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1. 发明申请

WO2005105732A8 SUBSTITUTED METHYL ARYL OR HETEROARYL AMIDE COMPOUNDS 审中-公开
标题翻译：取代的甲基或芳基化合物
公开(公告)号：WO2005105732A8
公开(公告)日：2007-04-19
申请号：PCT/IB2005001134
申请日：2005-04-22
申请人： PFIZER JAPAN INC , PFIZER , KOIKE HIROKI , MATSUMOTO YUKARI , YAMAGISHI TATSUYA , KON-I KANA , OKUMURA YOSHIYUKI , NAKAO KAZUNARI
发明人： KOIKE HIROKI , MATSUMOTO YUKARI , YAMAGISHI TATSUYA , KON-I KANA , OKUMURA YOSHIYUKI , NAKAO KAZUNARI
IPC分类号： C07C235/42 , A61K31/195 , A61K31/455 , C07C235/46 , C07C235/70 , C07D213/56 , C07D213/65 , C07D213/74 , C07D213/82 , C07D213/89
CPC分类号： C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要： This invention provides a compound of the formula (I), wherein X represents a carbon atom or the like: Y represents imino, or the like: R 1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R 2 and R 3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）化合物，其中X表示碳原子等：Y表示亚氨基等：R 1表示具有1至6个碳原子的烷基 R 2，R 3和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

2. 发明申请

WO2006134486A3 ALPHA-(ARYL-OR HETEROARYL-METHYL)-BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为ORL1受体拮抗剂的ALPHA-（芳基或异丁基 - 甲基）-BETA哌啶丙酰胺化合物
公开(公告)号：WO2006134486A3
公开(公告)日：2007-02-22
申请号：PCT/IB2006001642
申请日：2006-06-09
申请人： PFIZER JAPAN INC , PFIZER , HASHIZUME YOSHINOBU , HIROTA MASAKO , KOIKE HIROKI , MATSUMOTO YUKARI , MIHARA SACHIKO , NAKAMURA HIROSHI
发明人： HASHIZUME YOSHINOBU , HIROTA MASAKO , KOIKE HIROKI , MATSUMOTO YUKARI , MIHARA SACHIKO , NAKAMURA HIROSHI
IPC分类号： C07D451/06 , A61K31/46 , A61P25/04
CPC分类号： C07D451/06
摘要： This invention provides the compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 independently represent hydrogen or the like; R 3 and R 4 independently represents hydrogen or the like; R 5 represents aryl or the like; -X-Y- represents -CH 2 O- or the like; and n represents 0, 1 or 2.These compounds have ORL1 -receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R 1和R 2独立代表氢或类似物; R 3和R 4独立地表示氢等; R 5表示芳基等; -X-Y-表示-CH 2 O-等; 并且n代表0,1或2.这些化合物具有ORL1-受体拮抗剂活性; 因此，可用于治疗诸如疼痛，各种CNS疾病等疾病或病症。

3. 发明申请

WO2006134486A2 ALPHA-(ARYL-OR HETEROARYL-METHYL)-BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为ORL1受体拮抗剂的ALPHA-（芳基或异丁基 - 甲基）-BETA哌啶丙酰胺化合物
公开(公告)号：WO2006134486A2
公开(公告)日：2006-12-21
申请号：PCT/IB2006/001642
申请日：2006-06-09
申请人： PFIZER JAPAN INC. , PFIZER INC. , HASHIZUME, Yoshinobu , HIROTA, Masako , KOIKE, Hiroki , MATSUMOTO, Yukari , MIHARA, Sachiko , NAKAMURA, Hiroshi
发明人： HASHIZUME, Yoshinobu , HIROTA, Masako , KOIKE, Hiroki , MATSUMOTO, Yukari , MIHARA, Sachiko , NAKAMURA, Hiroshi
IPC分类号： C07D451/06 , A61K31/46 , A61P25/04
CPC分类号： C07D451/06
摘要： This invention provides the compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 independently represent hydrogen or the like; R 3 and R 4 independently represents hydrogen or the like; R 5 represents aryl or the like; -X-Y- represents -CH 2 O- or the like; and n represents 0, 1 or 2.These compounds have ORL1 -receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R 1和R 2独立代表氢或类似物; R 3和R 4独立地表示氢等; R 5表示芳基等; -X-Y-表示-CH 2 O-等; 并且n代表0,1或2.这些化合物具有ORL1-受体拮抗剂活性; 因此，可用于治疗诸如疼痛，各种CNS疾病等疾病或病症。

4. 发明申请

WO2006134485A1 ALPHA-(ARYL-OR HETEROARYL-METHYL)-BETA-PIPERIDINOPROPANOIC ACID COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为ORL1受体拮抗剂的ALPHA-（芳基或杂芳基 - 甲基） - 哌嗪 - 哌嗪二磷酸化合物
公开(公告)号：WO2006134485A1
公开(公告)日：2006-12-21
申请号：PCT/IB2006/001624
申请日：2006-06-08
申请人： PFIZER JAPAN INC. , PFIZER INC. , HASHIZUME, Yoshinobu , HIROTA, Masako , KOIKE, Hiroki , MATSUMOTO, Yukari , MIHARA, Sachiko , NAKAMURA, Hiroshi
发明人： HASHIZUME, Yoshinobu , HIROTA, Masako , KOIKE, Hiroki , MATSUMOTO, Yukari , MIHARA, Sachiko , NAKAMURA, Hiroshi
IPC分类号： C07D491/10 , A61K31/343
摘要： This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester or salt thereof, wherein R 1 and R 2 independently represent hydrogen or the like; R 3 represents aryl or the like; -X-Y- represents -CH 2 O- or the like; and n represents 0, 1 or 2. These compounds have ORL1 -receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯或盐，其中R 1和R 2独立代表氢或类似物; R 3表示芳基等; -X-Y-表示-CH 2 O-等; 并且n表示0,1或2.这些化合物具有ORL1-受体拮抗剂活性; 因此，可用于治疗诸如疼痛，各种CNS疾病等疾病或病症。

5. 发明申请

WO2005092895A3 ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANOIC ACID COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS 审中-公开
标题翻译： ALPHA ARYL或HETEROARYL METHYL BETA PIPERIDINO丙酸化合物作为ORL1受体拮抗剂
公开(公告)号：WO2005092895A3
公开(公告)日：2006-03-02
申请号：PCT/IB2005000679
申请日：2005-03-16
申请人： PFIZER JAPAN INC , PFIZER , HASHIZUME YOSHINOBU , HIROTA MASAKO , MIHARA SACHIKO , NAKAMURA HIROSHI , KOIKE HIROKI , MATSUMOTO YUKARI
发明人： HASHIZUME YOSHINOBU , HIROTA MASAKO , MIHARA SACHIKO , NAKAMURA HIROSHI , KOIKE HIROKI , MATSUMOTO YUKARI
IPC分类号： A61K31/438 , A61K31/4747 , C07D221/20 , C07D401/06 , C07D471/06 , C07D471/10 , C07D491/10 , C07D513/10
CPC分类号： C07D221/20 , C07D401/06 , C07D471/06 , C07D471/10 , C07D491/10 , C07D513/10
摘要： This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯或其药学上可接受的盐，其中R

6. 发明申请

WO2005092895A2 ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANOIC ACID COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为ORL1受体拮抗剂的ALPHA ARYL或HETEROARYL METHYL BETA PIPERIDINO丙酸化合物
公开(公告)号：WO2005092895A2
公开(公告)日：2005-10-06
申请号：PCT/IB2005/000679
申请日：2005-03-16
申请人： PFIZER JAPAN INC. , PFIZER INC. , HASHIZUME, Yoshinobu , HIROTA, Masako , MIHARA, Sachiko , NAKAMURA, Hiroshi , KOIKE, Hiroki , MATSUMOTO, Yukari
发明人： HASHIZUME, Yoshinobu , HIROTA, Masako , MIHARA, Sachiko , NAKAMURA, Hiroshi , KOIKE, Hiroki , MATSUMOTO, Yukari
IPC分类号： C07D491/00
CPC分类号： C07D221/20 , C07D401/06 , C07D471/06 , C07D471/10 , C07D491/10 , C07D513/10
摘要： This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 independently represent a hydrogen atom or the like; R 3 represents an aryl group having from 6 to 10 ring atoms or the like ; X represents an oxygen atom , or the like; Y represents an oxygen atom or the like; and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonists activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
摘要翻译：本发明提供了式（I）化合物或这类化合物或其药学上可接受的盐的药学上可接受的酯，其中R 1和R 2独立地表示氢原子等; R 3表示具有6〜10个环原子等的芳基; X表示氧原子等; Y表示氧原子等; 并且n表示整数0,1或2.这些化合物具有ORL1-受体拮抗剂活性; 因此，可用于治疗诸如疼痛，各种CNS疾病等疾病或病症。

7. 发明申请

WO2005092858A3 ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST 审中-公开
公开(公告)号：WO2005092858A3
公开(公告)日：2005-10-06
申请号：PCT/IB2005/000751
申请日：2005-03-16
申请人： PFIZER JAPAN INC. , PFIZER INC. , HASHIZUME, Yoshinobu , HIROTA, Masako , MIHARA, Sachiko , NAKAMURA, Hiroshi , KOIKE, Hiroki , MATSUMOTO, Yukari
发明人： HASHIZUME, Yoshinobu , HIROTA, Masako , MIHARA, Sachiko , NAKAMURA, Hiroshi , KOIKE, Hiroki , MATSUMOTO, Yukari
IPC分类号： C07D221/20
摘要： This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 independently represent a hydrogen atom or the like; R 3 represents a hydrogen atom, or the like; R 4 represents a hydrogen atom or the like; (formula II) represents one of the following or the like; R 5 represents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxgen atom or the like and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.

8. 发明申请

WO2005105732A1 SUBSTITUTED METHYL ARYL OR HETEROARYL AMIDE COMPOUNDS 审中-公开
标题翻译：取代的甲基或芳基化合物
公开(公告)号：WO2005105732A1
公开(公告)日：2005-11-10
申请号：PCT/IB2005/001134
申请日：2005-04-22
申请人： PFIZER JAPAN INC. , PFIZER INC. , KOIKE, Hiroki , MATSUMOTO, Yukari , YAMAGISHI, Tatsuya , KON-I, Kana , OKUMURA, Yoshiyuki , NAKAO, Kazunari
发明人： KOIKE, Hiroki , MATSUMOTO, Yukari , YAMAGISHI, Tatsuya , KON-I, Kana , OKUMURA, Yoshiyuki , NAKAO, Kazunari
IPC分类号： C07C235/42
CPC分类号： C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要： This invention provides a compound of the formula (I), wherein X represents a carbon atom or the like: Y represents imino, or the like: R 1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R 2 and R 3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）化合物，其中X表示碳原子等：Y表示亚氨基等：R 1表示碳原子数1〜6的烷基等：R <2>和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

9. 发明申请

WO2007107827A1 CHROMANE DERIVATIVES 审中-公开
标题翻译：色素衍生物
公开(公告)号：WO2007107827A1
公开(公告)日：2007-09-27
申请号：PCT/IB2007/000599
申请日：2007-03-06
申请人： PFIZER JAPAN INC. , PFIZER INC. , MATSUMOTO, Yukari , SHIMOKAWA, Hirohisa , YAMAGISHI, Tatsuya
发明人： MATSUMOTO, Yukari , SHIMOKAWA, Hirohisa , YAMAGISHI, Tatsuya
IPC分类号： C07D471/04 , A61P1/04
CPC分类号： C07D471/04
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8， A和B各自如本文所述或其药学上可接受的盐，以及含有这些化合物的组合物及其治疗和使用方法，其包含用于治疗由酸泵拮抗活性介导的病症的化合物，所述活性例如但不限于，胃肠疾病，胃食管疾病，胃食管反流病（GERD），咽喉反流病，消化性溃疡，胃溃疡，十二指肠溃疡，NSAID诱发的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃里森综合征，非侵蚀性反流病（NERD），内脏痛，癌症，胃灼热，恶心，食管炎，吞咽困难，过度激活，气道障碍或哮喘。

10. 发明申请

WO2007026218A3 CHROMANE SUBSTITUTED 2-ALKYL IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS ACID PUMP ANTAGONISTS 审中-公开
标题翻译： CHROMANE取代的2-烷基咪唑并吡啶衍生物及其作为酸性尿素拮抗剂的用途
公开(公告)号：WO2007026218A3
公开(公告)日：2007-07-12
申请号：PCT/IB2006002363
申请日：2006-08-21
申请人： PFIZER JAPAN INC , PFIZER , MATSUMOTO YUKARI , SHIMOKAWA HIROHISA
发明人： MATSUMOTO YUKARI , SHIMOKAWA HIROHISA
IPC分类号： A61K31/437 , A61P1/04 , C07D471/04
CPC分类号： C07D471/04
摘要： This invention relates to compounds of the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein: A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method and use of such compounds in the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.
摘要翻译：本发明涉及式（I）化合物：（I）或其药学上可接受的盐，其中：A，B，R 1，R 2， R 4，R 4，R 5，R 6和R 7各自各自为或其药学上可接受的盐，以及含有这些化合物的组合物，以及这些化合物在治疗由酸泵拮抗活性（例如但不限于胃肠道疾病，胃食管疾病，胃食管反流）介导的病症中的方法和用途疾病（GERD），消化性溃疡，胃溃疡，十二指肠溃疡，NSAID诱发的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃利森综合征，非侵蚀性反流疾病（NERD），内脏痛，胃灼热，恶心，食管炎，吞咽困难，过度激活，气道障碍或哮喘。

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