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2. 发明申请

WO1995008529A1 CHIRAL SURFACTANTS AND METHODS FOR THEIR USE IN CHIRAL SEPARATIONS 审中-公开
标题翻译： CHIRAL表面活性剂及其在CHIRAL分离中使用的方法
公开(公告)号：WO1995008529A1
公开(公告)日：1995-03-30
申请号：PCT/US1994010655
申请日：1994-09-20
申请人： WATERS CORPORATION , MAZZEO, Jeffrey, R. , GROVER, Edward, R. , SCHWARTZ, Michael, E. , MERION, Michael , PETERSEN, John, S.
发明人： WATERS CORPORATION
IPC分类号： C07C233/47
CPC分类号： C07C237/06 , B01F17/00 , C07B57/00 , C07C233/18 , C07C233/47 , C07C235/06 , C07C271/16 , C07C271/22 , C07C271/34 , C07C275/10 , C07C275/16 , C07C305/06 , C07C309/18 , C07C311/06 , C07C2601/14 , C07D207/16 , C07J41/0055
摘要： Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using micellar capillary electrophoresis is disclosed. A chiral surfactant having general formula (I) is described. R1 is the hydrophobic tail, Y-A-X is the linker, the brackets define a chiral center, and the hydrophilic head group is Z. All the various components may potentiate the enantioselectivity of the chiral surfactant. The capillary electrophoresis (CE) system includes a narrow diameter capillary, a high voltage power supply, an electrolyte reservoir at each end of the capillary, a means for injecting a sample, and a detector. Chiral surfactants are dissolved in the electrolyte above their critical micelle concentration (cmc), resulting in the formation of chiral micelles. The elecrolyte reservoirs and capillary tube are filled with the electrolyte. A sample containing a mixture of enantiomers is then injected into the capillary, and a high voltage potential is applied across the capillary. The sample components migrate through the capillary due to the influence of the applied electric field. An example separation of the four stereoisomers of aspartame is shown.
摘要翻译：公开了手性表面活性剂，它们的合成和使用方法，以及设计用于促进使用胶束毛细管电泳的手性分离的装置。描述了具有通式（I）的手性表面活性剂。 R1是疏水尾，Y-A-X是接头，支架定义手性中心，亲水性头基为Z。所有各种成分均可加强手性表面活性剂的对映体选择性。毛细管电泳（CE）系统包括窄直径毛细管，高压电源，毛细管两端的电解质储存器，注射样品的装置和检测器。手性表面活性剂溶解在电解质中高于其临界胶束浓度（cmc），导致手性胶束的形成。电解液储存器和毛细管充满电解液。然后将含有对映异构体混合物的样品注入毛细管中，并在毛细管上施加高电压电位。由于施加的电场的影响，样品组分迁移通过毛细管。示出了阿斯巴甜的四种立体异构体的实例分离。

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