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1. 发明申请

WO2010025961A2 COMPUTER IMPLEMENTED MODEL OF BIOLOGICAL NETWORKS 审中-公开
标题翻译：计算机实现生物网络的实现模型
公开(公告)号：WO2010025961A2
公开(公告)日：2010-03-11
申请号：PCT/EP2009/007223
申请日：2009-09-03
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN , LEHRACH, Hans , HERWIG, Ralf , WIERLING, Christoph
发明人： LEHRACH, Hans , HERWIG, Ralf , WIERLING, Christoph
IPC分类号： G06F19/00
CPC分类号： G06F19/12 , G06F17/10

2. 发明申请

WO2003076702A1 VERFAHREN ZUR HERSTELLUNG VON HOHLFASERN 审中-公开
标题翻译：用于生产中空纤维
公开(公告)号：WO2003076702A1
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002492
申请日：2003-03-11
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN , TRANSMIT GESELLSCHAFT FÜR TECHNOLOGIETRANSFER MBH , WEHRSPOHN, Ralf , NIELSCH, Kornelius , STEINHART, Martin , GREINER, Andreas , WENDORFF, Joachim
发明人： WEHRSPOHN, Ralf , NIELSCH, Kornelius , STEINHART, Martin , GREINER, Andreas , WENDORFF, Joachim
IPC分类号： D01D5/24
CPC分类号： B01D69/08 , B01D67/0069 , B01D67/0072 , B01D67/0081 , B01D69/081 , B01D69/12 , B01D71/022 , B01D71/28 , B01D71/34 , B01D71/36 , B01D71/40 , B01D71/52 , B01D2323/08 , B01D2323/24 , B01J2219/00781 , B82Y30/00 , D01D5/24 , H01M2300/0068
摘要： Die Erfindung betrifft ein Verfahren zur Herstellung von Hohlfasern, insbesondere zur Herstellung von Meso- und Nanoröhren, bei denen die Röhren oder Hohlfasern mit einem Innendurchmesser im Nano- bis Mikrometerbereich vorzugsweise in einer Richtung orientiert sind, sowie deren Verwendung. Gegenstand dieser Erfindung sind weiterhin die durch das Verfahren hergestellten Hohlfasern bzw. Röhren und diese enthaltende poröse Verbundmaterialien.
摘要翻译：本发明涉及一种用于制造中空纤维，特别是用于生产内消旋和纳米管，其中，管或中空纤维优选具有内径取向在纳米在一个方向到微米范围，并且它们的使用的方法。本发明还提供由该方法或管和含有这些复合多孔材料制备的中空纤维。

3. 发明申请

WO1997019181A3 VIRUS VECTOR FOR THE TRANSFER OF STABLE EPISOMES 审中-公开
公开(公告)号：WO1997019181A3
公开(公告)日：1997-05-29
申请号：PCT/DE1996002230
申请日：1996-11-15
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN , STRAUSS, Michael , SANDIG, Volker , GOTTHARDT, Michael , HOFMANN, Christian
发明人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN
IPC分类号： C12N15/86

4. 发明申请

WO2002064657A1 WÄSSRIGE POLYURETHANDISPERSION 审中-公开
标题翻译：水性聚氨酯分散体
公开(公告)号：WO2002064657A1
公开(公告)日：2002-08-22
申请号：PCT/EP2002/001029
申请日：2002-02-01
申请人： BASF AKTIENGESELLSCHAFT , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN , LICHT, Ulrike , ANTONIETTI, Markus , LANDFESTER, Katharina , TIARKS, Franca
发明人： LICHT, Ulrike , ANTONIETTI, Markus , LANDFESTER, Katharina , TIARKS, Franca
IPC分类号： C08G18/08
CPC分类号： C08J3/03 , C08G18/0861 , C08G18/3206 , C08G18/3215 , C08G18/48 , C08J2375/04 , C09D175/04
摘要： Die vorliegende Erfindung betrifft wässrige Primärdispersionen, die ein hydrophobes Polyurethan enthalten, welches in Miniemulsion durch Umsetzung von (a) Polyisocyanat und (b) Verbindungen mit Isocyanat-reaktiven Gruppen hergestellt wird. Ferner betrifft die Erfindung ein Verfahren zur Herstellung dieser Dispersionen sowie deren Verwendung für die Herstellung von Beschichtungen und Klebstoffen.
摘要翻译：本发明涉及含水含有其在微乳液通过（a）聚异氰酸酯和（b）的化合物具有异氰酸酯反应性基团产生的疏水性聚氨酯主分散体。此外，本发明涉及一种用于制备这些分散体以及它们用于生产涂料和粘合剂中的用途。

5. 发明申请

WO1998021225A1 HELICOBACTER POLYPEPTIDES AND CORRESPONDING POLYNUCLEOTIDE MOLECULES 审中-公开
标题翻译：呼吸道多肽和相应的多核苷酸分子
公开(公告)号：WO1998021225A1
公开(公告)日：1998-05-22
申请号：PCT/US1997021353
申请日：1997-11-14
申请人： MERIEUX ORAVAX SOCIETE EN NOM COLLECTIF PASTEUR MERIEUX SERUMS ET VACCINS S.A. , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN , HUMAN GENOME SCIENCES, INC.
发明人： MERIEUX ORAVAX SOCIETE EN NOM COLLECTIF PASTEUR MERIEUX SERUMS ET VACCINS S.A. , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN , HUMAN GENOME SCIENCES, INC. , HAAS, Rainer , KLEANTHOUS, Harold , TOMB, Jean-Francois , MILLER, Charles , AL-GARAWI, Amal , ODENBREIT, Stefan , MEYER, Thomas
IPC分类号： C07H21/02
CPC分类号： C07K16/121 , A61K38/00 , A61K39/00 , C07K14/205 , Y02A50/472
摘要： The invention provides Helicobacter polypeptides that can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
摘要翻译：本发明提供可用于预防或治疗幽门螺杆菌感染的疫苗接种方法中的幽门螺杆菌多肽，以及编码这些多肽的多核苷酸。

6. 发明申请

WO1995023965A1 REFERENCE ELECTRODE FOR ELECTROLYTIC CELLS HAVING A CATIONICALLY CONDUCTIVE SOLID ELECTROLYTE 审中-公开
标题翻译：参考电极用于与阳离子导电性固体电解质的原电池
公开(公告)号：WO1995023965A1
公开(公告)日：1995-09-08
申请号：PCT/EP1995000700
申请日：1995-02-27
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN, DE , NÄFE, Helfried , RETTIG, Dieter
发明人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN, DE
IPC分类号： G01N27/407
CPC分类号： G01N27/4076
摘要： The present invention concerns a reference electrode having a cationically conductive solid electrolyte, sensors comprising a reference electrode according to the invention, and the use of such sensors for analysing gases.
摘要翻译：本发明涉及一种具有阳离子导电性固体电解质传感器，包括根据本发明的参比电极，和用于气体的测定使用这种传感器的参比电极。

7. 发明申请

WO2010015421A1 USE OF CONKUNITZIN-S1 FOR THE MODULATION OF GLUCOSE-INDUCED INSULIN SECRETION 审中-公开
标题翻译：用于调节葡萄糖诱导的胰岛素分泌的康宁嗪-S1
公开(公告)号：WO2010015421A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/005801
申请日：2009-08-10
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN , UNIVERSITÄT ZU LÜBECK , TERLAU, Heinrich , FINOL-URDANETA, Rocio , BECKER, Stefan , RAASCH, Walter
发明人： TERLAU, Heinrich , FINOL-URDANETA, Rocio , BECKER, Stefan , RAASCH, Walter
IPC分类号： C07K14/435
CPC分类号： C07K14/43504 , C07K14/8114
摘要： The present invention relates to a (poly)peptide or a peptidomimetic thereof having the biological activity of Conkunitzin-S1, wherein said (poly)peptide is selected from (a) a polypeptide comprising or having the amino acid sequence of SEQ ID NO: 1; (b) a polypeptide having at least 85% sequence identity to SEQ ID NO:1; or (c) a fragment of a) or b); wherein said (poly)peptide or peptidomimetic specifically modulates the activity of a channel having the activity of a Kv1.7 containing channel, for the treatment or prevention of metabolic diseases or conditions, or secondary diseases or conditions related to said metabolic diseases or conditions. The present invention furthermore relates to a method of screening for (poly)peptides derived from Conkunitzin-S1 suitable for specifically modulating the activity of a channel having the activity of a Kv1.7 containing channel, comprising: (a) altering the amino acid sequence of Conkunitzin-S1 represented by SEQ ID NO: 1 by deleting and/or inserting and/or replacing at least one amino acid; and (b) determining the modulatory effect of the (poly)peptide obtained in step (a) (i) on a channel having the activity of a Kv1.7 containing channel and (ii) on channels, preferably potassium channels, not having the activity of a Kv1.7 containing channel, which are optionally expressed on the same cell as the channel having the activity of a Kv1.7 containing channel; wherein a modulatory effect of the (poly)peptide determined in step (i) that is at least 50% of the modulatory effect of Conkunitzin-S1 indicates that the (poly)peptide re suitable for modulating the activity of said channel having the activity of a Kv1.7 containing channel; and wherein the determination of essentially no modulatory effect in step (ii) indicates that the (poly)peptide is specifically modulating the activity of channels having the activity of a Kv1.7 containing channel.
摘要翻译：本发明涉及具有Conkunitzin-S1生物活性的（多）肽或其肽模拟物，其中所述（多）肽选自（a）包含或具有SEQ ID NO：1的氨基酸序列的多肽 ; （b）与SEQ ID NO：1具有至少85％序列同一性的多肽; 或（c）a）或b）的片段; 其中所述（多）肽或肽模拟物特异性调节具有Kv1.7含有通道活性的通道的活性，用于治疗或预防代谢疾病或病症，或与所述代谢疾病或病症有关的继发性疾病或病症。本发明还涉及一种筛选衍生自Conkunitzin-S1的（多）肽的方法，其适用于特异性调节含有Kv1.7含有通道活性的通道的活性，其包括：（a）改变氨基酸序列通过删除和/或插入和/或替换至少一个氨基酸的由SEQ ID NO：1表示的Conkunitzin-S1; （b）确定步骤（a）（i）中获得的（多）肽对具有Kv1.7含有通道活性的通道的调节作用，和（ii）在不具有含有Kv1.7的通道的活性，其任选地在与具有含有Kv1.7的通道的活性的通道相同的细胞上表达; 其中在步骤（i）中测定的所述（多）肽的调节作用是Conkunitzin-S1的调节作用的至少50％，这表明（多）肽适合于调节具有活性的所述通道的活性包含Kv1.7通道; 并且其中在步骤（ii）中基本上没有调节作用的测定表明（多）肽特异性调节具有含有Kv1.7的通道的活性的通道的活性。

8. 发明申请

WO2009124776A1 A TEST SYSTEM FOR DETECTING INTRACELLULAR CYCLIC NUCLEOTIDE LEVEL AND METHODS AND USES THEREOF 审中-公开
标题翻译：用于检测细胞核循环核酸水平的测试系统及其方法及其用途
公开(公告)号：WO2009124776A1
公开(公告)日：2009-10-15
申请号：PCT/EP2009/002679
申请日：2009-04-09
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. BERLIN , WICHER, Dieter , HANSSON, Bill
发明人： WICHER, Dieter , HANSSON, Bill
IPC分类号： G01N33/50 , G01N33/566
CPC分类号： G01N33/6872 , G01N2500/10
摘要： The present invention relates to a test system for detecting a cyclic nucleotide, the test system comprising (i) a cell comprising an insect cyclic nucleotide-activated ion channel protein or a derivative thereof and (ii) means for detecting the activity of the ion channel protein, methods for detecting a change of an intracellular cyclic nucleotide level, methods of identifying an agent capable of modifying an intracellular cyclic nucleotide level, a kit comprising the cell or means for producing the cell and means for detecting activity and the use of the test system for detecting a change of an intracellular cyclic nucleotide level or for identifying an agent capable of modifying intracellular cyclic nucleotide level.
摘要翻译：本发明涉及一种用于检测环状核苷酸的测试系统，该测试系统包括（i）包含昆虫环状核苷酸活化的离子通道蛋白或其衍生物的细胞和（ii）用于检测离子通道的活性的方法蛋白质，检测细胞内环核苷酸水平变化的方法，鉴定能够修饰细胞内环核苷酸水平的试剂的方法，包含该细胞的试剂盒或用于产生该细胞的装置以及用于检测活性的方法和使用该试验用于检测细胞内环核苷酸水平的变化或用于鉴定能够修饰细胞内环核苷酸水平的试剂的系统。

9. 发明公开

EP2835135A2 Means and methods for treating pseudomonas infection 审中-公开
标题翻译：治疗假单胞菌感染的手段和方法
公开(公告)号：EP2835135A2
公开(公告)日：2015-02-11
申请号：EP14172834.5
申请日：2014-06-17
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： Grossmann, Tom N. , Ottmann, Christian , Glas, Adrian , Bier, David
IPC分类号： A61K38/16 , A61P31/04
CPC分类号： A61K38/164
摘要： The present invention relates to a peptide or depsipeptide of formula (I)

(Y) k X 1 YZ 1 X 2 Z 2 (Y) m (I),

wherein X 1 is an α-amino acid residue or an α-hydroxy acid residue of formula (IIa)

-A-CR 1 R 2 -CO- (IIa),

X 2 is an α-amino acid residue or an α-hydroxy acid residue of formula (IIb)

-A-CR 3 R 4 -CO- (IIb),

wherein A is NH or O; R 1 and R 3 are independently selected from H, halogen such as F, substituted or unsubstituted C 1 to C 4 alkyl such as methyl, substituted or unsubstituted aryl and substituted or unsubstituted arylalkyl, aryl being a 5- or 6-membered ring with 0, 1, 2 or 3 heteroatoms, heteroatoms being selected from O, N and S, alkyl in said arylalkyl being C 1 to C 4 alkyl, said alkyl in said arylalkyl optionally being substituted, the term "substituted", when relating to R 1 and R 3 , providing for, as valence permits, 1, 2, 3, 4, 5, 6, 7 or 8 substituents, said substituents being chosen from halogen such as F; R 2 and R 4 together are chosen to be substituted or unsubstituted n-alk-1,ω-diyl or substituted or unsubstituted n-alken-1,ω-diyl, ω being an integer number selected from 6, 7, 8, 9, 10, 11, 12, 13 and 14, the term "substituted", when relating to R 2 and R 4 , providing for 1 or 2, in case of the substituents being halogen 1, 2, 3, 4, 5, 6, 7 or 8 substituents, said substituents being chosen from halogen such as F and C 1 to C 4 alkyl such as methyl, said C 1 to C 4 alkyl in turn optionally being substituted with, as valence permits, 1, 2, 3, 4, 5, 6, 7 or 8 substituents, said substituents being chosen from halogen such as F, and the double bond in said n-alken-1,ω-diyl being at any one of positions 1, 2, 3, 4,... and (ω-1); each occurrence of Y is independently selected to be an α-amino acid or α-hydroxy acid; k is an integer number selected from 0, 1, 2, 3, 4, 5, 6 and 7; m is an integer number selected from 1, 2, 3 and 4; Z 1 is a polar or negatively charged α-amino acid or α-hydroxy acid; and Z 2 is a an aliphatic hydrophobic α-amino acid or α-hydroxy acid; the N-terminus of said peptide or depsipeptide is free; protected, preferably acetylated; or conjugated, preferably to a cell-penetrating peptide or a lipid; and the C-terminus of said peptide or depsipeptide is free; protected, preferably amidated; or conjugated, preferably to a cell-penetrating peptide or a lipid.
摘要翻译：本发明涉及式（I）（Y）kX1YZ1X2Z2（Y）m（I）的肽或缩肽，其中X1是式（IIa）-A- （IIb）-A-CR 3 R 4 -CO-（IIb）的α-氨基酸残基或α-羟基酸残基，其中A是NH或O; R1和R3独立地选自H，卤素如F，取代或未取代的C1至C4烷基如甲基，取代或未取代的芳基和取代或未取代的芳基烷基，芳基为与0,1或2元连接的5元或6元环， 2或3个杂原子，杂原子选自O，N和S，所述芳基烷基中的烷基为C 1 -C 4烷基，所述芳基烷基中的所述烷基任选被取代，当涉及R 1和R 3时，术语“取代的” 作为化合价允许有1,2,3,4,5,6,7或8个取代基，所述取代基选自卤素如F; R2和R4一起被选择为取代或未取代的n-烷基-1，ω-二基或取代或未取代的n-链烯-1，ω-二基，ω是选自6,7,8,9,10的整数，11,12,13和14中，当涉及R2和R4时，术语“取代的”提供1或2，在取代基为卤素1,2,3,4,5,6,7或8的情况下取代基，所述取代基选自卤素如F和C1-C4烷基如甲基，所述C1-C4烷基进而任选地被1,2,3或4个取代基取代， 8个取代基，所述取代基选自卤素如F，并且所述正链烯-1，ω-二基中的双键位于1,2,3,4，...和（ω-1））; 每次出现的Y独立地选择为α-氨基酸或α-羟基酸; k是选自0,1,2,3,4,5,6和7的整数; m是选自1,2,3和4的整数; Z1是极性或带负电荷的α-氨基酸或α-羟基酸; Z2是脂肪族疏水性α-氨基酸或α-羟基酸; 所述肽或缩肽的N-末端是游离的; 保护的，优选乙酰化的; 或缀合的，优选地与细胞穿透肽或脂质偶联; 并且所述肽或缩肽的C末端是游离的; 受保护的，优选酰胺化的; 或缀合的，优选地与细胞穿透肽或脂质缀合。

10. 发明公开

EP1599497A2 CRYSTAL STRUCTURE OF THE TERNARY COMPELEX OF 14-3-3, FUSICOCCIN, AND PLASMA MEMBRANE ATPASE AND METHODS FOR DESIGNING NEW HERBICIDES 有权
标题翻译： 14-3-3，fusicoccin和质膜ATP酶和方法的三元复合物的晶体结构来设计新型除草剂
公开(公告)号：EP1599497A2
公开(公告)日：2005-11-30
申请号：EP04714780.6
申请日：2004-02-26
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： WITTINGHOFER, Alfred , WÜRTELE, Martin , OECKING, Claudia , JELICH-OTTMANN, Christian
IPC分类号： C07K14/415 , C12N15/29 , A01H5/00
CPC分类号： C07K14/415 , C07K2299/00
摘要： The present invention relates to a crystal of a ternary complex composed of the protein 14-3-3, a ligand thereof and a fragment of Plasma Membrane ATPase (PMA) comprising the coordinates of table 4 or coordinates which differ from the coordinates of table 4 by a root mean square deviation of the C-alpha atoms of less than 3 Angstrom, wherein (a) protein 14-3-3 consists of the amino acid sequence of SEQ ID NO: 1 or of the sequence of a species homolog; (b) the ligand is Fusicoccin; (c) PMA is a C-terminal peptide of up to 15 amino acid residues in 'length; comprising the amino acid sequence of SEQ ID NO: 2 or comprising the sequence of a species homolog. Moreover, the invention also relates to methods for obtaining crystals of 14-3-3 in ternary complex and to methods relating to the determination of said 14-3-3 crystal coordinates. In addition, the present invention relates to computer modeling of crystal coordinates, to methods for developing a ligand binding to the complex of protein 14-3-3 and PMA and to methods for identifying a potential ligand to the complex of 14-3-3 and PMA. Furthermore, the present invention relates to a method for identifying and selecting a protein or protein complex with increased affinity to a ligand, to nucleic acid molecules encoding PMA or 14-3-3 with decreased affinity to a ligand and to methods of generating transgenic plants encoding PMA or 14-3-3 with decreased affinity to said ligand. Finally, the present invention relates to a device for developing a ligand for the complex of PMA and 14-3-3 and to the use of said device.

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