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1. 发明申请

WO2006029110A1 METHOD AND APPARATUS FOR HANDLING SAMPLE HOLDERS 审中-公开
标题翻译：处理样品瓶的方法和装置
公开(公告)号：WO2006029110A1
公开(公告)日：2006-03-16
申请号：PCT/US2005/031608
申请日：2005-09-06
申请人： PROTEDYNE CORPORATION , MASSARO, Peter
发明人： MASSARO, Peter
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , B01L9/06 , B01L9/50 , B01L2300/021
摘要： A sample handling apparatus identifies sample holders and their location in a sample holder carrier. This information may be used to determine the identity of sample holders based only on location in the carrier during subsequent processing of material contained in the sample holders. Sample holder identity may be automatically read, and placement of holders in a carrier may be automatically determined and correlated with the holder identity. Such information may be stored, e.g., in a memory in the carrier so that sample holders can be easily identified later.
摘要翻译：样品处理装置识别样品保持器及其在样品架载体中的位置。该信息可用于仅在样品持有者所包含的材料的后续处理中仅基于载体中的位置来确定样品持有者的身份。样品持有者身份可以自动读取，并且载体中的持有者的放置可以被自动确定并与持有者身份相关联。这样的信息可以存储在例如载体中的存储器中，以便稍后可以容易地识别样品保持器。

2. 发明申请

WO2010134966A1 SYSTEM AND METHOD FOR VESSEL ALIGNMENT 审中-公开
标题翻译：用于船舶对齐的系统和方法
公开(公告)号：WO2010134966A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/001440
申请日：2010-05-14
申请人： PROTEDYNE CORPORATION , MASSARO, Peter
发明人： MASSARO, Peter
IPC分类号： B01L9/06 , G01N35/00 , B01L3/14
CPC分类号： B01L9/00 , B01L3/5453 , B01L9/06 , B01L2200/025 , B01L2300/021 , B01L2300/0829 , G01N35/00732
摘要： A vessel including an identification region may be placed in a holder. Through interaction of a positioning feature on the vessel and an orientation feature on the holder, the vessel can be placed into an alignment orientation, e.g., such that the identification region may be reliably read by a reader. The identification region may provides information related to the sample, such as vessel identity, sample volume, processes to be performed on the sample, and so on.
摘要翻译：包括识别区域的容器可以放置在保持器中。通过容器上的定位特征和保持器上的取向特征的相互作用，容器可以被放置成对准取向，例如使得识别区域可以被读取器可靠地读取。识别区域可以提供与样品相关的信息，例如容器标识，样品体积，对样品进行的处理等。

3. 发明申请

WO2010134964A1 METHOD AND APPARATUS FOR REMOVING RESIDUAL MATERIAL FROM SAMPLE PLATES 审中-公开
标题翻译：从样品板上移除残余材料的方法和装置
公开(公告)号：WO2010134964A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/001432
申请日：2010-05-14
申请人： PROTEDYNE CORPORATION , MASSARO, Peter
发明人： MASSARO, Peter
IPC分类号： B01L99/00 , B08B9/00 , G01N35/10
CPC分类号： B08B3/02 , B01L3/5085 , B01L99/00 , B01L2300/0829 , B08B9/00 , G01N35/028
摘要： Method and apparatus for removing residual material from sample wells (12) of a multiwell plate (10). Wells (12) located on a multiwell plate (10) are placed in fluid communication with wash wells (22) of a wash reservoir (20) where cleaning fluid is provided to remove residual material (14) from the sample wells (12) of the multiwell plate (10).
摘要翻译：用于从多孔板（10）的样品孔（12）中除去残余物质的方法和装置。位于多孔板（10）上的孔（12）与洗涤储存器（20）的洗涤孔（22）流体连通，其中提供清洁流体以从样品孔（12）中除去残余物质（14）多孔板（10）。

4. 发明申请

WO2006017186A1 LIQUID HANDLING DEVICE WITH SURFACE FEATURES AT A SEAL 审中-公开
标题翻译：具有表面特征的液体处理装置
公开(公告)号：WO2006017186A1
公开(公告)日：2006-02-16
申请号：PCT/US2005024281
申请日：2005-07-07
申请人： PROTEDYNE CORP , MASSARO PETER , PASCHETTO MICHAEL
发明人： MASSARO PETER , PASCHETTO MICHAEL
IPC分类号： A61M5/315 , B01L3/02
CPC分类号： B01L3/0217 , A61M5/31513 , A61M2005/3131 , B01L2200/0689 , G01N35/1065 , G01N2035/103 , G01N2035/1039
摘要： A sample handling tool includes a body having at least one plunger associated with a channel and arranged for axial movement within the channel. A seal is provided in the channel and sealingly engaged with a contact surface. The contact surface may include a surface feature, such that when contact surface moves, the seal and surface feature come into at least partial contact with one another. The seal may include an elastomeric member, such as an O-ring or X-ring, and the contact surface may be formed from any suitable material, including ceramic. The surface feature may take on a variety of forms including any suitable texture, surface porosity or include one or more grooves, holes, recesses, indentations, bumps, protrusions, etc., or a combination thereof.
摘要翻译：样品处理工具包括具有至少一个与通道相关联的柱塞并且布置成用于在通道内轴向运动的主体的主体。密封件设置在通道中并与接触表面密封接合。接触表面可以包括表面特征，使得当接触表面移动时，密封和表面特征彼此至少部分接触。密封件可以包括诸如O形环或X形环的弹性体构件，并且接触表面可以由包括陶瓷的任何合适的材料形成。表面特征可以采取各种形式，包括任何合适的纹理，表面孔隙率或包括一个或多个凹槽，孔，凹槽，凹痕，凸起，突起等，或其组合。

5. 发明申请

WO2004069413A9 SAMPLE HANDLING TOOL WITH PIEZOELECTRIC ACTUATOR 审中-公开
标题翻译：带压电执行器的样品处理工具
公开(公告)号：WO2004069413A9
公开(公告)日：2004-09-30
申请号：PCT/US2004002499
申请日：2004-01-29
申请人： PROTEDYNE , MASSARO PETER
发明人： MASSARO PETER
IPC分类号： B01L3/02 , C40B40/06 , C40B60/14 , G01N35/10 , H01L41/09
CPC分类号： B01L3/022 , B01J2219/00364 , B01J2219/00376 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , B01J2219/0074 , B01L3/0227 , B01L3/0241 , B01L2400/0478 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N35/1065 , H02N2/0025 , H02N2/026 , Y10T436/2575
摘要： A material handling tool (10) includes a piezoelectric motor (3) that causes actuation of a needle (4). Actuation of the needle may include aspiration and/or dispensing of a fluid sample and/or movement of the needle to pick or place a material sample. Since in this illustrative embodiment each of the piezoelectric motors (3) is coupled to a corresponding pipette cavity, movement of the drive shaft (31) by the piezoelectric motor (3) actuates a corresponding needle (4). Thus, each needle (4) of the array on the tool (10) may be individually actuated by providing appropriate signals to the piezoelectric motors (3).
摘要翻译：材料处理工具（10）包括致使针（4）致动的压电马达（3）。针的致动可以包括流体样本的抽吸和/或分配和/或针的移动以拾取或放置材料样本。因为在这个说明性实施例中，每个压电马达（3）都连接到相应的移液管腔，所以驱动轴（31）通过压电马达（3）的移动致动相应的针（4）。因此，工具（10）上的阵列的每个针（4）可以通过向压电马达（3）提供适当的信号而单独致动。

6. 发明申请

WO2003085407A1 ROBOTICALLY MANIPULABLE SAMPLE HANDLING TOOL 审中-公开
标题翻译：机器人操作样品处理工具
公开(公告)号：WO2003085407A1
公开(公告)日：2003-10-16
申请号：PCT/US2003/009470
申请日：2003-03-28
申请人： PROTEDYNE CORPORATION , MASSARO, Peter
发明人： MASSARO, Peter
IPC分类号： G01N35/00
CPC分类号： G01N35/10 , G01N35/0099
摘要： A robotically manipulable sample handling tool (10), such as a colony picking head or robotic pipetting tool, includes needles (4) arranged on the tool. Actuators (3) are associated with each needle to control flow for the needle, e.g., to move the needle and/or draw fluid into/expel fluid from the needle. The actuators (3) are arranged so that needles may be individually controlled by a controller (2) that is capable of outputting a number of control signals that is less than the total number of needles. The actuators may be membrane valves that receive two signals from a controller, a first signal that opens or closes the valve, and a second signal that causes fluid flow through the valve.
摘要翻译：机器人可操作的样品处理工具（10），例如集落采摘头或机器人移液工具，包括布置在工具上的针（4）。致动器（3）与每个针相关联，以控制针的流动，例如使针和/或将流体从针抽出/排出流体。致动器（3）被布置成使得针可以由能够输出小于总针数的多个控制信号的控制器（2）来单独控制。致动器可以是从控制器接收两个信号的膜阀，打开或关闭阀的第一信号，以及使流体流过阀的第二信号。

7. 发明申请

WO2011008249A1 TUBE FOR SEPARATING PORTIONS OF A SAMPLE 审中-公开
标题翻译：用于分离样品部分的管
公开(公告)号：WO2011008249A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/001891
申请日：2010-07-02
申请人： PROTEDYNE CORPORATION , MASSARO, Peter
发明人： MASSARO, Peter
IPC分类号： B01L3/14 , G01N33/50
CPC分类号： B01D23/00 , B01L3/502 , B01L3/5082 , B01L2300/0681 , B01L2300/0858 , G01N33/491 , Y10T436/25375
摘要： A method and tube for separating a sample. The tube is configured to separate agglomerated or clumped material or other sample components having over a particular size from other smaller size portions of the sample. For example, blood clots may be separated from serum of a blood sample. The tube includes a chamber with a closed bottom and a sidewall extending upwardly from the bottom, and a sample inlet branch coupled to the chamber. A slit is positioned between the chamber and the sample inlet branch so that after a sample is placed into the sample inlet branch, a portion of the sample having a size smaller than the slit (e.g., liquid material) passes through the slit and into the chamber, and material in the sample having a size larger than the slit remains in the sample inlet branch.
摘要翻译：用于分离样品的方法和管。管被配置成将具有特定尺寸的聚集或聚集的材料或其它样品组分与样品的其它较小尺寸部分分离。例如，血液凝块可以与血液样品的血清分离。管包括具有封闭底部的腔室和从底部向上延伸的侧壁，以及耦合到腔室的样品入口分支。狭缝位于室和样品入口分支之间，使得在将样品放入样品入口分支中后，具有小于狭缝的尺寸（例如液体材料）的样品的一部分穿过狭缝并进入并且样品中具有大于狭缝的尺寸的材料保留在样品入口分支中。

8. 发明申请

WO2007127270A2 ROBOTIC SYSTEM WITH AUTONOMOUSLY OPERABLE TOOLS 审中-公开
标题翻译：具有自动操作工具的机器人系统
公开(公告)号：WO2007127270A2
公开(公告)日：2007-11-08
申请号：PCT/US2007010073
申请日：2007-04-24
申请人： PROTEDYNE CORP , MASSARO PETER
发明人： MASSARO PETER
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/0099 , G01N35/1009 , G01N35/1074 , G01N2035/00811
摘要： Method and apparatus for performing a liquid handling process involves the use of a robotic device that manipulates a plurality of separate tools. A first tool may be removable engaged with the robotic device, which manipulates and control the first tool to perform at least one liquid handling task or operation with respect to at least one liquid sample. The first tool may then be positioned at a first location on a support, and disengaged from the robotic device. Thereafter, the first tool may perform at least one liquid handling task or operation while on the support and separated from the robotic device.
摘要翻译：用于执行液体处理过程的方法和装置涉及使用操纵多个单独工具的机器人装置。第一工具可以与机器人装置可拆卸地接合，其操纵和控制第一工具以对至少一个液体样品执行至少一个液体处理任务或操作。然后可以将第一工具定位在支撑件上的第一位置处，并与机器人装置脱离接合。此后，第一工具可以在支撑件上执行至少一个液体处理任务或操作，并与机器人装置分离。

9. 发明申请

WO2007087295A2 SCARA-TYPE ROBOTIC SYSTEM 审中-公开
标题翻译： SCARA型机器人系统
公开(公告)号：WO2007087295A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/001752
申请日：2007-01-23
申请人： PROTEDYNE CORPORATION , MASSARO, Peter
发明人： MASSARO, Peter
IPC分类号： B25J9/04
CPC分类号： B25J9/042 , Y10S483/901 , Y10T483/17
摘要： A robotic system including a rotatable turntable that has an arm pivotally mounted on the turntable for rotation about an axis displaced from the turntable's rotational axis. The arm's axis of rotation may be positioned nearer the turntable's axis of rotation than a bearing that supports the turntable on a base. The arm may have a portion that extends in a direction transverse to the arm's axis of rotation located below the turntable. The turntable may be supported on the base by a single bearing having portions located in a common plane.
摘要翻译：一种包括可旋转转台的机器人系统，其具有枢转地安装在转台上的臂，用于围绕从转台的旋转轴线偏移的轴线旋转。臂的旋转轴线可以位于转盘的旋转轴线附近，而不是支撑在基座上的转盘的轴承。臂可以具有在横向于位于转盘下方的臂的旋转轴线的方向上延伸的部分。转盘可以由具有位于公共平面中的部分的单个轴承支撑在基座上。

10. 发明申请

WO2006015012A9 METHOD AND APPARATUS FOR APPLYING PRESSURE DIFERENTIAL TO MULTI-WELL PLATE 审中-公开
标题翻译：将压力应用于多孔板的方法和装置
公开(公告)号：WO2006015012A9
公开(公告)日：2006-03-09
申请号：PCT/US2005026582
申请日：2005-07-27
申请人： PROTEDYNE CORP , MASSARO PETER , CATALANO MICHAEL
发明人： MASSARO PETER , CATALANO MICHAEL
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L3/5085 , B01L2300/0829 , B01L2300/14 , B01L2400/049 , Y10T436/25375 , Y10T436/2575
摘要： A method and apparatus for moving material in a multi-well plate includes applying positive and negative pressure to one or more wells in the plate, e.g., to enhance a flow rate of material from the well through a filter element. Wells requiring application of positive pressure may be identified, e.g., by image analysis performed by a machine vision system. Those wells determined to require enhanced throughput may have negative and positive pressure applied to the well, while other wells have only negative pressure applied.
摘要翻译：用于在多孔板中移动材料的方法和装置包括向板中的一个或多个孔施加正压和负压，例如以增加材料从井穿过过滤元件的流速。需要施加正压力的井可以例如通过机器视觉系统执行的图像分析来识别。确定要求提高生产量的那些井可能对井施加负压和正压，而其他井只施加负压。

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