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1. 发明专利

CA2729187C PRODUCTION OF ALKENES BY ENZYMATIC DECARBOXYLATION OF 3-HYDROXYALKANOIC ACIDS 未知
公开(公告)号：CA2729187C
公开(公告)日：2016-04-19
申请号：CA2729187
申请日：2009-07-06
申请人： MARLIERE PHILIPPE
发明人： MARLIERE PHILIPPE
IPC分类号： C12P5/02 , C12N1/20 , C12N1/21 , C12N9/88 , C12N15/60 , C12N15/63
摘要： The present invention relates to a method for generating alkenes biologically It relates more particularly to a method for producing terminal alkenes by enzymatic decarboxylation of 3--hydroxyalkanoate molecules The invention also relates to the enzymatic systems and the microbial strains used, and also to the products obtained

2. 发明公开

EP1636246A1 PRODUCTION OF 2 -DEOXYNUCLEOSIDES AND 2 -DEOXYNUCLEOSIDE PRECURSORS FROM 2-DEHYDRO-3-DEOXY-D-GLUCONATE 有权
标题翻译：制备2-脱氧核苷和2-DESOXYNUKLEOSIDVORSTUFEN由2-脱氢-3-脱氧-D-葡萄糖酸
公开(公告)号：EP1636246A1
公开(公告)日：2006-03-22
申请号：EP04740261.5
申请日：2004-06-24
申请人： Evologic S.A. , Marliere Technologies Société Civile , RHODIA CHIMIE , Marliere, Philippe
发明人： MARLIERE, Philippe , DÖRING, Volker , THIBAUT, Denis , KREIMEYER, Annett
IPC分类号： C07H7/027 , C07H1/00 , C12P7/42 , C12N9/88 , C12N1/20
CPC分类号： C07H1/00 , C07H7/027 , C12N9/88 , C12P7/24 , C12P7/42
摘要： This invention relates to a process for preparing 2'-deoxynucleoside compounds or 2'-deoxynucleoside precursors using 2-dehydro-3-deoxy-D-gluconic acid (usually abbreviated as KDG) or its salts as a starting material. A variety of 2'-deoxynucleosides and their analogues are used as a starting material for synthesis or drug formulation in production of an antiviral, anticancer or antisense agent.

3. 发明专利

BRPI0914215A2 produção de alcenos por descarboxilação enzimática de ácidos 3-hidróxi-alcanoicos 未知
公开(公告)号：BRPI0914215A2
公开(公告)日：2016-01-05
申请号：BRPI0914215
申请日：2009-07-06
申请人： MARLIERE PHILIPPE
发明人： MARLIERE PHILIPPE
IPC分类号： C12N9/88 , C12P5/02

4. 发明公开

EP2304040A2 PRODUCTION D'ALCENES PAR DECARBOXYLATION ENZYMATIQUE D'ACIDES 3-HYDROXY-ALCANOÏQUES 有权转让
标题翻译： HERSTELLUNG VON ALKENEN DURCH ENZYMATISCHE DECARBOXYLIUNGUNG VON 3-HYDROXYALKANSÄUREN
公开(公告)号：EP2304040A2
公开(公告)日：2011-04-06
申请号：EP09772760.6
申请日：2009-07-06
申请人： Marliere, Philippe
发明人： Marliere, Philippe
IPC分类号： C12P5/02 , C12N15/63 , C12N9/88 , C12N15/60 , C12N1/20 , C12N1/21
CPC分类号： C12P5/026 , C07C2/28 , C12N9/88 , C12Y401/01033 , C07C11/02
摘要： The present invention relates to a method for generating alkenes biologically. It relates more particularly to a method for producing terminal alkenes by enzymatic decarboxylation of 3-hydroxyalkanoate molecules. The invention also relates to the enzymatic systems and the microbial strains used, and also to the products obtained.
摘要翻译：本发明涉及一种生物烯烃生产方法。更具体地涉及通过3-羟基链烷酸酯分子的酶脱羧生产末端烯烃的方法。本发明还涉及酶系统和所用的微生物菌株，以及所获得的产物。

5. 发明公开

EP2295593A1 Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA 审中-公开
标题翻译： Verfahren zur酶学家Herstellung von 3-Hydroxy-3-Methylbuttersäureaus Aceton und Acetyl-CoA
公开(公告)号：EP2295593A1
公开(公告)日：2011-03-16
申请号：EP09170312.4
申请日：2009-09-15
申请人： Marliere, Philippe
发明人： Marliere, Philippe
IPC分类号： C12P7/52 , C12N15/52 , C12N9/10 , C12N9/88 , C12N1/21
CPC分类号： C12P7/52 , C12N9/1025 , C12N9/88 , C12P7/42 , C12Y203/0301 , C12Y401/03004 , Y02P20/52
摘要： Described is a method for the production of 3-hydroxy-3-methylbutyric acid (also referred to as beta-hydroxyisovalerate or HIV) from acetone and a compound which provides an activated acetyl group comprising the enzymatic conversion of acetone and a compound which provides an activated acetyl group into 3-hydroxy-3-methylbutyric acid. The conversion makes use of an enzyme which is capable of catalyzing the formation of a covalent bond between the carbon atom of the oxo (i.e. the C=O) group of acetone and the methyl group of the compound which provides an activated acetyl group. Preferably, the enzyme employed in the process is an enzyme with the activity of a HMG CoA synthase (EC 2.3.3.10) and/or a PksG protein and/or an enzyme with the activity of a C-C bond cleavage/condensation lyase, such as a HMG CoA lyase (EC 4.1.3.4). Also described are organisms which are able to produce 3-hydroxy-3-methylbutyric acid from acetone, a compound which provides an activated acetyl group, the use of the above-mentioned enzymes and organisms for the production of 3-hydroxy-3-methylbutyric acid as well as the use of acetone for the production of 3-hydroxy-3-methylbutyric acid.
摘要翻译：描述了一种从丙酮生产3-羟基-3-甲基丁酸（也称为β-羟基异戊酸酯或HIV）的方法和提供活化乙酰基的化合物，其包括丙酮的酶转化和提供活化乙酰基转化为3-羟基-3-甲基丁酸。该转化使用能够催化丙酮的氧代（即C = O）基团的碳原子与提供活化的乙酰基的化合物的甲基之间形成共价键的酶。优选地，该方法中使用的酶是具有HMG CoA合成酶（EC 2.3.3.10）和/或PksG蛋白和/或具有CC键切割/冷凝裂合酶活性的酶的酶，例如 HMG CoA裂解酶（EC 4.1.3.4）。还描述了能够从丙酮产生3-羟基-3-甲基丁酸的生物体，提供活化乙酰基的化合物，使用上述酶和生物体来生产3-羟基-3-甲基丁酸酸以及使用丙酮生产3-羟基-3-甲基丁酸。

6. 发明专利

AU2010297362A1 Method for the enzymatic production of 3-hydroxy-S-methylbutyric acid from acetone and acetyl-CoA 未知
公开(公告)号：AU2010297362A1
公开(公告)日：2012-03-15
申请号：AU2010297362
申请日：2010-09-14
申请人： MARLIERE PHILIPPE
发明人： MARLIERE PHILIPPE
IPC分类号： C12P7/52 , C12N1/21 , C12N9/10 , C12N9/88 , C12N15/52
摘要： Described is a method for the production of 3-hydroxy-3-methylbutyric acid (also referred to as beta-hydroxyisovalerate or HiV) from acetone and a compound which provides an activated acetyl group comprising the enzymatic conversion of acetone and a compound which provides an activated acetyl group into 3-hydroxy-3- methylbutyric acid. The conversion makes use of an enzyme which is capable of catalyzing the formation of a covaient bond between the carbon atom of the oxo (i.e. the C=O) group of acetone and the methyl group of the compound which provides an activated acetyl group. Preferably, the enzyme employed in the process is an enzyme with the activity of a HMG CoA synthase (EC 2.3.3.10) and/or a PksG protein and/or an enzyme with the activity of a C-C bond cleavage/condensation lyase, such as a HMG CoA lyase (EC 4.1.3.4). Also described are organisms which are able to produce 3-hydroxy-3-methylbuty&pgr;c acid from acetone, a compound which provides an activated acetyl group, the use of the above-mentioned enzymes and organisms for the production of 3-hydroxy-3-methylbutyric acid as well as the use of acetone for the production of 3-hydroxy-3-methylbutyric acid.

7. 发明专利

CA2772279A1 METHOD FOR THE ENZYMATIC PRODUCTION OF 3-HYDROXY-S-METHYLBUTYRIC ACID FROM ACETONE AND ACETYL-COA 未知
公开(公告)号：CA2772279A1
公开(公告)日：2011-03-24
申请号：CA2772279
申请日：2010-09-14
申请人： MARLIERE PHILIPPE
发明人： MARLIERE PHILIPPE
IPC分类号： C12P7/52 , C12N1/21 , C12N9/10 , C12N9/88 , C12N15/52
摘要： Described is a method for the production of 3-hydroxy-3-methylbutyric acid (also referred to as beta-hydroxyisovalerate or HiV) from acetone and a compound which provides an activated acetyl group comprising the enzymatic conversion of acetone and a compound which provides an activated acetyl group into 3-hydroxy-3- methylbutyric acid. The conversion makes use of an enzyme which is capable of catalyzing the formation of a covaient bond between the carbon atom of the oxo (i.e. the C=O) group of acetone and the methyl group of the compound which provides an activated acetyl group. Preferably, the enzyme employed in the process is an enzyme with the activity of a HMG CoA synthase (EC 2.3.3.10) and/or a PksG protein and/or an enzyme with the activity of a C-C bond cleavage/condensation lyase, such as a HMG CoA lyase (EC 4.1.3.4). Also described are organisms which are able to produce 3-hydroxy-3-methylbutypc acid from acetone, a compound which provides an activated acetyl group, the use of the above-mentioned enzymes and organisms for the production of 3-hydroxy-3-methylbutyric acid as well as the use of acetone for the production of 3-hydroxy-3-methylbutyric acid.

8. 发明专利

CA2729187A1 PRODUCTION OF ALKENES BY ENZYMATIC DECARBOXYLATION OF 3-HYDROXYALKANOIC ACIDS 未知
公开(公告)号：CA2729187A1
公开(公告)日：2010-01-07
申请号：CA2729187
申请日：2009-07-06
申请人： MARLIERE PHILIPPE
发明人： MARLIERE PHILIPPE
IPC分类号： C12P5/02 , C12N1/20 , C12N1/21 , C12N9/88 , C12N15/60 , C12N15/63
摘要： The present invention relates to a method for generating alkenes biologically. It relates more particularly to a method for producing terminal alkenes by enzymatic decarboxylation of 3-hydroxyalkanoate molecules. The invention also relates to the enzymatic systems and the microbial strains used, and also to the products obtained.

9. 发明公开

EP2336341A1 Method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step 审中-公开
标题翻译：一种用于通过醇的酶脱氢制备烯烃的过程
公开(公告)号：EP2336341A1
公开(公告)日：2011-06-22
申请号：EP09180143.1
申请日：2009-12-21
申请人： Marliere, Philippe
发明人： Marliere, Philippe
IPC分类号： C12P5/00 , C12P5/02 , C12N9/88
CPC分类号： C12N9/88 , C12P5/026
摘要： Described is a method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step. The conversion preferably makes use of an unsaturated fatty acid hydratase, in particular of an oleate hydratase (EC 4.2.1.53). Moreover, the present invention describes a recombinant organism which produces an alcohol and which expresses a hydratase enzyme which is capable of catalyzing the conversion of said alcohol into an alkene.
摘要翻译：描述的是用于在烯烃包括通过酶促步骤的脱水转化为醇的步骤的制造方法。转化优选利用一种不饱和脂肪酸水合酶，在油酸水合酶的具体（EC 4.2.1.53）。更过地，本发明描述了一种重组生物体，其产生烯烃酒精和表达培养水合酶酶能够催化所有这些是酒精对转换到所述的。

10. 发明公开

EP2336340A1 Method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step 审中-公开
标题翻译：一种用于通过醇的酶脱氢制备烯烃的过程
公开(公告)号：EP2336340A1
公开(公告)日：2011-06-22
申请号：EP09180145.6
申请日：2009-12-21
申请人： Marliere, Philippe
发明人： Marliere, Philippe
IPC分类号： C12P5/00 , C12P5/02 , C12N9/88
CPC分类号： C12P5/026 , C12N9/88
摘要： Described is a method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step. The conversion preferably makes use of a prenyl isoflavonoid hydratase, in particular of a kievitone hydratase (EC 4.2.1.95) or of a phaseollidin hydratase (EC 4.2.1.97). Moreover, the present invention describes a recombinant organism which produces an alcohol and which expresses a hydratase enzyme which is capable of catalyzing the conversion of said alcohol into an alkene.
摘要翻译：描述的是用于在烯烃包括通过酶促步骤的脱水转化为醇的步骤的制造方法。转化优选利用异戊二烯基异黄酮水合酶，在kievitone水合酶的具体（EC 4.2.1.95）或phaseollidin水合酶（EC 4.2.1.97）。更过地，本发明描述了一种重组生物体，其产生烯烃酒精和表达培养水合酶酶能够催化所有这些是酒精对转换到所述的。

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