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1. 发明申请

WO2017088148A1 HYBRID COOLING APPLIANCE 审中-公开
标题翻译：混合冷却装置
公开(公告)号：WO2017088148A1
公开(公告)日：2017-06-01
申请号：PCT/CN2015/095688
申请日：2015-11-26
申请人： DOMETIC SWEDEN AB , LUNDQVIST, Anton , LI, Dahua , YANG, Xingbiao , ZHANG, Yongbin , LI, Junbao , MCCONNELL, Patrick , MEYERS, Clayton
发明人： LUNDQVIST, Anton , LI, Dahua , YANG, Xingbiao , ZHANG, Yongbin , LI, Junbao , MCCONNELL, Patrick , MEYERS, Clayton
IPC分类号： F25B25/02
CPC分类号： F25B25/02 , F25B25/00 , F25D11/00 , F25D11/022
摘要： A hybrid cooling system and a method of controlling the same. The hybrid cooling system (50) comprises an absorption refrigeration system (52), a compression refrigeration system (54) and a controller (80) which operates the absorption refrigeration system (52) and the compression refrigeration system (54) in three modes.
摘要翻译：混合冷却系统及其控制方法。混合冷却系统（50）包括吸收式制冷系统（52），压缩式制冷系统（54）和控制器（80），其以三种模式操作吸收式制冷系统（52）和压缩式制冷系统（54）。

2. 发明申请

WO2004105862A3 MEASURING HUMAN HEART MUSCLE VIABILITY USING MYOCARDIAL ELECTRICAL IMPEDANCE 审中-公开
标题翻译：使用MYOCARDIAL电气阻抗测量人体心脏肌肉功能
公开(公告)号：WO2004105862A3
公开(公告)日：2005-03-03
申请号：PCT/US2004017224
申请日：2004-05-28
申请人： UNIV OHIO STATE , DZWONCZYK ROGER R , DEL RIO CARLOS L , MCCONNELL PATRICK I , HOWIE MICHAEL B
发明人： DZWONCZYK ROGER R , DEL RIO CARLOS L , MCCONNELL PATRICK I , HOWIE MICHAEL B
IPC分类号： A61B5/05 , A61B5/053 , A61N20060101
CPC分类号： A61B5/053 , A61B5/413
摘要： A method for detecting a quantitative measure of a physiologic state of a myocardium or coronary artery by detecting the extent of change of myocardial electrical impedance from a mean baseline value to provide diagnosis of the extent of ischemia, stenosis, tissue rejection, reperfusion and the effectiveness of cardioplegia . Electrodes (16,18) are attached to the myocardium (14), baseline measurements of the mean myocardial impedance are stored, and the variance of the myocardial electrical impedance and a baseline value of mean myocardial electrical impedance are computed from the baseline measurements using custom circuitry (12) and a computer (10). After a mean myocardial electrical impedance changes from a computed baseline value by at least the measured variance, the extent of change in the myocardial physiologic state is diagnosed as a continuous, smooth, function of the extent or rate of change of a periodically measured myocardial electrical impedance from the baseline value.
摘要翻译：通过从平均基线值检测心肌电阻抗的变化程度来检测心肌或冠状动脉的生理状态的定量测量的方法，以提供缺血，狭窄，组织排斥，再灌注和有效性的程度的诊断的心脏停跳。电极（16,18）连接到心肌（14），存储平均心肌阻抗的基线测量，并且使用定制从基线测量计算心肌电阻抗的方差和平均心肌电阻抗的基线值电路（12）和计算机（10）。在平均心肌电阻抗从计算基线值至少改变测量方差之后，心肌生理状态的变化程度被诊断为周期性测量的心肌电气的变化程度或速率的连续，平滑的功能阻抗从基线值。

3. 发明申请

WO2004105862A2 MEASURING HUMAN HEART MUSCLE VIABILITY USING MYOCARDIAL ELECTRICAL IMPEDANCE 审中-公开
标题翻译：使用MYOCARDIAL电气阻抗测量人体心脏肌肉功能
公开(公告)号：WO2004105862A2
公开(公告)日：2004-12-09
申请号：PCT/US2004/017224
申请日：2004-05-28
申请人： THE OHIO STATE UNIVERSITY , DZWONCZYK, Roger, R. , DEL RIO, Carlos, L. , MCCONNELL, Patrick, I. , HOWIE, Michael, B.
发明人： DZWONCZYK, Roger, R. , DEL RIO, Carlos, L. , MCCONNELL, Patrick, I. , HOWIE, Michael, B.
IPC分类号： A61N
CPC分类号： A61B5/053 , A61B5/413
摘要： A method for detecting a quantitative measure of a physiologic state of a human myocardium or coronary artery. Implementations of the method detect the extent of change of myocardial electrical impedance from a mean baseline value to provide diagnosis of the extent of ischemia, stenosis, tissue rejection, and reperfusion and the effectiveness of cardioplegia and ischemia preconditioning as well as the general effectiveness of coronary bypass surgery as measured by post-operative reperfusion. Electrodes are attached to the myocardium, baseline measurements of the mean myocardial electrical impedance are stored and the variance of the myocardial electrical impedance and a baseline value of mean myocardial electrical impedance are computed from the baseline measurements and stored. Mean myocardial electrical impedance values are periodically measured between each electrode pair over an interval of time and stored. After the mean myocardial electrical impedance changes from the computed baseline value by at least the measured variance, the extent of change in the myocardial physiologic state is diagnosed as a continuous, smooth, function of the extent of change, or rate of change, of the periodically measured myocardial electrical impedance from the baseline value.
摘要翻译：一种用于检测人心肌或冠状动脉的生理状态的定量测量的方法。该方法的实施方法从平均基线值检测心肌电阻抗的变化程度，以提供缺血，狭窄，组织排斥和再灌注程度的诊断以及心脏停搏和缺血预处理的有效性以及冠状动脉的一般功效旁路手术按术后再灌注测量。电极连接到心肌，存储平均心肌电阻抗的基线测量，并从基线测量计算心肌电阻抗的方差和平均心肌电阻抗的基线值，并存储。在一段时间间隔内，在每个电极对之间周期性地测量平均心肌电阻抗值并存储。在平均心肌电阻抗从计算基线值至少改变测量方差之后，心肌生理状态的变化程度被诊断为变化程度或变化率的连续，平滑的功能从基线值定期测量心肌电阻抗。

4. 发明申请

WO2003054180A1 MODIFIED MEK1 AND MEK2, CRYSTAL OF A PEPTIDE: LIGAND: COFACTOR COMPLEX CONTAINING SUCH MODIFIED MEK1 OR MEK2, AND METHODS OF USE THEREOF 审中-公开
标题翻译：修饰的MEK1和MEK2，肽的晶体：配体：包含这种修饰的MEK1或MEK2的供体复合物及其使用方法
公开(公告)号：WO2003054180A1
公开(公告)日：2003-07-03
申请号：PCT/IB2002/005340
申请日：2002-12-09
申请人： WARNER-LAMBERT COMPANY LLC , OHREN, Jeffrey, Francis , CHEN, Huifen , DELANEY, Amy, Marie , DUDLEY, David, Thomas , HASEMANN, Charles, Albert, Jr. , KUFFA, Peter , MCCONNELL, Patrick, Charles , PAVLOVSKY, Alexander, Gregory , TECLE, Haile , WHITEHEAD, Christopher, Emil , YAN, Chunhong , ZHANG, Erli
发明人： OHREN, Jeffrey, Francis , CHEN, Huifen , DELANEY, Amy, Marie , DUDLEY, David, Thomas , HASEMANN, Charles, Albert, Jr. , KUFFA, Peter , MCCONNELL, Patrick, Charles , PAVLOVSKY, Alexander, Gregory , TECLE, Haile , WHITEHEAD, Christopher, Emil , YAN, Chunhong , ZHANG, Erli
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C07K2299/00
摘要： Modified MEK1 peptides and modified MEK2 peptides, polynucleotides encoding those peptides, and methods for purifying the peptides and crystallizing them as peptide: cofactor: ligand complexes have been discovered. The three-dimensional structures of MEK1 peptide and MEK2 peptide, including the cofactor-and ligand-binding pockets, and uses of this information, for example, in molecular replacement and the modification, design and screening of compounds that may associate with MEK1, MEK2, or peptides structurally related thereto, have also been discovered.
摘要翻译：已经发现修饰的MEK1肽和修饰的MEK2肽，编码那些肽的多核苷酸，以及纯化肽并将其结晶为肽：辅因子：配体复合物的方法。 MEK1肽和MEK2肽的三维结构，包括辅因子和配体结合口袋，以及该信息的用途，例如分子替代和可能与MEK1，MEK2相关的化合物的修饰，设计和筛选，或其结构相关的肽也已被发现。

5. 发明申请

WO2004034288A1 THE THREE-DIMENSIONAL CRYSTAL STRUCTURE OF BCATC COMPLEXES AND METHODS OF USE THEREOF 审中-公开
标题翻译： BCATC复合物的三维晶体结构及其使用方法
公开(公告)号：WO2004034288A1
公开(公告)日：2004-04-22
申请号：PCT/IB2003/004301
申请日：2003-09-29
申请人： WARNER-LAMBERT COMPANY LLC , RUBIN, John, Ronald , HU, Lain-Yen , MISTRY, Anil , SCHOLTEN, Jeffrey, David , MORELAND, David, Winslow , MUELLER, William, Thomas , MCCONNELL, Patrick, Charles
发明人： RUBIN, John, Ronald , HU, Lain-Yen , MISTRY, Anil , SCHOLTEN, Jeffrey, David , MORELAND, David, Winslow , MUELLER, William, Thomas , MCCONNELL, Patrick, Charles
IPC分类号： G06F17/50
CPC分类号： C12N9/1096 , C07K2299/00
摘要： The three-dimensional crystal structures of BCATc peptide: co-factor and BCATc peptide: co-factor: ligand complexes, and methods for obtaining the crystals, are described. The structures provide three-dimensional descriptions of BCATc and its binding sites and can be used, for example, in drug discovery and design.
摘要翻译：描述了BCATc肽：辅因子和BCATc肽：辅因子：配体配合物的三维晶体结构以及获得晶体的方法。该结构提供了BCATc及其结合位点的三维描述，可用于例如药物发现和设计。

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