methods and devices for the detection of proteins secreted by the hyphal growth form of Candida species are disclosed. The disclosed devices may constitute a method for the diagnosis of acute or chronic infections, including candidiasis, caused by microorganisms of the species Candida, such as C. albicans, for example. The devices of the present invention incorporate antibodies specific to secreted aspartyl protease proteins whose expression is upregulated upon the conversion of the Candida species from the commensal to the pathogenic form. The antibodies may be used in assays to allow the diagnosis of candidal infections and disease conditions. Either monoclonal antibodies or polyclonal antibodies may be used, and in the case of the monoclonals, the specific epitopes of the SAP protein may be detected as well as the SAP protein itself.
摘要翻译：公开了用于检测由假丝酵母属菌丝生长形式分泌的蛋白质的方法和装置。所公开的装置可以构成用于诊断例如由诸如白色念珠菌之类的假丝酵母属的微生物引起的急性或慢性感染（包括念珠菌病）的方法。本发明的装置包含对分泌的天冬氨酰蛋白酶蛋白特异性的抗体，其在将假丝酵母菌种从共生转化为致病形式时，其表达被上调。抗体可用于测定以允许诊断念珠菌感染和疾病状况。可以使用单克隆抗体或多克隆抗体，并且在单克隆的情况下，可以检测SAP蛋白的特异性表位以及SAP蛋白本身。

10. 发明申请

WO2005063307A1 BACTERIA BINDING PRODUCTS 审中-公开
标题翻译：细菌结合产品
公开(公告)号：WO2005063307A1
公开(公告)日：2005-07-14
申请号：PCT/US2004/043301
申请日：2004-12-22
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , VILLANUEVA, Julie, M. , SAYRE, Curtis, Neil , HUANG, Lei , MCGRATH, Kevin, Peter , WEI, Ning
发明人： VILLANUEVA, Julie, M. , SAYRE, Curtis, Neil , HUANG, Lei , MCGRATH, Kevin, Peter , WEI, Ning
IPC分类号： A61L2/02
CPC分类号： D06M11/45 , A61L2/02 , A61L2/232 , D01F1/103 , D06M11/79 , D06M15/55 , D06M15/61 , D06M23/08 , Y10T442/2525
摘要： There is provided products for the removal of negatively charged particles like bacteria from surfaces. The products have a positive charge that may be developed through the use of cationic treatments. The product or substrate from which it is made may be dipped in an aqueous solution of a non-antimicrobial treatment having a positive charge and the excess solution squeezed out. Treatment of the resulting coated substrate with heat at a temperature and for a time sufficient adheres the coating to the substrate. Alternatively, a non-antimicrobial, cationically charged chemical may be imbedded in a substrate web such that it will bloom to the surface when the web is exposed to water. A suitable substrate web may be a pulp and synthetic fiber fabric made by coforming or hydroengling and may be a laminate including other layers. The treated substrate and product remove a substantial amount of the bacteria from a surface yet do not appreciably kill the bacteria. Harsh, oxidizing, chemicals are not used in the preparation of the products and so the products are mild in their effect on the user's skin. The removal of the bacteria, in contrast to killing the bacteria, does not encourage the bacteria to develop immunity to the treatment.
摘要翻译：提供了从表面除去带负电荷的颗粒如细菌的产品。这些产品具有通过使用阳离子处理可以开发的正电荷。可以将其制成的产品或基材浸渍在具有正电荷且过量溶液挤出的非抗微生物处理的水溶液中。在一段温度和一段时间内用热量处理所得的涂覆的基材足以将涂层粘附到基材上。或者，非抗微生物的带阳离子电荷的化学品可以嵌入基材网中，使得当幅材暴露于水时，其将盛开到表面。合适的基材纤维网可以是通过共成型或水化加工制成的纸浆和合成纤维织物，并且可以是包括其它层的层压体。经处理的底物和产物从表面除去大量的细菌，但不会明显杀死细菌。苛刻，氧化，化学品不用于制备产品，因此产品对用户皮肤的影响温和。与杀死细菌相反，细菌的去除不会鼓励细菌发挥对治疗的免疫力。

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