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1. 发明申请

WO1997016461A1 MONOCLONAL ANTIBODY SPECIFIC FOR PROSTAGLANDIN D SYNTHETASE 审中-公开
标题翻译：用于PROSTAGLANDIN D合成酶的单克隆抗体特异性
公开(公告)号：WO1997016461A1
公开(公告)日：1997-05-09
申请号：PCT/JP1996003190
申请日：1996-10-31
申请人： MARUHA CORPORATION , OSAKA BIOSCIENCE INSTITUTE , ODA, Hiroshi , SATO, Nobuyuki , NISHIKAWA, Masazumi , SEIKI, Kosuke , URADE, Yoshihiro , SAJI, Fumitaka
发明人： MARUHA CORPORATION , OSAKA BIOSCIENCE INSTITUTE
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , Y10S530/809
摘要： A monoclonal antibody specifically recognizing a cerebral prostaglandin D synthetase; hybridomas producing the monoclonal antibody; a method for detecting a cerebral prostaglandin D synthetase or diseases which comprises detecting the synthetase with the use of the monoclonal antidody; and a kit for detecting a cerebral prostaglandin D synthetase which contains the monoclonal antibody.
摘要翻译：特异性识别脑前列腺素D合成酶的单克隆抗体; 产生单克隆抗体的杂交瘤; 检测脑前列腺素D合成酶或疾病的方法，其包括使用所述单克隆抗体检测所述合成酶; 和用于检测含有单克隆抗体的脑前列腺素D合成酶的试剂盒。

2. 发明申请

US20040038314A1 Prostaglandin D synthase-specific monoclonal antibody 审中-公开
标题翻译：前列腺素D合成酶特异性单克隆抗体
公开(公告)号：US20040038314A1
公开(公告)日：2004-02-26
申请号：US10460754
申请日：2003-06-12
申请人： Maruha Corporation , Osaka Bioscience Institute, a Japanese corporation
发明人： Hiroshi Oda , Nobuyuki Sato , Masazumi Nishikawa , Kosuke Seiki , Yoshihiro Urade , Fumitaka Saji
IPC分类号： G01N033/53 , G01N033/567 , C12N005/06 , C07K016/40
CPC分类号： C07K16/40 , Y10S530/809
摘要： The invention relates to a monoclonal antibody specifically recognizing lipocalin-type prostaglandin D synthase (L-PGDS), a hybridoma producing said monoclonal antibody, methods for detection of L-PGDS or diseases by said monoclonal antibody, and a kit for detection of L-PGDS by said monoclonal antibody. According to the invention, there is provided a monoclonal antibody specific to L-PGDS.
摘要翻译：本发明涉及特异性识别脂质运载蛋白型前列腺素D合成酶（L-PGDS）的单克隆抗体，产生所述单克隆抗体的杂交瘤，所述单克隆抗体检测L-PGDS或疾病的方法， PGDS由所述单克隆抗体。根据本发明，提供了对L-PGDS特异性的单克隆抗体。

3. 发明公开

EP1746108A1 FISH-ORIGIN CHONDROITIN SULFATE/DERMATAN SULFATE HYBRID CHAIN 审中-公开
标题翻译： EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP1746108A1
公开(公告)日：2007-01-24
申请号：EP05736922.5
申请日：2005-04-25
申请人： MARUHA CORPORATION , Sugahara, Kazuyuki
发明人： SUGAHARA, Kazuyuki
IPC分类号： C08B37/08 , A61K31/737 , A61P7/02 , A61P25/00 , A61P25/28 , A61K35/60
CPC分类号： C08B37/0069 , A61K31/715
摘要： It is intended to provide a novel chondroitin sulfate/dermatan sulfate hybrid chain having biding activity toward a variety of growth factors, neurite outgrowth-promoting activity, and anticoagulant activity and to provide a composition for neurological disease treatment. The novel chondroitin sulfate/dermatan sulfate hybrid chain was separated and purified from the bodies of fishes other than bony fishes. When shark skin is used, the hybrid chain comprises a disaccharide GlcUA(2S)-GalNAc(4S) and has an average molecular weight of 65 to 75 kDa, and the degree of sulfation per disaccharide molecule falls within the range of 0.7 or more to less than 1.20. The hybrid chain is capable of binding to a variety of growth factors and further possesses neurite outgrowth-promoting activity and anticoagulant activity.
摘要翻译：本发明提供一种硫酸软骨素/硫酸皮肤素复合链，其具有针对各种生长因子，神经突促生长活性和抗凝血活性的粘合活性，并提供用于神经系统疾病治疗的组合物。将硫酸软骨素/硫酸皮肤素杂交链从骨鱼以外的鱼体中分离纯化。当使用鲨鱼皮时，杂交链包含二糖GlcUA（2S）-GalNAc（4S），平均分子量为65至75kDa，每个二糖分子的硫酸化程度在0.7以上至小于1.20。杂交链能够与多种生长因子结合，进一步具有神经突促生长活性和抗凝血活性。

4. 发明公开

EP1111387A1 METHOD FOR DETECTING KIDNEY DISEASES AND PATHOLOGICAL CONTROL 有权
标题翻译：检测方法的肾脏疾病病理监测中的
公开(公告)号：EP1111387A1
公开(公告)日：2001-06-27
申请号：EP99940663.0
申请日：1999-09-03
申请人： Maruha Corporation , OSAKA BIOSCIENCE INSTITUTE , Japan Science and Technology Corporation
发明人： ODA, Hiroshi Central Research Institute , SEIKI, Kosuke Central Research Institute , NAKAJIMA, Hiroshi Central Research Institute, , SATO, Nobuyuki Central Research Institute, , URADE, Yoshihiro T. City-copo 706,440 Furunishicho , HIRAWA, Nobuhito Camelot Kaminagaya 409 , UEHARA, Yoshio
IPC分类号： G01N33/573
CPC分类号： G01N33/6893 , G01N33/573 , G01N33/70 , G01N33/88 , G01N2800/347 , Y10S436/811
摘要： The present invention relates to a method of detection of an early-stage renal disease, comprising determining the concentration of human lipocalin-type prostaglandin D synthase in a body fluid sample taken from a subject and comparing the determined concentration with a reference value set by determining the concentrations of human lipocalin-type prostaglandin D synthase in body fluid samples taken from healthy subjects; and a method of disease state management for a renal disease, comprising determining the concentration of human lipocalin-type prostaglandin D synthase in a body fluid sample taken from a subject and evaluating the glomerular filtration ability of the subject from the determined concentration.
摘要翻译：本发明涉及到检测早期末期肾脏疾病的方法，包括确定性采矿取自受试者的体液样本中的人脂笼蛋白型前列腺素D合成酶的浓度和确定性开采浓度与由确定性采矿设定的基准值进行比较取自健康受试者的体液样品中的脂笼蛋白的人型前列腺素D合成酶的浓度; 和疾病状态管理的对肾病的方法，包括确定性采矿取自受试者的体液样本中的人脂笼蛋白型前列腺素D合成酶的浓度和评估从确定性开采浓度受试者的肾小球滤过能力。

5. 发明公开

EP0701780A3 Process for producing flake style food from meat or fish 失效
标题翻译：一种用于生产肉或鱼薄片的过程
公开(公告)号：EP0701780A3
公开(公告)日：1996-08-21
申请号：EP95113793.4
申请日：1995-09-01
申请人： MARUHA CORPORATION
发明人： Takeda, Hideyuki
IPC分类号： A23L1/311 , A23L1/326 , A23L1/315
CPC分类号： A23L17/75 , A23L13/03 , A23L13/422
摘要： A process for producing a flake style food which comprises adding a dehydrated vegetable and a polysaccharide thickener to a seasoning solution, emulsifying the obtained mixture by stirring at a high speed of from 1,000 to 10,000 rpm within a temperature zone of from 10 to 80 °C for 1 to 10 minutes and mixing the emulsified product thus obtained with one or more of fish meat, poultry meat or cattle meat which is in the form of flakes.

6. 发明授权

EP0613949B1 Gene encoding chondroitinase ABC and uses therefor 失效
标题翻译：基因为软骨素酶ABC及其用途
公开(公告)号：EP0613949B1
公开(公告)日：2004-12-29
申请号：EP94250046.3
申请日：1994-02-23
申请人： MARUHA CORPORATION
发明人： Sato, Nobuyuki , Shimada, Masahiko , Oda, Hiroshi
IPC分类号： C12N15/60 , C12N9/88 , C12P21/08 , A61K38/51 , G01N33/68
CPC分类号： C12Y402/02004 , A61K38/00 , C12N9/88 , G01N33/573

7. 发明公开

EP1158298A1 METHOD FOR PRESUMING RESTENOSIS FOLLOWING CORONARY VESSEL INTERVENTION 审中-公开
标题翻译：赫尔辛基·维克森（VERFAHREN ZUM ERKENNEN VON RESTENUS NACH EIFRIFFEN INHERZKRANZGEFÄSSEN）
公开(公告)号：EP1158298A1
公开(公告)日：2001-11-28
申请号：EP00905354.7
申请日：2000-02-25
申请人： Maruha Corporation , OSAKA BIOSCIENCE INSTITUTE , Japan Science and Technology Corporation
发明人： SEIKI, Kosuke, Central Res. Inst., Maruha Corp. , ODA, Hiroshi, Central Res. Inst., Maruha Corp. , NAKAJIMA, Hiroshi, Cent. Res. Inst., Maruha Corp. , SATO, Nobuyuki, Central Res. Inst., Maruha Corp. , URADE, Yoshihiro, Towa City-Copo 706 , UEHARA, Yoshio , INOUE, Teruo
IPC分类号： G01N33/573 , C12Q1/25
CPC分类号： C12Q1/25 , G01N33/573 , G01N2333/9015
摘要： The present invention provides a method for predicting restenosis following coronary intervention by measuring human lipocalin-type prostaglandin D synthase (L-PGDS) in a body fluid sample. More particularly, this method comprises measuring the L-PGDS concentration in the sample and predicting restenosis following coronary intervention by using a change therein as an indicator.
摘要翻译：本发明提供一种通过测量体液样品中的人脂质运载蛋白型前列腺素D合成酶（L-PGDS）来预测冠状动脉介入后再狭窄的方法。更具体地，该方法包括测量样品中的L-PGDS浓度并且通过使用其中的改变作为指标来预测冠状动脉介入后的再狭窄。

8. 发明公开

EP0613949A2 Gene encoding chondroitinase ABC and uses therefor 失效
标题翻译：软骨素酶ABC和Dessen Verwendungen。
公开(公告)号：EP0613949A2
公开(公告)日：1994-09-07
申请号：EP94250046.3
申请日：1994-02-23
申请人： MARUHA CORPORATION
发明人： Sato, Nobuyuki , Shimada, Masahiko , Oda, Hiroshi
IPC分类号： C12N15/60 , C12N9/88 , C12P21/08 , A61K37/56 , G01N33/68
CPC分类号： C12Y402/02004 , A61K38/00 , C12N9/88 , G01N33/573
摘要： Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABC protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABC protein are described. Chondroitinase ABC prepared by chemical synthesis is also described. Monoclonal and polyclonal antibodies which are specifically reactive with chondroitinase ABC protein are disclosed. The isolated chondroitinase ABC can be used in methods of treating intervertebral disc displacement, promoting neurite regeneration, and detecting galactosaminoglycans.
摘要翻译：描述了编码软骨素酶ABC基因的核酸序列和在用指导编码软骨素酶ABC蛋白的核苷酸序列的表达的核酸载体转化的宿主细胞中产生的分离的软骨素酶ABC蛋白。还描述了通过化学合成制备的软骨素酶ABC。公开了与软骨素酶ABC蛋白特异性反应的单克隆和多克隆抗体。分离的软骨素酶ABC可用于治疗椎间盘置换，促进神经突再生和检测半乳糖胺聚糖的方法。

9. 发明授权

EP0913405B1 MONOCLONAL ANTIBODY SPECIFIC FOR PROSTAGLANDIN D SYNTHETASE 失效
标题翻译：具体为前列腺素D合成酶的单克隆抗体
公开(公告)号：EP0913405B1
公开(公告)日：2006-01-04
申请号：EP96935508.0
申请日：1996-10-31
申请人： MARUHA CORPORATION , OSAKA BIOSCIENCE INSTITUTE
发明人： ODA, Hiroshi Central Research Institute , SATO, Nobuyuki Central Research Institute , NISHIKAWA, Masazumi Central Research Institute , SEIKI, Kosuke Central Research Institute , URADE, Yoshihiro Towa City-copo 706 440,Furunishi , SAJI, Fumitaka
IPC分类号： C07K16/40 , C12N15/08 , C12P21/08 , G01N33/536 , G01N33/573
CPC分类号： C07K16/40 , Y10S530/809
摘要： A monoclonal antibody specifically recognizing a cerebral prostaglandin D synthetase; hybridomas producing the monoclonal antibody; a method for detecting a cerebral prostaglandin D synthetase or diseases which comprises detecting the synthetase with the use of the monoclonal antidody; and a kit for detecting a cerebral prostaglandin D synthetase which contains the monoclonal antibody.

10. 发明授权

EP0701780B1 Process for producing flake style food from meat or fish 失效
标题翻译：一种用于生产肉或鱼薄片的过程
公开(公告)号：EP0701780B1
公开(公告)日：2001-06-27
申请号：EP95113793.4
申请日：1995-09-01
申请人： MARUHA CORPORATION
发明人： Takeda, Hideyuki
IPC分类号： A23L1/311 , A23L1/326 , A23L1/315
CPC分类号： A23L17/75 , A23L13/03 , A23L13/422

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