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1. 发明申请

WO2002101359A2 INTEGRATED BLOOD SAMPLING ANALYSIS SYSTEM WITH MULTI-USE SAMPLING MODULE 审中-公开
标题翻译：具有多用途采样模块的综合血液采样分析系统
公开(公告)号：WO2002101359A2
公开(公告)日：2002-12-19
申请号：PCT/US2002/019059
申请日：2002-06-12
申请人： PELIKAN TECHNOLOGIES, INC. , BOECKER, Dirk , FREEMAN, Dominique, M. , MAUZE, Ganapati
发明人： BOECKER, Dirk , FREEMAN, Dominique, M. , MAUZE, Ganapati
IPC分类号： G01N
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/150022 , A61B5/150412 , A61B5/150503 , A61B5/15087 , A61B5/15113 , A61B5/15123 , A61B5/15151 , A61B5/15163 , A61B5/15176 , G01N15/06 , G01N33/49 , G01N2015/0065 , G01N2015/0693 , G01N2035/00891
摘要： A simple, miniaturized, disposable acquisition and test module for monitoring glucose or other analytes successively for multiple times is described. The apparatus is designed to collect and test small volumes of blood in a single step. Many samples can be acquired and analyzed using a single disposable sampling module, minimizing the number of disposables and improving ease of use of the system.
摘要翻译：描述了一种用于多次连续监测葡萄糖或其他分析物的简单，小型化的一次性采集和测试模块。该装置被设计成在一个步骤中收集和测试小体积的血液。可以使用单个一次性取样模块获取和分析许多样品，从而最大限度地减少一次性物品的数量并提高系统的易用性。

2. 发明申请

WO2005006939A3 METHOD AND APPARATUS FOR BODY FLUID SAMPLING AND ANALYTE SENSING 审中-公开
标题翻译：用于体液采样和分析仪感测的方法和装置
公开(公告)号：WO2005006939A3
公开(公告)日：2005-03-31
申请号：PCT/US2004019125
申请日：2004-06-14
申请人： PELIKAN TECHNOLOGIES INC , BRIGGS BARRY DEAN , SHULTE TOM , ALDEN DON , ROSS JAMES , MAUZE GANAPATI , FREEMAN DOMINIQUE M
发明人： BRIGGS BARRY DEAN , SHULTE TOM , ALDEN DON , ROSS JAMES , MAUZE GANAPATI , FREEMAN DOMINIQUE M
IPC分类号： A61B20060101 , A61B5/00 , A61B5/15 , B65D33/00 , B65D81/00
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150274 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/150786 , A61B5/150824 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15128 , A61B5/15132 , A61B5/15146 , A61B5/15151 , A61B5/15161 , A61B5/15163 , A61B5/15176 , A61B5/15182 , A61B5/15186 , A61B17/32093
摘要： The method comprises providing a lancing device comprising a penetrating member (68) driver having a position sensor (74) and a processor (60) that can determine the relative position and velocity of the penetrating member (18,72) based on measuring relative position of the penetrating member with respect to time; providing a predetermined velocity control trajectory based on a model of the driver (68) and a model of tissue to be contacted. Furthermore, a feedforward control is able to maintain penetrating member velocity along the trajectory.
摘要翻译：该方法包括提供一种穿刺装置，其包括具有位置传感器（74）和处理器（60）的穿透构件（68）驱动器，该处理器可基于测量相对位置确定穿透构件（18,72）的相对位置和速度穿透成员的时间; 基于所述驱动器（68）的模型和待接触的组织的模型提供预定的速度控制轨迹。此外，前馈控制能够沿着轨迹保持穿透构件的速度。

3. 发明申请

WO2005120199A3 METHODS AND APPARATUS FOR AN INTEGRATED SAMPLE CAPTURE AND ANALYSIS DISPOSABLE 审中-公开
标题翻译：用于集成样本捕获和分析的方法和装置
公开(公告)号：WO2005120199A3
公开(公告)日：2006-08-17
申请号：PCT/US2005019590
申请日：2005-06-03
申请人： PELIKAN TECHNOLOGIES INC , MAUZE GANAPATI , LUM PAUL , DESHMUKH AJAY , MARSOT TRAVIS , BOECKER DIRK , FREEMAN DOMINIQUE M , ALDEN DON , CANE MICHAEL , SCHUMANN MATT , ROSS JAMES
发明人： MAUZE GANAPATI , LUM PAUL , DESHMUKH AJAY , MARSOT TRAVIS , BOECKER DIRK , FREEMAN DOMINIQUE M , ALDEN DON , CANE MICHAEL , SCHUMANN MATT , ROSS JAMES
IPC分类号： A61B5/00 , A61B5/15 , A61B5/155 , A61B17/14 , A61B17/32 , B65D81/00
CPC分类号： A61B5/15176 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15161 , A61B5/157
摘要： Methods and apparatus are provided for an analyte detecting device. In one embodiment, the device comprises a cartridge having a plurality of cavities; and a plurality of penetrating members at least partially contained in the cavities of the single cartridge wherein the penetrating members are slidably movable to extend outward from lateral openings on the cartridge to penetrate tissue. The device may also include a sterility barrier coupled to the cartridge, the sterility barrier covering a plurality of the lateral openings, wherein the sterility barrier covering the lateral openings is configured to be moved so that a penetrating member exits the lateral opening without contacting the barrier; a plurality of analyte detecting members coupled to an underside of the cartridge; and a plurality of sample capture devices, the sample capture devices each having a vertical portion and a horizontal portion, the vertical portion having a opening therethrough to allow a penetrating member to pass through.
摘要翻译：为分析物检测装置提供方法和装置。在一个实施例中，该装置包括具有多个空腔的盒; 以及多个穿透构件，其至少部分地容纳在单个筒的空腔中，其中穿透构件可滑动地移动以从筒上的侧向开口向外延伸以穿透组织。该装置还可以包括耦合到盒的无菌屏障，覆盖多个侧向开口的无菌屏障，其中覆盖侧向开口的无菌屏障构造成移动，使得穿透构件离开侧向开口而不接触屏障 ; 耦合到所述盒的下侧的多个分析物检测构件; 以及多个样本捕获装置，所述样本捕获装置各自具有垂直部分和水平部分，所述垂直部分具有穿过其中的开口以允许穿透构件通过。

4. 发明申请

WO2005065415A3 BODY FLUID SAMPLING DEVICE WITH CONDUCTIVE MEDIA 审中-公开
标题翻译：具有导电介质的身体液体采样装置
公开(公告)号：WO2005065415A3
公开(公告)日：2006-03-30
申请号：PCT/US2004044055
申请日：2004-12-31
申请人： PELIKAN TECHNOLOGIES INC , LUM PAUL , MAUZE GANAPATI , MARSOT TRAVIS
发明人： LUM PAUL , MAUZE GANAPATI , MARSOT TRAVIS
IPC分类号： A61B5/15 , A61B5/00
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15161 , A61B5/15176
摘要： A body fluid sampling device (230) includes a set of pins (310) that obviate the need for leads from the disposable device. The pins (310) may be integrated into the tissue penetrating device. The pins are inserted into the printed electrochemical electrodes (300) and are reusable. In one embodiment, the device (400) includes a support structure (412, 600), a sensory material (414, 540) on one side of the support structure, and a conductor material (416, 550) on an opposite side of the support structure. A plurality of holes (418)in the support structure allow the sensory material to contact the conductor material.
摘要翻译：体液采样装置（230）包括一组销（310），其消除了对来自一次性装置的引线的需要。销（310）可以集成到组织穿透装置中。引脚插入印刷的电化学电极（300）中并且是可重复使用的。在一个实施例中，装置（400）包括在支撑结构的一侧上的支撑结构（412,600），感觉材料（414,540）和位于所述支撑结构的相对侧上的导体材料（416,550）支撑结构。支撑结构中的多个孔（418）允许感官材料接触导体材料。

5. 发明申请

WO2005120197A3 TISSUE INTERFACE ON A FLUID SAMPLING DEVICE 审中-公开
公开(公告)号：WO2005120197A3
公开(公告)日：2005-12-22
申请号：PCT/US2005/019512
申请日：2005-06-03
申请人： PELIKAN TECHNOLOGIES, INC. , DESHMUKH, Ajay , HEGENER, Jason, H. , MAUZE, Ganapati , VON DUERING, Monika, U. , FREEMAN, Dominique, M.
发明人： DESHMUKH, Ajay , HEGENER, Jason, H. , MAUZE, Ganapati , VON DUERING, Monika, U. , FREEMAN, Dominique, M.
IPC分类号： A61B17/14
摘要： Methods and apparatus are provided for an analyte detecting device. In one embodiment, the apparatus for assisting fluid sampling comprising a tissue interface having a tissue interface surface. The surface is shaped to provide pressure on the tissue, except at one location. The tissue interface may be made of a pliable material. The tissue interface may apply an even amount of pressure to the tissue that is engaged to facilitate fluid sampling.

6. 发明申请

WO2003088851A1 TISSUE PENETRATION DEVICE 审中-公开
标题翻译：组织渗透装置
公开(公告)号：WO2003088851A1
公开(公告)日：2003-10-30
申请号：PCT/US2002/019180
申请日：2002-06-12
申请人： PELIKAN TECHNOLOGIES, INC. , FREEMAN, Ray , GOGUE, George , FREEMAN, Dominique, M. , BOECKER, Dirk , ALDEN, Don , BRIGGS, Barry, Dean , LEONARD, John, Hewitt , LUM, Paul , VERDONK, Edward , MAUZE, Ganapati, Ramanth , STAWITCKE, Frederick , PITTARO, Rick , TEMPLIN, Catherine , LEONARD, Leslie, Ann , DRBAL, Vladimir
发明人： FREEMAN, Ray , GOGUE, George , FREEMAN, Dominique, M. , BOECKER, Dirk , ALDEN, Don , BRIGGS, Barry, Dean , LEONARD, John, Hewitt , LUM, Paul , VERDONK, Edward , MAUZE, Ganapati, Ramanth , STAWITCKE, Frederick , PITTARO, Rick , TEMPLIN, Catherine , LEONARD, Leslie, Ann , DRBAL, Vladimir
IPC分类号： A61B17/14
CPC分类号： A61B5/15178 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150061 , A61B5/150068 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/151 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15153 , A61B5/15169 , A61B5/15171 , A61B5/15174 , A61B5/15176 , A61B5/15184 , A61B5/15186 , A61B5/157 , A61B17/32093 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905 , G01N33/557
摘要： A tissue penetration device and method of using same. The tissue penetration device may optionally include sampling and analyzing functions, which may be integrated. An embodiment provides control of a lancet (24,183) used for sampling blood. Electric field coils or solenoids (20,30) may drive the lancet (24,183) using electromagnetic force. Advancement and retraction of a lancet (24,183) may be controlled by a feedback loop monitoring the position and velocity of the lancet (24,183) embodiments of the lancet driver (48) can be configured to follow a predetermined tissue lancing profile. Embodiments of the invention include a lancet (24,183) and method for using a lancet (24,183) to maintain the patency of the wound tract once the lancet (24,183) has cut into the skin.
摘要翻译：组织穿透装置及其使用方法。组织穿透装置可以可选地包括可以集成的取样和分析功能。实施例提供了用于对血液进行取样的刺血针（24,183）的控制。电磁线圈或螺线管（20,30）可以使用电磁力驱动柳叶刀（24,183）。刺血针（24,183）的前进和缩回可以通过监测柳叶刀（24,183）的位置和速度的反馈回路来控制，所述刺血针（24,183）的实施例可被配置为遵循预定的组织牵线轮廓。本发明的实施例包括柳叶刀（24,183）和柳叶刀（24,183）一旦柳叶刀（24,183）已经切入皮肤中时使用刺血针（24,183）来维持伤口的通畅的方法。

7. 发明申请

WO2005120199A2 METHODS AND APPARATUS FOR AN INTEGRATED SAMPLE CAPTURE AND ANALYSIS DISPOSABLE 审中-公开
标题翻译：用于集成样本捕获和分析的方法和装置
公开(公告)号：WO2005120199A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/019590
申请日：2005-06-03
申请人： PELIKAN TECHNOLOGIES, INC. , MAUZE, Ganapati , LUM, Paul , DESHMUKH, Ajay , MARSOT, Travis , BOECKER, Dirk , FREEMAN, Dominique, M. , ALDEN, Don , CANE, Michael , SCHUMANN, Matt , ROSS, James
发明人： MAUZE, Ganapati , LUM, Paul , DESHMUKH, Ajay , MARSOT, Travis , BOECKER, Dirk , FREEMAN, Dominique, M. , ALDEN, Don , CANE, Michael , SCHUMANN, Matt , ROSS, James
IPC分类号： A61B5/00 , A61B5/15 , A61B5/155
CPC分类号： A61B5/15176 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15161 , A61B5/157
摘要： Methods and apparatus are provided for an analyte detecting device. In one embodiment, the device comprises a cartridge having a plurality of cavities; and a plurality of penetrating members at least partially contained in the cavities of the single cartridge wherein the penetrating members are slidably movable to extend outward from lateral openings on the cartridge to penetrate tissue. The device may also include a sterility barrier coupled to the cartridge, the sterility barrier covering a plurality of the lateral openings, wherein the sterility barrier covering the lateral openings is configured to be moved so that a penetrating member exits the lateral opening without contacting the barrier; a plurality of analyte detecting members coupled to an underside of the cartridge; and a plurality of sample capture devices, the sample capture devices each having a vertical portion and a horizontal portion, the vertical portion having a opening therethrough to allow a penetrating member to pass through.
摘要翻译：为分析物检测装置提供方法和装置。在一个实施例中，该装置包括具有多个空腔的盒; 以及多个穿透构件，其至少部分地容纳在单个筒的空腔中，其中穿透构件可滑动地移动以从筒上的侧向开口向外延伸以穿透组织。该装置还可以包括耦合到盒的无菌屏障，覆盖多个侧向开口的无菌屏障，其中覆盖侧向开口的无菌屏障构造成移动，使得穿透构件离开侧向开口而不接触屏障 ; 耦合到所述盒的下侧的多个分析物检测构件; 以及多个样本捕获装置，所述样本捕获装置各自具有垂直部分和水平部分，所述垂直部分具有穿过其中的开口以允许穿透构件通过。

8. 发明申请

WO2005065415A2 METHOD AND APPARATUS FOR CONNECTING CONDUCTIVE MEDIA 审中-公开
标题翻译：用于连接导电介质的方法和装置
公开(公告)号：WO2005065415A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/044055
申请日：2004-12-31
申请人： PELIKAN TECHNOLOGIES, INC. , LUM, Paul , MAUZE, Ganapati , MARSOT, Travis
发明人： LUM, Paul , MAUZE, Ganapati , MARSOT, Travis
IPC分类号： A61B5/15
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15161 , A61B5/15176
摘要： A body fluid sampling device is provided. In one embodiment, the invention comprises a set of pins that obviate the need for leads from the disposable device. The pins may be integrated into the tissue penetrating device. The pins are inserted into the printed electrochemical electrodes and are reusable. The disposable chemistry is simplified in the process. The use of the simplified disposable in an integrated sampling device also creates a potential for miniaturization. In another embodiment, the device comprises a support structure. The device includes sensory material is on a first side of said support structure and a conductor material on a second side of said support structure. A plurality of holes defined by the support structure may be used. The hole allows the conductor material to Contact the sensory material. In yet another embodiment, the invention teaches a design and method of providing conduction lines originating from a sensor on one side of the substrate and terminating in such a way that they are accessible from the reverse side.
摘要翻译：提供体液取样装置。在一个实施例中，本发明包括一组销，其消除了对来自一次性装置的引线的需要。销可以集成到组织穿透装置中。引脚插入到印刷的电化学电极中并且是可重复使用的。一次性化学品在此过程中被简化。在集成采样装置中使用简化的一次性也产生了小型化的潜力。在另一个实施例中，该装置包括支撑结构。所述装置包括在所述支撑结构的第一侧上的感觉材料和在所述支撑结构的第二侧上的导体材料。可以使用由支撑结构限定的多个孔。该孔允许导体材料接触感官材料。在另一个实施例中，本发明教导了一种设计和方法，该设计和方法提供了源自基板一侧的传感器的导线，并以这样一种方式终止，使得它们可从反面接近。

9. 发明申请

WO2004112602A1 METHOD AND APPARATUS FOR A POINT OF CARE DEVICE 审中-公开
标题翻译：一种护理装置的方法和装置
公开(公告)号：WO2004112602A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/019129
申请日：2004-06-14
申请人： PELIKAN TECHNOLOGIES, INC. , FREEMAN, Dominique, M , BOECKER, Dirk , ALDEN, Don , MAUZE, Ganapati
发明人： FREEMAN, Dominique, M , BOECKER, Dirk , ALDEN, Don , MAUZE, Ganapati
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150755 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15161
摘要： A plurality of Point-of-Care (POC) tests on a single cartridge (300) is provided such that sequential or nonsequential tests may be performed in an integrated fashion without changing the test cartridge. Each cartridge can contain a penetrating member sensor (302) combination in a radial disk format, interrogated and read by a single illumination/detection device. Alternatively a series of tests can be measured electrochemically and reported. Only those tests, which are required at the time, the sample is taken need to be reported, though all tests are carried out.
摘要翻译：提供在单个盒（300）上的多个点护理（POC）测试，使得可以以集成的方式执行顺序或非顺序测试而不改变测试盒。每个筒可以包含径向盘格式的穿透构件传感器（302）组合，被单个照明/检测装置询问和读取。或者，可以电化学测量并报告一系列测试。只有当时所需的那些测试需要报告，尽管进行了所有测试。

10. 发明申请

WO2004072164A3 REDUCTION OF RADIATION DAMAGE TO POLYMERS 审中-公开
标题翻译：降低对聚合物的辐射损伤
公开(公告)号：WO2004072164A3
公开(公告)日：2004-11-11
申请号：PCT/US2004003594
申请日：2004-02-06
申请人： ARADIGM CORP , MAUZE GANAPATI , TRILOKEKAR NIKHIL
发明人： MAUZE GANAPATI , TRILOKEKAR NIKHIL
IPC分类号： B32B27/08 , B65B55/08 , B65B55/16 , C08J3/28 , A61J1/05 , A61J1/10 , C08J7/00
CPC分类号： B65B55/08 , B32B27/08 , B65B55/16 , C08J3/28 , Y10T428/1352 , Y10T428/2809 , Y10T428/3154
摘要： A film resistant to degradation caused by sterilising radiation is made. The film is made by minimizing the production of free radicals in the polymer (2 in Figure) during sterilization via the use of inert gas and reactant scavenger (6 and 8 in Figure), both within a sterilizable pouch. The scavengers can be acid adsorbents that react after sterilization. The films retain their physical and mechanical properties during storage and are useful for packaging pharmaceutical, food, semiconductor and medical products.
摘要翻译：制成耐消毒辐射引起的退化的膜。通过使用惰性气体和反应物清除剂（图中的6和8），在灭菌袋内，最小化灭菌过程中聚合物（图2中）自由基的产生。清除剂可以是灭菌后反应的酸吸附剂。这些胶片在储存期间保持其物理和机械性能，并且可用于包装药物，食品，半导体和医疗产品。

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