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1. 发明公开

EP0742287A3 Modified nucleic acid probes 失效
标题翻译：修饰的核酸探针
公开(公告)号：EP0742287A3
公开(公告)日：1997-12-29
申请号：EP96303245
申请日：1996-05-09
申请人： MCGALL GLENN H , MIYADA CHARLES G , CRONIN MAUREEN T , TAN JENNIFER D , CHEE MARK S
发明人： MCGALL GLENN H , MIYADA CHARLES G , CRONIN MAUREEN T , TAN JENNIFER D , CHEE MARK S
IPC分类号： C07H21/00 , C12Q1/68 , B01J19/00
CPC分类号： C07H21/00

2. 发明授权

EP0742287B1 Modified nucleic acid probes 失效
标题翻译：修饰的核酸探针
公开(公告)号：EP0742287B1
公开(公告)日：2006-01-18
申请号：EP96303245.3
申请日：1996-05-09
申请人： McGall, Glenn H. , Miyada, Charles G. , Cronin, Maureen T. , Tan, Jennifer D. , Chee, Mark S.
发明人： McGall, Glenn H. , Miyada, Charles G. , Cronin, Maureen T. , Tan, Jennifer D. , Chee, Mark S.
IPC分类号： C12Q1/68 , C07H21/00 , B01J19/00
CPC分类号： C07H21/00

3. 发明公开

EP0742287A2 Modified nucleic acid probes 失效
标题翻译： ModifizierteNukleinsäuresonden
公开(公告)号：EP0742287A2
公开(公告)日：1996-11-13
申请号：EP96303245.3
申请日：1996-05-09
申请人： McGall, Glenn H. , Miyada, Charles G. , Cronin, Maureen T. , Tan, Jennifer D. , Chee, Mark S.
发明人： McGall, Glenn H. , Miyada, Charles G. , Cronin, Maureen T. , Tan, Jennifer D. , Chee, Mark S.
IPC分类号： C12Q1/68 , C07H21/00 , B01J19/00
CPC分类号： C07H21/00
摘要： Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or lower specificity than corresponding unmodified oligonucleotides. Target nucleic acids which comprise nucleotide analogues are bound to oligonucleotide and oligonucleotide analogue arrays.
摘要翻译：提供了连接到固体底物的寡核苷酸类似物阵列以及与其使用相关的方法。寡核苷酸类似物与具有比相应的未修饰寡核苷酸更高或更低特异性的核酸杂交。包含核苷酸类似物的靶核酸与寡核苷酸和寡核苷酸类似物阵列结合。

4. 发明专利

HK1014561A1 Modified nucleic acid probes 未知
公开(公告)号：HK1014561A1
公开(公告)日：1999-09-30
申请号：HK98115796
申请日：1998-12-28
申请人： MCGALL GLENN H , MIYADA CHARLES G , CRONIN MAUREEN T , TAN JENNIFER D , CHEE MARK S
发明人： MCGALL GLENN H , MIYADA CHARLES G , CRONIN MAUREEN T , TAN JENNIFER D , CHEE MARK S
IPC分类号： C07H21/00 , C12Q1/68 , C12Q , C07H , B01J
摘要： Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or lower specificity than corresponding unmodified oligonucleotides. Target nucleic acids which comprise nucleotide analogues are bound to oligonucleotide and oligonucleotide analogue arrays.

5. 发明申请

WO2007081664A3 USE OF ACID SCAVENGERS FOR THE SYNTHESIS OF STANDARD LENGTH AND LONG-MER NUCLEIC ACID ARRAYS 审中-公开
标题翻译：酸性清除剂在合成标准长度和长链核酸阵列中的应用
公开(公告)号：WO2007081664A3
公开(公告)日：2007-11-22
申请号：PCT/US2006062669
申请日：2006-12-28
申请人： AFFYMETRIX INC , KUIMELIS ROBERT G , MCGALL GLENN H , GOLDBERG MARTIN J , XU GUANGYU
发明人： KUIMELIS ROBERT G , MCGALL GLENN H , GOLDBERG MARTIN J , XU GUANGYU
IPC分类号： B01J19/00 , C07H21/00 , C40B50/14
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00646 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C07H21/00 , C07K1/047 , C40B50/14 , Y02P20/55
摘要： Protective groups which may be cleaved with an activatable deprotecting reagent are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
摘要翻译：采用可用可活化去保护试剂裂解的保护基团来实现各种聚合物的图案阵列的高灵敏度，高分辨率，组合合成。在本发明的优选实施方案中，可活化的脱保护试剂是光酸产生剂，保护基团是核酸的DMT和氨基酸的tBOC。本发明具有广泛的应用范围，特别适用于聚合物的固相组合合成。

6. 发明申请

WO0006771A2 NUCLEIC ACID LABELING COMPOUNDS 审中-公开
标题翻译：核酸标签化合物
公开(公告)号：WO0006771A2
公开(公告)日：2000-02-10
申请号：PCT/US9912390
申请日：1999-07-20
申请人： AFFYMETRIX INC , MCGALL GLENN H , BARONE ANTHONY D
发明人： MCGALL GLENN H , BARONE ANTHONY D
IPC分类号： G01N33/50 , C07F9/6558 , C07F9/6561 , C07H19/04 , C07H19/052 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/23 , C07H21/00 , C07H21/04 , C12N15/09 , C12N15/10 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/566
CPC分类号： C07H19/052 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/12 , C07H21/00
摘要： Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.
摘要翻译：公开了含有杂环衍生物的核酸标记化合物。通过将杂环衍生物与环状基团（例如呋喃核糖衍生物）缩合来合成含杂环衍生物的化合物。标记化合物适合于在末端或内部酶促附着于核酸，以提供核酸检测机制。

7. 发明申请

WO1998020967A1 CHEMICAL AMPLIFICATION FOR THE SYNTHESIS OF PATTERNED ARRAYS 审中-公开
标题翻译：用于合成图案阵列的化学放大
公开(公告)号：WO1998020967A1
公开(公告)日：1998-05-22
申请号：PCT/US1997021209
申请日：1997-11-13
申请人： AFFYMETRIX, INC. , BEECHER, Jody, E. , GOLDBERG, Martin, J. , MCGALL, Glenn, H.
发明人： AFFYMETRIX, INC.
IPC分类号： B01J19/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00427 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , C07B61/00 , C07B2200/11 , C07H21/00 , C07H21/04 , C07K1/04 , C07K1/045 , C12Q1/6837 , C40B40/06 , C40B50/14 , C40B60/14 , Y02P20/55
摘要： Radiation-activated catalyst (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
摘要翻译：使用辐射活化催化剂（RAC），自催化反应和保护基团来实现多种聚合物图案阵列的高灵敏度，高分辨率的辐射导向组合合成。当照射时，RAC产生可与增强剂反应的催化剂，例如参与自催化反应的那些。自催化反应产生至少一种从合成中间体中除去保护基的产物。本发明具有广泛的应用，并且对聚合物的固相组合合成特别有用。

8. 发明申请

WO0220150A3 PHOTOCLEAVABLE PROTECTING GROUPS 审中-公开
标题翻译：光电保护组
公开(公告)号：WO0220150A3
公开(公告)日：2003-03-13
申请号：PCT/IB0101650
申请日：2001-09-11
申请人： AFFYMETRIX INC , MCGALL GLENN H , BARONE ANTHONY D
发明人： MCGALL GLENN H , BARONE ANTHONY D
IPC分类号： C07B61/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K1/04 , C07K1/06 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C07K17/06
CPC分类号： B82Y30/00 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K1/04 , C07K1/047 , C07K1/062 , C07K1/063 , C07K1/064 , C07K1/065 , C07K1/066 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , Y02P20/55
摘要： Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. The compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting groups has the general formula (Y), wherein: (Y) is a chemical structure as shown the Figure. Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.
摘要翻译：提供了新的化合物，其可用作化学合成中的连接基团，优选在寡核苷酸和多肽的固相合成中。化合物通常是光不稳定的，并且包含可以通过光解除去以揭示反应性基团的保护基团。保护基具有通式（Y），其中：（Y）是如图所示的化学结构。还提供了使用上述保护的化合物从成分分子在载体上形成多种化合物的方法，每种化合物占据支持体的单独的预定区域。

9. 发明申请

WO2000006771A3 NUCLEIC ACID LABELING COMPOUNDS 审中-公开
公开(公告)号：WO2000006771A3
公开(公告)日：2000-02-10
申请号：PCT/US1999/012390
申请日：1999-07-20
申请人： AFFYMETRIX, INC. , MCGALL, Glenn, H. , BARONE, Anthony, D.
发明人： MCGALL, Glenn, H. , BARONE, Anthony, D.
IPC分类号： C07H19/04
摘要： Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.

10. 发明申请

WO1997027317A1 NUCLEIC ACID ANALYSIS TECHNIQUES 审中-公开
标题翻译：核酸分析技术
公开(公告)号：WO1997027317A1
公开(公告)日：1997-07-31
申请号：PCT/US1997001603
申请日：1997-01-22
申请人： AFFYMETRIX, INC. , LOCKHART, David, J. , CHEE, Mark , GUNDERSON, Kevin , LAI, Chaoqiang , WODICKA, Lisa , CRONIN, Maureen, T. , LEE, Danny , TRAN, Huu, M. , MATSUZAKI, Hajime , McGALL, Glenn, H. , BARONE, Anthony, D.
发明人： AFFYMETRIX, INC.
IPC分类号： C12Q01/00
CPC分类号： C12Q1/6809 , C07H19/052 , C07H19/12 , C07H21/00 , C12Q1/6816 , C12Q1/6837 , C12Q2600/156 , C40B40/00 , C12Q2565/501 , C12Q2521/501
摘要： The present invention provides a simplified method for identifying differences in nucleic acid abundances (e.g., expression levels) between two or more samples. The methods involve providing an array containing a large number (e.g. greater then 1,000) of arbitrarily selected different oligonucleotide probes where the sequence and location of each different probe is known. Nucleic acid samples (e.g. mRNA) from two or more samples are hybridized to the probe arrays and the pattern of hybridization is detected. Differences in the hybridization patterns between the samples indicates differences in expression of various genes between those samples. This invention also provides a method of end-labeling a nucleic acid. In one embodiment, the method involves providing a nucleic acid, providing a labeled oligonucleotide and then enzymatically ligating the oligonucleotide to the nucleic acid. Thus, for example, where the nucleic acid is an RNA, a labeled oligoribonucleotide can be ligated using an RNA ligase. In another embodiment, the end labeling can be accomplished by providing a nucleic acid, providing labeled nucleoside triphosphates, and attaching the nucleoside triphosphates to the nucleic acid using a terminal transferase.
摘要翻译：本发明提供用于鉴定两个或多个样品之间的核酸丰度差异（例如，表达水平）的简化方法。该方法包括提供包含大量（例如大于1,000个）任意选择的不同寡核苷酸探针的阵列，其中每个不同探针的序列和位置是已知的。来自两个或更多个样品的核酸样品（例如mRNA）与探针阵列杂交，并检测杂交模式。样本之间的杂交模式的差异表明这些样品之间各种基因的表达差异。本发明还提供了一种终止标记核酸的方法。在一个实施方案中，该方法包括提供核酸，提供标记的寡核苷酸，然后将寡核苷酸酶连接到核酸上。因此，例如，当核酸是RNA时，可以使用RNA连接酶连接标记的寡核糖核苷酸。在另一个实施方案中，末端标记可以通过提供核酸，提供标记的核苷三磷酸和使用末端转移酶将核苷三磷酸与核酸连接来实现。

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