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1. 发明申请

WO2007072230A2 CONTROL OF INTESTINAL INFLAMMATORY SYNDROMES WITH A PREPARATION OF KILLED OR NON INFECTIOUS BACTERIA 审中-公开
标题翻译：具有杀伤性或非感染性细菌的准备的肠内炎症综合征的控制
公开(公告)号：WO2007072230A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006/004133
申请日：2006-12-21
申请人： INSTITUT PASTEUR , YISSUM RESEARCH DEVELOPMENT COMPANY , MARCHAL, Gilles , LAGRANDERIE, Micheline , ABOLHASSANI, Mohammad , BERCOVIER, Hervé
发明人： MARCHAL, Gilles , LAGRANDERIE, Micheline , ABOLHASSANI, Mohammad , BERCOVIER, Hervé
CPC分类号： C12N1/20 , A61K35/74 , C12N1/36 , C12R1/32
摘要： This invention relates to the use of a preparation of killed or non infectious Gram positive bacteria such as Gram positive facultative intracellular bacteria, for example mycobacteria, for the treatment of intestinal inflammatory syndromes such as Crohn's disease or ulcerative colitis.
摘要翻译：本发明涉及杀伤或非感染性革兰氏阳性菌如革兰氏阳性兼性细胞内细菌例如分枝杆菌的制剂用于治疗肠炎症综合征如克罗恩病或溃疡性结肠炎的用途。

2. 发明申请

WO2003049752A3 GRAM POSITIVE BACTERIA PREPARATIONS FOR THE TREATMENT OF DISEASES COMPRISING AN IMMUNE DYSREGULATION 审中-公开
公开(公告)号：WO2003049752A3
公开(公告)日：2003-06-19
申请号：PCT/IB2002/005760
申请日：2002-12-11
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , NAHORI, Marie-Anne , LAGRANDERIE, Micheline , MARCHAL, Gilles , VARGAFTIG, Bernardo, Boris , LEFORT, Jean , ROMAIN, Félix , HEKIMIAN, Georges , PELTRE, Philippe
发明人： NAHORI, Marie-Anne , LAGRANDERIE, Micheline , MARCHAL, Gilles , VARGAFTIG, Bernardo, Boris , LEFORT, Jean , ROMAIN, Félix , HEKIMIAN, Georges , PELTRE, Philippe
IPC分类号： A61K35/74
摘要： Compositions comprising components prepared from Gram positive bacteria such as Gram positive facultative intracellular bacteria, for example mycobacteria, including extended freeze-dried killed Gram positive bacteria, their method of preparation and their use in humans and animals, for the prevention and/or the treatment of disorders comprising an immune dysregulation such as cancer, autoimmune diseases, allergy and tuberculosis.

3. 发明申请

WO2011018769A1 USE OF MYCOBACTERIUM BOVIS BCG KILLED BY EXTENDED FREEZE DRYING (EFD) FOR PREVENTING OR TREATING ATHEROSCLEROSIS 审中-公开
标题翻译：用于预防或治疗甲状腺功能亢进的延长冻干（EFD）杀死的MYCOBACTERIUM BOVIS BCG的使用
公开(公告)号：WO2011018769A1
公开(公告)日：2011-02-17
申请号：PCT/IB2010/053652
申请日：2010-08-12
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , MARCHAL, Gilles , LAGRANDERIE, Micheline , SCHWARTZ-CORNIL, Isabelle
发明人： MARCHAL, Gilles , LAGRANDERIE, Micheline , SCHWARTZ-CORNIL, Isabelle
IPC分类号： A61K39/04
CPC分类号： A61K39/04 , A61K2039/58
摘要： Use of Mycobacterium bovis BCG killed by Extended Freeze Drying (EFD) for preventing or treating atherosclerosis.
摘要翻译：使用通过延长冷冻干燥（EFD）杀死的牛分枝杆菌BCG预防或治疗动脉粥样硬化。

4. 发明申请

WO2009127971A3 CONTROL OF DISEASES ASSOCIATED WITH DECREASE OF T-REGULATORY CELLS WITH A PREPARATION OF EXTENDED FREEZE-DRIED KILLED BACTERIA 审中-公开
公开(公告)号：WO2009127971A3
公开(公告)日：2009-10-22
申请号：PCT/IB2009/005498
申请日：2009-04-14
申请人： INSTITUT PASTEUR , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , MARCHAL, Gilles , LAGRANDERIE, Micheline , ABOLHASSANI, Muhammad , BERCOVIER, Hervé , MARON, Ayelet
发明人： MARCHAL, Gilles , LAGRANDERIE, Micheline , ABOLHASSANI, Muhammad , BERCOVIER, Hervé , MARON, Ayelet
IPC分类号： A61K35/74
摘要： This invention relates to the use of a preparation of extended freeze- dried (EFD) killed Gram positive bacteria such as Gram positive facultative intracellular bacteria, for example mycobacteria, for the treatment of diseases associated with a decrease of T-regulatory cells (Tregs), particularly CNS inflammatory diseases, and more particularly CNS demyelinating diseases such as multiple sclerosis (MS) and acute-disseminated encephalomyelitis.

5. 发明申请

WO0250108A3 IMMUNOGENIC GLYCOPEPTIDES, SCREENING, PREPARATION AND USES 审中-公开
标题翻译：免疫原性糖肽，筛选，制备和用途
公开(公告)号：WO0250108A3
公开(公告)日：2002-08-29
申请号：PCT/FR0104100
申请日：2001-12-20
申请人： PASTEUR INSTITUT , MARCHAL GILLES , ROMAIN FELIX , PESCHER PASCALE
发明人： MARCHAL GILLES , ROMAIN FELIX , PESCHER PASCALE
IPC分类号： G01N33/50 , A61K39/00 , A61K39/04 , A61K39/39 , A61P31/04 , A61P31/10 , A61P37/04 , C07K9/00 , C07K14/35 , C07K16/12 , G01N33/53 , G01N33/569 , C07H5/02
CPC分类号： C07K9/00 , A61K39/00 , C07K14/35
摘要： The invention concerns immunogenic glycopeptides derived from pathogenic micro-organisms, useful for vaccination and diagnosis of infections caused by said pathogenic micro-organisms (bacteria or fungi), and methods for selecting them and preparing them. Said glycopeptides are selected in the group consisting of: a1) glycopeptides essentially consisting of a glycosylated T epitope, comprising 14 to 25 amino acids, among which at least a neutral amino acid is bound to a di- or to a trisaccharide (glycoside linkage) and at least 15 % among said amino acids are proline, one of the proline being located in position -1 to -4, relative to the position of said neutral amino acid, which glycopeptides are: exhibited by a class II MHC molecule, specifically identified by T CD+4 lymphocytes induced by immunisation with the native glycopeptide from which they are derived, but are not identified by the T CD+4 lymphocytes induced by immunisation with a non-glycosylated peptide of same sequence and capable of inducing a proliferation of said T CD+4 lymphocytes by which they are identified and the secretion of cytokines by said lymphocytes and b1) glycopeptides having a sequence of 15 to 39 amino acids including the sequence of the glycopeptide as defined in a1), excluding the glycopeptide of sequence SEQ ID NO:11.
摘要翻译：本发明涉及源自致病微生物的免疫原性糖肽，其可用于接种和诊断由所述致病微生物（细菌或真菌）引起的感染，以及选择它们并制备它们的方法。所述糖肽选自由以下组成的组：a1）基本上由糖基化T表位组成的组的糖肽，其包含14至25个氨基酸，其中至少中性氨基酸与二糖或三糖（糖苷键）结合，并且所述氨基酸中至少15％是脯氨酸，相对于所述中性氨基酸的位置，脯氨酸中的一个位于-1至-4位，所述糖肽是：由II类MHC分子展示的，特异性鉴定的 T CD + 4淋巴细胞通过用它们所来源的天然糖肽进行免疫诱导，但未被用相同序列的非糖基化肽免疫诱导的T CD + 4淋巴细胞鉴定，并且能够诱导所述的增殖 T CD + 4淋巴细胞，以及由所述淋巴细胞分泌细胞因子，和b1）具有15至39个氨基酸序列的糖肽，包括糖肽的序列，作为def 排除在a1），排除序列SEQ ID NO：11的糖肽。

6. 发明申请

WO2007072230A3 CONTROL OF INTESTINAL INFLAMMATORY SYNDROMES WITH A PREPARATION OF KILLED OR NON INFECTIOUS BACTERIA 审中-公开
标题翻译：用杀死或非感染性细菌制备肠道炎症综合征的控制
公开(公告)号：WO2007072230A3
公开(公告)日：2007-11-22
申请号：PCT/IB2006004133
申请日：2006-12-21
申请人： PASTEUR INSTITUT , YISSUM RES DEV CO , MARCHAL GILLES , LAGRANDERIE MICHELINE , ABOLHASSANI MOHAMMAD , BERCOVIER HERVE
发明人： MARCHAL GILLES , LAGRANDERIE MICHELINE , ABOLHASSANI MOHAMMAD , BERCOVIER HERVE
IPC分类号： A61K35/74 , A61P1/04
CPC分类号： C12N1/20 , A61K35/74 , C12N1/36 , C12R1/32
摘要： This invention relates to the use of a preparation of killed or non infectious Gram positive bacteria such as Gram positive facultative intracellular bacteria, for example mycobacteria, for the treatment of intestinal inflammatory syndromes such as Crohn's disease or ulcerative colitis.
摘要翻译：本发明涉及杀伤或非感染革兰氏阳性细菌如革兰氏阳性兼性细胞内细菌如分枝杆菌制剂用于治疗肠炎症综合征如克罗恩氏病或溃疡性结肠炎的用途。

7. 发明申请

WO2006035317A3 IMMUNOGENIC GLYCOPEPTIDES FOR DIAGNOSING PATHOGENIC MICROORGANISMS INFECTIONS 审中-公开
标题翻译：免疫原性糖蛋白用于诊断致病微生物感染
公开(公告)号：WO2006035317A3
公开(公告)日：2006-08-17
申请号：PCT/IB2005003303
申请日：2005-09-29
申请人： PASTEUR INSTITUT , MARCHAL GILLES , ROMAIN FELIX , PESCHER PASCALE , BALEUX FRANCOISE , SCOTT-ALGARA DANIEL , MULARD LAURENCE
发明人： MARCHAL GILLES , ROMAIN FELIX , PESCHER PASCALE , BALEUX FRANCOISE , SCOTT-ALGARA DANIEL , MULARD LAURENCE
IPC分类号： G01N33/569
CPC分类号： G01N33/5695
摘要： A method for diagnosing an infection in a patient likely to be infected with a pathogenic microorganism, comprising the detection of CD4+ T lymphocytes recognizing at least one glycopeptide derived from said pathogenic microorganism, essentially consisting of a glycosylated T epitope, comprising from 14 to 25 amino acids, among which at least one neutral amino acid is bonded to a disaccharide or to a trisaccharide, and at least 15% of said amino acids are prolines, one of the prolines being located in position -1 to -4, relative to the position of said neutral amino acid.
摘要翻译：一种用于诊断可能感染致病微生物的患者的感染的方法，包括检测识别至少一种来源于所述病原微生物的糖肽的CD4 + T淋巴细胞，所述糖肽基本上由糖基化的T表位组成，所述糖基化的T表位包含14至25个氨基酸，其中至少一个中性氨基酸与二糖或三糖结合，并且至少15％的所述氨基酸是脯氨酸，其中一个脯氨酸相对于位置在-1至-4位的所述中性氨基酸。

8. 发明申请

WO2006035317A2 IMMUNOGENIC GLYCOPEPTIDES FOR DIAGNOSING PATHOGENIC MICROORGANISMS INFECTIONS 审中-公开
标题翻译：用于诊断病原微生物感染的免疫球蛋白
公开(公告)号：WO2006035317A2
公开(公告)日：2006-04-06
申请号：PCT/IB2005/003303
申请日：2005-09-29
申请人： INSTITUT PASTEUR , MARCHAL, Gilles , ROMAIN, Felix , PESCHER, Pascale , BALEUX, Françoise , SCOTT-ALGARA, Daniel , MULARD, Laurence
发明人： MARCHAL, Gilles , ROMAIN, Felix , PESCHER, Pascale , BALEUX, Françoise , SCOTT-ALGARA, Daniel , MULARD, Laurence
IPC分类号： G01N33/569
CPC分类号： G01N33/5695
摘要： A method for diagnosing an infection in a patient likely to be infected with a pathogenic microorganism, comprising the detection of CD4+ T lymphocytes recognizing at least one glycopeptide derived from said pathogenic microorganism, essentially consisting of a glycosylated T epitope, comprising from 14 to 25 amino acids, among which at least one neutral amino acid is bonded to a disaccharide or to a trisaccharide, and at least 15% of said amino acids are prolines, one of the prolines being located in position -1 to -4, relative to the position of said neutral amino acid.
摘要翻译：用于诊断可能被病原微生物感染的患者感染的方法，包括检测识别至少一种源自所述病原微生物的至少一种糖肽的CD4 + T淋巴细胞，其基本上由糖基化的T表位组成，包含14至25个氨基酸，其中至少一个中性氨基酸与二糖或三糖结合，并且至少15％的所述氨基酸是脯氨酸，一个脯氨酸位于-1至-4的位置，相对于位置的所述中性氨基酸。

9. 发明申请

WO2003049752A2 GRAM POSITIVE BACTERIA PREPARATIONS FOR THE TREATMENT OF DISEASES COMPRISING AN IMMUNE DYSREGULATION 审中-公开
标题翻译：用于治疗包含免疫缺陷症的疾病的GRAM阳性细菌制剂
公开(公告)号：WO2003049752A2
公开(公告)日：2003-06-19
申请号：PCT/IB2002/005760
申请日：2002-12-11
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , NAHORI, Marie-Anne , LAGRANDERIE, Micheline , MARCHAL, Gilles , VARGAFTIG, Bernardo, Boris , LEFORT, Jean , ROMAIN, Félix , HEKIMIAN, Georges , PELTRE, Philippe
发明人： NAHORI, Marie-Anne , LAGRANDERIE, Micheline , MARCHAL, Gilles , VARGAFTIG, Bernardo, Boris , LEFORT, Jean , ROMAIN, Félix , HEKIMIAN, Georges , PELTRE, Philippe
IPC分类号： A61K35/74
CPC分类号： A61K35/74 , A61K45/06 , C12N1/20
摘要： Compositions comprising components prepared from Gram positive bacteria such as Gram positive facultative intracellular bacteria, for example mycobacteria, including extended freeze-dried killed Gram positive bacteria, their method of preparation and their use in humans and animals, for the prevention and/or the treatment of disorders comprising an immune dysregulation such as cancer, autoimmune diseases, allergy and tuberculosis.
摘要翻译：组合物包含由革兰氏阳性细菌如革兰氏阳性兼性细胞内细菌制备的组分，例如分枝杆菌，包括延长的冷冻干燥杀死的革兰氏阳性细菌，其制备方法及其在人和动物中的用途，用于预防和/或治疗的疾病，其包括免疫调节异常，例如癌症，自身免疫疾病，变态反应和结核病。

10. 发明申请

WO2009098592A3 PREPARATION COMPRISING MYCOBACTERIUM BOVIS BCG KILLED BY EXTENDED FREEZE DRYING (EFD) FOR PREVENTING OR TREATING RHEUMATOID ARTHRITIS. 审中-公开
标题翻译：包含由膨胀冷冻干燥（EFD）杀死的白僵菌卡介苗的制剂，用于预防或治疗类风湿关节炎。
公开(公告)号：WO2009098592A3
公开(公告)日：2009-12-03
申请号：PCT/IB2009000401
申请日：2009-02-06
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIV PARIS 13 NORD , MARCHAL GILLES , LAGRANDERIE MICHELINE , BOISSIER MARIE-CHRISTOPHE , BESSIS NATACHA
发明人： MARCHAL GILLES , LAGRANDERIE MICHELINE , BOISSIER MARIE-CHRISTOPHE , BESSIS NATACHA
IPC分类号： A61K35/74 , A61K39/04 , A61P37/00
CPC分类号： A61K39/04 , A61K2039/521 , A61K2039/58
摘要： Preparation comprising Mycobacterium bovis BCG killed by Extended Freeze Drying (EFD) for preventing and/or treating rheumatoid arthritis.
摘要翻译：包含由延长冷冻干燥（EFD）杀死的用于预防和/或治疗类风湿性关节炎的牛分枝杆菌BCG的制剂。

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