专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004094398A3 SYNTHESIS OF 2-HYDROXY-N,N-DIMETHYL-3-[[2-[1(R)-(5-METHYL-2-FURANYL)PROPYL]AMINO]-3,4-DIOXO-1-CYCLOBUTEN-1-YL]AMINO]BENZAMIDE 审中-公开
公开(公告)号：WO2004094398A3
公开(公告)日：2004-11-04
申请号：PCT/US2004/011882
申请日：2004-04-16
申请人： SCHERING CORPORATION , YIN, Jianguo , FU, Xiaoyong , ZHANG, Shuyi , MCALLISTER, Timothy, L. , KIM-MEADE, Agnes, S. , WINTERS, Jason, L. , SUDHAKAR, Anantha , SCHUMACHER, Doris, P.
发明人： YIN, Jianguo , FU, Xiaoyong , ZHANG, Shuyi , MCALLISTER, Timothy, L. , KIM-MEADE, Agnes, S. , WINTERS, Jason, L. , SUDHAKAR, Anantha , SCHUMACHER, Doris, P.
IPC分类号： C07D307/52
摘要： Disclosed is a process for making the compound of formula (I), using the compounds of formulas (II), (Q), and (XI) or (XII) (II), wherein A is selected from the group consisting of Br, Cl and (I) (with Br being preferred); and R represents (C 1 -C 10 )alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.

2. 发明申请

WO1992004314A2 PROCESS FOR PREPARING ALBUTEROL, ACETAL, HEMI-ACETAL, AND HYDRATES OF ARYLGLYOXAL INTERMEDIATES THEREOF 审中-公开
标题翻译：制备阿尔伯特尔，乙酰胆碱，乙酰丙酸及其芳香族中间体的水合物的方法
公开(公告)号：WO1992004314A2
公开(公告)日：1992-03-19
申请号：PCT/US1991006248
申请日：1991-09-06
申请人： SCHERING CORPORATION , TANN, Chou-Hong , THIRUVENGADAM, T., K. , CHIU, John , GREEN, Michael , MCALLISTER, Timothy, L. , COLON, Cesar , LEE, Junning
发明人： SCHERING CORPORATION
IPC分类号： C07C215/60
CPC分类号： C07C215/60 , C07C69/88 , C07C235/84 , C07F5/022 , C07F5/04
摘要： The preparation of arylethanolamines, and in particular albuterol (salbutamol), together with their novel boron, acetal and hemi-acetal intermediates is described.
摘要翻译：描述了芳基乙醇胺，特别是沙丁胺醇（沙丁胺醇）的制备及其新型的硼，缩醛和半缩醛中间体。

3. 发明申请

WO2008021235A3 PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 2-(QUINOLIN-5-YL)-4,5 DISUBSTITUTED-AZOLE DERIVATIVES 审中-公开
公开(公告)号：WO2008021235A3
公开(公告)日：2008-02-21
申请号：PCT/US2007/017796
申请日：2007-08-10
申请人： SCHERING CORPORATION , CUTARELLI, Timothy, D. , FU, Xiaoyong , MCALLISTER, Timothy, L. , REEDER, Michael, R. , YIN, Jianguo , YONG, Kelvin, H. , ZHANG, Shuyi
发明人： CUTARELLI, Timothy, D. , FU, Xiaoyong , MCALLISTER, Timothy, L. , REEDER, Michael, R. , YIN, Jianguo , YONG, Kelvin, H. , ZHANG, Shuyi
IPC分类号： C07C211/00 , C07D413/04 , C07D413/14
摘要： This application discloses a novel process to synthesize 2-(Quinolin-5yo)-4,5- Disubstituted-Azole derivatives, which may be used, for example, as PDE IV inhibitor compounds in pharmaceutical preparations.

4. 发明申请

WO2008021235A2 PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 2-(QUINOLIN-5-YL)-4,5 DISUBSTITUTED-AZOLE DERIVATIVES 审中-公开
标题翻译：合成2-（喹啉-5-基）-4,5-取代的四氢呋喃衍生物的方法和中间体
公开(公告)号：WO2008021235A2
公开(公告)日：2008-02-21
申请号：PCT/US2007017796
申请日：2007-08-10
申请人： SCHERING CORP , CUTARELLI TIMOTHY D , FU XIAOYONG , MCALLISTER TIMOTHY L , REEDER MICHAEL R , YIN JIANGUO , YONG KELVIN H , ZHANG SHUYI
发明人： CUTARELLI TIMOTHY D , FU XIAOYONG , MCALLISTER TIMOTHY L , REEDER MICHAEL R , YIN JIANGUO , YONG KELVIN H , ZHANG SHUYI
IPC分类号： C07C211/00 , C07D413/04 , C07D413/14
CPC分类号： C07D413/04 , C07C271/22 , C07D413/14
摘要： This application discloses a novel process to synthesize 2-(Quinolin-5yo)-4,5-Disubstituted-Azole derivatives, which may be used, for example, as PDE IV inhibitor compounds in pharmaceutical preparations.
摘要翻译：本申请公开了一种合成2-（喹啉-5-基）-4,5-二取代 - 唑衍生物的新方法，其可用作药物制剂中的PDE IV抑制剂化合物。

5. 发明申请

WO2004094398A2 SYNTHESIS OF 2-HYDROXY-N,N-DIMETHYL-3-[[2-[1(R)-(5-METHYL-2-FURANYL)PROPYL]AMINO]-3,4-DIOXO-1-CYCLOBUTEN-1-YL]AMINO]BENZAMIDE 审中-公开
标题翻译：合成2-羟基-N，N-二甲基-3 - [[2- [1（R） - （5-甲基-2-呋喃基）丙基]氨基] -3,4-二氧代-1-环丙基-1- YL]氨基]苯甲酰胺
公开(公告)号：WO2004094398A2
公开(公告)日：2004-11-04
申请号：PCT/US2004011882
申请日：2004-04-16
申请人： SCHERING CORP , YIN JIANGUO , FU XIAOYONG , ZHANG SHUYI , MCALLISTER TIMOTHY L , KIM-MEADE AGNES S , WINTERS JASON L , SUDHAKAR ANANTHA , SCHUMACHER DORIS P
发明人： YIN JIANGUO , FU XIAOYONG , ZHANG SHUYI , MCALLISTER TIMOTHY L , KIM-MEADE AGNES S , WINTERS JASON L , SUDHAKAR ANANTHA , SCHUMACHER DORIS P
IPC分类号： C07C235/60 , C07D307/52 , C07C205/60
CPC分类号： C07D307/52 , C07C235/60
摘要： Disclosed is a process for making the compound of formula (I), using the compounds of formulas II, Q, and XI or XII (II), wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
摘要翻译：公开了使用式II，Q和XI或XII（II）的化合物制备式（I）化合物的方法，其中A选自Br，Cl和I（其中Br是优选的））; R表示（C1-C10）烷基。还公开了在所公开的方法中制备的中间体化合物。

6. 发明申请

WO2009005801A1 PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS 审中-公开
标题翻译：合成1,2-取代的3,4-二氧代-1-环己基化合物的方法和中间体
公开(公告)号：WO2009005801A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/008187
申请日：2008-07-01
申请人： SCHERING CORPORATION , FU, Xiaoyong , GUENTER, Frank, Bruno , KIM-MEADE, Agnes, S. , MATTHEWS, Kenneth, Stanley , MAUST, Mathew, Thomas , MCALLISTER, Timothy, L. , WERNE, Gerald , WINTERS, Jason, L. , YIN, Jianguo , ZHANG, Shuyi
发明人： FU, Xiaoyong , GUENTER, Frank, Bruno , KIM-MEADE, Agnes, S. , MATTHEWS, Kenneth, Stanley , MAUST, Mathew, Thomas , MCALLISTER, Timothy, L. , WERNE, Gerald , WINTERS, Jason, L. , YIN, Jianguo , ZHANG, Shuyi
IPC分类号： C07C233/65 , C07D307/52
CPC分类号： C07D307/52 , C07C231/12 , C07C237/44
摘要： This application discloses a novel process for the preparation of 1.2 - substituted 3, 4 - dioxo - 1 - cyclobutene compounds of formula (A), which have utility, for example, in the treatment of CXC chemokine -mediated diseases, and intermediates useful in the synthesis thereof.
摘要翻译：本申请公开了一种制备式（A）的1.2-取代的3,4-二氧代-1-环丁烯化合物的新方法，其可用于例如治疗CXC趋化因子介导的疾病，以及可用于其合成。

7. 发明申请

WO2009079490A1 PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF HETEROCYCLIC SUBSTITUTED PIPERAZINES WITH CXCR3 ANTAGONIST ACTIVITY 审中-公开
标题翻译：用CXCR3拮抗剂活性合成杂环取代的哌啶的方法和中间体
公开(公告)号：WO2009079490A1
公开(公告)日：2009-06-25
申请号：PCT/US2008/086949
申请日：2008-12-16
申请人： SCHERING CORPORATION , CHEN, Frank, Xing , CUTARELLI, Timothy, D. , FU, Xiaoyong , LIANG, Xian , MCALLISTER, Timothy, L. , ORR, Robert, K. , YIN, Jianguo , YONG, Kelvin, H. , ZHU, Man
发明人： CHEN, Frank, Xing , CUTARELLI, Timothy, D. , FU, Xiaoyong , LIANG, Xian , MCALLISTER, Timothy, L. , ORR, Robert, K. , YIN, Jianguo , YONG, Kelvin, H. , ZHU, Man
IPC分类号： C07D211/44 , C07D239/42 , C07D413/14 , C07D295/205 , A61K31/497
CPC分类号： C07D413/14 , C07D211/44 , C07D239/42 , C07D295/205
摘要： The present invention relates to novel processes for the preparation of the compound of the Formula A45: [Chemical formula should be inserted here as it appears in the paper abstract.] or a physiologically acceptable salt, solvate or prodrug thereof, which has utility, for example, as a pharmaceutically active compound with CXCR3 antagonist activity, and to novel intermediates useful in the synthesis thereof.
摘要翻译：本发明涉及制备式A45化合物的新方法：[化学式应该如本文中所示插入本文摘要]或其生理上可接受的盐，溶剂合物或前体药物，其可用于作为具有CXCR3拮抗剂活性的药物活性化合物，以及可用于其合成的新型中间体。

8. 发明申请

WO2006068990A1 PROCESS FOR THE SYNTHESIS OF AZETIDINONES 审中-公开
标题翻译：合成AZETIDINONES的方法
公开(公告)号：WO2006068990A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/045901
申请日：2005-12-19
申请人： SCHERING CORPORATION , THIRUVETTIPURAM, Thiruvengadam, K. , CHIU, John, S. , FU, Xiaoyong , MCALLISTER, Timothy, L.
发明人： THIRUVETTIPURAM, Thiruvengadam, K. , CHIU, John, S. , FU, Xiaoyong , MCALLISTER, Timothy, L.
IPC分类号： C07D205/08
CPC分类号： C07D205/08 , C07H17/02
摘要： A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a ß-(substituted-amino)amide, a ß-(substituted-amino)acid ester, or a ß-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl.
摘要翻译：提供了一种制备氮杂环丁酮的方法，所述氮杂环丁酮可用作半乳聚糖和低胆固醇血症药的合成中的中间体，包括使β-（取代 - 氨基）酰胺，β-（取代的 - 氨基）酸酯或β- 氨基）硫代碳酸酯与甲硅烷基化剂和选自碱金属羧酸盐，季铵羧酸盐，季铵氢氧化物，季铵醇盐，季铵氧化物及其水合物的环化剂，或其反应产物：（i ）至少一种季铵卤化物和至少一种碱金属羧酸盐; 或（ii）至少一种季铵氯化物，季铵溴化物或季铵碘化物和至少一种碱金属氟化物，其中环化剂的季铵部分是未取代的或被一至四个独立地选自由烷基，芳烷基和芳基烷基 - 烷基组成。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式