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1. 发明申请

WO9819708A3 METHOD FOR ENHANCING THE SOLUBILITY OF SUBSTANTIALLY WATER-INSOLUBLE COMPOUNDS 审中-公开
标题翻译：提高主要水不溶性化合物溶解性的方法
公开(公告)号：WO9819708A3
公开(公告)日：1998-08-20
申请号：PCT/US9719831
申请日：1997-10-31
申请人： UNION CARBIDE CHEM PLASTIC , DONABEDIAN DAVID H , MARLIN LAWRENCE , CLARK ELKE M A
发明人： DONABEDIAN DAVID H , MARLIN LAWRENCE , CLARK ELKE M A
IPC分类号： A61K9/14 , A61K47/10 , A61K47/38 , A61K47/34
CPC分类号： A61K47/38 , A61K9/146 , A61K47/10
摘要： Methods for enhancing the water-solubility of substantially water-insoluble compounds are disclosed by combining such compounds with a water-soluble polymer, e.g., polyalkylene oxide polymer or a cellulose ether, having a molecular weight of from about 50,000 to 7,000,000 grams/per gram in an amount effective to enhance the water-solubility of the compound in an acidic environment, e.g., pH less than about 5. Compositions comprising the compounds having enhanced water solubility are also disclosed.

2. 发明申请

WO1998019708A2 METHOD FOR ENHANCING THE SOLUBILITY OF SUBSTANTIALLY WATER-INSOLUBLE COMPOUNDS 审中-公开
标题翻译：提高主要水不溶性化合物溶解性的方法
公开(公告)号：WO1998019708A2
公开(公告)日：1998-05-14
申请号：PCT/US1997019831
申请日：1997-10-31
申请人： UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION , DONABEDIAN, David, H. , MARLIN, Lawrence , CLARK, Elke, M., A.
发明人： UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION
IPC分类号： A61K47/34
CPC分类号： A61K47/38 , A61K9/146 , A61K47/10
摘要： Methods for enhancing the water-solubility of substantially water-insoluble compounds are disclosed by combining such compounds with a water-soluble polymer, e.g., polyalkylene oxide polymer or a cellulose ether, having a molecular weight of from about 50,000 to 7,000,000 grams/per gram in an amount effective to enhance the water-solubility of the compound in an acidic environment, e.g., pH less than about 5. Compositions comprising the compounds having enhanced water solubility are also disclosed.
摘要翻译：通过将这样的化合物与分子量为约50,000至700,000克/每克的水溶性聚合物，例如聚环氧烷聚合物或纤维素醚组合来提高基本上不溶于水的化合物的水溶性的方法其量可以有效地提高化合物在酸性环境中的水溶性，例如pH小于约5.还包括具有增强的水溶性的化合物的组合物。

3. 发明申请

WO1992011877A1 BIOCOMPATIBLE ABRASION RESISTANT COATED SUBSTRATES 审中-公开
标题翻译：可生物降解耐磨涂层基材
公开(公告)号：WO1992011877A1
公开(公告)日：1992-07-23
申请号：PCT/US1991009531
申请日：1991-12-27
申请人： UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY ... , FAN, You-Ling , MARLIN, Lawrence
发明人： UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY ...
IPC分类号： A61L29/00
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/606 , C08J7/042 , C08J2375/12 , C08J2423/06 , C08J2433/10 , C08L75/04 , C08L71/02 , C08L39/04 , C08L33/00
摘要： Biocompatible polymeric coatings are provided which have excellent adhesion to a variety of substrate materials. The biocompatible coatings of the invention are comprised of a poly(alkylene oxide), a poly(carboxylic acid) or a poly(N-vinyl lactam) or mixtures thereof. The polymers adhere to the substrate through a polyisocyanate coating which bonds with the biocompatible coating when dried or irradiated or both. The biocompatible polymeric complexes have utility in medical devices such as catheters.

4. 发明授权

US07706807B2 Systems and methods for evaluating point of communications locations 失效
标题翻译：用于评估通信位置点的系统和方法
公开(公告)号：US07706807B2
公开(公告)日：2010-04-27
申请号：US11690066
申请日：2007-03-22
申请人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose
发明人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose
IPC分类号： H04Q7/20
CPC分类号： H04W16/18 , H04B7/10 , H04B17/391 , H04W16/00 , H04W24/00 , H04W28/18
摘要： A computer-based program performs calculations to analyze, vary, test, manage, and/or improve the performance of channels and/or frequencies in the communication spectrum. The program varies parameters of a point of communication, such as the location, transmission power, channel frequency, antenna height, and the like, alone or in combination, to measure, test, and/or evaluate which parameter changes increase the market coverage of a target market or area. In some scenarios, changes to one point of communication cause the regulations governing the broadcast relationship between one or more nearby points of communication to be violated. When this occurs, the program determines which of the parameters, such as the location, transmission power, channel and/or frequency, antenna height, and the like, alone or in combination, of the point of communication interfering with the increased market coverage scenario to vary to overcome the conflict with communications and/or regulatory law. In addition, the program can determine simultaneously which of the parameters of multiple points of communication to vary to overcome the conflict with communications and/or regulatory law. The program outputs multiple solutions with varying degrees of difficulty and varying amounts of performance improvement.
摘要翻译：基于计算机的程序执行计算以分析，改变，测试，管理和/或改善通信频谱中的频道和/或频率的性能。该程序单独或组合地改变通信点的参数，例如位置，发送功率，信道频率，天线高度等，以测量，测试和/或评估哪些参数变化增加市场覆盖范围目标市场或地区。在某些情况下，对一个通信点的更改导致违反了一个或多个附近的通信点之间的广播关系的规则。当这种情况发生时，程序确定通信点单独或组合地中的哪些参数，例如位置，发送功率，信道和/或频率，天线高度等干扰市场覆盖情况的增加以克服与通信和/或监管法律的冲突。此外，该程序可以同时确定多个通信点的哪些参数不同以克服与通信和/或监管法律的冲突。该程序输出具有不同难度和不同数量的性能改进的多个解决方案。

5. 发明授权

US07613465B2 Systems and methods for determining feasibility of communication spectrum maximization 失效
标题翻译：确定通信频谱最大化可行性的系统和方法
公开(公告)号：US07613465B2
公开(公告)日：2009-11-03
申请号：US11690023
申请日：2007-03-22
申请人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose , Neil Jennings Keon , Joakim Kalvenes
发明人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose , Neil Jennings Keon , Joakim Kalvenes
IPC分类号： H04Q7/20
CPC分类号： H04W16/18 , H04B7/10 , H04B17/391 , H04W16/00 , H04W24/00 , H04W28/18
摘要： A computer-based program performs calculations to analyze, vary, test, manage, and/or improve the performance of channels and/or frequencies in the communication spectrum. The program varies parameters of a point of communication, such as the location, transmission power, channel frequency, antenna height, and the like, alone or in combination, to measure, test, and/or evaluate which parameter changes increase the market coverage of a target market or area. In some scenarios, changes to one point of communication cause the regulations governing the broadcast relationship between one or more nearby points of communication to be violated. When this occurs, the program determines which of the parameters, such as the location, transmission power, channel and/or frequency, antenna height, and the like, alone or in combination, of the point of communication interfering with the increased market coverage scenario to vary to overcome the conflict with communications and/or regulatory law. In addition, the program can determine simultaneously which of the parameters of multiple points of communication to vary to overcome the conflict with communications and/or regulatory law. The program outputs multiple solutions with varying degrees of difficulty and varying amounts of performance improvement.
摘要翻译：基于计算机的程序执行计算以分析，改变，测试，管理和/或改善通信频谱中的频道和/或频率的性能。该程序单独或组合地改变通信点的参数，例如位置，发送功率，信道频率，天线高度等，以测量，测试和/或评估哪些参数变化增加市场覆盖范围目标市场或地区。在某些情况下，对一个通信点的更改导致违反了一个或多个附近的通信点之间的广播关系的规则。当这种情况发生时，程序确定通信点单独或组合地中的哪些参数，例如位置，发送功率，信道和/或频率，天线高度等干扰市场覆盖情况的增加以克服与通信和/或监管法律的冲突。此外，该程序可以同时确定多个通信点的哪些参数不同以克服与通信和/或监管法律的冲突。该程序输出具有不同难度和不同数量的性能改进的多个解决方案。

6. 发明授权

US07613464B2 Systems and methods for scoring communication spectrum maximization 失效
标题翻译：通信频谱最大化评分的系统和方法
公开(公告)号：US07613464B2
公开(公告)日：2009-11-03
申请号：US11690022
申请日：2007-03-22
申请人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose , Neil Jennings Keon , Joakim Kalvenes
发明人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose , Neil Jennings Keon , Joakim Kalvenes
IPC分类号： H04Q7/20
CPC分类号： H04W16/18 , H04B7/10 , H04B17/391 , H04W16/00 , H04W24/00 , H04W28/18
摘要： A computer-based program performs calculations to analyze, vary, test, manage, and/or improve the performance of channels and/or frequencies in the communication spectrum. The program varies parameters of a point of communication, such as the location, transmission power, channel frequency, antenna height, and the like, alone or in combination, to measure, test, and/or evaluate which parameter changes increase the market coverage of a target market or area. In some scenarios, changes to one point of communication cause the regulations governing the broadcast relationship between one or more nearby points of communication to be violated. When this occurs, the program determines which of the parameters, such as the location, transmission power, channel and/or frequency, antenna height, and the like, alone or in combination, of the point of communication interfering with the increased market coverage scenario to vary to overcome the conflict with communications and/or regulatory law. In addition, the program can determine simultaneously which of the parameters of multiple points of communication to vary to overcome the conflict with communications and/or regulatory law. The program outputs multiple solutions with varying degrees of difficulty and varying amounts of performance improvement.
摘要翻译：基于计算机的程序执行计算以分析，改变，测试，管理和/或改善通信频谱中的频道和/或频率的性能。该程序单独或组合地改变通信点的参数，例如位置，发送功率，信道频率，天线高度等，以测量，测试和/或评估哪些参数变化增加市场覆盖范围目标市场或地区。在某些情况下，对一个通信点的更改导致违反了一个或多个附近的通信点之间的广播关系的规则。当这种情况发生时，程序确定通信点单独或组合地中的哪些参数，例如位置，发送功率，信道和/或频率，天线高度等干扰市场覆盖情况的增加以克服与通信和/或监管法律的冲突。此外，该程序可以同时确定多个通信点的哪些参数不同以克服与通信和/或监管法律的冲突。该程序输出具有不同难度和不同数量的性能改进的多个解决方案。

7. 发明授权

US07706806B2 Systems and methods for evaluating a change in class for a point of communication 失效
标题翻译：用于评估交流点课程变化的系统和方法
公开(公告)号：US07706806B2
公开(公告)日：2010-04-27
申请号：US11690051
申请日：2007-03-22
申请人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose
发明人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose
IPC分类号： H04Q7/20
CPC分类号： H04W16/18 , H04B7/10 , H04B17/391 , H04W16/00 , H04W24/00 , H04W28/18
摘要： A computer-based program performs calculations to analyze, vary, test, manage, and/or improve the performance of channels and/or frequencies in the communication spectrum. The program varies parameters of a point of communication, such as the location, transmission power, channel frequency, antenna height, and the like, alone or in combination, to measure, test, and/or evaluate which parameter changes increase the market coverage of a target market or area. In some scenarios, changes to one point of communication cause the regulations governing the broadcast relationship between one or more nearby points of communication to be violated. When this occurs, the program determines which of the parameters, such as the location, transmission power, channel and/or frequency, antenna height, and the like, alone or in combination, of the point of communication interfering with the increased market coverage scenario to vary to overcome the conflict with communications and/or regulatory law. In addition, the program can determine simultaneously which of the parameters of multiple points of communication to vary to overcome the conflict with communications and/or regulatory law. The program outputs multiple solutions with varying degrees of difficulty and varying amounts of performance improvement.
摘要翻译：基于计算机的程序执行计算以分析，改变，测试，管理和/或改善通信频谱中的频道和/或频率的性能。该程序单独或组合地改变通信点的参数，例如位置，发送功率，信道频率，天线高度等，以测量，测试和/或评估哪些参数变化增加市场覆盖范围目标市场或地区。在某些情况下，对一个通信点的更改导致违反了一个或多个附近的通信点之间广播关系的规定。当这种情况发生时，程序确定通信点单独或组合地中的哪些参数，例如位置，发送功率，信道和/或频率，天线高度等干扰市场覆盖情况的增加以克服与通信和/或监管法律的冲突。此外，该程序可以同时确定多个通信点的哪些参数不同以克服与通信和/或监管法律的冲突。该程序输出具有不同难度和不同数量的性能改进的多个解决方案。

8. 发明授权

US07613466B2 Systems and methods for evaluating changes in transmissions for a point of communication 失效
标题翻译：用于评估通信点传输变化的系统和方法
公开(公告)号：US07613466B2
公开(公告)日：2009-11-03
申请号：US11690044
申请日：2007-03-22
申请人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose
发明人： Ronald A. Unkefer , Gary Marlin Lawrence , William Roland Hieatt, III , Harold A. Rose
IPC分类号： H04Q7/20
CPC分类号： H04W16/18 , H04B7/10 , H04B17/391 , H04W16/00 , H04W24/00 , H04W28/18
摘要： A computer-based program performs calculations to analyze, vary, test, manage, and/or improve the performance of channels and/or frequencies in the communication spectrum. The program varies parameters of a point of communication, such as the location, transmission power, channel frequency, antenna height, and the like, alone or in combination, to measure, test, and/or evaluate which parameter changes increase the market coverage of a target market or area. In some scenarios, changes to one point of communication cause the regulations governing the broadcast relationship between one or more nearby points of communication to be violated. When this occurs, the program determines which of the parameters, such as the location, transmission power, channel and/or frequency, antenna height, and the like, alone or in combination, of the point of communication interfering with the increased market coverage scenario to vary to overcome the conflict with communications and/or regulatory law. In addition, the program can determine simultaneously which of the parameters of multiple points of communication to vary to overcome the conflict with communications and/or regulatory law. The program outputs multiple solutions with varying degrees of difficulty and varying amounts of performance improvement.
摘要翻译：基于计算机的程序执行计算以分析，改变，测试，管理和/或改善通信频谱中的频道和/或频率的性能。该程序单独或组合地改变通信点的参数，例如位置，发送功率，信道频率，天线高度等，以测量，测试和/或评估哪些参数变化增加市场覆盖范围目标市场或地区。在某些情况下，对一个通信点的更改导致违反了一个或多个附近的通信点之间的广播关系的规则。当这种情况发生时，程序确定通信点单独或组合地中的哪些参数，例如位置，发送功率，信道和/或频率，天线高度等干扰市场覆盖情况的增加以克服与通信和/或监管法律的冲突。此外，该程序可以同时确定多个通信点的哪些参数不同以克服与通信和/或监管法律的冲突。该程序输出具有不同难度和不同数量的性能改进的多个解决方案。

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