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1. 发明申请

WO2013006809A3 AEROSOLIZING PARTICLES 审中-公开
标题翻译：气溶胶颗粒
公开(公告)号：WO2013006809A3
公开(公告)日：2013-06-13
申请号：PCT/US2012045792
申请日：2012-07-06
申请人： BREATHABLE FOODS INC , EDWARDS DAVID A , MAN JONATHAN , KAMLER JONATHAN JACQUES , BRETILLOT MARC
发明人： EDWARDS DAVID A , MAN JONATHAN , KAMLER JONATHAN JACQUES , BRETILLOT MARC
IPC分类号： A61K9/00 , A61K9/12
CPC分类号： A61K9/12 , A23L27/31 , A23L27/36 , A23L33/10 , A23L33/15 , A23L33/16 , A61K9/0007 , A61K9/006 , A61K31/522
摘要： A composition comprising: caffeine; a vitamin; and a sweetener.
摘要翻译：一种组合物，其包含：咖啡因; 维他命和甜味剂。

2. 发明申请

WO2010065744A9 DELIVERING AEROSOLIZABLE FOOD PRODUCTS 审中-公开
标题翻译：提供可溶性食品
公开(公告)号：WO2010065744A9
公开(公告)日：2010-09-10
申请号：PCT/US2009066590
申请日：2009-12-03
申请人： LE LABOGROUP SAS , EDWARDS DAVID A , MAN JONATHAN , KAMLER JONATHAN JACQUES , SANCHEZ JOSE , BRETILLOT MARC
发明人： EDWARDS DAVID A , MAN JONATHAN , KAMLER JONATHAN JACQUES , SANCHEZ JOSE , BRETILLOT MARC
IPC分类号： B05B7/00 , B05B17/06
CPC分类号： A61M11/005 , A61M11/002 , A61M15/0025 , A61M15/06
摘要： Aerosolized food products in a determined particle size range are suspended in the air and deposited in the mouth without easily entering into the respiratory tract. An apparatus incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a manner suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus represents a novel means for delivering food to the mouths of humans and animals. Indeed, the apparatus of the invention is designed to produce, transport, and direct aerosolized food particles in a determined size range, suspended in air, to be deposited in the mouth without substantial exposure or entry into the respiratory tract.
摘要翻译：确定粒度范围的气溶胶食品悬浮在空气中并沉积在口中，而不会容易地进入呼吸道。包含烟雾发生装置和食品的装置可以允许以适合于吸入或沉积并随后摄取的方式使食品雾化和输送。食物输送装置代表将食物输送到人类和动物口腔的新颖手段。实际上，本发明的装置被设计成生产，运输和引导悬浮在空气中的确定尺寸范围的雾化食物颗粒，以便沉积在口中而不会大量暴露或进入呼吸道。

3. 发明申请

WO2013006809A2 AEROSOLIZING PARTICLES 审中-公开
标题翻译：气溶胶颗粒
公开(公告)号：WO2013006809A2
公开(公告)日：2013-01-10
申请号：PCT/US2012/045792
申请日：2012-07-06
申请人： BREATHABLE FOODS, INC. , EDWARDS, David A. , MAN, Jonathan , KAMLER, Jonathan Jacques , BRETILLOT, Marc
发明人： EDWARDS, David A. , MAN, Jonathan , KAMLER, Jonathan Jacques , BRETILLOT, Marc
IPC分类号： A61K31/522 , A61K9/12
CPC分类号： A61K9/12 , A23L27/31 , A23L27/36 , A23L33/10 , A23L33/15 , A23L33/16 , A61K9/0007 , A61K9/006 , A61K31/522
摘要： A composition comprising: caffeine; a vitamin; and a sweetener.
摘要翻译：一种组合物，其包含：咖啡因; 一种维生素; 和甜味剂。

4. 发明申请

WO2010065744A8 DELIVERING AEROSOLIZABLE FOOD PRODUCTS 审中-公开
标题翻译：提供可溶性食品
公开(公告)号：WO2010065744A8
公开(公告)日：2011-02-03
申请号：PCT/US2009066590
申请日：2009-12-03
申请人： LE LABOGROUP SAS , EDWARDS DAVID A , MAN JONATHAN , KAMLER JONATHAN JACQUES , SANCHEZ JOSE , BRETILLOT MARC
发明人： EDWARDS DAVID A , MAN JONATHAN , KAMLER JONATHAN JACQUES , SANCHEZ JOSE , BRETILLOT MARC
IPC分类号： B05B7/00 , B05B17/06
CPC分类号： A61M11/005 , A61M11/002 , A61M15/0025 , A61M15/06
摘要： Aerosolized food products in a determined particle size range are suspended in the air and deposited in the mouth without easily entering into the respiratory tract. An apparatus incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a manner suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus represents a novel means for delivering food to the mouths of humans and animals. Indeed, the apparatus of the invention is designed to produce, transport, and direct aerosolized food particles in a determined size range, suspended in air, to be deposited in the mouth without substantial exposure or entry into the respiratory tract.
摘要翻译：确定粒度范围的气溶胶食品悬浮在空气中并沉积在口中，不会轻易进入呼吸道。包含烟雾发生装置和食品的装置可以允许以适于吸入或沉积并随后摄入的方式使食品气雾化和输送。食物输送装置代表将食物输送到人和动物口中的新颖手段。实际上，本发明的装置被设计成产生，运输和直接雾化的食物颗粒在确定的大小范围内悬浮在空气中，以沉积在口中而不会大量暴露或进入呼吸道。

5. 发明申请

WO2010065744A3 DELIVERING AEROSOLIZABLE FOOD PRODUCTS 审中-公开
标题翻译：提供可气溶性食品
公开(公告)号：WO2010065744A3
公开(公告)日：2010-11-04
申请号：PCT/US2009066590
申请日：2009-12-03
申请人： LE LABOGROUP SAS , EDWARDS DAVID A , MAN JONATHAN , KAMLER JONATHAN JACQUES , SANCHEZ JOSE , BRETILLOT MARC
发明人： EDWARDS DAVID A , MAN JONATHAN , KAMLER JONATHAN JACQUES , SANCHEZ JOSE , BRETILLOT MARC
IPC分类号： B05B7/00 , B05B17/06
CPC分类号： A61M11/005 , A61M11/002 , A61M15/0025 , A61M15/06
摘要： Aerosolized food products in a determined particle size range are suspended in the air and deposited in the mouth without easily entering into the respiratory tract. An apparatus incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a manner suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus represents a novel means for delivering food to the mouths of humans and animals. Indeed, the apparatus of the invention is designed to produce, transport, and direct aerosolized food particles in a determined size range, suspended in air, to be deposited in the mouth without substantial exposure or entry into the respiratory tract.
摘要翻译：确定粒度范围的雾化食品悬浮在空气中并沉积在口中而不容易进入呼吸道。并入有气雾产生装置和食品的装置可以允许食物产品的气雾化以及以适于吸入或沉积和随后摄入的方式递送食物产品。食物输送装置代表了一种将食物输送到人类和动物的口腔的新型手段。实际上，本发明的设备被设计成生产，运输和引导悬浮在空气中的确定尺寸范围内的雾化食物颗粒，以沉积在口中而不会显着暴露或进入呼吸道。

6. 发明申请

WO2009079078A1 DELIVERING AEROSOLIZABLE FOOD PRODUCTS 审中-公开
标题翻译：提供可气溶性食品
公开(公告)号：WO2009079078A1
公开(公告)日：2009-06-25
申请号：PCT/US2008/079214
申请日：2008-10-08
申请人： LABOGROUP S.A.S. , EDWARDS, David A. , MAN, Jonathan , KAMLER, Jonathan Jacques , SANCHEZ, José
发明人： EDWARDS, David A. , MAN, Jonathan , KAMLER, Jonathan Jacques , SANCHEZ, José
IPC分类号： A23L1/00 , A61M11/00 , B05B7/00 , A23G3/56 , B05B1/26
CPC分类号： A23G1/505 , A23G1/305 , A23G1/50 , A24F7/00 , A61M11/001 , A61M11/005
摘要： Aerosolized food products can be of sufficient size to deposit in the mouth without easily entering into the respiratory tract and of small enough size so as to allow for suspension in air. An apparatus (110) incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a matter suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus (110) represents a novel means of delivering food to the mouths of humans and animals. Indeed, the apparatus (110) of the invention is designed to produce, transport, and direct aerosolized food particles of sufficient size to deposit in the mouth without substantial exposure or entry into the respiratory tract and of small enough size so as to allow for suspension in air.
摘要翻译：气雾化食品可以具有足够的尺寸以在嘴中沉积而不容易进入呼吸道并且具有足够小的尺寸以允许悬浮在空气中。包含气雾剂产生装置和食品的设备（110）可以允许食品的雾化和其适合于吸入或沉积以及随后摄入的物质的递送。食物输送装置（110）代表将食物输送到人和动物的嘴部的新型手段。实际上，本发明的设备（110）被设计成产生，运输和引导具有足够尺寸的雾化食物颗粒以沉积在口中而不会大量暴露或进入呼吸道并且尺寸足够小以允许悬浮在空气中。

7. 发明申请

WO2006076265A3 METHOD AND DEVICE FOR DECREASING CONTAMINATION 审中-公开
标题翻译：减少污染的方法和装置
公开(公告)号：WO2006076265A3
公开(公告)日：2006-12-14
申请号：PCT/US2006000618
申请日：2006-01-10
申请人： PULMATRIX INC , EDWARDS DAVID A , GABRIELSON MARK J , CLARKE ROBERT WILLIAM , DEHAAN WESLEY HUGH , BRANDE MATTHEW FREDERICK , MAN JONATHAN CHUN-WAH
发明人： EDWARDS DAVID A , GABRIELSON MARK J , CLARKE ROBERT WILLIAM , DEHAAN WESLEY HUGH , BRANDE MATTHEW FREDERICK , MAN JONATHAN CHUN-WAH
IPC分类号： A61B5/097 , G01N15/02 , G01N33/497
CPC分类号： G01N33/497 , A61B5/0816 , A61B5/0878 , A61B5/097 , G01N15/0205
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12) , a filter (14) , a low resistance one-way valve (16) , a particle counter (20) and a computer (30) . Optionally, the device also contains a gas flow meter (22) . The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained.
摘要翻译：本文描述了确定颗粒产生速率的方法和装置以及针对个体生产的颗粒的尺寸范围。装置（10）包括一个接口（12），一个过滤器（14），一个低阻力单向阀（16），一个粒子计数器（20）和一个计算机（30）。可选地，该装置还包含气体流量计（22）。使用该装置获得的数据可用于确定是否应向个体施用用于减少颗粒呼气的制剂。该设备在进入洁净室之前和/或之后特别有用，以确保洁净室标准得到维护。

8. 发明申请

WO2006076265A2 METHOD AND DEVICE FOR DECREASING CONTAMINATION 审中-公开
标题翻译：减少污染的方法和装置
公开(公告)号：WO2006076265A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/000618
申请日：2006-01-10
申请人： PULMATRIX, INC. , EDWARDS, David, A. , GABRIELSON, Mark, J. , CLARKE, Robert, William , DEHAAN, Wesley, Hugh , BRANDE, Matthew, Frederick , MAN, Jonathan, Chun-Wah
发明人： EDWARDS, David, A. , GABRIELSON, Mark, J. , CLARKE, Robert, William , DEHAAN, Wesley, Hugh , BRANDE, Matthew, Frederick , MAN, Jonathan, Chun-Wah
CPC分类号： G01N33/497 , A61B5/0816 , A61B5/0878 , A61B5/097 , G01N15/0205
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as "over producers", "super-producers", or "superspreaders"). Formulations to reduce particle production are also described herein. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. When applied to mucosal lining fluids, the formulation alters the physical properties such as the gel characteristics at the air/liquid interface, surface elasticity, surface viscosity, surface tension and bulk viscoelasticity of the mucosal lining. The formulation is administered in an effective amount to minimize ambient contamination due to particle formation during breathing, coughing, sneezing, or talking, which is particularly important in cleanroom applications. In one embodiment, the formulation for administration is a non-surfactant solution. In one embodiment, the formulations are conductiv formulations containing conductive agents, such as salts, ionic surfactants, o other substances that are in an ionized state or easily ionized in an aqueous o organic solvent environment. Preferably the formulation is administered in the form of an aerosol.
摘要翻译：本文描述了确定颗粒产生速率的方法和装置以及针对个体生产的颗粒的尺寸范围。装置（10）包括一个接口（12），一个过滤器（14），一个低阻力单向阀（16），一个粒子计数器（20）和一个计算机（30）。可选地，该装置还包含气体流量计（22）。使用该装置获得的数据可用于确定是否应向个体施用用于减少颗粒呼气的制剂。该设备在进入洁净室之前和/或之后特别有用，以确保洁净室标准得到维护。该装置还可以用于鉴定具有更高呼吸气溶胶倾向的动物和人（在本文中称为“超过生产者”，“超级生产者”或“超级扩张者”）。本文还描述了减少颗粒生产的制剂。该制剂的施用量足以改变身体粘膜内衬的生物物理性质。当施用于粘膜衬里液时，制剂改变物理性质，例如在空气/液体界面处的凝胶特性，表面弹性，表面粘度，表面张力和粘膜衬里的体粘弹性。该制剂以有效的量施用以最小化由于在呼吸，咳嗽，打喷嚏或说话期间形成颗粒而造成的环境污染，这在洁净室应用中特别重要。在一个实施方案中，用于给药的制剂是非表面活性剂溶液。在一个实施方案中，制剂是含有导电剂，例如盐，离子表面活性剂，或其它物质，其处于离子化状态或容易在有机溶剂水溶液环境中电离的导电配方。优选地，制剂以气溶胶的形式施用。

9. 发明申请

WO2005084638A3 FORMULATIONS DECREASING INFECTIVITY OF PULMONARY DISEASES 审中-公开
公开(公告)号：WO2005084638A3
公开(公告)日：2005-09-15
申请号：PCT/US2005/006903
申请日：2005-03-03
申请人： PULMATRIX, INC. , EDWARDS, David, A. , MAN, Jonathan, C. , KATSTRA, Jeffrey, P. , CLARKE, Robert, W.
发明人： EDWARDS, David, A. , MAN, Jonathan, C. , KATSTRA, Jeffrey, P. , CLARKE, Robert, W.
IPC分类号： A61K47/02
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

10. 发明申请

WO2010065744A2 DELIVERING AEROSOLIZABLE FOOD PRODUCTS 审中-公开
标题翻译：提供可气溶性食品
公开(公告)号：WO2010065744A2
公开(公告)日：2010-06-10
申请号：PCT/US2009/066590
申请日：2009-12-03
申请人： LE LABOGROUP SAS , EDWARDS, David, A. , MAN, Jonathan , KAMLER, Jonathan, Jacques , SANCHEZ, Jose , BRETILLOT, Marc
发明人： EDWARDS, David, A. , MAN, Jonathan , KAMLER, Jonathan, Jacques , SANCHEZ, Jose , BRETILLOT, Marc
IPC分类号： B05B7/00 , B05B17/06
CPC分类号： A61M11/005 , A61M11/002 , A61M15/0025 , A61M15/06
摘要： Aerosolized food products in a determined particle size range are suspended in the air and deposited in the mouth without easily entering into the respiratory tract. An apparatus incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a manner suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus represents a novel means for delivering food to the mouths of humans and animals. Indeed, the apparatus of the invention is designed to produce, transport, and direct aerosolized food particles in a determined size range, suspended in air, to be deposited in the mouth without substantial exposure or entry into the respiratory tract.
摘要翻译：在确定的粒度范围内的气雾化食品悬浮在空气中并沉积在口中而不容易进入呼吸道。并入有气雾产生装置和食品的装置可以允许食物产品的气雾化以及以适于吸入或沉积和随后摄入的方式递送食物产品。食物输送装置代表了一种将食物输送到人类和动物的口腔的新型手段。实际上，本发明的设备被设计用于在确定的尺寸范围内生产，运输和引导悬浮在空气中的雾化食物颗粒，以沉积在口中而不会显着暴露或进入呼吸道。

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