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1. 发明申请

WO2009049568A2 STERILE AUTOLOGOUS, ALLOGENIC OR XENOGENIC IMPLANT AND THE METHOD OF ITS PRODUCTION 审中-公开
标题翻译：无菌自动，异源性或生殖植入物及其生产方法
公开(公告)号：WO2009049568A2
公开(公告)日：2009-04-23
申请号：PCT/CZ2008/000128
申请日：2008-10-17
申请人： BIO-SKIN, a.s. , DRUNECKY, Tomas , MATOUSKOVA, Eva , STEHLICEK, Petr , STOY, Vladimir , VESELY, Pavel
发明人： DRUNECKY, Tomas , MATOUSKOVA, Eva , STEHLICEK, Petr , STOY, Vladimir , VESELY, Pavel
CPC分类号： A61K38/39 , A61L27/3633 , A61L27/3691 , A61L27/38 , A61L27/3813 , A61L27/50 , A61L27/60 , A61L2430/40
摘要： The subject of the invention is a sterile, dehydrated acellular implant, which during its rehydration by water or bodily fluids displays anisotropic expansion and can act as a substrate for adhesion, migration and growth of live cells. Collagen structures of the transplant are at least partially denatured through the action of heat or organic solvents, such as lower aliphatic alcohols and ketones, which simultaneously act as preservative and sterilization agents, especially for certain types of viruses. The implant is sterilized by radiation while in an substantially dehydrated state, preferably by accelerated electrons. The transplant can be derived from various animal tissues, especially mammalian tissues, such as human or porcine tissues. The tissues suitable for the invention can be, for example, skin, placenta, pericardium, peritoneum, intestinal wall, tendon, blood vessel, etc. The implant is suitable for use in human and veterinary medicine, for instance as a temporary wound and burn cover, for the repair, substitution and regeneration of tissues, and also as a substrate for laboratory cell cultivation.
摘要翻译：本发明的主题是无菌，脱水的无细胞植入物，其在水或体液的再水化过程中显示各向异性膨胀，并且可以作为活细胞粘附，迁移和生长的底物。移植物的胶原结构通过热或有机溶剂（例如低级脂族醇和酮）的作用至少部分变性，其同时用作防腐剂和消毒剂，特别是对于某些类型的病毒。植入物在处于基本脱水状态时通过放射线灭菌，优选通过加速的电子灭菌。移植可衍生自各种动物组织，特别是哺乳动物组织，如人或猪组织。适用于本发明的组织可以是例如皮肤，胎盘，心包膜，腹膜，肠壁，肌腱，血管等。植入物适合用于人和兽医学，例如作为临时伤口和烧伤覆盖，用于组织的修复，替代和再生，以及用作实验室细胞培养的底物。

2. 发明申请

WO2009049568A3 ANISOTROPIC IMPLANT AND ITS METHOD OF PRODUCTION 审中-公开
标题翻译：各向异性植入物及其生产方法
公开(公告)号：WO2009049568A3
公开(公告)日：2009-12-23
申请号：PCT/CZ2008000128
申请日：2008-10-17
申请人： BIO SKIN A S , DRUNECKY TOMAS , MATOUSKOVA EVA , STEHLICEK PETR , STOY VLADIMIR , VESELY PAVEL
发明人： DRUNECKY TOMAS , MATOUSKOVA EVA , STEHLICEK PETR , STOY VLADIMIR , VESELY PAVEL
IPC分类号： A61L27/36 , A61K38/39 , A61L27/60
CPC分类号： A61K38/39 , A61L27/3633 , A61L27/3691 , A61L27/38 , A61L27/3813 , A61L27/50 , A61L27/60 , A61L2430/40
摘要： The subject of the invention is a sterile, dehydrated acellular implant, which during its rehydration by water or bodily fluids displays anisotropic expansion and can act as a substrate for adhesion, migration and growth of live cells. Collagen structures of the transplant are at least partially denatured through the action of heat or organic solvents, such as lower aliphatic alcohols and ketones, which simultaneously act as preservative and sterilization agents, especially for certain types of viruses. The implant is sterilized by radiation while in an substantially dehydrated state, preferably by accelerated electrons. The transplant can be derived from various animal tissues, especially mammalian tissues, such as human or porcine tissues. The tissues suitable for the invention can be, for example, skin, placenta, pericardium, peritoneum, intestinal wall, tendon, blood vessel, etc. The implant is suitable for use in human and veterinary medicine, for instance as a temporary wound and burn cover, for the repair, substitution and regeneration of tissues, and also as a substrate for laboratory cell cultivation.
摘要翻译：本发明的主题是无菌，脱水的无细胞植入物，其在水或体液的再水化过程中显示各向异性膨胀，并且可以作为活细胞粘附，迁移和生长的底物。移植物的胶原结构通过热或有机溶剂（例如低级脂族醇和酮）的作用至少部分变性，其同时用作防腐剂和消毒剂，特别是对于某些类型的病毒。植入物在处于基本脱水状态时通过放射线灭菌，优选通过加速的电子灭菌。移植可衍生自各种动物组织，特别是哺乳动物组织，如人或猪组织。适用于本发明的组织可以是例如皮肤，胎盘，心包膜，腹膜，肠壁，肌腱，血管等。植入物适合用于人和兽医学，例如作为临时伤口和烧伤覆盖，用于组织的修复，替代和再生，以及用作实验室细胞培养的底物。

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