专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

IL294916A Arylamide derivative having antitumor activity 未知
公开(公告)号：IL294916A
公开(公告)日：2022-09-01
申请号：IL29491622
申请日：2022-07-20
申请人： CHUGAI PHARMACEUTICAL CO LTD , YOSHIAKI ISSHIKI , WATANABE FUMIO , MASAKI TOMIZAWA , KIHITO HADA , KAZUO HATTORI , KENICHI KAWASAKI , IKUMI HYODO , TOSHIHIRO AOKI
发明人： YOSHIAKI ISSHIKI , FUMIO WATANABE , MASAKI TOMIZAWA , KIHITO HADA , KAZUO HATTORI , KENICHI KAWASAKI , IKUMI HYODO , TOSHIHIRO AOKI
IPC分类号： A61K31/166 , A61K31/18 , A61K31/44 , A61K31/4436 , A61K31/444 , A61P35/00 , A61P43/00 , C07C31/125
摘要： The present disclosure provides, for example, a compound represented by general formula (6) below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt:wherein X 1 , X 2 , X 3 and X 4 are each independently -CR 2 = or -N=, R 2 is, for example, a halogen atom, R 1 is, for example, -S(=O) 2 -NH-R 8 , R 8 is, for example, a C1-6 alkyl group, R 3 is, for example, a hydrogen atom, R 5 is, for example, a halogen atom, R 6 is, for example, a hydrogen atom, and R 4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.

2. 发明申请

US20120310005A1 METHOD FOR PRODUCING 2-AZAADAMANTANE 有权
标题翻译：生产2-氮杂AD啶的方法
公开(公告)号：US20120310005A1
公开(公告)日：2012-12-06
申请号：US13585592
申请日：2012-08-14
申请人： Toshimasa HAMADA , Noriaki NAGAHAMA , Masami KOZAWA , Yoshiharu IWABUCHI , Masatoshi SHIBUYA , Masaki TOMIZAWA , Yusuke SASANO
发明人： Toshimasa HAMADA , Noriaki NAGAHAMA , Masami KOZAWA , Yoshiharu IWABUCHI , Masatoshi SHIBUYA , Masaki TOMIZAWA , Yusuke SASANO
IPC分类号： C07C271/24
CPC分类号： C07D451/14
摘要： To provide a method whereby a 2-azaadamantane can easily be obtained in good yield.A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.
摘要翻译：提供可以容易地以良好的产率获得2-氮杂金刚烷的方法。一种制备由式（1）表示的2-氮杂金刚烷的方法，其包括在酸存在下环化下式（2）表示的化合物。

3. 发明申请

US20100311977A1 METHOD FOR PRODUCING 2-AZAADAMANTANE 有权
标题翻译：生产2-氮杂AD啶的方法
公开(公告)号：US20100311977A1
公开(公告)日：2010-12-09
申请号：US12744015
申请日：2008-11-20
申请人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
发明人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
IPC分类号： C07D451/14 , C07C271/24 , C07C211/41 , C07C61/29 , C07C247/00
CPC分类号： C07D451/14
摘要： To provide a method whereby a 2-azaadamantane can easily be obtained in good yield.A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.
摘要翻译：提供可以容易地以良好的产率获得2-氮杂金刚烷的方法。一种制备由式（1）表示的2-氮杂金刚烷的方法，其包括在酸存在下环化下式（2）表示的化合物。

4. 发明授权

US08669367B2 Method for producing 2-azaadamantane 有权
标题翻译： 2-氮杂金刚烷的制备方法
公开(公告)号：US08669367B2
公开(公告)日：2014-03-11
申请号：US13585592
申请日：2012-08-14
申请人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
发明人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
IPC分类号： C07D451/14 , C07C61/29 , C07C211/41 , C07C247/00 , C07C271/24
CPC分类号： C07D451/14
摘要： To provide a method whereby a 2-azaadamantane can easily be obtained in good yield.A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.
摘要翻译：提供可以容易地以良好的产率获得2-氮杂金刚烷的方法。一种制备由式（1）表示的2-氮杂金刚烷的方法，其包括在酸存在下环化下式（2）表示的化合物。

5. 发明申请

US20090124806A1 PROCESS FOR PRODUCING CARBOXYLIC ACID FROM PRIMARY ALCOHOL 审中-公开
标题翻译：从一级酒精生产羧酸的方法
公开(公告)号：US20090124806A1
公开(公告)日：2009-05-14
申请号：US12115847
申请日：2008-05-06
申请人： Yoshiharu IWABUCHI , Masatoshi Shibuya , Masaki Tomizawa , Takahisa Sato , Susumu Sato
发明人： Yoshiharu IWABUCHI , Masatoshi Shibuya , Masaki Tomizawa , Takahisa Sato , Susumu Sato
IPC分类号： C07D471/08 , C07D211/94
CPC分类号： C07D471/08 , C07D207/08 , C07D211/94
摘要： To provide an industrially-useful and environmentally-friendly novel oxidation reaction.A process for producing a carboxylic acid from a primary alcohol, which comprises using an alkali metal chlorite as a co-oxidizing agent and using, as a catalyst, an oxoammonium salt of the formula (1):
摘要翻译：提供工业上有用和环保的新型氧化反应。一种由伯醇生产羧酸的方法，其包括使用碱金属亚氯酸盐作为助氧化剂并使用式（1）的氧代铵盐作为催化剂：

6. 发明申请

US20070232838A1 Alcohol Oxidation Catalyst and Method of Synthesizing the Same 审中-公开
标题翻译：醇氧化催化剂及其合成方法
公开(公告)号：US20070232838A1
公开(公告)日：2007-10-04
申请号：US11570756
申请日：2005-06-24
申请人： Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa
发明人： Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa
IPC分类号： C07D487/00 , B01J31/02 , C07C29/00
CPC分类号： C07D471/08 , B01J31/006 , B01J31/0235 , B01J31/0237 , B01J2231/70 , C07C45/29
摘要： An organic oxidation catalyst for alcohols which is environmentally less harmful and with which efficient oxidation can be conducted. The oxidation catalyst for alcohols is a 1-alkyl-2-azadamantan-N-oxyl which has a nitroxyl group incorporated in the adamantane skeleton and was synthesized from as a base material a bicyclic compound obtained by the Grob-type ring-opening reaction of 1,3-adamantanediol. Due to the nitroxyl group on the adamantane skeleton, the α-position hydrogen is stabilized based on Bredt's rule and the stability of the oxoammonium group generated by the oxidation thereof is ensured. Compared to TEMPO, which is a conventional oxidation catalyst, this catalyst is reduced in steric hindrance and is usable in a wide range of reaction fields. Because of this, not only a primary alcohol but a secondary alcohol having a sterically complicated structure, which has been difficult to oxidize with TEMPO, can be oxidized at a high efficiency.
摘要翻译：用于醇的有机氧化催化剂，其对环境无害且能够进行有效的氧化。醇的氧化催化剂是在金刚烷骨架中具有硝酰基的1-烷基-2-氮杂金刚烷-N-氧基，其作为基材通过由Grob型开环反应获得的双环化合物合成， 1,3-金刚烷二醇由于金刚烷骨架上的硝酰基，基于Bredt规则使α位氢稳定，并且确保了通过其氧化产生的氧代铵基团的稳定性。与作为常规氧化催化剂的TEMPO相比，该催化剂的空间位阻减小，可用于广泛的反应领域。因此，不仅可以高效地氧化难以用TEMPO氧化的伯醇和具有空间复杂结构的仲醇。

7. 发明授权

US08273889B2 Method for producing 2-azaadamantane 有权
标题翻译： 2-氮杂金刚烷的制备方法
公开(公告)号：US08273889B2
公开(公告)日：2012-09-25
申请号：US12744015
申请日：2008-11-20
申请人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
发明人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
IPC分类号： C07D451/14 , C07C61/29 , C07C211/41 , C07C247/00 , C07C271/24
CPC分类号： C07D451/14
摘要： The invention provides a method for producing 2-azaadamantanes represented by formula (1) in good yields. The method includes cyclizing a compound represented by formula (2) in the presence of an acid.
摘要翻译：本发明提供以良好的产率制备由式（1）表示的2-氮杂金刚烷的方法。该方法包括在酸存在下环化由式（2）表示的化合物。

8. 发明授权

US07705152B2 Alcohol oxidation catalyst and its preparation process 失效
标题翻译：醇氧化催化剂及其制备方法
公开(公告)号：US07705152B2
公开(公告)日：2010-04-27
申请号：US11943836
申请日：2007-11-21
申请人： Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa
发明人： Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa
IPC分类号： C07D453/06
CPC分类号： C07D453/06 , C07C45/30 , C07C2601/14 , C07D487/04 , C07D493/20 , C07C47/228 , C07C49/657 , C07C49/603 , C07C49/76 , C07C49/04
摘要： An alcohol oxidation catalyst which is an organic oxidation catalyst to oxidize an alcohol, which contains azabicyclo[3.3.1]nonane N-oxyl represented by the following formula (1) having an N-oxyl group incorporated in a bicycle[3.3.1]nonane skeleton: wherein X is H2, O or NOH.
摘要翻译：作为氧化醇的有机氧化催化剂的醇氧化催化剂，其含有结合在自行车中的具有N-氧基的由下式（1）表示的氮杂双环[3.3.1]壬烷N-氧基[3.3.1] 壬烷骨架：其中X是H 2，O或NOH。

9. 发明申请

US20080221331A1 ALCOHOL OXIDATION CATALYST AND ITS PREPARATION PROCESS 失效
标题翻译：酒精氧化催化剂及其制备方法
公开(公告)号：US20080221331A1
公开(公告)日：2008-09-11
申请号：US11943836
申请日：2007-11-21
申请人： Yoshiharu IWABUCHI , Masatoshi Shibuya , Masaki Tomizawa
发明人： Yoshiharu IWABUCHI , Masatoshi Shibuya , Masaki Tomizawa
IPC分类号： C07D453/06
CPC分类号： C07D453/06 , C07C45/30 , C07C2601/14 , C07D487/04 , C07D493/20 , C07C47/228 , C07C49/657 , C07C49/603 , C07C49/76 , C07C49/04
摘要： An alcohol oxidation catalyst which is an organic oxidation catalyst to oxidize an alcohol, which contains azabicyclo [3.3.1]nonane N-oxyl represented by the following formula (1) having an N-oxyl group incorporated in a bicycle[3.3.1]nonane skeleton: wherein X is H2, O or NOH.
摘要翻译：作为氧化醇的有机氧化催化剂的醇氧化催化剂，其含有结合在自行车中的具有N-氧基的由下式（1）表示的氮杂双环[3.3.1]壬烷N-氧基[3.3.1] 壬烷骨架：其中X是H 2，O或NOH。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式