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1. 发明申请

WO2010078150A1 PACKAGING SOLUTIONS 审中-公开
标题翻译：包装解决方案
公开(公告)号：WO2010078150A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069181
申请日：2009-12-22
申请人： BAUSCH & LOMB INCORPORATED , MCGEE, Joseph, A. , VANDERBILT, David, Paul , VALINT, Paul, L., Jr.
发明人： MCGEE, Joseph, A. , VANDERBILT, David, Paul , VALINT, Paul, L., Jr.
IPC分类号： A61L12/00 , A61L12/08 , G02B1/04
CPC分类号： A61L12/086 , A61L12/00 , G02B1/043 , C08L85/04 , C08L51/085 , C08L83/10
摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed.
摘要翻译：公开了用于存储诸如隐形眼镜的眼科装置的包装系统以及用于包装这些眼科装置的方法以提供在穿戴期间镜片的舒适度的解决方案。

2. 发明申请

WO2007027500A2 SURFACE-MODIFIED MEDICAL DEVICES AND METHODS OF MAKING 审中-公开
标题翻译：表面修饰医疗器械及其制造方法
公开(公告)号：WO2007027500A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/033089
申请日：2006-08-24
申请人： BAUSCH & LOMB INCORPORATED , SALAMONE, Joseph, C. , KUNZLER, Jay, F. , MCGEE, Joseph, A.
发明人： SALAMONE, Joseph, C. , KUNZLER, Jay, F. , MCGEE, Joseph, A.
CPC分类号： A61L27/34 , C08L33/26
摘要： A surface-modified medical device comprises a hydrophilic coating that comprises units of a hydrophilic monomer and a coupling agent that has coupling functional groups, at least a portion of which is coupled to the surface functional groups of the medical device. A method for producing such a surface-modified medical device comprises forming the hydrophilic coating by coupling units of the hydrophilic monomer to the medical device through the coupling agent. Medical devices, such as stents, implants, catheters, and ophthalmic devices, are included.
摘要翻译：表面改性的医疗装置包括亲水性涂层，其包含亲水性单体的单元和具有偶联官能团的偶联剂，其偶联剂的至少一部分与医疗装置的表面官能团连接。制造这种表面改性医疗器械的方法包括通过偶联剂将亲水性单体的单元与医疗器件结合而形成亲水性涂层。包括医疗装置，例如支架，植入物，导管和眼科装置。

3. 发明申请

WO2010077646A3 METHOD OF APPLYING RENEWABLE POLYMERIC LENS COATING 审中-公开
标题翻译：应用可再生聚合物镜片涂层的方法
公开(公告)号：WO2010077646A3
公开(公告)日：2011-04-07
申请号：PCT/US2009067126
申请日：2009-12-08
申请人： BAUSCH & LOMB , MCGEE JOSEPH A , VANDERBILT DAVID P , VALINT PAUL L JR
发明人： MCGEE JOSEPH A , VANDERBILT DAVID P , VALINT PAUL L JR
IPC分类号： A61L27/26 , A61L27/50 , A61L31/04 , A61L31/14 , G02B1/04
CPC分类号： G02B1/043 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2430/16
摘要： Disclosed are biomedical devices having a hydrophilic coating on a portion of a surface thereof, the biomedical device comprising: (a) a biomedical device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) a biomedical device-forming comonomer; and (b) a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the complementary reactive functionalities along the polymer chain of the hydrophilic reactive polymer of (b) bind with the boronic acid moieties of the biomedical device of (a), thereby producing a biocompatible coating which can be removed and re-applied to restore the surface properties of the biomedical device to substantially as-new condition. Methods for treating the biomedical device are also disclosed.
摘要翻译：公开了在其表面的一部分上具有亲水涂层的生物医学装置，所述生物医学装置包括：（a）由单体混合物的聚合产物获得的生物医学装置，其包含（i）含有硼酸部分的可聚合单体和吸电子部分; 和（ii）生物医学装置形成共聚单体; 和（b）沿着聚合物链具有互补的反应性官能团的亲水性反应性聚合物，其中沿（b）的亲水性反应性聚合物的聚合物链的互补反应性官能团与（a）生物医学装置的硼酸部分结合，从而产生生物相容性涂层，其可以被去除并重新施加以将生物医学装置的表面性质恢复到基本上新的状态。还公开了用于治疗生物医学装置的方法。

4. 发明申请

WO2007061919A3 CONTACT LENSES WITH MUCIN AFFINITY 审中-公开
标题翻译：联系眼镜与MUCIN AFFINITY
公开(公告)号：WO2007061919A3
公开(公告)日：2007-11-08
申请号：PCT/US2006044814
申请日：2006-11-17
申请人： BAUSCH & LOMB , VALINT PAUL L JR , MCGEE JOSEPH A , VANDERBILT DAVID P , SALAMONE JOSEPH C
发明人： VALINT PAUL L JR , MCGEE JOSEPH A , VANDERBILT DAVID P , SALAMONE JOSEPH C
IPC分类号： A61L27/34 , A61L12/08 , C08L85/04 , G02B1/04
CPC分类号： C08J7/047 , A61L27/34 , C08J2443/00 , G02B1/043 , C08L101/02
摘要： A biomedical device, such as a contact lens, has a surface linked to a polymer comprising boronic acid moieties. The boronic acid monomelic units may be derived from an ethylenically unsaturated monomer containing a boronic acid moiety, such as a vinylphenyl boronic acid or a (meth)acrylamido phenyl boronic acid. The boronic acid moieties may be complexed with mucin, especially epithelial mucin.
摘要翻译：诸如隐形眼镜的生物医学装置具有与包含硼酸部分的聚合物连接的表面。硼酸单体单元可以衍生自含有硼酸部分的烯属不饱和单体，例如乙烯基苯基硼酸或（甲基）丙烯酰胺基苯基硼酸。硼酸部分可能与粘蛋白，特别是上皮粘蛋白复合。

5. 发明申请

WO2007061919A2 CONTACT LENSES WITH MUCIN AFFINITY 审中-公开
标题翻译：与MUCIN AFFINITY联系镜片
公开(公告)号：WO2007061919A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/044814
申请日：2006-11-17
申请人： BAUSCH & LOMB INCORPORATED , VALINT, Paul, L., Jr. , MCGEE, Joseph, A. , VANDERBILT, David, P. , SALAMONE, Joseph, C.
发明人： VALINT, Paul, L., Jr. , MCGEE, Joseph, A. , VANDERBILT, David, P. , SALAMONE, Joseph, C.
IPC分类号： A61L27/34 , G02B1/04 , C08L85/04 , A61L12/08
CPC分类号： C08J7/047 , A61L27/34 , C08J2443/00 , G02B1/043 , C08L101/02
摘要： A biomedical device, such as a contact lens, has a surface linked to a polymer comprising boronic acid moieties. The boronic acid monomelic units may be derived from an ethylenically unsaturated monomer containing a boronic acid moiety, such as a vinylphenyl boronic acid or a (meth)acrylamido phenyl boronic acid. The boronic acid moieties may be complexed with mucin, especially epithelial mucin.
摘要翻译：生物医学装置，例如隐形眼镜，具有与包含硼酸部分的聚合物连接的表面。硼酸单体单元可以衍生自含有硼酸部分的烯属不饱和单体，例如乙烯基苯基硼酸或（甲基）丙烯酰胺基苯基硼酸。硼酸部分可以与粘蛋白复合，特别是上皮粘蛋白。

6. 发明申请

WO2010147864A3 BIOMEDICAL DEVICES, POLYMERIC MATERIALS AND CONTACT LENSES COMPRISING THE SAME 审中-公开
标题翻译：生物医学装置，聚合材料和包含其的接触镜
公开(公告)号：WO2010147864A3
公开(公告)日：2011-02-17
申请号：PCT/US2010038447
申请日：2010-06-14
申请人： BAUSCH & LOMB , NUNEZ IVAN M , LINHARDT JEFFREY G , MCGEE JOSEPH A , HUNT JENNIFER , ALTON MICHELE , SHIPP DEVON A , KUNZLER JAY FRIEDRICH , AMMON DANIEL M
发明人： NUNEZ IVAN M , LINHARDT JEFFREY G , MCGEE JOSEPH A , HUNT JENNIFER , ALTON MICHELE , SHIPP DEVON A , KUNZLER JAY FRIEDRICH , AMMON DANIEL M
IPC分类号： G02B1/04 , A61L27/52
CPC分类号： G02B1/043 , A61L27/52 , C08L81/00 , C08L83/10
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) one or more hydrophilic polymer comprising one or more hydrophilic units and one or more thio carbonyl thio fragments of a reversible addition fragmentation chain transfer ("RAFT") agent; and (b) one or more biomedical device-forming monomers are disclosed.
摘要翻译：生物医学装置，例如由混合物的聚合产物形成的隐形眼镜，所述混合物包含（a）一种或多种包含一个或多个亲水单元的亲水性聚合物和一个或多个可逆加成断裂链转移（“RAFT”）试剂的一个或多个硫羰基硫代片段 ; 和（b）公开了一种或多种生物医学装置形成单体。

7. 发明申请

WO2010147875A3 BIOMEDICAL DEVICES, POLYMERIC MATERIALS AND CONTACT LENSES COMPRISING THE SAME 审中-公开
公开(公告)号：WO2010147875A3
公开(公告)日：2010-12-23
申请号：PCT/US2010/038464
申请日：2010-06-14
申请人： BAUSCH & LOMB INCORPORATED , LINHARDT, Jeffrey, G. , MCGEE, Joseph, A. , NUNEZ, Ivan, M.
发明人： LINHARDT, Jeffrey, G. , MCGEE, Joseph, A. , NUNEZ, Ivan, M.
IPC分类号： G02B1/04 , A61L27/52
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising one or more random copolymers comprising hydrophilic units and hydrophobic units, wherein the one or more random copolymers have at least one thio carbonyl thio fragment of a reversible addition fragmentation chain transfer ("RAFT") agent are disclosed.

8. 发明申请

WO2010077709A2 BIOMEDICAL DEVICES 审中-公开
标题翻译：生物医学设备
公开(公告)号：WO2010077709A2
公开(公告)日：2010-07-08
申请号：PCT/US2009067239
申请日：2009-12-09
申请人： BAUSCH & LOMB , LAI YU-CHIN , LANG WEIHONG , VANDERBILT DAVID P , VALINT PAUL L JR , MCGEE JOSEPH A
发明人： LAI YU-CHIN , LANG WEIHONG , VANDERBILT DAVID P , VALINT PAUL L JR , MCGEE JOSEPH A
IPC分类号： A61L27/26 , A61L27/50 , A61L31/04 , A61L31/14
CPC分类号： A61L27/16 , A61L2430/16 , C08L101/02
摘要： Biomedical devices are provided herein which are formed from a polymerization product of a monomeric mixture comprising (a) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (b) a biomedical device- forming comonomer.
摘要翻译：本文提供由包含（a）含有硼酸部分和吸电子部分的可聚合单体的单体混合物的聚合产物形成的生物医学装置; 和（b）生物医学装置形成共聚单体。

9. 发明申请

WO2008079495A3 COATINGS AND SOLUTIONS FOR CONTACT LENSES 审中-公开
公开(公告)号：WO2008079495A3
公开(公告)日：2008-07-03
申请号：PCT/US2007/082318
申请日：2007-10-24
申请人： BAUSCH & LOMB INCORPORATED , VANDERBILT, David, P. , VALINT, Paul, L. , MCGEE, Joseph, A.
发明人： VANDERBILT, David, P. , VALINT, Paul, L. , MCGEE, Joseph, A.
IPC分类号： A61L27/34 , G02B1/04
摘要： A contact lens is coated with a layer of a polymer having affinity for mucin, such as a polymer with boronic acid moieties. This polymer is coated with a diol. While the contact lens is worn, the diol is replaced with mucin.

10. 发明申请

WO2007061916A3 CONTACT LENSES WITH MUCIN AFFINITY 审中-公开
标题翻译：联系镜头与MUCIN AFFINITY
公开(公告)号：WO2007061916A3
公开(公告)日：2007-07-19
申请号：PCT/US2006044807
申请日：2006-11-17
申请人： BAUSCH & LOMB , VALINT PAUL L JR , MCGEE JOSEPH A , VANDERBILT DAVID P
发明人： VALINT PAUL L JR , MCGEE JOSEPH A , VANDERBILT DAVID P
IPC分类号： A61L27/50
CPC分类号： A61L27/34 , A61L27/50 , G02B1/043
摘要： A biomedical device surface, such as a contact lens surface, is covalently linked to a cationic copolymer. The copolymer may include monomeric units derived from an ethylenically unsaturated monomer containing a quaternary ammonium moiety and monomeric units derived from an ethylenically unsaturated monomer containing a moiety reactive with complementary reactive functionalities at the lens surface. The copolymer may be covalently linked directly to the lens surface, or covalently linked with an intermediate polymer reactive with both the lens surface and the copolymer.
摘要翻译：诸如隐形眼镜表面的生物医学装置表面与阳离子共聚物共价连接。共聚物可以包括衍生自含有季铵部分的烯属不饱和单体的单体单元和衍生自含有在透镜表面上与互补反应性官能团反应的部分的烯属不饱和单体的单体单元。共聚物可以直接与透镜表面相连，或者与与透镜表面和共聚物两者反应的中间体聚合物共价连接。

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